Development of an oral once-weekly drug delivery system for HIV antiretroviral therapy
Open accessAbstract
The efficacy of antiretroviral therapy is significantly compromised by medication non-adherence. Long-acting enteral systems that can ease the burden of daily adherence have not yet been developed. Here we describe an oral dosage form composed of distinct drug–polymer matrices which achieved week-long systemic drug levels of the antiretrovirals dolutegravir, rilpivirine and cabotegravir in a pig. Simulations of viral dynamics and patient adherence patterns indicate that such systems would significantly reduce therapeutic failures and epidemiological modelling suggests that using such an intervention prophylactically could avert hundreds of thousands of new HIV cases. In sum, weekly administration of long-acting antiretrovirals via a novel oral dosage form is a promising intervention to help control the HIV epidemic worldwide.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
The authors have developed an orally administered gastric retentive dosage form that can reduce dosing frequency from daily to weekly.
“we have developed an orally administered gastric retentive dosage form that can reduce dosing frequency from daily to weekly 98 .”
From Nanotechnology approaches for global infectious diseases (2021) · cites this paper as [98]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
Palella, F. J., Delaney, K. M., Moorman, A. C., Loveless, M. O., Fuhrer, J., Satten, G. A., Aschman, D. J., & Holmberg, S. D. (1998) · New England Journal of Medicine · doi:10.1056/nejm199803263381301 · Cited by 9,393 · see citing works
Preexposure chemoprophylaxis for HIV prevention in men who have sex with men.
Grant, R. M., Lama, J. R., Anderson, P. L., McMahan, V., Liu, A. Y., Vargas, L., Goicochea, P., Casapía, M., Guanira-Carranza, J. V., Ramirez-Cardich, M. E., et al. (2010) · New England Journal of Medicine · doi:10.1056/nejmoa1011205 · Cited by 5,096 · see citing works
Abdool Karim, Q., Abdool Karim, S. S., Frohlich, J. A., Grobler, A. C., Baxter, C., Mansoor, L. E., Kharsany, A. B. M., Sibeko, S., Mlisana, K. P., Omar, Z., et al. (2010) · Science · doi:10.1126/science.1193748 · Cited by 2,435 · see citing works
Preexposure Prophylaxis for HIV Infection among African Women
Damme, L. V., Corneli, A. L., Ahmed, K., Agot, K. E., Lombaard, J. J., Kapiga, S., Malahleha, M., Owino, F., Manongi, R. N., Onyango, J., et al. (2012) · New England Journal of Medicine · doi:10.1056/nejmoa1202614 · Cited by 1,605 · see citing works
Samji, H., Cescon, A., Hogg, R. S., Modur, S. P., Althoff, K. N., Buchacz, K. A., Burchell, A. N., Cohen, M. H., Gebo, K. A., Gill, M. J., et al. (2013) · PLoS ONE · doi:10.1371/journal.pone.0081355 · Cited by 1,420 · see citing works
Tenofovir-based preexposure prophylaxis for HIV infection among African women.
Marrazzo, J. M., Ramjee, G., Richardson, B. A., Gomez, K., Mgodi, N., Nair, G., Palanee, T., Nakabiito, C., van der Straten, A., Noguchi, L., et al. (2015) · New England Journal of Medicine · doi:10.1056/nejmoa1402269 · Cited by 1,296 · see citing works
Effectiveness and safety of oral HIV preexposure prophylaxis for all populations
Fonner, V. A., Dalglish, S. L., Kennedy, C. E., Baggaley, R. C., O’Reilly, K., Koechlin, F. M., Rodolph, M., Hodges-Mameletzis, I., & Grant, R. M. (2016) · AIDS · doi:10.1097/qad.0000000000001145 · Cited by 991 · see citing works
Non-adherence to highly active antiretroviral therapy predicts progression to AIDS
Bangsberg, D. R., Perry, S., Charlebois, E. D., Clark, R. A. F., Roberston, M., Zolopa, A. R., & Moss, A. R. (2001) · AIDS · doi:10.1097/00002030-200106150-00015 · Cited by 960 · see citing works
Adherence to Antiretroviral Therapy in Sub-Saharan Africa and North America: A Meta-analysis
Mills, E. J., Nachega, J. B., Buchan, I., Orbinski, J., Attaran, A., Singh, S., Rachlis, B., Wu, P., Cooper, C., Thabane, L., et al. (2006) · JAMA · doi:10.1001/jama.296.6.679 · Cited by 899 · see citing works
Use of a vaginal ring containing dapivirine for HIV-1 prevention in women.
Baeten, J. M., Palanee-Phillips, T., Brown, E. R., Schwartz, K., Soto-Torres, L. E., Govender, V., Mgodi, N. M., Matovu Kiweewa, F., Nair, G., Mhlanga, F., et al. (2016) · New England Journal of Medicine · doi:10.1056/nejmoa1506110 · Cited by 772 · see citing works
Factors Affecting Adherence to Antiretroviral Therapy
Chesney, M. A. (2000) · Clinical Infectious Diseases · doi:10.1086/313849 · Cited by 703 · see citing works
The Pig as a Model for Human Nutrition
Miller, E. R., & Ullrey, D. E. (1987) · Annual Review of Nutrition · doi:10.1146/annurev.nu.07.070187.002045 · Cited by 638 · see citing works
Oral Delivery of Peptide Drugs
Hamman, J. H., Enslin, G. M., & Kotz, A. F. (2005) · BioDrugs · doi:10.2165/00063030-200519030-00003 · Cited by 504 · see citing works
Eaton, J. W., Johnson, L. F., Salomon, J. A., Bärnighausen, T., Bendavid, E., Bershteyn, A., Bloom, D. E., Cambiano, V., Fraser, C., Hontelez, J. A. C., et al. (2012) · PLoS Medicine · doi:10.1371/journal.pmed.1001245 · Cited by 395 · see citing works
Self-citationUse of a Vaginal Ring Containing Dapivirine for HIV-1 Prevention in Women
Baeten, J. M., Palanee‐Phillips, T., Brown, E. R., Schwartz, K. D., Soto-Torres, L. E., Govender, V., Mgodi, N. M., Kiweewa, F. M., Nair, G., Mhlanga, F., et al. (2016) · Obstetrical & Gynecological Survey · doi:10.1097/01.ogx.0000489577.60775.40 · Cited by 373 · see citing works
