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Cited by 278Influenza Virus Research StudiesVaccine Coverage and HesitancyRespiratory viral infections research

Clinical effectiveness of influenza vaccination in Manitoba.

Fedson, David S.·1993·JAMA: The Journal of the American Medical Association
DOI 10.1001/jama.1993.03510160074032
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Abstract

OBJECTIVE: To assess the clinical effectiveness of influenza vaccination in preventing influenza-associated hospitalization and death. DESIGN: Case-control study. SETTING AND PATIENTS: Noninstitutionalized persons aged 45 years or older living in Manitoba, on December 1, 1982, and December 1, 1985. METHODS: Linked records of the Manitoba population registry, hospital-discharge abstracts, physician claims for ambulatory-patient visits and influenza vaccination, and vital statistics were used. A matched-set analysis estimated the clinical effectiveness of influenza vaccination in preventing hospital admissions and deaths from influenza-associated conditions during influenza A (H3N2) outbreak periods in 1982 to 1983 (12 weeks) and 1985 to 1986 (10 weeks). The analysis adjusted for hospital discharge and ambulatory care for high-risk conditions within the previous 15 months and 3 months, respectively. RESULTS: Influenza vaccination prevented 32% to 39% of hospital admissions with pneumonia and influenza and 15% to 34% of admissions with all respiratory conditions. Vaccination was 43% to 65% effective in preventing hospital deaths with these conditions (all listed diagnoses) and 27% to 30% effective in preventing deaths from all causes. CONCLUSION: Influenza vaccination has substantial clinical effectiveness in preventing hospital admission and death from influenza-associated conditions in noninstitutionalized individuals.

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Crossref · 10.1001/jama.1993.03510160074032

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  • Influenza vaccination can reduce the occurrence of bacterial pneumonia.

    “Studies have shown that influenza vaccination can reduce the occurrence of bacterial pneumonia (Fedson et al., 1993; Nichol et al., 1998).”

    From Secondary bacterial infections associated with influenza pandemics (2017) · cites this paper as Fedson et al., 1993

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Authors
Fedson, D. S.
Affiliations
University of Virginia (US)
Corresponding author
Fedson, David S.
ORCID
Fedson, David S.
Venue
JAMA: The Journal of the American Medical Association
Publisher
American Medical Association (AMA)
Published
1993-10-27
Volume
270
Issue
16
Pages
1956
ISSN
  • 0002-9955 (ISSN-L)
  • 0098-7484
DOI
10.1001/jama.1993.03510160074032
OpenAlex
W2021697429
Cited by
278
References
37
Citations by year
2023: 1 · 2022: 1 · 2019: 2 · 2018: 3 · 2017: 4 · 2016: 2 · 2015: 4 · 2014: 2 · 2013: 5 · 2012: 6
FWCI
13.92
Type
journal article
Language
en
Open access
closed
Locations
  • JAMA (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • National Institutes of Health (5r01ag009145-02)
  • National Institute on Aging (5-R01 AG 09145)
Topics
  • Health Sciences › Medicine › Epidemiology › Influenza Virus Research Studies
  • Social Sciences › Health › Vaccine Coverage and Hesitancy
  • Health Sciences › Medicine › Epidemiology › Respiratory viral infections research
Keywords
influenza vaccination, vaccine effectiveness, influenza-associated hospitalizations, influenza-associated deaths, H3N2, respiratory hospital admissions, older adults, Manitoba
MeSH terms
Aged, Disease Outbreaks, Female, Hospitalization, Humans, Influenza, Human, Influenza Vaccines, Male, Manitoba, Middle Aged, Morbidity, Influenza A virus, Risk Factors, Case-Control Studies

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