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Cited by 35Influenza Virus Research StudiesStatistical Methods in EpidemiologyStatistical Methods in Clinical Trials

The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.

Magnitude of Potential Biases in a Simulated Case-Control Study of the Effectiveness of Influenza Vaccination

Ferdinands, J. M., Shay, D. K.·2012·Clinical Infectious Diseases
DOI 10.1093/cid/cir750
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Abstract

Background Many influenza vaccine effectiveness estimates have been made using case-control methods. Although several forms of bias may distort estimates of vaccine effectiveness derived from case-control studies, there have been few attempts to quantify the magnitude of these biases. Methods We estimated the magnitude of potential biases in influenza vaccine effectiveness values derived from case-control studies from several factors, including bias from differential use of diagnostic testing based on influenza vaccine status, imperfect diagnostic test characteristics, and confounding. A decision tree model was used to simulate an influenza vaccine effectiveness case-control study in children. Using probability distributions, we varied the value of factors that influence vaccine effectiveness estimates, including diagnostic test characteristics, vaccine coverage, likelihood of receiving a diagnostic test for influenza, likelihood that a child hospitalized with acute respiratory infection had influenza, and others. Bias was measured as the difference between the effectiveness observed in the simulated case-control study and a true underlying effectiveness value. Results and conclusions We found an average difference between observed and true vaccine effectiveness of -11.9%. Observed vaccine effectiveness underestimated the true effectiveness in 88% of model iterations. Diagnostic test specificity exhibited the strongest association with observed vaccine effectiveness, followed…

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Crossref · 10.1093/cid/cir750

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  • Waning of efficacy over time has been demonstrated with other vaccines.

    “waning of efficacy over time has been demonstrated with other vaccines. 20”

    From Efficacy and Safety of the mRNA-1273 SARS-CoV-2 Vaccine (2021) · cites this paper as [20]

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Metadata

Authors
Ferdinands, J. M., & Shay, D. K.
Affiliations
Centers for Disease Control and Prevention (US)
ORCID
Venue
Clinical Infectious Diseases
Publisher
Oxford University Press (OUP)
Published
2011-11-17
Volume
54
Issue
1
Pages
25-32
ISSN
  • 1058-4838 (ISSN-L)
  • 1537-6591
DOI
10.1093/cid/cir750
OpenAlex
W2112338048
Cited by
35
References
1
Citations by year
2025: 1 · 2024: 1 · 2021: 3 · 2020: 3 · 2019: 1 · 2018: 5 · 2017: 3 · 2016: 2 · 2015: 2 · 2014: 4 · 2013: 8 · 2012: 2
FWCI
3.36
Type
journal article
Language
en
Open access
closed
Locations
  • Clinical Infectious Diseases (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Epidemiology › Influenza Virus Research Studies
  • Physical Sciences › Mathematics › Statistics and Probability › Statistical Methods in Epidemiology
  • Physical Sciences › Mathematics › Statistics and Probability › Statistical Methods in Clinical Trials
Keywords
influenza vaccine effectiveness, diagnostic specificity, confounding, children, acute respiratory infections, hospitalized children
MeSH terms
Adolescent, Antibodies, Viral, Child, Child, Preschool, Computer Simulation, Humans, Infant, Influenza, Human, Influenza Vaccines, Vaccination, Bias, Case-Control Studies

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