Thiamine deficiency disorders: Diagnosis, prevalence, and a roadmap for global control programs
Open accessAbstract
Thiamine is an essential micronutrient that plays a key role in energy metabolism. Many populations worldwide may be at risk of clinical or subclinical thiamine deficiencies, due to famine, reliance on staple crops with low thiamine content, or food preparation practices, such as milling grains and washing milled rice. Clinical manifestations of thiamine deficiency are variable; this, along with the lack of a readily accessible and widely agreed upon biomarker of thiamine status, complicates efforts to diagnose thiamine deficiency and assess its global prevalence. Strategies to identify regions at risk of thiamine deficiency through proxy measures, such as analysis of food balance sheet data and month-specific infant mortality rates, may be valuable for understanding the scope of thiamine deficiency. Urgent public health responses are warranted in high-risk regions, considering the contribution of thiamine deficiency to infant mortality and research suggesting that even subclinical thiamine deficiency in childhood may have lifelong neurodevelopmental consequences. Food fortification and maternal and/or infant thiamine supplementation have proven effective in raising thiamine status and reducing the incidence of infantile beriberi in regions where thiamine deficiency is prevalent, but trial data are limited. Efforts to determine culturally and environmentally appropriate food vehicles for thiamine fortification are ongoing.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Beriberi, the disease resulting from severe thiamine deficiency, affects several organs, including the muscular and peripheral nervous systems, and causes fatigue, ataxia, muscle pain, and dyspnoea on exertion.
“Beriberi, the disease resulting from severe thiamine (vitamin B1) deficiency affects several organs, including the muscular and peripheral nervous systems [99]. General symptoms include fatigue, ataxia due to muscle weakness in the legs and arms, muscle pain and tenderness, and dyspnoea on exertion.”
From Vitamins and Minerals for Energy, Fatigue and Cognition: A Narrative Review of the Biochemical and Clinical Evidence (2020) · cites this paper as [99]
Accidental thiamine deficiency in children fed thiamine-lacking infant formula results in persistent cognitive and motor deficits.
“An accidental thiamine deficiency in children fed an infant formula erroneously lacking thiamine, resulted in persistent cognitive and motor deficits. Even the children who initially appeared unaffected subsequently displayed a range of cognitive dysfunction, including delayed language acquisition, language impairment and dyslexia, poor coordination skills, and learning disabilities; quoted in [99”
From Vitamins and Minerals for Energy, Fatigue and Cognition: A Narrative Review of the Biochemical and Clinical Evidence (2020) · cites this paper as [99]
Cerebral beriberi (thiamine deficiency) may lead to encephalopathies and cognitive impairment, including memory disorder and amnesia.
“Cerebral beriberi (thiamine (vitamin B1) deficiency) may lead to encephalopathies, characterized by abnormal eye movements, and cognitive impairment, involving a confused, apathetic state and a profound memory disorder, with severe amnesia and loss of recent and working memory.”
From Vitamins and Minerals for Energy, Fatigue and Cognition: A Narrative Review of the Biochemical and Clinical Evidence (2020) · cites this paper as [99]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
Institute of Medicine (1998) · National Academies Press eBooks · doi:10.17226/6015 · Cited by 2,464 · see citing works
Principles Of Nutritional Assessment
Gibson, R. S. (2005) · doi:10.1093/oso/9780195171693.001.0001 · Cited by 1,887 · see citing works
Modern Nutrition in Health and Disease
Solomons, N. W. (1994) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/60.4.643 · Cited by 1,701 · see citing works
Guidelines on food fortification with micronutrients
Allen, L. H. (2006) · Cited by 1,562 · see citing works
The Optimal Duration of Exclusive Breastfeeding
Kramer, M. S., & Kakuma, R. (2004) · Advances in experimental medicine and biology · doi:10.1007/978-1-4757-4242-8_7 · Cited by 987 · see citing works
Origin, dispersal, cultivation and variation of rice
Khush, G. S. (1997) · Plant Molecular Biology · doi:10.1023/a:1005810616885 · Cited by 984 · see citing works
Origin, dispersal, cultivation and variation of rice
Khush, G. S. (1997) · Springer eBooks · doi:10.1007/978-94-011-5794-0_3 · Cited by 972 · see citing works
Dewey, K. G., & Brown, K. H. (2003) · Food and Nutrition Bulletin · doi:10.1177/156482650302400102 · Cited by 800 · see citing works
Global trends in dietary micronutrient supplies and estimated prevalence of inadequate intakes
Beal, T., Massiot, E., Arsenault, J. E., Smith, M. R., & Hijmans, R. J. (2017) · PLoS ONE · doi:10.1371/journal.pone.0175554 · Cited by 441 · see citing works
Origin, dispersal, cultivation and variation of rice.
