The DOI matches its Crossref record; 31 of the 31 references it cites were found in a registry or an index.
Lyme Disease Testing by Large Commercial Laboratories in the United States
Open accessAbstract
Large commercial laboratories in the United States were surveyed to determine Lyme disease testing frequency, practices, and results. Approximately 3.4 million tests were conducted in 2008; 62% in accordance with recommendations. We estimate that 288 000 infections occurred among 2.4 million patients from whom samples were submitted. Background. Laboratory testing is helpful when evaluating patients with suspected Lyme disease (LD). A 2-tiered antibody testing approach is recommended, but single-tier and nonvalidated tests are also used. We conducted a survey of large commercial laboratories in the United States to assess laboratory practices. We used these data to estimate the cost of testing and number of infections among patients from whom specimens were submitted. Methods. Large commercial laboratories were asked to report the type and volume of testing conducted nationwide in 2008, as well as the percentage of positive tests for 4 LD-endemic states. The total direct cost of testing was calculated for each test type. These data and test-specific performance parameters available in published literature were used to estimate the number of infections among source patients. Results. Seven participating laboratories performed approximately 3.4 million LD tests on approximately 2.4 million specimens nationwide at an estimated cost of $492 million. Two-tiered testing accounted for at least 62% of assays performed; alternative testing accounted for <3% of assays. The estimated frequency of infection among patients from whom specimens were submitted ranged from 10% to 18.5%. Applied to the total numbers of specimens, this yielded an estimated 240 000 to 444 000 infected source patients in 2008. Discussion. LD testing is common and costly, with most testing in accordance with diagnostic recommendations. These results highlight the importance of considering clinical and exposure history when interpreting laboratory results for diagnostic and surveillance purposes.
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The Early Clinical Manifestations of Lyme Disease
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Incidence of Clinician-Diagnosed Lyme Disease, United States, 2005–2010
Nelson, C. A., Saha, S., Kugeler, K. J., Delorey, M. J., Shankar, M. B., Hinckley, A. F., & Mead, P. S. (2015) · Emerging Infectious Diseases · doi:10.3201/eid2109.150417 · Cited by 396
Self-citationPritt, B. S., Mead, P. S., Johnson, D. K. H., Neitzel, D. F., Respicio-Kingry, L. B., Davis, J. P., Schiffman, E., Sloan, L. M., Schriefer, M. E., Replogle, A. J., et al. (2016) · The Lancet Infectious Diseases · doi:10.1016/s1473-3099(15)00464-8 · Cited by 355
Self-citationTick-Borne Zoonoses in the United States: Persistent and Emerging Threats to Human Health
Eisen, R. J., Kugeler, K. J., Eisen, L., Beard, C. B., & Paddock, C. D. (2017) · ILAR Journal · doi:10.1093/ilar/ilx005 · Cited by 312
Lyme neuroborreliosis—epidemiology, diagnosis and management
Koedel, U., Fingerle, V., & Pfister, H.-W. (2015) · Nature Reviews Neurology · doi:10.1038/nrneurol.2015.121 · Cited by 284
Pritt, B. S., Respicio-Kingry, L. B., Sloan, L. M., Schriefer, M. E., Replogle, A. J., Bjork, J., Liu, G., Kingry, L. C., Mead, P. S., Neitzel, D. F., et al. (2016) · INTERNATIONAL JOURNAL OF SYSTEMATIC AND EVOLUTIONARY MICROBIOLOGY · doi:10.1099/ijsem.0.001445 · Cited by 176
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Metadata
- Authors
- Hinckley, A. F., Connally, N. P., Meek, J. I., Johnson, B. J., Kemperman, M. M., Feldman, K. A., White, J. L., & Mead, P. S.
- Venue
- Clinical Infectious Diseases
- Publisher
- Oxford University Press (OUP)
- Published
- 2014-05-30
- Volume
- 59
- Issue
- 5
- Pages
- 676-681
- ISSN
- 1058-4838 (ISSN-L)
- 1537-6591
- OpenAlex
- W2126969588
- Cited by
- 386
- References
- 31
- FWCI
- 28.23
- Type
- journal article
- Language
- en
- Open access
- green
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