Nachega, J. B., Parienti, J., Uthman, O. A., Gross, R., Dowdy, D. W., Sax, P. E., Gallant, J. E., Mugavero, M. J., Mills, E. J., & Giordano, T. P. (2014) · Clinical Infectious Diseases · doi:10.1093/cid/ciu046 · Cited by 357 · see citing works
Donnell, D. J., Baeten, J. M., Bumpus, N. N., Brantley, J., Bangsberg, D. R., Haberer, J. E., Mujugira, A., Mugo, N., Ndase, P., Hendrix, C. W., et al. (2014) · JAIDS Journal of Acquired Immune Deficiency Syndromes · doi:10.1097/qai.0000000000000172 · Cited by 356 · see citing works
A pH-responsive supramolecular polymer gel as an enteric elastomer for use in gastric devices
Zhang, S., Bellinger, A. M., Glettig, D. L., Barman, R. A., Lee, Y. L., Zhu, J., Cleveland, C., Montgomery, V. A., Gu, L., Nash, L. D., et al. (2015) · Nature Materials · doi:10.1038/nmat4355 · Cited by 328 · see citing works
Self-citationBangsberg, D. R., Acosta, E. P., Gupta, R., Guzman, D., Riley, E. D., Harrigan, P. R., Parkin, N. T., & Deeks, S. G. (2006) · AIDS · doi:10.1097/01.aids.0000199825.34241.49 · Cited by 312 · see citing works
Lima, V. D., Harrigan, R., Bangsberg, D. R., Hogg, R. S., Gross, R., Yip, B., & Montaner, J. S. G. (2009) · JAIDS Journal of Acquired Immune Deficiency Syndromes · doi:10.1097/qai.0b013e31819675e9 · Cited by 304 · see citing works
Unraveling the divergent results of pre-exposure prophylaxis trials for HIV prevention
van der Straten, A., Damme, L. V., Haberer, J. E., & Bangsberg, D. R. (2012) · AIDS · doi:10.1097/qad.0b013e3283522272 · Cited by 297 · see citing works
Oral, ultra–long-lasting drug delivery: Application toward malaria elimination goals
Bellinger, A. M., Jafari, M., Grant, T. M., Zhang, S., Slater, H., Wenger, E. A., Mo, S., Lee, Y. L., Mazdiyasni, H., Kogan, L., et al. (2016) · Science Translational Medicine · doi:10.1126/scitranslmed.aag2374 · Cited by 263 · see citing works
Self-citationLong-acting injectable antiretrovirals for HIV treatment and prevention
Spreen, W. R., Margolis, D. A., & Pottage, J. C. (2013) · Current Opinion in HIV and AIDS · doi:10.1097/coh.0000000000000002 · Cited by 247 · see citing works
Polyanhydrides. I. Preparation of high molecular weight polyanhydrides
Domb, A. J., & Langer, R. (1987) · Journal of Polymer Science Part A Polymer Chemistry · doi:10.1002/pola.1987.080251217 · Cited by 235 · see citing works
Self-citationBaert, L., Klooster, G. A. E. V. '., Dries, W., François, M., Wouters, A., Basstanie, E. D., Iterbeke, K., Stappers, F., Stevens, P., Schueller, L., et al. (2009) · European Journal of Pharmaceutics and Biopharmaceutics · doi:10.1016/j.ejpb.2009.03.006 · Cited by 224 · see citing works
Effect of adherence to newly initiated antiretroviral therapy on plasma viral load
Gross, R. A., Bilker, W. B., Friedman, H. M., & Strom, B. L. (2001) · AIDS · doi:10.1097/00002030-200111090-00006 · Cited by 215 · see citing works
The effect of density on the gastric emptying of single- and multiple-unit dosage forms
Davis, S. S., Stockwell, A. F., Taylor, M. J., Hardy, J. G., WHALLEY, D. R., WILSON, C. G., Bechgaard, H., & Christensen, F. N. (1986) · Pharmaceutical Research · doi:10.1023/a:1016334629169 · Cited by 210 · see citing works
Margolis, D. A., Brinson, C. C., Smith, G. H. R., de Vente, J., Hagins, D. P., Eron, J. J., Griffith, S. K., Clair, M. H. S., Stevens, M. C., Williams, P. E., et al. (2015) · The Lancet Infectious Diseases · doi:10.1016/s1473-3099(15)00152-8 · Cited by 204 · see citing works
Granich, R., Crowley, S., Vitória, M., Smyth, C., Kahn, J. G., Bennett, R., Lo, Y.-R. J., Souteyrand, Y., & Williams, B. G. (2010) · Current Opinion in HIV and AIDS · doi:10.1097/coh.0b013e32833a6c32 · Cited by 200 · see citing works
Merten, S., Kenter, E., Mckenzie, O., Musheke, M., Ntalasha, H., & Martin‐Hilber, A. (2010) · Tropical Medicine & International Health · doi:10.1111/j.1365-3156.2010.02510.x · Cited by 192 · see citing works
Antiretroviral dynamics determines HIV evolution and predicts therapy outcome
Rosenbloom, D. I. S., Hill, A. L., Rabi, S. A., Siliciano, R. F., & Nowak, M. A. (2012) · Nature Medicine · doi:10.1038/nm.2892 · Cited by 188 · see citing works
Self-citationMucoadhesive nanomedicines: characterization and modulation of mucoadhesion at the nanoscale
das Neves, J., Bahia, M. F., Amiji, M. M., & Sarmento, B. F. C. C. (2011) · Expert Opinion on Drug Delivery · doi:10.1517/17425247.2011.586334 · Cited by 154 · see citing works
Spreen, W. R., Ford, S. L., Chen, S., Wilfret, D. A., Margolis, D. M., Gould, E. P., & Piscitelli, S. C. (2014) · JAIDS Journal of Acquired Immune Deficiency Syndromes · doi:10.1097/qai.0000000000000301 · Cited by 146 · see citing works
Innovative strategies for the oral delivery of drugs and peptides
Fasano, A. (1998) · Trends in biotechnology · doi:10.1016/s0167-7799(97)01170-0 · Cited by 133 · see citing works
Spreen, W. R., Williams, P. E., Margolis, D. M., Ford, S. L., Crauwels, H. M., Lou, Y., Gould, E. P., Stevens, M., & Piscitelli, S. C. (2014) · JAIDS Journal of Acquired Immune Deficiency Syndromes · doi:10.1097/qai.0000000000000365 · Cited by 112 · see citing works
The promise and pitfalls of long-acting injectable agents for HIV prevention
Landovitz, R. J., Kofron, R., & McCauley, M. (2016) · Current Opinion in HIV and AIDS · doi:10.1097/coh.0000000000000219 · Cited by 110 · see citing works
Jackson, A., Else, L., Mesquita, P. M. M., Egan, D., Back, D. J., Karolia, Z., Ringner-Nackter, L., Higgs, C., Herold, B. C., Gazzard, B., et al. (2014) · Clinical Pharmacology & Therapeutics · doi:10.1038/clpt.2014.118 · Cited by 106 · see citing works
Patterns of antiretroviral therapy adherence and impact on HIV RNA among patients in North America