Khush, G. S. (1997) · PubMed · Cited by 433 · see citing works
A Review of the Biochemistry, Metabolism and Clinical Benefits of Thiamin(e) and Its Derivatives
Lonsdale, D. (2006) · Evidence-based Complementary and Alternative Medicine · doi:10.1093/ecam/nek009 · Cited by 391 · see citing works
Thiamin Function, Metabolism, Uptake, and Transport
Manzetti, S., Zhang, J., & van der Spoel, D. (2014) · Biochemistry · doi:10.1021/bi401618y · Cited by 337 · see citing works
Assessing the prevalence of nutrient inadequacy
Carriquiry, A. L. (1999) · Public Health Nutrition · doi:10.1017/s1368980099000038 · Cited by 324 · see citing works
Donnino, M. W., Andersen, L. W., Chase, M., Berg, K. M., Tidswell, M., Giberson, T. A., Wolfe, R. E., Moskowitz, A. L., Smithline, H. A., Ngo, L. H., et al. (2016) · Critical Care Medicine · doi:10.1097/ccm.0000000000001572 · Cited by 299 · see citing works
CheapStat: An Open-Source, “Do-It-Yourself” Potentiostat for Analytical and Educational Applications
Rowe, A. A., Bonham, A. J., White, R. J., Zimmer, M. P., Yadgar, R. J., Hobza, T. M., Honea, J. W., Ben-Yaacov, I., & Plaxco, K. W. (2011) · PLoS ONE · doi:10.1371/journal.pone.0023783 · Cited by 286 · see citing works
Universal mobile electrochemical detector designed for use in resource-limited applications
Nemiroski, A., Christodouleas, D. C., Hennek, J. W., Kumar, A. A., Maxwell, E. J., Fernández-Abedul, M. T., & Whitesides, G. M. (2014) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1405679111 · Cited by 285 · see citing works
Allen, L. H. (2012) · Advances in Nutrition · doi:10.3945/an.111.001172 · Cited by 283 · see citing works
Microfluidics and point-of-care testing
Sia, S. K., & Kricka, L. J. (2008) · Lab on a Chip · doi:10.1039/b817915h · Cited by 279 · see citing works
Bayoumi, R. A. L., & Rosalki, S. B. (1976) · Clinical Chemistry · doi:10.1093/clinchem/22.3.327 · Cited by 257 · see citing works
Wernicke-Korsakoff-syndrome: Under-recognized and under-treated
Isenberg-Grzeda, E., Kutner, H. E., & Nicolson, S. E. (2012) · Psychosomatics · doi:10.1016/j.psym.2012.04.008 · Cited by 253 · see citing works
Fortification and Health: Challenges and Opportunities
Dwyer, J. T., Wiemer, K. L., Dary, O., Keen, C. L., King, J. C., Miller, K. B., Philbert, M. A., Tarasuk, V. S., Taylor, C. L., Gaine, P. C., et al. (2015) · Advances in Nutrition · doi:10.3945/an.114.007443 · Cited by 224 · see citing works
Gut microbiota of healthy and malnourished children in bangladesh
Monira, S., Nakamura, S., Gotoh, K., Izutsu, K., Watanabe, H., Alam, N. H., Endtz, H. P., Cravioto, A., Ali, S. I., Nakaya, T., et al. (2011) · Frontiers in Microbiology · doi:10.3389/fmicb.2011.00228 · Cited by 223 · see citing works
DStat: A Versatile, Open-Source Potentiostat for Electroanalysis and Integration
Dryden, M. D. M., & Wheeler, A. R. (2015) · PLoS ONE · doi:10.1371/journal.pone.0140349 · Cited by 221 · see citing works
Gangolf, M., Czerniecki, J., Radermecker, M., Detry, O., Nisolle, M., Jouan, C., Martin, D., Chantraine, F., Lakaye, B., Wins, P., et al. (2010) · PLoS ONE · doi:10.1371/journal.pone.0013616 · Cited by 221 · see citing works
Gut microbiota and malnutrition
