The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
Efficacy, Safety, and Tolerability of Herpes Zoster Vaccine in Persons Aged 50-59 Years
Open accessAbstract
BACKGROUND: Herpes zoster (HZ) adversely affects individuals aged 50-59, but vaccine efficacy has not been assessed in this population. This study was designed to determine the efficacy, safety, and tolerability of zoster vaccine for preventing HZ in persons aged 50-59 years. METHODS: This was a randomized, double-blind, placebo-controlled study of 22 439 subjects aged 50-59 years conducted in North America and Europe. Subjects were given 1 dose of licensed zoster vaccine (ZV) (Zostavax; Merck) and followed for occurrence of HZ for ≥1 year (mean, 1.3 years) postvaccination until accrual of ≥96 confirmed HZ cases (as determined by testing lesions swabs for varicella zoster virus DNA by polymerase chain reaction). Subjects were followed for all adverse events (AEs) from day 1 to day 42 postvaccination and for serious AEs (SAEs) through day 182 postvaccination. RESULTS: The ZV reduced the incidence of HZ (30 cases in vaccine group, 1.99/1000 person-years vs 99 cases in placebo group, 6.57/1000 person-years). Vaccine efficacy for preventing HZ was 69.8% (95% confidence interval, 54.1-80.6). AEs were reported by 72.8% of subjects in the ZV group and 41.5% in the placebo group, with the difference primarily due to higher rates of injection-site AEs and headache. The proportion of subjects reporting SAEs occurring within 42 days postvaccination (ZV, 0.6%; placebo, 0.5%) and 182 days postvaccination (ZV, 2.1%; placebo, 1.9%) was similar between groups. CONCLUSIONS: In subjects aged 50-59 years, the ZV significantly reduced the incidence of HZ and was well tolerated. CLINICAL TRIALS REGISTRATION: NCT00534248.
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Cites
A Vaccine to Prevent Herpes Zoster and Postherpetic Neuralgia in Older Adults
Oxman, M. N., Levin, M. J., Johnson, G. R., Schmader, K. E., Straus, S. E., Gelb, L. D., Arbeit, R. D., Simberkoff, M. S., Gershon, A. A., Davis, L. E., et al. (2005) · New England Journal of Medicine · doi:10.1056/nejmoa051016 · Cited by 2,412
Self-citationRecommendations for the management of herpes zoster
Dworkin, R. H., Johnson, R. W., Breuer, J., Gnann, J. W., Levin, M. J., Backonja, M., Betts, R. F., Gershon, A. A., Haanpää, M. L., McKendrick, M. W., et al. (2007) · Clinical Infectious Diseases · doi:10.1086/510206 · Cited by 869 · cited 1×
“The incidence, severity, and duration of HZ pain and PHN increase with increasing age [6–10].”
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Cited by
Efficacy of an Adjuvanted Herpes Zoster Subunit Vaccine in Older Adults
Lal, H., Cunningham, A. L., Godeaux, O., Chlibek, R., Diez-Domingo, J., Hwang, S.-J., Levin, M. J., McElhaney, J. E., Poder, A., Puig-Barberà, J., et al. (2015) · New England Journal of Medicine · doi:10.1056/nejmoa1501184 · Cited by 1,454
Self-citationRondaan, C., Furer, V., Heijstek, M. W., Agmon-Levin, N., Bijl, M., Breedveld, F. C., D’Amelio, R., Dougados, M., Kapetanovic, M. C., van Laar, J. M., et al. (2019) · RMD Open · doi:10.1136/rmdopen-2019-001035 · Cited by 154
Chlibek, R., Bayas, J. M., Collins, H., de la Pinta, M. L. R., Ledent, E., Mols, J. F., & Heineman, T. C. (2013) · Journal of Infectious Diseases · doi:10.1093/infdis/jit365 · Cited by 149
Herpes Zoster: Diagnostic, Therapeutic, and Preventive Approaches
Bader, M. S. (2013) · Postgraduate Medicine · doi:10.3810/pgm.2013.09.2703 · Cited by 90
Monslow, M. A., Elbashir, S., Sullivan, N. L., Thiriot, D. S., Ahl, P., Smith, J., Miller, E., Cook, J., Cosmi, S., Thoryk, E., et al. (2020) · Vaccine · doi:10.1016/j.vaccine.2020.06.062 · Cited by 75
Variability in the immune system: of vaccine responses and immune states
Shen-Orr, S. S., & Furman, D. (2013) · Current Opinion in Immunology · doi:10.1016/j.coi.2013.07.009 · Cited by 61
Maréchal, C., Lal, H., Poder, A., Ferguson, M., Enweonye, I., Heineman, T. C., Hervé, C., Rheault, P., Talli, J., Wauters, D., et al. (2018) · Vaccine · doi:10.1016/j.vaccine.2018.05.110 · Cited by 36
Ohfuji, S., Ito, K., Inoue, M., Ishibashi, M., Kumashiro, H., Hirota, Y., Kayano, E., & Ota, N. (2019) · BMC Infectious Diseases · doi:10.1186/s12879-019-3719-7 · Cited by 18
Picard, E., Bowdish, D. M. E., McElhaney, J. E., Pawelec, G., Loeb, M., & Verschoor, C. P. (2021) · Clinical and Experimental Immunology · doi:10.1111/cei.13593 · Cited by 3
Metadata
- Authors
- Schmader, K. E., Levin, M. J., Gnann, J. W., McNeil, S. A., Vesikari, T., Betts, R. F., Keay, S., Stek, J. E., Bundick, N. D., Su, S.-C., Zhao, Y., Li, X., Chan, I. S. F., Annunziato, P. W., & Parrino, J.
- Venue
- Clinical Infectious Diseases
- Publisher
- Oxford University Press (OUP)
- Published
- 2012-01-30
- Volume
- 54
- Issue
- 7
- Pages
- 922-928
- ISSN
- 1058-4838 (ISSN-L)
- 1537-6591
- OpenAlex
- W2149820050
- Cited by
- 430
- References
- 2
- FWCI
- 26.28
- Type
- journal article
- Language
- en
- Open access
- bronze
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