Genberg, B. L., Wilson, I. B., Bangsberg, D. R., Arnsten, J. H., Goggin, K., Remien, R. H., Simoni, J. M., Gross, R., Reynolds, N. R., Rosen, M. I., et al. (2012) · AIDS · doi:10.1097/qad.0b013e328354bed6 · Cited by 105 · see citing works
Bekker, L., Rebe, K. B., Venter, F., Maartens, G., Moorhouse, M. A., Conradie, F., Wallis, C. L., Black, V., Harley, B., & Eakle, R. (2016) · Southern African Journal of HIV Medicine · doi:10.4102/sajhivmed.v17i1.455 · Cited by 105 · see citing works
Andrews, C. D., Yueh, Y. L., Spreen, W. R., Bernard, L. S., Boente-Carrera, M., Rodriguez, K., Gettie, A., Russell‐Lodrigue, K., Blanchard, J., Ford, S. L., et al. (2015) · Science Translational Medicine · doi:10.1126/scitranslmed.3010298 · Cited by 95 · see citing works
Pharmacokinetics of Metformin Gastric‐Retentive Tablets in Healthy Volunteers
Gusler, G., Gorsline, J., Levy, G., Zhang, S. Z., Weston, I. E., Naret, D. G., & Berner, B. (2001) · The Journal of Clinical Pharmacology · doi:10.1177/00912700122010546 · Cited by 90 · see citing works
Long-acting antiviral agents for HIV treatment
Margolis, D. A., & Boffito, M. (2015) · Current Opinion in HIV and AIDS · doi:10.1097/coh.0000000000000169 · Cited by 83 · see citing works
Kishimoto, H., & Maehara, M. (2015) · Archives of Osteoporosis · doi:10.1007/s11657-015-0231-6 · Cited by 80 · see citing works
Adherence to Antiretroviral Medications for HIV Pre-Exposure Prophylaxis
Koenig, L. J., Lyles, C. M., & Smith, D. K. (2012) · American Journal of Preventive Medicine · doi:10.1016/j.amepre.2012.09.047 · Cited by 79 · see citing works
McGowan, I., Dezzutti, C. S., Siegel, A., Engstrom, J. C., Nikiforov, A., Duffill, K., Shetler, C., Richardson‐Harman, N., Abebe, K. Z., Back, D. J., et al. (2016) · The Lancet HIV · doi:10.1016/s2352-3018(16)30113-8 · Cited by 79 · see citing works
Buscher, A. L., Hartman, C. M., Kallen, M. A., & Giordano, T. P. (2012) · International Journal of STD & AIDS · doi:10.1258/ijsa.2011.011292 · Cited by 78 · see citing works
Radzio, J., Spreen, W. R., Yueh, Y. L., Mitchell, J. M., Jenkins, L. T., Garcia-Lerma, J. G., & Heneine, W. (2015) · Science Translational Medicine · doi:10.1126/scitranslmed.3010297 · Cited by 76 · see citing works
Cargill, R., Caldwell, L. J., Engle, K., Fix, J. A., Porter, P. A., & Gardner, C. R. (1988) · Pharmaceutical Research · doi:10.1023/a:1015981627525 · Cited by 73 · see citing works
Hendrix, C. W. (2013) · Cell · doi:10.1016/j.cell.2013.09.030 · Cited by 70 · see citing works
Assessing regional differences in contraceptive discontinuation, failure and switching in Brazil
Leite, I. C., & Gupta, N. (2007) · Reproductive Health · doi:10.1186/1742-4755-4-6 · Cited by 69 · see citing works
Iglay, K., Cao, X., Mavros, P., Joshi, K., Yu, S., & Tunceli, K. (2015) · Clinical Therapeutics · doi:10.1016/j.clinthera.2015.05.505 · Cited by 61 · see citing works
Gubavu, C., Prazuck, T., Niang, M., Buret, J., Mille, C., Guinard, J., Avettand-Fènoël, V., & Hocqueloux, L. (2015) · Journal of Antimicrobial Chemotherapy · doi:10.1093/jac/dkv430 · Cited by 61 · see citing works
Snoeck, V., Huyghebaert, N., Cox, E., Vermeire, A., Saunders, J. H., Remon, J. P., Verschooten, F., & Goddeeris, B. M. (2003) · Journal of Controlled Release · doi:10.1016/j.jconrel.2003.09.015 · Cited by 60 · see citing works
von Wyl, V., Klimkait, T., Yerly, S., Nicca, D., Furrer, H., Cavassini, M. L., Calmy, A., Bernasconi, E., Böni, J., Aubert, V., et al. (2013) · PLoS ONE · doi:10.1371/journal.pone.0077691 · Cited by 60 · see citing works
Eaton, J. W., Bacaër, N., Bershteyn, A., Cambiano, V., Cori, A., Dorrington, R., Fraser, C., Gopalappa, C., Hontelez, J. A. C., Johnson, L. F., et al. (2015) · The Lancet Global Health · doi:10.1016/s2214-109x(15)00080-7 · Cited by 59 · see citing works
Self-citationMurphy, P. A., & Brixner, D. I. (2008) · Contraception · doi:10.1016/j.contraception.2008.01.002 · Cited by 53 · see citing works
Age-dependent partnering and the HIV transmission chain: a microsimulation analysis
Bershteyn, A., Klein, D. J., & Eckhoff, P. A. (2013) · Journal of The Royal Society Interface · doi:10.1098/rsif.2013.0613 · Cited by 52 · see citing works
Self-citationMeasurement of the diameter of the pylorus in man
Salessiotis, N. A. (1972) · The American Journal of Surgery · doi:10.1016/0002-9610(72)90036-0 · Cited by 49 · see citing works
Dolutegravir monotherapy in HIV-infected patients with sustained viral suppression
Rojas, J., Blanco, J. L., Marcos, M. Á., Loncà, M., Tricas, A., Moreno, L., Gonzalez‐Cordón, A., Torres, B., Mallolas, J., García, F., et al. (2016) · Journal of Antimicrobial Chemotherapy · doi:10.1093/jac/dkw078 · Cited by 44 · see citing works
Capetti, A. F., D, G. S. M., Cossu, M. V., Orofino, G., Barbarini, G., Socio, G. V. D., Giambenedetto, S. D., Biagio, A. D., Celesia, B. M., Argenteri, B., et al. (2016) · PLoS ONE · doi:10.1371/journal.pone.0164753 · Cited by 44 · see citing works
Jonsson‐Oldenbüttel, C., Wolf, E., Ritter, A., Noé, S., Heldwein, S., Pascucci, R., Wiese, C., von Krosigk, A., Jägel-Guedes, E., Jaeger, H., et al. (2016) · Antiviral Therapy · doi:10.3851/imp3082 · Cited by 39 · see citing works
Mojaverian, P. (1996) · Drug Development Research · doi:10.1002/(sici)1098-2299(199606)38:2 · Cited by 38 · see citing works
Frey, B. M., Sieber, M., Mettler, D., Gänger, H., & Frey, F. J. (1988) · Drug Metabolism and Disposition · doi:10.1016/s0090-9556(25)06930-2 · Cited by 36 · see citing works
Radioimmunoassay of atropine in plasma.