Million, M., Diallo, A., & Raoult, D. (2016) · Microbial Pathogenesis · doi:10.1016/j.micpath.2016.02.003 · Cited by 221 · see citing works
Talwar, D. K., Davidson, H., Cooney, J., & JO’Reilly, D. S. (2000) · Clinical Chemistry · doi:10.1093/clinchem/46.5.704 · Cited by 209 · see citing works
Standardizing vitamin D assays: The way forward
Binkley, N., Sempos, C. T., & (VDSP), F. T. V. D. S. P. (2014) · Journal of Bone and Mineral Research · doi:10.1002/jbmr.2252 · Cited by 204 · see citing works
Fattal‐Valevski, A., Kesler, A., Sela, B., Nitzan, D., Rotstein, M. S., Mesterman, R., Toledano‐Alhadef, H., Stolovitch, C., Hoffmann, C., Globus, O., et al. (2005) · PEDIATRICS · doi:10.1542/peds.2004-1255 · Cited by 191 · see citing works
Rapid HPLC Measurement of Thiamine and Its Phosphate Esters in Whole Blood
Lu, J. L., & Frank, E. L. (2008) · Clinical Chemistry · doi:10.1373/clinchem.2007.099077 · Cited by 185 · see citing works
Thuy, P. V., Berger, J., Davidsson, L., Khẩn, N. C., Lâm, N. T., Cook, J. D., Hurrell, R. F., & Khoi, H. H. (2003) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/78.2.284 · Cited by 169 · see citing works
Dietary supplementation of lactating Gambian women. I. Effect on breast-milk volume and quality.
Prentice, A. M., Roberts, S. B., Prentice, A., Aa, P., Watkinson, M., Aa, W., & Whitehead, R. G. (1983) · PubMed · Cited by 146 · see citing works
Konzo: From Poverty, Cassava, and Cyanogen Intake to Toxico-Nutritional Neurological Disease
Nzwalo, H., & Cliff, J. (2011) · PLoS neglected tropical diseases · doi:10.1371/journal.pntd.0001051 · Cited by 144 · see citing works
Kirksey, A., Wachs, T., Yunis, F. A., Srinath, U., Rahmanifar, A., McCabe, G. P., Galal, O., Harrison, G. G., & Jerome, N. (1994) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/60.5.782 · Cited by 142 · see citing works
Fattal‐Valevski, A. (2011) · Journal of Evidence-Based Complementary & Alternative Medicine · doi:10.1177/1533210110392941 · Cited by 137 · see citing works
Thiamine Intestinal Transport and Related Issues: Recent Aspects
Rindi, G., & Laforenza, U. (2000) · Proceedings of The Society for Experimental Biology and Medicine · doi:10.1046/j.1525-1373.2000.22428.x · Cited by 134 · see citing works
The Neurological Complications of Nutritional Deficiency following Bariatric Surgery
Becker, D. A., Balcer, L. J., & Galetta, S. L. (2012) · Journal of Obesity · doi:10.1155/2012/608534 · Cited by 132 · see citing works
Food-Based Dietary Guidelines Can Be Developed and Tested Using Linear Programming Analysis
Ferguson, E., Darmon, N., Briend, A., & Premachandra, I. M. (2004) · Journal of Nutrition · doi:10.1093/jn/134.4.951 · Cited by 129 · see citing works
Fortified Foods Are Major Contributors to Nutrient Intakes in Diets of US Children and Adolescents
Berner, L. A., Keast, D. R., Bailey, R. L., & Dwyer, J. T. (2014) · Journal of the Academy of Nutrition and Dietetics · doi:10.1016/j.jand.2013.10.012 · Cited by 129 · see citing works
Drake, I., Gullberg, B., Sonestedt, E., Wallström, P., Persson, M., Hlebowicz, J., Nilsson, J. Å., Hedblad, B., & Wirfält, E. (2012) · Public Health Nutrition · doi:10.1017/s1368980012002789 · Cited by 126 · see citing works
