Added benefit of nucleic acid amplification testing for the diagnosis of Trichomonas vaginalis among men and women attending a sexually transmitted diseases clinic.

Muzny, C. A.; Blackburn, R. J.; Sinsky, R. J.; Austin, E. L.; Schwebke, J. R.

doi:10.1093/cid/ciu446

Cited by 60Reproductive tract infections researchCervical Cancer and HPV ResearchUrinary Tract Infections Management

Added benefit of nucleic acid amplification testing for the diagnosis of Trichomonas vaginalis among men and women attending a sexually transmitted diseases clinic.

Muzny, C. A., Blackburn, R. J., Sinsky, R. J., Austin, E. L., Schwebke, J. R.·2014·Clinical Infectious Diseases

DOI 10.1093/cid/ciu446

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Abstract

BACKGROUND: Trichomonas vaginalis (TV) is the most common nonviral sexually transmitted infection (STI) in the world. However, TV is not a reportable STI and, with the exception of HIV-positive women, there are no guidelines for screening in women or men. The objective of this study was to determine the added value of nucleic acid amplification tests (NAATs) for detection of TV in men and women at high risk for infection as well as correlates of infection. METHODS: This was a review of clinical and laboratory data of men and women presenting to the Jefferson County Department of Health Sexually Transmitted Diseases (STD) Clinic and receiving a TV NAAT. RESULTS: During 2012-2013, 6335 patients (3821 women and 2514 men) received a TV NAAT on endocervical, urethral, or urine specimens. Overall TV prevalence was 20.2%; 27.0% in women and 9.8% in men. Correlates of TV among men included age >40 years, African American race, and ≥5 polymorphonuclear cells per high-power field on urethral Gram stain. Age >40 years, African American race, leukorrhea on wet mount, elevated vaginal pH, positive whiff test, and concurrent gonococcal infection were positively associated with TV among women. TV NAAT detected approximately one-third more infections among women than wet mount alone. CONCLUSIONS: TV prevalence among men and women was high in this study, suggesting that both groups should be routinely screened, including those aged >40 years. Improved detection of TV by routine implementation of NAATs should result in better control of this common, treatable STI.

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Trichomonas is a relatively common infection among WSW and WSWM, with prevalence rates higher than for chlamydia or gonorrhea, and direct transmission of trichomonas between female partners has been demonstrated.
“Trichomonas is a relatively common infection among WSW and WSWM, with prevalence rates higher than for chlamydia or gonorrhea (306,307), and direct transmission of trichomonas between female partners has been demonstrated (293,294).”
From Sexually Transmitted Infections Treatment Guidelines, 2021 (2021) · cites this paper as [307]
The Results report trichomonas in 27.0% of women attending the STD clinic; Table 3 gives lower counts for chlamydial and gonococcal infection in that clinic population (page not specified). The paper does not identify WSW or WSWM separately, so it does not establish those prevalence comparisons for either group. The sentence cites different sources (293, 294) for direct transmission between female partners, so that clause is not attributed to this paper. (LLM, conf=0.84)
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Sexually Transmitted Infections Treatment Guidelines, 2021
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Authors: Muzny, C. A., Blackburn, R. J., Sinsky, R. J., Austin, E. L., & Schwebke, J. R.
Affiliations: University of Alabama at Birmingham (US)
Jefferson County Department of Health (US)
Corresponding author: Muzny, C. A.
ORCID: Muzny, C. A.
Blackburn, R. J.
Venue: Clinical Infectious Diseases
Publisher: Oxford University Press (OUP)
Published: 2014-06-13
Volume: 59
Issue: 6
Pages: 834-841
ISSN: 1058-4838 (ISSN-L)
1537-6591
DOI: 10.1093/cid/ciu446
OpenAlex: W2105570389
Cited by: 60
References: 44
Citations by year: 2026: 3 · 2025: 4 · 2024: 4 · 2023: 5 · 2022: 2 · 2021: 3 · 2020: 5 · 2019: 5 · 2018: 6 · 2017: 11 · 2016: 5 · 2015: 4 · 2014: 3
FWCI: 6.24
Type: journal article
Language: en
Open access: closed
Locations: Clinical Infectious Diseases (publishedVersion)
PubMed (publishedVersion)
Funders: American Sexually Transmitted Diseases Association
Topics: Life Sciences › Immunology and Microbiology › Microbiology › Reproductive tract infections research
Health Sciences › Medicine › Epidemiology › Cervical Cancer and HPV Research
Health Sciences › Medicine › Epidemiology › Urinary Tract Infections Management
Keywords: Trichomonas vaginalis, trichomoniasis, nucleic acid amplification tests, sexually transmitted infections, screening, men, women, prevalence, wet mount, gonorrhea, risk factors
MeSH terms: Adult, Antiprotozoal Agents, Female, Humans, Male, Metronidazole, Middle Aged, Risk Factors, Sensitivity and Specificity, Sexually Transmitted Diseases, Texas, Trichomonas vaginalis, Trichomonas Vaginitis, Prevalence, Nucleic Acid Amplification Techniques, Young Adult

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Added benefit of nucleic acid amplification testing for the diagnosis of Trichomonas vaginalis among men and women attending a sexually transmitted diseases clinic.

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