Revised Definitions of Invasive Fungal Disease from the European Organization for Research and Treatment of Cancer/Invasive Fungal Infections Cooperative Group and the National Institute of Allergy and Infectious Diseases Mycoses Study Group (EORTC/MSG) Consensus Group
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BACKGROUND: Invasive fungal diseases are important causes of morbidity and mortality. Clarity and uniformity in defining these infections are important factors in improving the quality of clinical studies. A standard set of definitions strengthens the consistency and reproducibility of such studies. METHODS: After the introduction of the original European Organization for Research and Treatment of Cancer/Invasive Fungal Infections Cooperative Group and the National Institute of Allergy and Infectious Diseases Mycoses Study Group (EORTC/MSG) Consensus Group definitions, advances in diagnostic technology and the recognition of areas in need of improvement led to a revision of this document. The revision process started with a meeting of participants in 2003, to decide on the process and to draft the proposal. This was followed by several rounds of consultation until a final draft was approved in 2005. This was made available for 6 months to allow public comment, and then the manuscript was prepared and approved. RESULTS: The revised definitions retain the original classifications of "proven," "probable," and "possible" invasive fungal disease, but the definition of "probable" has been expanded, whereas the scope of the category "possible" has been diminished. The category of proven invasive fungal disease can apply to any patient, regardless of whether the patient is immunocompromised, whereas the probable and possible categories are proposed for immunocompromised patients only. CONCLUSIONS: These revised definitions of invasive fungal disease are intended to advance clinical and epidemiological research and may serve as a useful model for defining other infections in high-risk patients.
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The development of standardized diagnostic criteria for invasive aspergillosis has been a major improvement for IPA.
“The development of standardized diagnostic criteria for invasive aspergillosis has been a major improvement for IPA (94).”
From Aspergillus fumigatus and Aspergillosis in 2019 (2019) · cites this paper as [94]
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- Authors
- De Pauw, B., Walsh, T. J., Donnelly, J. P., Stevens, D. A., Edwards, J. E., Calandra, T., Pappas, P. G., Maertens, J., Lortholary, O., Kauffman, C. A., Denning, D. W., Patterson, T. F., Maschmeyer, G., Bille, J., Dismukes, W. E., Herbrecht, R., Hope, W. W., Kibbler, C. C., Kullberg, B. J., Marr, K. A., Muñoz, P., Odds, F. C., Perfect, J. R., Restrepo, A., Ruhnke, M., Segal, B. H., Sobel, J. D., Sorrell, T. C., Viscoli, C., Wingard, J. R., Zaoutis, T., & Bennett, J. E.
- Affiliations
- Radboud University Medical Center (NL)
- Corresponding author
- Donnelly, J. Peter
- ORCID
- Walsh, Thomas J.
- Donnelly, J. Peter
- Stevens, David A.
- Edwards, John E.
- Calandra, Thierry
- Pappas, Peter G.
- Maertens, Johan
- Lortholary, Olivier
- Denning, David W.
- Patterson, Thomas F.
- Maschmeyer, Georg
- Herbrecht, Raoul
- Hope, William W.
- Kullberg, Bart Jan
- Marr, Kieren A.
- Perfect, John R.
- Ruhnke, Markus
- Segal, Brahm H.
- Sobel, Jack D.
- Sorrell, Tania C.
- Wingard, John R.
- Zaoutis, Theoklis
- Bennett, John E.
- Venue
- Clinical Infectious Diseases
- Publisher
- Oxford University Press (OUP)
- Published
- 2008-06-15
- Volume
- 46
- Issue
- 12
- Pages
- 1813-1821
- ISSN
- 1058-4838 (ISSN-L)
- 1537-6591
- PMC
- PMC2671227
- OpenAlex
- W2166734004
- Cited by
- 4,917
- References
- 28
- Citations by year
- 2026: 85 · 2025: 146 · 2024: 169 · 2023: 172 · 2022: 203 · 2021: 280 · 2020: 362 · 2019: 424 · 2018: 383 · 2017: 354 · 2016: 345 · 2015: 376 · 2014: 363 · 2013: 299 · 2012: 279
- FWCI
- 140.34
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Clinical Infectious Diseases (publishedVersion)
- PubMed (publishedVersion)
- Institutional Repository University of Antioquia (University of Antioquia) (publishedVersion, cc-by-nc-nd)
- PubMed Central (acceptedVersion)
- IRIS (submittedVersion)
- UCL Discovery (University College London) (submittedVersion)
- CINECA IRIS Institutial Research Information System (University of Genoa) (submittedVersion)
- Research Explorer (The University of Manchester) (submittedVersion)
- Radboud Repository (Radboud University) (submittedVersion)
- SERVAL (Université de Lausanne) (submittedVersion, other-oa)
- Radboud Repository (Radboud University) (submittedVersion, other-oa)
- Funders
- Amgen
- Pfizer
- GlaxoSmithKline
- Sanofi
- Gilead Sciences
- Children's Hospital of Philadelphia
- Wayne State University
- University of Pennsylvania
- Wellcome Trust
- Valeant Pharmaceuticals International
- European Commission
- University of Aberdeen
- European Organisation for Research and Treatment of Cancer
- Astellas Pharma
- Centre Hospitalier Universitaire Vaudois
- Basilea Pharmaceutica
- Italfarmaco
- National Institutes of Health
- University at Buffalo
- Medical School, University of Michigan
- University of Texas Health Science Center at San Antonio
- Medical Research Council
- National Health and Medical Research Council
- National Institute of Allergy and Infectious Diseases (Z01AI000654)
- Janssen Pharmaceuticals
- UCB Pharma
- Daiichi Sankyo Europe
- Topics
- Health Sciences › Medicine › Infectious Diseases › Antifungal resistance and susceptibility
- Health Sciences › Medicine › Epidemiology › Fungal Infections and Studies
- Health Sciences › Medicine › Oncology › Neutropenia and Cancer Infections
- Keywords
- invasive fungal infections, diagnostic definitions, immunocompromised patients, clinical trial endpoints, fungal epidemiology
- MeSH terms
- Humans, Mycoses, Terminology as Topic
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