Thiamine Intestinal Transport and Related Issues: Recent Aspects
Rindi, G., & Laforenza, U. (2000) · Proceedings of The Society for Experimental Biology and Medicine · doi:10.1111/j.1525-1373.2000.22428.x · Cited by 126 · see citing works
INTERDEPARTMENTAL COMMITTEE ON NUTRITION FOR NATIONAL DEFENSE
Schaefer, A. E. (2009) · Nutrition Reviews · doi:10.1111/j.1753-4887.1958.tb00753.x · Cited by 125 · see citing works
Shih, S. C. C., Yang, H., Jebrail, M. J., Fobel, R., McIntosh, N., Al-Dirbashi, O. Y., Chakraborty, P. K., & Wheeler, A. R. (2012) · Analytical Chemistry · doi:10.1021/ac300305s · Cited by 123 · see citing works
Bettendorff, L., & Wins, P. (2009) · FEBS Journal · doi:10.1111/j.1742-4658.2009.07019.x · Cited by 122 · see citing works
Tallaksen, C. M. E., Sande, S. A., B�hmer, T., Bell, H., & Karlsen, J. R. (1993) · European Journal of Clinical Pharmacology · doi:10.1007/bf00315284 · Cited by 120 · cited 2× · see citing works
“Diseases associated with thiamine deficiency Overt thiamine deficiency syndromes represent a spectrum of clinical presentations that have been historically divided into two categories based on symptomology: (1) beriberi, which can be “wet” if it predominantly affects the cardiovascular system and is accompanied by ede…”
BackgroundLow dietary diversity and micronutrient adequacy among lactating women in a peri-urban area of Nepal
Henjum, S., Torheim, L. E., Thorne‐Lyman, A., Chandyo, R., Fawzi, W. W., Shrestha, P. S., & Strand, T. A. (2015) · Public Health Nutrition · doi:10.1017/s1368980015000671 · Cited by 113 · see citing works
Erythrocyte as a Biopsy Tissue for Functional Evaluation of Thiamine Adequacy
Brin, M. (1964) · JAMA · doi:10.1001/jama.1964.03060230090022 · Cited by 112 · see citing works
Barennes, H., Simmala, C., Odermatt, P., Thaybouavone, T., Vallée, J., Martinez-Aussel, B., Newton, P. N., & Strobel, M. (2007) · European Journal of Clinical Nutrition · doi:10.1038/sj.ejcn.1602928 · Cited by 108 · see citing works
Beri-beri: the major cause of infant mortality in Karen refugees
Luxemburger, C., White, N. J., ter Kuile, F., Singh, H. M., Allier-Frachon, I., Ohn, M., Chongsuphajaisiddhi, T., & Nosten, F. (2003) · Transactions of the Royal Society of Tropical Medicine and Hygiene · doi:10.1016/s0035-9203(03)90134-9 · Cited by 107 · see citing works
Wernicke Encephalopathy in Nonalcoholic Patients
Ogershok, P. R., Rahman, A., Brick, J. E., & Nestor, S. L. (2002) · The American Journal of the Medical Sciences · doi:10.1097/00000441-200202000-00010 · Cited by 106 · see citing works
Vitamin B1 in critically ill patients: needs and challenges
Collie, J. T. B., Greaves, R. F., Jones, O. A. H., Lam, Q. T., Eastwood, G. M., & Bellomo, R. (2017) · Clinical Chemistry and Laboratory Medicine (CCLM) · doi:10.1515/cclm-2017-0054 · Cited by 105 · see citing works
THE BIOSYNTHESIS OF THIAMINE IN MAN
Najjar, V. A. (1943) · JAMA · doi:10.1001/jama.1943.02840460017005 · Cited by 102 · see citing works
Dietary Reference Intakes: Guiding Principles for Nutrition Labeling and Fortification
(2004) · Nutrition Reviews · doi:10.1111/j.1753-4887.2004.tb00028.x · Cited by 101 · see citing works
Beriberi (Thiamine Deficiency) and High Infant Mortality in Northern Laos
