CoChat
Sign Up
Cited by 208HIV Research and TreatmentInfectious Diseases and TuberculosisHIV/AIDS drug development and treatment

Assessment, diagnosis, and treatment of HIV-associated neurocognitive disorder:A consensus report of the mind exchange program

Open access
The Mind Exchange Working Group, Antinori, A., Arendt, G., Grant, I., Letendre, S., Chair, Munoz-Moreno, J. A., Eggers, C. +59 more·2013·Clinical Infectious Diseases
DOI 10.1093/cid/cis975PMC PMC3657494
Open this paper in CoChat — free account

Abstract

Many practical clinical questions regarding the management of human immunodeficiency virus (HIV)-associated neurocognitive disorder (HAND) remain unanswered. We sought to identify and develop practical answers to key clinical questions in HAND management. Sixty-six specialists from 30 countries provided input into the program, which was overseen by a steering committee. Fourteen questions were rated as being of greatest clinical importance. Answers were drafted by an expert group based on a comprehensive literature review. Sixty-three experts convened to determine consensus and level of evidence for the answers. Consensus was reached on all answers. For instance, good practice suggests that all HIV patients should be screened for HAND early in disease using standardized tools. Follow-up frequency depends on whether HAND is already present or whether clinical data suggest risk for developing HAND. Worsening neurocognitive impairment may trigger consideration of antiretroviral modification when other causes have been excluded. The Mind Exchange program provides practical guidance in the diagnosis, monitoring, and treatment of HAND.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Integrity signals

Registry

Crossref · 10.1093/cid/cis975

Cites

111 of 111 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

  • Risk factors commonly associated with HAD include female sex, being elderly, higher HIV viral titers, lower socioeconomic group, substance abuse, and iron-deficiency anemia.

    “Risk factors commonly associated with HAD are female sex, being elderly, higher HIV viral titers, lower socioeconomic group, substance abuse, and iron-deficiency anemia.[7]”

    From Management of psychiatric disorders with HIV and dermatological disorders (2022) · cites this paper as [7]

    The Results risk-factor table lists high HIV RNA, older age, poverty, illicit drug or alcohol abuse, anemia, and female sex in some countries where it is associated with lower socioeconomic status. But the table addresses HAND and/or non-HIV-related neurocognitive impairment, not HAD specifically; it also does not identify the anemia as iron-deficiency anemia or present female sex as an unqualified risk factor. (LLM, conf=0.88)

    Experimental — accuracy not yet measured

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Cites

Flagged first, then by citations

Research works printed but not linked: 8

  1. [12]European AIDS Clinical Society. Guidelines on neurocognitive impairment: diagnosis and management, Version 6. :48–9. October 2011 Available at http://www.europeanaidsclinicalsociety.org/images/stories/EACS-Pdf/EACSguidelines-v6.0-English.pdf. Accessed 25 June 2012. [Google Scholar]
  2. [13]National Institute for Health and Clinical Excellence. Donor breast milk banks: the operation of donor breast milk bank services. Available at http://www.nice.org.uk/guidance/CG93. Accessed 6 August 2011. [PubMed] [Google Scholar]
  3. [29]Sacktor NC, Wong M, Nakasujja N, et al. The International HIV Dementia Scale: a new rapid screening test for HIV dementia. AIDS. 2005;19:1367–74. [PubMed] [Google Scholar]
  4. [62]Pan Y, Dore G, van der Bij A, Kaldor J, Brew B. Prognosis of AIDS dementia complex (ADC) and predictors of post-ADC survival. Australasian Society of HIV Medicine 12th Annual Conference, Melbourne, Australia, October 2000 Abstract 61. [Google Scholar]
  5. [65]Navia B, Harezlak J, Schifitto G, et al. A longitudinal study of neurological injury in HIV-infected subjects on stable ART: the HIV Neuroimaging Consortium Cohort Study. 18th Conference on Retroviruses and Opportunistic Infections, Boston, MA, 27 February–2 March 2011. Abstract 56. [Google Scholar]
  6. [87]McClernon D, Letendre S, Benjamin R, et al. Low-level HIV-1 viral load monitoring in cerebral spinal fluid: possible correlation to antiviral drug penetration. 2007 EACS poster: P6.11/101 Available at: http://www.abstractserver.com/eacs2007/oaa/documents/P6.11-01_1.pdf. Accessed 25 June 2012. [Google Scholar]
  7. [88]Letendre S, McClernon D, Ellis RJ, et al. Persistent HIV in the central nervous system during treatment is associated with worse antiretroviral therapy penetration and cognitive impairment. 2009 16th Conference on Retroviruses and Opportunistic Infections, Montreal, Canada, 8–11 February Poster 484b. [Google Scholar]
  8. [99]Hoffman C, Rockstroh J, Kamps BS. HIV medicine. 15th ed. 2007. Paris, Cagliari, Wuppertal: Flying Publisher Available at: http://hivmedicine.com/textbook/download.htm. Accessed 25 June 2012. [Google Scholar]

