The DOI matches its Crossref record; 61 of the 61 references it cites were found in a registry or an index.
Lower Pill Burden and Once-Daily Antiretroviral Treatment Regimens for HIV Infection: A Meta-Analysis of Randomized Controlled Trials
Open accessAbstract
BACKGROUND: Contemporary antiretroviral treatment regimens are simpler than in the past, with lower pill burden and once-daily dosing frequency common. We performed a meta-analysis of randomized controlled trials (RCTs) to investigate the impact of pill burden and once-daily vs twice-daily dosing on ART adherence and virological outcomes. METHODS: A literature search of 4 electronic databases through 31 March 2013 was used. RCTs comparing once-daily vs twice-daily ART regimens that also reported on adherence and virological suppression were included. Study design, study population characteristics, intervention, outcome measures, and study quality were extracted. Study quality was rated using the Cochrane risk-of-bias tool. RESULTS: Nineteen studies met our inclusion criteria (N = 6312 adult patients). Higher pill burden was associated with both lower adherence rates (P = .004) and worse virological suppression (P < .0001) in both once-daily and twice-daily subgroups, although the association with adherence in the once-daily subgroup was not statistically significant. The average adherence was modestly higher in once-daily regimens than twice-daily regimens (weighted mean difference = 2.55%; 95% confidence interval [CI], 1.23 to 3.87; P = .0002). Patients on once-daily regimens did not achieve virological suppression more frequently than patients on twice-daily regimens (relative risk [RR] = 1.01; 95% CI, 0.99 to 1.03; P = .50). Both adherence and viral load suppression decreased over time, but adherence decreased less with once-daily dosing than with twice-daily dosing. CONCLUSIONS: Lower pill burden was associated with both better adherence and virological suppression. Adherence, but not virological suppression, was slightly better with once- vs twice-daily regimens.
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Cited by
Uthman, O. A., Magidson, J. F., Safren, S. A., & Nachega, J. B. (2014) · Current HIV/AIDS Reports · doi:10.1007/s11904-014-0220-1 · Cited by 466
Self-citationDevelopment of an oral once-weekly drug delivery system for HIV antiretroviral therapy
Kirtane, A. R., Abouzid, O., Minahan, D., Bensel, T., Hill, A. L., Selinger, C., Bershteyn, A., Craig, M., Mo, S. S., Mazdiyasni, H., et al. (2018) · Nature Communications · doi:10.1038/s41467-017-02294-6 · Cited by 227
Nachega, J. B., Uthman, O. A., Peltzer, K., Richardson, L. A., Mills, E. J., Amekudzi, K., & Ouédraogo, A. (2015) · Bulletin of the World Health Organization · doi:10.2471/blt.14.138149 · Cited by 125
Self-citationAdherence and HIV RNA Suppression in the Current Era of Highly Active Antiretroviral Therapy
Viswanathan, S., Justice, A. C., Alexander, G. C., Brown, T. T., Gandhi, N. R., McNicholl, I. R., Rimland, D., Rodriguez-Barradas, M. C., & Jacobson, L. P. (2015) · JAIDS Journal of Acquired Immune Deficiency Syndromes · doi:10.1097/qai.0000000000000643 · Cited by 98
Park, D. Y., Goering, E. M., Head, K. J., & Bartlett Ellis, R. J. (2017) · JMIR Formative Research · doi:10.2196/formative.8027 · Cited by 24
Metadata
- Authors
- Nachega, J. B., Parienti, J.-J., Uthman, O. A., Gross, R., Dowdy, D. W., Sax, P. E., Gallant, J. E., Mugavero, M. J., Mills, E. J., & Giordano, T. P.
- Venue
- Clinical Infectious Diseases
- Publisher
- Oxford University Press (OUP)
- Published
- 2014-01-22
- Volume
- 58
- Issue
- 9
- Pages
- 1297-1307
- ISSN
- 1058-4838 (ISSN-L)
- 1537-6591
- OpenAlex
- W2121737909
- Cited by
- 357
- References
- 61
- FWCI
- 7.96
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Nachega, J. B., Parienti, J.-J., Uthman, O. A., Gross, R., Dowdy, D. W., Sax, P. E., Gallant, J. E., Mugavero, M. J., Mills, E. J., & Giordano, T. P. (2014). Lower Pill Burden and Once-Daily Antiretroviral Treatment Regimens for HIV Infection: A Meta-Analysis of Randomized Controlled Trials. Clinical Infectious Diseases. https://doi.org/10.1093/cid/ciu046
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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