Wurzburger, R. J., Miller, R. L., Boxenbaum, H. G., & Spector, S. (1977) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(25)31064-5 · Cited by 35 · see citing works
Klein, D. J., Bershteyn, A., & Eckhoff, P. A. (2014) · AIDS · doi:10.1097/qad.0000000000000081 · Cited by 29 · see citing works
Self-citationBershteyn, A., Klein, D. J., & Eckhoff, P. A. (2016) · International Health · doi:10.1093/inthealth/ihw010 · Cited by 28 · see citing works
Self-citationPast, Present, and Future Drug Delivery Systems for Antiretrovirals
Kirtane, A. R., Langer, R., & Traverso, G. (2016) · Journal of Pharmaceutical Sciences · doi:10.1016/j.xphs.2016.09.015 · Cited by 28 · see citing works
Self-citationCargill, R., Engle, K., Gardner, C. R., Porter, P., Sparer, R. V., & Fix, J. A. (1989) · Pharmaceutical Research · doi:10.1023/a:1015976709043 · Cited by 26 · see citing works
Bangsberg, D., & Mills, E. (2013) · Antiviral Therapy · doi:10.3851/imp2536 · Cited by 25 · see citing works
Dolutegravir as maintenance monotherapy: first experiences in HIV-1 patients: Table 1.
Rokx, C., Schurink, C. A. M., Boucher, C. A., & Rijnders, B. J. A. (2016) · Journal of Antimicrobial Chemotherapy · doi:10.1093/jac/dkw011 · Cited by 24 · see citing works
Meresse, M., Carrieri, P., Laurent, C., Kouanfack, C., Protopopescu, C., Blanche, J., Cohen, J., Laborde-Balen, G., Aghokeng, A. F., Spire, B., et al. (2013) · Antiviral Therapy · doi:10.3851/imp2535 · Cited by 23 · see citing works
Heredia, A., Hassounah, S. A., Medina-Moreno, S., Zapata, J. C., Le, N. M., Han, Y.-S., Foulke, J. S., Davis, C., Bryant, J., Redfield, R., et al. (2017) · Journal of Antimicrobial Chemotherapy · doi:10.1093/jac/dkx195 · Cited by 18 · see citing works
Dinarvand, R., Alimorad, M. M., Amanlou, M., & Javar, H. A. (2005) · Journal of Biomedical Materials Research Part A · doi:10.1002/jbm.a.30398 · Cited by 16 · see citing works
Klein, D. J., Eckhoff, P. A., & Bershteyn, A. (2015) · International Health · doi:10.1093/inthealth/ihv011 · Cited by 13 · see citing works
Self-citationArticle Commentary: Dolutegravir Monotherapy: When Should Clinical Practice be Clinical Research?
Gallant, J. E., & Sugarman, J. (2016) · Antiviral Therapy · doi:10.3851/imp3113 · Cited by 8 · see citing works
Long-term Safety of Gastroretentive Gabapentin in Postherpetic Neuralgia Patients
Jensen, M. P., Irving, G. A., Rauck, R. L., Wallace, M. S., Sweeney, M., & Vanhove, G. F. (2013) · Clinical Journal of Pain · doi:10.1097/ajp.0b013e31827b32ab · Cited by 6 · see citing works
Eaton, J., Pham, Q., Wilson, D., & Zhang, L. (2014) · UNSWorks (UNSW Sydney) · Cited by 2 · see citing works
Flagged first, then by citations
Research works printed but not linked: 2
- [61]Andrew Owen et al. Human confirmation of oral dose reduction potential of nanoparticle ARV formulations. Conference on Retroviruses and Opportunistic Infections, abstr. 39 (2017).
- [71]Wijting I. et al. Dolutegravir as maintenance monotherapy for HIV-1: a randomized clinical trial. Conference on Retroviruses and Opportunistic Infections, abstr. 451LB (2017).
Cited by
Sorted by citations
The evolution of spiropyran: fundamentals and progress of an extraordinarily versatile photochrome
Kortekaas, L., & Browne, W. R. (2019) · Chemical Society Reviews · doi:10.1039/c9cs00203k · Cited by 782 · see citing works
An ingestible bacterial-electronic system to monitor gastrointestinal health
Mimee, M., Nadeau, P., Hayward, A., Carim, S., Flanagan, S., Jerger, L., Collins, J., McDonnell, S., Swartwout, R., Citorik, R. J., et al. (2018) · Science · doi:10.1126/science.aas9315 · Cited by 606 · see citing works
Self-citationMaterials for oral delivery of proteins and peptides
Brown, T. D., Whitehead, K. A., & Mitragotri, S. (2019) · Nature Reviews Materials · doi:10.1038/s41578-019-0156-6 · Cited by 527 · see citing works
Nanotechnology approaches for global infectious diseases
Kirtane, A. R., Verma, M., Karandikar, P., Furin, J., Langer, R., & Traverso, G. (2021) · Nature Nanotechnology · doi:10.1038/s41565-021-00866-8 · Cited by 520 · see citing works
Self-citationZero-order drug delivery: State of the art and future prospects
Laracuente, M., Yu, M. H., & McHugh, K. J. (2020) · Journal of Controlled Release · doi:10.1016/j.jconrel.2020.09.020 · Cited by 398 · see citing works
Approaches for Long Lifetime Organic Light Emitting Diodes
Swayamprabha, S. S., Dubey, D. K., Shahnawaz, S., Yadav, R. A. K., Nagar, M. R., Sharma, A., Tung, F., & Jou, J. (2020) · Advanced Science · doi:10.1002/advs.202002254 · Cited by 320 · see citing works
Foundations of gastrointestinal-based drug delivery and future developments
Chu, J. N., & Traverso, G. (2021) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/s41575-021-00539-w · Cited by 297 · see citing works
Self-citationGao, J., Karp, J. M., Langer, R., & Joshi, N. (2023) · Chemistry of Materials · doi:10.1021/acs.chemmater.2c03003 · Cited by 283 · see citing works
Self-citationMicro and nanoscale technologies in oral drug delivery
Ahadian, S., Finbloom, J. A., Mofidfar, M., Di̇ltemi̇z, S. E., Nasrollahi, F., Davoodi, E., Hosseini, V., Mylonaki, I., Sangabathuni, S., Montazerian, H., et al. (2020) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2020.07.012 · Cited by 271 · see citing works
Defect Engineering on Carbon-Based Catalysts for Electrocatalytic CO2 Reduction
Xue, D., Xia, H., Yan, W., Zhang, J., & Mu, S. C. (2020) · Nano-Micro Letters · doi:10.1007/s40820-020-00538-7 · Cited by 252 · see citing works
Overcoming negatively charged tissue barriers: Drug delivery using cationic peptides and proteins
Vedadghavami, A., Zhang, C., & Bajpayee, A. G. (2020) · Nano Today · doi:10.1016/j.nantod.2020.100898 · Cited by 213 · see citing works
