The DOI matches its Crossref record; 35 of the 35 references it cites were found in a registry or an index.
The Global Enteric Multicenter Study (GEMS) of Diarrheal Disease in Infants and Young Children in Developing Countries: Epidemiologic and Clinical Methods of the Case/Control Study
Open accessAbstract
BACKGROUND: Diarrhea is a leading cause of illness and death among children aged <5 years in developing countries. This paper describes the clinical and epidemiological methods used to conduct the Global Enteric Multicenter Study (GEMS), a 3-year, prospective, age-stratified, case/control study to estimate the population-based burden, microbiologic etiology, and adverse clinical consequences of acute moderate-to-severe diarrhea (MSD) among a censused population of children aged 0-59 months seeking care at health centers in sub-Saharan Africa and South Asia. METHODS: GEMS was conducted at 7 field sites, each serving a population whose demography and healthcare utilization practices for childhood diarrhea were documented. We aimed to enroll 220 MSD cases per year from selected health centers serving each site in each of 3 age strata (0-11, 12-23, and 24-59 months), along with 1-3 matched community controls. Cases and controls supplied clinical, epidemiologic, and anthropometric data at enrollment and again approximately 60 days later, and provided enrollment stool specimens for identification and characterization of potential diarrheal pathogens. Verbal autopsy was performed if a child died. Analytic strategies will calculate the fraction of MSD attributable to each pathogen and the incidence, financial costs, nutritional consequences, and case fatality overall and by pathogen. CONCLUSIONS: When completed, GEMS will provide estimates of the incidence, etiology, and outcomes of MSD among infants and young children in sub-Saharan Africa and South Asia. This information can guide development and implementation of public health interventions to diminish morbidity and mortality from diarrheal diseases.
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Cites
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Diarrhoea: why children are still dying and what can be done
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Estimating the causes of 4 million neonatal deaths in the year 2000
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The 2023 WHO World malaria report
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Cited by
Roth, G. A., Abate, D., Abate, K. H., Abay, S. M., Abbafati, C., Abbasi, N., Abbastabar, H., Abd-Allah, F., Abdela, J., Abdelalim, A., et al. (2018) · The Lancet · doi:10.1016/s0140-6736(18)32203-7 · Cited by 8,600
Kotloff, K. L., Nataro, J. P., Blackwelder, W. C., Nasrin, D., Farag, T. H., Panchalingam, S., Wu, Y., Sow, S. O., Sur, D., Breiman, R. F., et al. (2013) · The Lancet · doi:10.1016/s0140-6736(13)60844-2 · Cited by 3,560
Self-citationThe Burden and Etiology of Diarrheal Illness in Developing Countries.
Kotloff, K. L. (2017) · Pediatric Clinics of North America · doi:10.1016/j.pcl.2017.03.006 · Cited by 270
Self-citationKotloff, K. L., Nasrin, D., Blackwelder, W. C., Wu, Y., Farag, T., Panchalingham, S., Sow, S. O., Sur, D., Zaidi, A. K. M., Faruque, A. S. G., et al. (2019) · The Lancet Global Health · doi:10.1016/s2214-109x(19)30076-2 · Cited by 258
Self-citationFletcher, S. M., McLaws, M.-L., & Ellis, J. T. (2013) · Journal of Public Health Research · doi:10.4081/jphr.2013.e9 · Cited by 172
Metadata
- Authors
- Kotloff, K. L., Blackwelder, W. C., Nasrin, D., Nataro, J. P., Farag, T. H., van Eijk, A., Adegbola, R. A., Alonso, P. L., Breiman, R. F., Golam Faruque, A. S., Saha, D., Sow, S. O., Sur, D., Zaidi, A. K. M., Biswas, K., Panchalingam, S., Clemens, J. D., Cohen, D., Glass, R. I., Mintz, E. D., Sommerfelt, H., & Levine, M. M.
- Venue
- Clinical Infectious Diseases
- Publisher
- Oxford University Press (OUP)
- Published
- 2012-12-15
- Volume
- 55
- Issue
- suppl_4
- Pages
- S232-S245
- ISSN
- 1058-4838 (ISSN-L)
- 1537-6591
- OpenAlex
- W2171475272
- Cited by
- 373
- References
- 35
- FWCI
- 13.15
- Type
- journal article
- Language
- en
- Open access
- hybrid
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- The paper
- Kotloff, K. L., Blackwelder, W. C., Nasrin, D., Nataro, J. P., Farag, T. H., van Eijk, A., Adegbola, R. A., Alonso, P. L., Breiman, R. F., Golam Faruque, A. S., Saha, D., Sow, S. O., Sur, D., Zaidi, A. K. M., Biswas, K., Panchalingam, S., Clemens, J. D., Cohen, D., Glass, R. I., . . . Levine, M. M. (2012). The Global Enteric Multicenter Study (GEMS) of Diarrheal Disease in Infants and Young Children in Developing Countries: Epidemiologic and Clinical Methods of the Case/Control Study. Clinical Infectious Diseases. https://doi.org/10.1093/cid/cis753
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