Cited by

Sorted by citations

Related

Authors
The Mind Exchange Working Group, Antinori, A., Arendt, G., Grant, I., Letendre, S., Chair, Munoz-Moreno, J. A., Eggers, C., Brew, B., Brouillette, M.-J., Bernal-Cano, F., Carvalhal, A., Christo, P. P., Cinque, P., Cysique, L., Ellis, R., Everall, I., Gasnault, J., Husstedt, I., Korten, V., Machala, L., Obermann, M., Ouakinin, S., Podzamczer, D., Portegies, P., Rackstraw, S., Rourke, S., Sherr, L., Streinu-Cercel, A., Winston, A., Wojna, V., Yazdanpannah, Y., Arbess, G., Baril, J.-G., Begovac, J., Bergin, C., Bonfanti, P., Bonora, S., Brinkman, K., Canestri, A., Cholewinska-Szymanska, G., Chowers, M., Cooney, J., Corti, M., Doherty, C., Elbirt, D., Esser, S., Florence, E., Force, G., Gill, J., Goffard, J.-C., Harrer, T., Li, P., de Kerckhove, L. V., Knecht, G., Matsushita, S., Matulionyte, R., McConkey, S., Mouglignier, A., Oka, S., Penalva, A., Riesenberg, K., Sambatakou, H., Tozzi, V., Vassallo, M., Wetterberg, P., & Drapato, A. W.
Affiliations
  • Heinrich Heine University Düsseldorf (DE)
  • University of California San Diego (US)
  • Universitat Autònoma de Barcelona (ES)
Corresponding author
  • Cinque, P.
  • Cysique, L.
  • Korten, V.
  • Obermann, M.
  • Ouakinin, S.
  • Portegies, P.
  • Rackstraw, S.
  • Rourke, S.
  • Bonfanti, P.
  • Corti, M.
  • Doherty, C.
  • Elbirt, D.
  • Esser, S.
  • Goffard, J.-C.
  • Knecht, G.
  • Matsushita, S.
  • Mouglignier, A.
ORCID
Venue
Clinical Infectious Diseases
Publisher
Oxford University Press (OUP)
Published
2012-11-21
Volume
56
Issue
7
Pages
1004-1017
ISSN
  • 1058-4838 (ISSN-L)
  • 1537-6591
DOI
10.1093/cid/cis975
PMC
PMC3657494
OpenAlex
W2056277253
Cited by
208
References
111
Citations by year
2026: 3 · 2025: 6 · 2024: 9 · 2023: 14 · 2022: 14 · 2021: 16 · 2020: 19 · 2019: 21 · 2018: 16 · 2017: 18 · 2016: 15 · 2015: 18 · 2014: 25 · 2013: 14
FWCI
8.15
Type
journal article
Language
en
Open access
Locations
  • Clinical Infectious Diseases (publishedVersion)
  • Europe PMC (PubMed Central) (publishedVersion)
  • PubMed Central (publishedVersion)
  • PubMed (publishedVersion)
  • Data Archiving and Networked Services (DANS) (submittedVersion)
  • BOA (University of Milano-Bicocca) (submittedVersion)
  • Institutional Research Information System University of Turin (University of Turin) (submittedVersion)
  • Pure Amsterdam UMC (submittedVersion)
  • Repositorio Institucional (Pontificia Universidad Javeriana) (submittedVersion, cc-by-nc)
Funders
National Institute of Neurological Disorders and Stroke (S11NS046278, U54NS043011)
Topics
  • Life Sciences › Immunology and Microbiology › Virology › HIV Research and Treatment
  • Health Sciences › Medicine › Surgery › Infectious Diseases and Tuberculosis
  • Health Sciences › Medicine › Infectious Diseases › HIV/AIDS drug development and treatment
Keywords
HIV-associated neurocognitive disorders, HIV
MeSH terms
Humans, AIDS Dementia Complex, HIV Infections, Drug Monitoring, Practice Guidelines as Topic, Antiretroviral Therapy, Highly Active, Anti-Retroviral Agents

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review