Melocchi, A., Uboldi, M., Inverardi, N., Vangosa, F. B., Baldi, F., Pandini, S., Scalet, G., Auricchio, F., Cerea, M., Foppoli, A., et al. (2019) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2019.118700 · Cited by 201 · see citing works
Genome mining methods to discover bioactive natural products
Bauman, K. D., Butler, K. S., Moore, B. S., & Chekan, J. R. (2021) · Natural Product Reports · doi:10.1039/d1np00032b · Cited by 198 · see citing works
Stereolithography (SLA) 3D printing of a bladder device for intravesical drug delivery
Xu, X., Goyanes, Á., Trenfield, S. J., Díaz-Gómez, L. A., Alvarez‐Lorenzo, C., Gaisford, S., & Basit, A. W. (2020) · Materials Science and Engineering C · doi:10.1016/j.msec.2020.111773 · Cited by 158 · see citing works
Geraili, A., Xing, M. M. Q., & Mequanint, K. (2021) · Open Research (University of Surrey) · doi:10.1002/viw.20200126 · Cited by 155 · see citing works
Polymeric nano- and microparticulate drug delivery systems for treatment of biofilms
Birk, S. E., Boisen, A., & Nielsen, L. H. (2021) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2021.04.005 · Cited by 152 · see citing works
The role of excitons in 3D and 2D lead halide perovskites
Marongiu, D., Saba, M., Quochi, F., Mura, A., & Bongiovanni, G. (2019) · Journal of Materials Chemistry C · doi:10.1039/c9tc04292j · Cited by 130 · see citing works
Vrettos, N.-N., Roberts, C. J., & Zhu, Z. (2021) · Pharmaceutics · doi:10.3390/pharmaceutics13101591 · Cited by 130 · see citing works
Light-degradable hydrogels as dynamic triggers for gastrointestinal applications
Raman, R., Hua, T., Gwynne, D., Collins, J. E., Tamang, S. M., Zhou, J., Esfandiary, T., Soares, V. V., Pajovic, S., Hayward, A. M., et al. (2020) · Science Advances · doi:10.1126/sciadv.aay0065 · Cited by 129 · see citing works
Self-citationRecent advances in nanoengineering cellulose for cargo delivery
Sheikhi, A., Hayashi, J., Eichenbaum, J., Gutin, M., Kuntjoro, N., Khorsandi, D., & Khademhosseini, A. (2018) · Journal of Controlled Release · doi:10.1016/j.jconrel.2018.11.024 · Cited by 124 · see citing works
Long-Acting HIV Drugs for Treatment and Prevention
Gulick, R. M., & Flexner, C. W. (2018) · Annual Review of Medicine · doi:10.1146/annurev-med-041217-013717 · Cited by 119 · see citing works
Long-acting parenteral drug delivery systems for the treatment of chronic diseases
Jindal, A. B., Bhide, A. R., Salave, S., Rana, D., & Benival, D. M. (2023) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2023.114862 · Cited by 111 · see citing works
Yantara, N., Bruno, A., Iqbal, A., Jamaludin, N. F., Soci, C., Mhaisalkar, S. G., & Mathews, N. (2018) · Advanced Materials · doi:10.1002/adma.201800818 · Cited by 110 · see citing works
All‐Solution‐Processed Pure Formamidinium‐Based Perovskite Light‐Emitting Diodes
Wang, J., Song, C., He, Z., Mai, C., Xie, G., Mu, L., Cun, Y., Li, J., Wang, J., Peng, J., et al. (2018) · Advanced Materials · doi:10.1002/adma.201804137 · Cited by 108 · see citing works
Formulation strategies to improve the efficacy of intestinal permeation enhancers,
Maher, S., & Brayden, D. J. (2021) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2021.113925 · Cited by 107 · see citing works
Gan, Z., Cheng, Y., Chen, W., Loh, K. P., Jia, B., & Wen, X. (2021) · Advanced Science · doi:10.1002/advs.202001843 · Cited by 105 · see citing works
Halide perovskites scintillators: unique promise and current limitations
Moseley, O. D. I., Doherty, T. A. S., Parmee, R., Anaya, M., & Stranks, S. D. (2021) · Journal of Materials Chemistry C · doi:10.1039/d1tc01595h · Cited by 105 · see citing works
Long-acting drugs and formulations for the treatment and prevention of HIV infection
Flexner, C. W., Owen, A., Siccardi, M., & Swindells, S. (2020) · International Journal of Antimicrobial Agents · doi:10.1016/j.ijantimicag.2020.106220 · Cited by 104 · see citing works
3D‐Printed Gastric Resident Electronics
Kong, Y. L., Zou, X., McCandler, C. A., Kirtane, A. R., Ning, S., Zhou, J., Abid, A., Jafari, M., Rogner, J., Minahan, D. J., et al. (2018) · Advanced Materials Technologies · doi:10.1002/admt.201800490 · Cited by 101 · see citing works
Self-citationRahil, M., Ansari, R. M., Prakash, C., Islam, S. S., Dixit, A., & Ahmad, S. (2022) · Scientific Reports · doi:10.1038/s41598-022-06108-8 · Cited by 99 · see citing works
Temperature-responsive biometamaterials for gastrointestinal applications
Babaee, S., Pajovic, S., Kirtane, A. R., Shi, J., Caffarel–Salvador, E., Hess, K., Collins, J. E., Tamang, S. M., Wahane, A. V., Hayward, A. M., et al. (2019) · Science Translational Medicine · doi:10.1126/scitranslmed.aau8581 · Cited by 92 · see citing works
Self-citationMelocchi, A., Uboldi, M., Cerea, M., Foppoli, A., Maroni, A., Moutaharrik, S., Palugan, L., Zema, L., & Gazzaniga, A. (2020) · Journal of Pharmaceutical Sciences · doi:10.1016/j.xphs.2020.07.011 · Cited by 91 · see citing works
Dual Emission of Water‐Stable 2D Organic–Inorganic Halide Perovskites with Mn(II) Dopant
Ba, Q., Jana, A., Wang, L., & Kim, K. S. (2019) · Advanced Functional Materials · doi:10.1002/adfm.201904768 · Cited by 90 · see citing works
Highly Luminescent and Stable Green Quasi‐2D Perovskite‐Embedded Polymer Sheets by Inkjet Printing
Jia, S., Li, G., Liu, P., Cai, R., Tang, H., Xu, B., Wang, Z., Wu, Z., Wang, K., & Sun, X. W. (2020) · Advanced Functional Materials · doi:10.1002/adfm.201910817 · Cited by 85 · see citing works
In Vitro and In Vivo Test Methods for the Evaluation of Gastroretentive Dosage Forms
Schneider, F., Koziolek, M., & Weitschies, W. (2019) · Pharmaceutics · doi:10.3390/pharmaceutics11080416 · Cited by 84 · see citing works
Unconstrained 3D Shape Programming with Light‐Induced Stress Gradient
Liu, C., Tan, Y., He, C., Ji, S., & Xu, H. (2021) · Advanced Materials · doi:10.1002/adma.202105194 · Cited by 79 · see citing works
4D printing: a cutting-edge platform for biomedical applications
