Cited by 69Syphilis Diagnosis and TreatmentHistorical Medical Research and TreatmentsVector-borne infectious diseases

Response to therapy following retreatment of serofast early syphilis patients with benzathine penicillin.

Open access
Sena, A. C., Wolff, M., Behets, F., Van Damme, K., Martin, D. H., Leone, P., McNeil, L., Hook, E. W.·2013·Clinical Infectious Diseases

Abstract

Persistent nontreponemal titers after treatment are common among patients with early syphilis. We retreated 82 human immunodeficiency virus-negative early syphilis participants who were serofast at 6 months using benzathine penicillin. Only 27% exhibited serological response after retreatment and after an additional 6 months of follow-up.

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Crossref · 10.1093/cid/cis918

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  • Serologic titers might not decrease despite a negative CSF examination and a repeated 3-week therapy course.

    “Serologic titers might not decrease, despite a negative CSF examination and a repeated 3-week therapy course (599).”

    From Sexually Transmitted Infections Treatment Guidelines, 2021 (2021) · cites this paper as [599]

    The Discussion reports that 73% of patients remained serofast after retreatment, supporting the possibility that titers may not fall. But the Methods specify a single retreatment dose, and the brief report (p. 421) says the investigators did not perform CSF examinations at the 12-month visit; it mentions a three-week course only as recommended therapy, not as the course studied. The paper therefore does not establish the claim under the stated negative-CSF and three-week-treatment conditions. (LLM, conf=0.90)

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Authors
Sena, A. C., Wolff, M., Behets, F., Van Damme, K., Martin, D. H., Leone, P., McNeil, L., & Hook, E. W.
Affiliations
  • Emmes (United States) (US)
  • University of North Carolina at Chapel Hill (US)
  • Louisiana State University (US)
  • Family Health International 360 (US)
  • University of Alabama at Birmingham (US)
Venue
Clinical Infectious Diseases
Published
2012-11-01
Volume
56
Issue
3
Pages
420-422
ISSN
  • 1058-4838 (ISSN-L)
  • 1537-6591
OpenAlex
W2151862494
Cited by
69
References
8
Citations by year
2026: 6 · 2025: 5 · 2024: 5 · 2023: 7 · 2022: 3 · 2021: 5 · 2020: 12 · 2019: 3 · 2018: 4 · 2017: 1 · 2016: 2 · 2015: 8 · 2014: 5 · 2013: 2
FWCI
3.22
Type
journal article
Language
en
Open access
Locations
  • Clinical Infectious Diseases (publishedVersion)
  • Europe PMC (PubMed Central) (publishedVersion)
  • PubMed Central (publishedVersion)
  • PubMed (publishedVersion)
  • Carolina Digital Repository (University of North Carolina at Chapel Hill) (submittedVersion)
  • UNC Libraries
Funders
  • GlaxoSmithKline
  • Louisiana State University
  • U.S. Public Health Service (N01 A1 75329)
  • University of North Carolina at Chapel Hill
  • School of Medicine, Indiana University
  • Abbott Diagnostics
  • National Institute of Allergy and Infectious Diseases
Topics
  • Health Sciences › Medicine › Physiology › Syphilis Diagnosis and Treatment
  • Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Historical Medical Research and Treatments
  • Life Sciences › Immunology and Microbiology › Parasitology › Vector-borne infectious diseases
Keywords
early syphilis, benzathine penicillin, retreatment, serological response, treatment response
MeSH terms
Adolescent, Adult, Anti-Bacterial Agents, Female, Humans, Male, Middle Aged, Penicillin G Benzathine, Syphilis, Syphilis Serodiagnosis, Time Factors, Treatment Outcome, Retreatment, Young Adult

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