Increased risk for meningococcal disease among men who have sex with men in the United States, 2012–2015
Open accessAbstract
BACKGROUND: Several clusters of serogroup C meningococcal disease among men who have sex with men (MSM) have been reported in the United States in recent years. The epidemiology and risk of meningococcal disease among MSM is not well described. METHODS: All meningococcal disease cases among men aged 18-64 years reported to the National Notifiable Disease Surveillance System between January 2012 and June 2015 were reviewed. Characteristics of meningococcal disease cases among MSM and men not known to be MSM (non-MSM) were described. Annualized incidence rates among MSM and non-MSM were compared through calculation of the relative risk and 95% confidence intervals. Isolates from meningococcal disease cases among MSM were characterized using standard microbiological methods and whole-genome sequencing. RESULTS: Seventy-four cases of meningococcal disease were reported among MSM and 453 among non-MSM. Annualized incidence of meningococcal disease among MSM was 0.56 cases per 100000 population, compared to 0.14 among non-MSM, for a relative risk of 4.0 (95% confidence interval [CI], 3.1-5.1). Among the 64 MSM with known status, 38 (59%) were infected with human immunodeficiency virus (HIV). HIV-infected MSM had 10.1 times (95% CI, 6.1-16.6) the risk of HIV-uninfected MSM. All isolates from cluster-associated cases were serogroup C sequence type 11. CONCLUSIONS: MSM are at increased risk for meningococcal disease, although the incidence of disease remains low. HIV infection may be an important factor for this increased risk. Routine vaccination of HIV-infected persons with a quadrivalent meningococcal conjugate vaccine in accordance with Advisory Committee on Immunization Practices recommendations should be encouraged.
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- Authors
- Folaranmi, T. A., Kretz, C. B., Kamiya, H., MacNeil, J. R., Whaley, M. J., Blain, A., Antwi, M., Dorsinville, M., Pacilli, M., Smith, S., Civen, R., Ngo, V., Winter, K., Harriman, K., Wang, X., Bowen, V. B., Patel, M., Martin, S., Misegades, L., & Meyer, S. A.
- Affiliations
- Centers for Disease Control and Prevention (US)
- National Center for Immunization and Respiratory Diseases (US)
- New York City Department of Health and Mental Hygiene (US)
- Chicago Department of Public Health (US)
- Los Angeles County Department of Public Health (US)
- California Department of Public Health (US)
- Corresponding author
- Meyer, Sarah A
- ORCID
- Venue
- Clinical Infectious Diseases
- Publisher
- Oxford University Press (OUP)
- Published
- 2017-05-13
- Volume
- 65
- Issue
- 5
- Pages
- 756-763
- ISSN
- 1058-4838 (ISSN-L)
- 1537-6591
- PMC
- PMC5737672
- OpenAlex
- W2612185004
- Cited by
- 75
- References
- 27
- Citations by year
- 2026: 4 · 2025: 7 · 2024: 9 · 2023: 8 · 2022: 3 · 2021: 2 · 2020: 14 · 2019: 12 · 2018: 15 · 2017: 1
- FWCI
- 9.30
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- public-domain
- Locations
- Clinical Infectious Diseases (publishedVersion, public-domain)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- New York City Department of Health and Mental Hygiene
- California Department of Public Health
- National Institutes of Health (CC999999)
- Centers for Disease Control and Prevention
- Topics
- Life Sciences › Immunology and Microbiology › Microbiology › Bacterial Infections and Vaccines
- Life Sciences › Immunology and Microbiology › Microbiology › Microbial infections and disease research
- Health Sciences › Medicine › Infectious Diseases › HIV/AIDS Research and Interventions
- Keywords
- meningococcal disease, men who have sex with men, serogroup C meningococcal disease, HIV infection, incidence, whole genome sequencing, ST11, quadrivalent meningococcal conjugate vaccine, vaccination, notifiable disease surveillance, disease clusters
- MeSH terms
- Adolescent, Adult, Humans, Male, Meningococcal Infections, Middle Aged, Retrospective Studies, Risk Factors, United States, HIV Infections, Incidence, Homosexuality, Male, Young Adult
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