Naniz, M. A., Askari, M., Zolfagharian, A., Naniz, M. A., & Bodaghi, M. (2022) · Biomedical Materials · doi:10.1088/1748-605x/ac8e42 · Cited by 78 · see citing works
Jin, X., Wei, C., Wu, C., & Zhang, W. (2022) · Composites Part B Engineering · doi:10.1016/j.compositesb.2022.109816 · Cited by 75 · see citing works
Genome-wide association and multi-omic analyses reveal ACTN2 as a gene linked to heart failure
Arvanitis, M., Tampakakis, E., Zhang, Y., Wang, W., Auton, A., Agee, M., Aslibekyan, S. W., Bell, R. K., Bryc, K., Clark, S., et al. (2020) · Nature Communications · doi:10.1038/s41467-020-14843-7 · Cited by 75 · see citing works
The clinical significance of 4D printing
Sheikh, A., Abourehab, M. A. S., & Kesharwani, P. (2022) · Drug Discovery Today · doi:10.1016/j.drudis.2022.103391 · Cited by 74 · see citing works
Ahn, S., Park, M., Jeong, S., Kim, Y., Park, J., Kim, S., Kim, H., Cho, H., Wolf, C., Pei, M., et al. (2018) · Advanced Functional Materials · doi:10.1002/adfm.201807535 · Cited by 73 · see citing works
Cobb, D. A., Smith, N. S., Edagwa, B., & McMillan, J. (2020) · Expert Opinion on Drug Delivery · doi:10.1080/17425247.2020.1783233 · Cited by 70 · see citing works
Metal-organic framework and inorganic glass composites
Longley, L., Calahoo, C., Limbach, R., Xia, Y., Tuffnell, J. M., Sapnik, A. F., Thorne, M. F., Keeble, D. S., Keen, D. A., Wondraczek, L., et al. (2020) · Nature Communications · doi:10.1038/s41467-020-19598-9 · Cited by 70 · see citing works
Insight into treatment of HIV infection from viral dynamics models
Hill, A. L., Rosenbloom, D. I. S., Nowak, M. A., & Siliciano, R. F. (2018) · Immunological Reviews · doi:10.1111/imr.12698 · Cited by 70 · see citing works
Self-citationHenze, L. J., Koehl, N. J., Bennett-Lenane, H., Holm, R., Grimm, M. F., Schneider, F., Weitschies, W., Koziolek, M., & Griffin, B. T. (2020) · European Journal of Pharmaceutical Sciences · doi:10.1016/j.ejps.2020.105627 · Cited by 69 · see citing works
Mahmoud, D. B. E. D., & Schulz‐Siegmund, M. (2022) · Advanced Healthcare Materials · doi:10.1002/adhm.202202631 · Cited by 69 · see citing works
Recent advances in long-acting nanoformulations for delivery of antiretroviral drugs
Surve, D. H., & Jindal, A. B. (2020) · Journal of Controlled Release · doi:10.1016/j.jconrel.2020.05.022 · Cited by 68 · see citing works
Lin, C., Lee, J., Kim, J., Macdonald, T. J., Ngiam, J., Xu, B., Dabóczi, M., Xu, W., Pont, S., Park, B., et al. (2019) · Advanced Functional Materials · doi:10.1002/adfm.201906763 · Cited by 68 · see citing works
Lv, P., Zhang, D., Guo, M., Liu, J., Chen, X., Guo, R., Xu, Y., Zhang, Q., Liu, Y., Guo, H., et al. (2019) · Journal of Drug Delivery Science and Technology · doi:10.1016/j.jddst.2019.03.015 · Cited by 67 · see citing works
Image-guided intratumoral immunotherapy: Developing a clinically practical technology
Som, A., Rosenboom, J., Chandler, A., Sheth, R. A., & Wehrenberg-Klee, E. P. (2022) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2022.114505 · Cited by 63 · see citing works
Oral Drug Delivery: Conventional to Long Acting New-Age Designs
Bhutani, U., Basu, T., & Majumdar, S. (2021) · European Journal of Pharmaceutics and Biopharmaceutics · doi:10.1016/j.ejpb.2021.02.008 · Cited by 59 · see citing works
Alcalde, J., Heinemann, N., James, A., Bond, C. E., Ghanbari, S., Mackay, E. J., Haszeldine, R. S., Faulkner, D. R., Worden, R. H., & Allen, M. J. (2021) · Marine and Petroleum Geology · doi:10.1016/j.marpetgeo.2021.105309 · Cited by 59 · see citing works
Recent developments of nanotherapeutics for targeted and long-acting, combination HIV chemotherapy
Gao, Y., Kraft, J. C., Yu, D., & Ho, R. J. Y. (2018) · European Journal of Pharmaceutics and Biopharmaceutics · doi:10.1016/j.ejpb.2018.04.014 · Cited by 59 · see citing works
Iterative community-driven development of a SARS-CoV-2 tissue simulatorPreprint
Getz, M., Wang, Y., An, G. C., Asthana, M., Becker, A., Cockrell, C., Collier, N. T., Craig, M., Davis, C. L., Faeder, J. R., et al. (2020) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2020.04.02.019075 · Cited by 59 · see citing works
Self-citationAltreuter, D. H., Kirtane, A. R., Grant, T. M., Kruger, C., Traverso, G., & Bellinger, A. M. (2018) · Expert Opinion on Drug Delivery · doi:10.1080/17425247.2018.1544615 · Cited by 58 · see citing works
Self-citationAgrahari, V., Anderson, S. M., Peet, M. M., Wong, A. P., Singh, O., Doncel, G. F., & Clark, M. R. (2022) · Expert Opinion on Drug Delivery · doi:10.1080/17425247.2022.2135699 · Cited by 57 · see citing works
Abramson, A., Halperin, F., Kim, J., & Traverso, G. (2019) · Journal of Pharmaceutical Sciences · doi:10.1016/j.xphs.2019.04.022 · Cited by 54 · see citing works
Self-citationA gastric resident drug delivery system for prolonged gram-level dosing of tuberculosis treatment
Verma, M., Vishwanath, K., Eweje, F. R., Roxhed, N., Grant, T. M., Castaneda, M., Steiger, C., Mazdiyasni, H., Bensel, T., Minahan, D. J., et al. (2019) · Science Translational Medicine · doi:10.1126/scitranslmed.aau6267 · Cited by 53 · see citing works
Self-citationApplied evolution: phylogeny-based approaches in natural products research
Adamek, M., Alanjary, M. M., & Ziemert, N. (2019) · Natural Product Reports · doi:10.1039/c9np00027e · Cited by 52 · see citing works
Treatment and prevention of HIV infection with long-acting antiretrovirals
Benítez‐Gutiérrez, L., Soriano, V., Requena, S., Arias, A., Barreiro, P., & de Mendoza, C. (2018) · Expert Review of Clinical Pharmacology · doi:10.1080/17512433.2018.1453805 · Cited by 50 · see citing works
Yoon, E., Jang, K. Y., Park, J., & Lee, T. (2020) · Advanced Materials Interfaces · doi:10.1002/admi.202001712 · Cited by 50 · see citing works
Towards multifunctional robotic pills
Mundaca‐Uribe, R., Askarinam, N., Fang, R. H., Zhang, L., & Wang, J. (2023) · Nature Biomedical Engineering · doi:10.1038/s41551-023-01090-6 · Cited by 49 · see citing works
