The DOI matches its Crossref record; 19 of the 19 references it cites were found in a registry or an index.
A Randomized Trial of the Efficacy of Hand Disinfection for Prevention of Rhinovirus Infection
Open accessAbstract
BACKGROUND: Hand disinfection is frequently recommended for prevention of rhinovirus (RV) infection and RV-associated common colds. The effectiveness of this intervention has not been established in a natural setting. The purpose of this study was to determine the effect of hand disinfection on RV infection and RV-associated common cold illness in a natural setting. METHODS: A controlled clinical trial was done in young adult volunteers during 9 weeks of the fall 2009 RV season. Volunteers were randomized to either an antiviral hand treatment containing 2% citric acid and 2% malic acid in 62% ethanol (n = 116) or to a no-treatment control group (n = 96). The hand treatment was applied every 3 hours while the subjects were awake. All volunteers kept a daily diary of symptoms and had a nasal lavage for polymerase chain reaction once each week and 2 additional lavages around the time of each common cold illness. The primary endpoint was the number of RV-associated illnesses. The incidence of RV infection and of common cold illnesses were evaluated as secondary endpoints. RESULTS: The hand treatment did not significantly reduce RV infection or RV-related common cold illnesses. The total number of common cold illnesses was significantly reduced in the intent-to-treat analysis, but this effect was not seen in the per protocol analysis. CONCLUSIONS: In this study, hand disinfection did not reduce RV infection or RV-related common cold illnesses. CLINICAL TRIALS REGISTRATION: NCT00993759.
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Turner 2012 compared hand sanitiser to no treatment.
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From Physical interventions to interrupt or reduce the spread of respiratory viruses (2023) · cites this paper as Turner 2012
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Community study of role of viral infections in exacerbations of asthma in 9–11 year old children
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Rhinovirus Infections in an Industrial Population
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Mechanisms of transmission of rhinovirus infections
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Proper handwashing promotes wellness in child care
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Illness Transmission in the Home: A Possible Role for Alcohol-Based Hand Gels
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Efficacy of Organic Acids in Hand Cleansers for Prevention of Rhinovirus Infections
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Self-citationEffectiveness of Hand Sanitizers with and without Organic Acids for Removal of Rhinovirus from Hands
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Self-citationVirucidal hand treatments for prevention of rhinovirus infection
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Self-citationInactivation of rhinovirus on human fingers by virucidal activity of glutaric acid
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Physical interventions to interrupt or reduce the spread of respiratory viruses
Jefferson, T., Del Mar, C. B., Dooley, L., Ferroni, E., Al-Ansary, L. A., Bawazeer, G. A., van Driel, M. L., Nair, N. S., Jones, M. A., Thorning, S., et al. (2011) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd006207.pub4 · Cited by 805
Physical interventions to interrupt or reduce the spread of respiratory viruses
Jefferson, T., Dooley, L., Ferroni, E., Al-Ansary, L. A., van Driel, M. L., Bawazeer, G. A., Jones, M. A., Hoffmann, T. C., Clark, J., Beller, E. M., et al. (2023) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd006207.pub6 · Cited by 291
Metadata
- Authors
- Turner, R. B., Fuls, J. L., Rodgers, N. D., Goldfarb, H. B., Lockhart, L. K., & Aust, L. B.
- Affiliations
- University of Virginia (US)
- Corresponding author
- Turner, R. B.
- ORCID
- Turner, R. B.
- Venue
- Clinical Infectious Diseases
- Publisher
- Oxford University Press (OUP)
- Published
- 2012-03-12
- Volume
- 54
- Issue
- 10
- Pages
- 1-5
- ISSN
- 1058-4838 (ISSN-L)
- 1537-6591
- OpenAlex
- W2160523461
- Cited by
- 35
- References
- 19
- Citations by year
- 2025: 1 · 2023: 3 · 2022: 1 · 2020: 3 · 2019: 1 · 2017: 2 · 2016: 3 · 2015: 5 · 2014: 8 · 2013: 3 · 2012: 4
- FWCI
- 4.77
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Clinical Infectious Diseases (publishedVersion)
- PubMed (publishedVersion)
- HighWire Press Open Archive (submittedVersion)
- Topics
- Health Sciences › Medicine › Epidemiology › Respiratory viral infections research
- Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Pediatric health and respiratory diseases
- Health Sciences › Medicine › Infectious Diseases › Infection Control in Healthcare
- Keywords
- hand disinfection, rhinovirus infection, common cold, citric acid, malic acid, infection control, young adults, natural settings
- MeSH terms
- Ethanol, Disinfectants, Female, Hand Disinfection, Humans, Human Experimentation, Malates, Male, Picornaviridae Infections, Rhinovirus, Infection Control, Citric Acid, Young Adult
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