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Rapid Enzymatic Measurement of Blood Lactate and Pyruvate
Abstract
A modification of enzymatic technics for measurement of concentrations of lactate and pyruvate in blood is described. A common protein-free filtrate is prepared by adding blood directly to cold 5% metaphosphoric acid. Theoretical yields are obtained. Recoveries for lactate range from 98 to 102% and for pyruvate from 97 to 104%. Assay of both lactate and pyruvate is simplified and has a high order of reliability. Since both analyses are completed within a period of 20 mm., the method is especially valuable in the emergent clinical situation in which measurements of lactate and pyruvate are obtained for assessment of the severity of shock and other forms of cardiorespiratory failure.
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Citations
Cited by
Elevated Blood Cyanide Concentrations in Victims of Smoke Inhalation
Baud, F. J., Barriot, P., Toffis, V., Riou, B., Vicaut, E., Lecarpentier, Y., Bourdon, R., Astier, A., & Bismuth, C. (1991) · New England Journal of Medicine · doi:10.1056/nejm199112193252502 · Cited by 478
Cannon, R. O., Rosing, D. R., Maron, B. J., Leon, M. B., Bonow, R. O., Watson, R. M., & Epstein, S. E. (1985) · Circulation · doi:10.1161/01.cir.71.2.234 · Cited by 477
An Autocrine Lactate Loop Mediates Insulin-Dependent Inhibition of Lipolysis through GPR81
Ahmed, K., Tunaru, S., Tang, C., Müller, M., Gille, A., Sassmann, A., Hanson, J., & Offermanns, S. (2010) · Cell Metabolism · doi:10.1016/j.cmet.2010.02.012 · Cited by 440
Energy metabolism defects in Huntington's disease and effects of coenzyme Q10
Koroshetz, W. J., Jenkins, B. G., Rosen, B. R., & Beal, M. F. (1997) · Annals of Neurology · doi:10.1002/ana.410410206 · Cited by 405
Effect of coenzyme Q10 supplementation on simvastatin-induced myalgia
Young, J. M., Florkowski, C. M., Molyneux, S. L., McEwan, R. G., Frampton, C. M., George, P. M., & Scott, R. S. (2007) · The American Journal of Cardiology · doi:10.1016/j.amjcard.2007.06.030 · Cited by 185
Metadata
- Authors
- Marbach, E. P., & Weil, M. H.
- Venue
- Clinical Chemistry
- Publisher
- Oxford University Press (OUP)
- Published
- 1967-04-01
- Volume
- 13
- Issue
- 4
- Pages
- 314-325
- ISSN
- 0009-9147 (ISSN-L)
- 1530-8561
- OpenAlex
- W4297067344
- Cited by
- 395
- References
- 0
- FWCI
- 8.19
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: Rapid Enzymatic Measurement of Blood Lactate and Pyruvate. https://app.cochat.ai/papers/10.1093/clinchem/13.4.314
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- Marbach, E. P., & Weil, M. H. (1967). Rapid Enzymatic Measurement of Blood Lactate and Pyruvate. Clinical Chemistry. https://doi.org/10.1093/clinchem/13.4.314
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