A once-a-month oral contraceptive
Kirtane, A. R., Hua, T., Hayward, A. M., Bajpayee, A. G., Wahane, A. V., Lopes, A., Bensel, T., Ma, L., Stanczyk, F. Z., Brooks, S., et al. (2019) · Science Translational Medicine · doi:10.1126/scitranslmed.aay2602 · Cited by 49 · see citing works
Self-citationCombating Iron Overload: A Case for Deferoxamine-Based Nanochelators
Jones, G., Goswami, S. K., Kang, H., Choi, H. S., & Kim, J. (2020) · Nanomedicine · doi:10.2217/nnm-2020-0038 · Cited by 48 · see citing works
Biomimetic Nanomaterial Strategies for Virus Targeting: Antiviral Therapies and Vaccines
Jackman, J. A., Yoon, B. K., Ouyang, L., Wang, N., Ferhan, A. R., Kim, J., Majima, T., & Cho, N. (2020) · Advanced Functional Materials · doi:10.1002/adfm.202008352 · Cited by 46 · see citing works
Berryman, V. E. J., Shephard, J. J., Ochiai, T., Price, A. N., Arnold, P. L., Parsons, S., & Kaltsoyannis, N. (2020) · Physical Chemistry Chemical Physics · doi:10.1039/d0cp02947e · Cited by 45 · see citing works
Ingestible devices for long-term gastrointestinal residency: a review
Mau, M. M., Sarker, S., & Terry, B. S. (2021) · Progress in Biomedical Engineering · doi:10.1088/2516-1091/ac1731 · Cited by 44 · see citing works
Retentive drug delivery systems based on shape memory materials
Maroni, A., Melocchi, A., Zema, L., Foppoli, A., & Gazzaniga, A. (2019) · Journal of Applied Polymer Science · doi:10.1002/app.48798 · Cited by 43 · see citing works
Wu, S., Ahmad, Z., Li, J., & Chang, M. (2019) · Materials Science and Engineering C · doi:10.1016/j.msec.2019.110393 · Cited by 42 · see citing works
Self-citationEstimation of carbon dioxide emissions from the megafires of Australia in 2019–2020
Shiraishi, T., & Hirata, R. (2021) · Scientific Reports · doi:10.1038/s41598-021-87721-x · Cited by 42 · see citing works
Recent advances in alginate based gastroretentive technologies for drug delivery applications
Sen, O., Manna, S., Nandi, G., Jana, S., & Jana, S. (2023) · Medicine in Novel Technology and Devices · doi:10.1016/j.medntd.2023.100236 · Cited by 41 · see citing works
Inverardi, N., Scalet, G., Melocchi, A., Uboldi, M., Maroni, A., Zema, L., Gazzaniga, A., Auricchio, F., Vangosa, F. B., Baldi, F., et al. (2021) · Journal of the mechanical behavior of biomedical materials/Journal of mechanical behavior of biomedical materials · doi:10.1016/j.jmbbm.2021.104814 · Cited by 41 · see citing works
A Microstirring Pill Enhances Bioavailability of Orally Administered Drugs
Mundaca‐Uribe, R., Karshalev, E., de Ávila, B. E., Wei, X., Nguyen, B., Litvan, I., Fang, R. H., Zhang, L., & Wang, J. (2021) · Advanced Science · doi:10.1002/advs.202100389 · Cited by 40 · see citing works
The Promise of Long-Acting Antiretroviral Therapies: From Need to Manufacture
Gendelman, H. E., McMillan, J., Bade, A. N., Edagwa, B., & Kevadiya, B. D. (2019) · Trends in Microbiology · doi:10.1016/j.tim.2019.02.009 · Cited by 39 · see citing works
SINGULARISM about Episodic Memory
Andonovski, N. (2020) · Review of Philosophy and Psychology · doi:10.1007/s13164-020-00464-y · Cited by 39 · see citing works
Cheerios Effect Inspired Microbubbles as Suspended and Adhered Oral Delivery Systems
Zhao, C., Cai, L., Nie, M., Shang, L., Wang, Y., & Zhao, Y. (2021) · Advanced Science · doi:10.1002/advs.202004184 · Cited by 39 · see citing works
Multicellular In vitro Models of Cardiac Arrhythmias: Focus on Atrial Fibrillation
van Gorp, P. R. R., Trines, S. A. I. P., Pijnappels, D. A., & de Vries, A. A. F. (2020) · Frontiers in Cardiovascular Medicine · doi:10.3389/fcvm.2020.00043 · Cited by 38 · see citing works
Mahmoud, B. S., & McConville, C. (2021) · Pharmaceutics · doi:10.3390/pharmaceutics13040541 · Cited by 38 · see citing works
Smart pills and drug delivery devices enabling next generation oral dosage forms
Milián-Guimerá, C., McCabe, R., Thamdrup, L. H. E., Ghavami, M., & Boisen, A. (2023) · Journal of Controlled Release · doi:10.1016/j.jconrel.2023.10.041 · Cited by 37 · see citing works
Wu, S., Li, J., Mai, J., & Chang, M. (2018) · ACS Applied Materials & Interfaces · doi:10.1021/acsami.8b08880 · Cited by 37 · see citing works
Self-citationLeveraging Computational Modeling to Understand Infectious Diseases
Jenner, A. L., Aogo, R. A., Davis, C. L., Smith, A. M., & Craig, M. (2020) · Current Pathobiology Reports · doi:10.1007/s40139-020-00213-x · Cited by 37 · see citing works
Self-citationDharshini, K. P., Fang, H., Devi, D. R., Yang, J., Luo, R., Zheng, Y., Brzeziński, M., & Hari, B. N. V. (2020) · Carbohydrate Polymers · doi:10.1016/j.carbpol.2020.117440 · Cited by 37 · see citing works
Apetroaei, M.-M., Velescu, B. Ș., Nedea, M. I., Dinu‐Pîrvu, C. E., Drăgănescu, D., Fâcă, A. I., Udeanu, D. I., & Arsene, A. L. (2024) · Biomedicines · doi:10.3390/biomedicines12040915 · Cited by 35 · see citing works
Hatami, H., Mojahedian, M. M., Kesharwani, P., & Sahebkar, A. (2024) · European Polymer Journal · doi:10.1016/j.eurpolymj.2024.113245 · Cited by 35 · see citing works
Nachman, S., Townsend, C. L., Abrams, E. J., Archary, M., Capparelli, E. V., Clayden, P., Lockman, S., Jean‐Philippe, P., Mayer, K. H., Mirochnick, M. H., et al. (2019) · The Lancet HIV · doi:10.1016/s2352-3018(19)30147-x · Cited by 35 · see citing works
Morphological and physiological factors contributing to early vigor in the elite rice cultivar 9,311
Shi, Z., Chang, T.-G., Chen, F., Zhao, H., Song, Q., Wang, M., Wang, Y., Zhou, Z., Wang, C., Shao-chuan, Z., et al. (2020) · Scientific Reports · doi:10.1038/s41598-020-71913-y · Cited by 35 · see citing works
Recent progress in advanced biomaterials for long-acting reversible contraception
Yan, M., Zhang, Y., Wu, Z., Li, Y., Dou, K., Wang, B., Wang, Y., & Zhou, Q. (2022) · Journal of Nanobiotechnology · doi:10.1186/s12951-022-01329-5 · Cited by 35 · see citing works
