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Evaluation of methods of coenzyme activation of erythrocyte enzymes for detection of deficiency of vitamins B1, B2, and B6.
Abstract
We describe optimized, ultraviolet spectrophotometric procedures for determination of erythrocyte transketolase, glutathione reductase, and aspartate aminotransferase activity, and their activation by their respective coenzymes--thiamine pyrophosphate, flavin-adenine dinucleotide, and pyridoxal-5-phosphate--as tests for vitamin B1, B2, and B6 deficiency. With these procedures we have investigated healthy subjects on normal and vitamin-supplemented diets, and a series of (mainly) alcoholic hospital in-patients. The enzyme procedures described have good precision and can be readily carried out in the routine laboratory. Abnormal transketolase activation correlated well with clinical evidence of vitamin B1 deficiency.
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Cited by
Thiamine deficiency disorders: Diagnosis, prevalence, and a roadmap for global control programs
Whitfield, K. C., Bourassa, M. W., Adamolekun, B., Bergeron, G., Bettendorff, L., Brown, K. H., Cox, L., Fattal‐Valevski, A., Fischer, P. R., Frank, E. L., et al. (2018) · Annals of the New York Academy of Sciences · doi:10.1111/nyas.13919 · Cited by 336
India-US Case-Control Study of Age-Related Cataracts
Mohan, M. (1989) · Archives of Ophthalmology · doi:10.1001/archopht.1989.01070010688028 · Cited by 309
Metadata
- Authors
- Bayoumi, R. A., & Rosalki, S. B.
- Venue
- Clinical Chemistry
- Publisher
- Oxford University Press (OUP)
- Published
- 1976-03-01
- Volume
- 22
- Issue
- 3
- Pages
- 327-335
- ISSN
- 0009-9147 (ISSN-L)
- 1530-8561
- OpenAlex
- W1962964252
- Cited by
- 257
- References
- 0
- FWCI
- 5.11
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: Evaluation of methods of coenzyme activation of erythrocyte enzymes for detection of deficiency of vitamins B1, B2, and B6. https://app.cochat.ai/papers/10.1093/clinchem/22.3.327
- The paper
- Bayoumi, R. A., & Rosalki, S. B. (1976). Evaluation of methods of coenzyme activation of erythrocyte enzymes for detection of deficiency of vitamins B1, B2, and B6. Clinical Chemistry. https://doi.org/10.1093/clinchem/22.3.327
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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