Actively Triggerable Metals via Liquid Metal Embrittlement for Biomedical Applications
Feig, V. R., Remlova, E., Muller, B. N., Kuosmanen, J. L. P., Lal, N. B., Ginzburg, A., Nan, K., Patel, A., Jebran, A. M., Bantwal, M. P., et al. (2022) · Advanced Materials · doi:10.1002/adma.202208227 · Cited by 35 · see citing works
Self-citationMechanical underwater adhesive devices for soft substrates
Kang, Z., Gomez, J. A., Ross, A. M., Kirtane, A. R., Zhao, M., Cai, Y., Chen, F., Chen, C. L., Becdach, I. D., Dey, R., et al. (2025) · Nature · doi:10.1038/s41586-025-09304-4 · Cited by 34 · see citing works
Self-citationHigh performance complementary WS 2 devices with hybrid Gr/Ni contacts
Khan, M. F., Ahmed, F., Rehman, S., Akhtar, I., Rehman, M. A., Shinde, P. A., Khan, K., Kim, D., Eom, J., Lipsanen, H. K., et al. (2020) · Nanoscale · doi:10.1039/d0nr05737a · Cited by 34 · see citing works
Eshaghi, B., Fofana, J., Nodder, S. B., Gummuluru, S., & Reinhard, B. M. (2022) · ACS Applied Materials & Interfaces · doi:10.1021/acsami.1c17415 · Cited by 34 · see citing works
Administration strategies and smart devices for drug release in specific sites of the upper GI tract
Uboldi, M., Melocchi, A., Moutaharrik, S., Palugan, L., Cerea, M., Foppoli, A., Maroni, A., Gazzaniga, A., & Zema, L. (2022) · Journal of Controlled Release · doi:10.1016/j.jconrel.2022.06.005 · Cited by 34 · see citing works
Mechanical Metamaterials for Bioengineering: In Vitro, Wearable, and Implantable Applications
Kazim, M., Pal, A., & Goswami, D. (2025) · Advanced Engineering Materials · doi:10.1002/adem.202401806 · Cited by 33 · see citing works
The electronic origins of the “rare earth” texture effect in magnesium alloys
Mahjoub, R., & Stanford, N. E. (2021) · Scientific Reports · doi:10.1038/s41598-021-93703-w · Cited by 33 · see citing works
Circulating exosomal MicroRNAs: New non-invasive biomarkers of non-communicable disease
Avalos, J. A. J., Fernández-Macías, J. C., & González-Palomo, A. K. (2020) · Molecular Biology Reports · doi:10.1007/s11033-020-06050-w · Cited by 32 · see citing works
Chakraborty, K. S., Slater, G. F., Miller, H. M. ‐., Shirvalkar, P., & Rawat, Y. (2020) · Scientific Reports · doi:10.1038/s41598-020-72963-y · Cited by 31 · see citing works
Non-Nucleoside Reverse Transcriptase Inhibitors Join Forces with Integrase Inhibitors to Combat HIV
Himmel, D. M., & Arnold, E. (2020) · Pharmaceuticals · doi:10.3390/ph13060122 · Cited by 30 · see citing works
Matthews, T., Mbokazi, S. P., Dolla, T. H., Gwebu, S. S., Mugadza, K., Raseruthe, K. E., Sikeyi, L. L., Adegoke, K. A., Saliu, O. D., Adekunle, A. S., et al. (2023) · Small Science · doi:10.1002/smsc.202300057 · Cited by 30 · see citing works
Rödl, M., Kerschbaumer, S., Kopacka, H., Blaser, L., Purtscher, F. R. S., Huppertz, H., Hofer, T. S., & Schwartz, H. A. (2021) · RSC Advances · doi:10.1039/d0ra10500g · Cited by 30 · see citing works
Ramöller, I. K., Abbate, M. T. A., Vora, L. K., Hutton, A. R. J., Peng, K., Volpe‐Zanutto, F., Tekko, I. A., Moffatt, K., Paredes, A. J., McCarthy, H. O., et al. (2022) · Journal of Pharmaceutical and Biomedical Analysis · doi:10.1016/j.jpba.2022.114698 · Cited by 28 · see citing works
- Authors
- Kirtane, A. R., Abouzid, O., Minahan, D., Bensel, T., Hill, A. L., Selinger, C., Bershteyn, A., Craig, M., Mo, S. S., Mazdiyasni, H., Cleveland, C., Rogner, J., Lee, Y.-A. L., Booth, L., Javid, F., Wu, S. J., Grant, T., Bellinger, A. M., Nikolic, B., Hayward, A., Wood, L., Eckhoff, P. A., Nowak, M. A., Langer, R., & Traverso, G.
- Affiliations
- Koch Institute for Integrative Cancer Research At MIT (US)
- Harvard University (US)
- Institute for Disease Modeling (US)
- Brigham and Women's Hospital (US)
- Massachusetts Institute of Technology (US)
- Lyndra Therapeutics (United States) (US)
- Corresponding author
- Traverso, Giovanni
- ORCID
- Venue
- Nature Communications
- Published
- 2018-01-09
- Volume
- 9
- Issue
- 1
- Pages
- 2-2
- ISSN
- 2041-1723 (ISSN-L)
- PMC
- PMC5760734
- OpenAlex
- W2781350987
- Cited by
- 227
- References
- 77
- Citations by year
- 2026: 8 · 2025: 19 · 2024: 16 · 2023: 30 · 2022: 23 · 2021: 38 · 2020: 43 · 2019: 28 · 2018: 22
- FWCI
- 13.14
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Locations
- Nature Communications (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Digital Access to Scholarship at Harvard (DASH) (Harvard University) (submittedVersion, cc-by)
- RePEc: Research Papers in Economics (submittedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- DSpace@MIT (Massachusetts Institute of Technology) (submittedVersion, cc-by-nc)
- Funders
- Bill and Melinda Gates Foundation (OPP1139937, OPP1139921, OPP1148627)
- Brigham and Women's Hospital
- National Institutes of Health (DP5OD019851, 4r37eb000244-34, EB-000244)
- National Institute of Allergy and Infectious Diseases (R01AI131416, P30AI060354)
- National Institute of Biomedical Imaging and Bioengineering (R01EB000244, R37-EB000244)
- Topics
- Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmaceutical Science › Advanced Drug Delivery Systems
- Health Sciences › Medicine › Infectious Diseases › HIV/AIDS drug development and treatment
- Health Sciences › Medicine › Infectious Diseases › HIV/AIDS Research and Interventions
- Keywords
- HIV antiretroviral therapy, long-acting drug delivery, oral dosage forms, dolutegravir, rilpivirine, cabotegravir, medication adherence, viral dynamics, HIV prevention, prophylaxis, porcine model
- MeSH terms
- Rilpivirine, Proof of Concept Study, Dolutegravir, Administration, Oral, Animals, Drug Evaluation, Preclinical, Heterocyclic Compounds, 3-Ring, Humans, Models, Theoretical, Oxazines, Patient Compliance, Piperazines, Pyridones, Swine, Drug Delivery Systems, Anti-HIV Agents, Diketopiperazines
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review