Barennes, H., Sengkhamyong, K., René, J. P., & Phimmasane, M. (2015) · PLoS neglected tropical diseases · doi:10.1371/journal.pntd.0003581 · Cited by 99 · see citing works
Postpartum thiamine deficiency in a Karen displaced population
McGready, R. M., Simpson, J. A., Cho, T., Dubowitz, L. M. S., Changbumrung, S., Böhm, V., Munger, R., Sauberlich, H. E., White, N. J., & Nosten, F. H. (2001) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/74.6.808 · Cited by 98 · see citing works
Thuy, P. V., Berger, J., Nakanishi, Y., Khẩn, N. C., Lynch, S. R., & Dixon, P. M. (2005) · Journal of Nutrition · doi:10.1093/jn/135.11.2596 · Cited by 96 · see citing works
Harper, C. G., Sheedy, D. L., Lara, A. I., Garrick, T. M., Hilton, J. M. N., & Raisanen, J. M. (1998) · The Medical Journal of Australia · doi:10.5694/j.1326-5377.1998.tb139081.x · Cited by 95 · see citing works
de Lima, L. F. P., Leite, H. P., & Taddei, J. A. D. A. C. (2010) · American Journal of Clinical Nutrition · doi:10.3945/ajcn.2009.29078 · Cited by 95 · see citing works
Peng, Y., Zhou, T., Wang, Q., Liu, P., Zhang, T., Zetterström, R. H., & Strandvik, B. (2009) · Prostaglandins Leukotrienes and Essential Fatty Acids · doi:10.1016/j.plefa.2009.07.004 · Cited by 95 · see citing works
Thiamine deficiency and wernicke's encephalopathy in AIDS
Butterworth, R. F., Gaudreau, C., Vincelette, J., Bourgault, A., Lamothe, F., & Nutini, A.-M. (1991) · Metabolic Brain Disease · doi:10.1007/bf00996920 · Cited by 94 · see citing works
Beriberi, White Rice, and Vitamin B
Carpenter, K. J. (2000) · University of California Press eBooks · doi:10.1525/9780520923645 · Cited by 91 · see citing works
Mancinelli, R., Ceccanti, M., Guiducci, M. S., Sasso, G. F., Sebastiani, G., Attilia, M. L., & Allen, J. P. (2003) · Journal of Chromatography B · doi:10.1016/s1570-0232(03)00139-9 · Cited by 90 · see citing works
Hiffler, L., Rakotoambinina, B., Lafferty, N., & García, D. M. (2016) · Frontiers in Nutrition · doi:10.3389/fnut.2016.00016 · Cited by 85 · see citing works
Thiamine deficiency and malaria in adults from southeast Asia
Krishna, S., Taylor, A., Supanaranond, W., Pukrittayakamee, S., ter Kuile, F. O., Tawfiq, K., Holloway, P. A. H., & White, N. J. (1999) · The Lancet · doi:10.1016/s0140-6736(98)06316-8 · Cited by 78 · see citing works
Fattal, I., Friedmann, N., & Fattal‐Valevski, A. (2011) · Brain · doi:10.1093/brain/awr068 · Cited by 77 · see citing works
Morrison, A. B., & Campbell, J. A. (1960) · Journal of Nutrition · doi:10.1093/jn/72.4.435 · Cited by 71 · see citing works
Herve, C., Beyne, P., Lettéron, P., & Delacoux, E. (1995) · Clinica Chimica Acta · doi:10.1016/0009-8981(94)05980-7 · Cited by 70 · see citing works
Examining strategies to facilitate vitamin B1 biofortification of plants by genetic engineering
Pourcel, L., Moulin, M., & Fitzpatrick, T. B. (2013) · Frontiers in Plant Science · doi:10.3389/fpls.2013.00160 · Cited by 69 · see citing works
Thiamine Deficiency in Cambodian Infants with and without Beriberi
Coats, D., Shelton-Dodge, K., Ou, K., Khun, V., Seab, S., Sok, K., Prou, C., Tortorelli, S., Moyer, T. P., Cooper, L. E., et al. (2012) · The Journal of Pediatrics · doi:10.1016/j.jpeds.2012.05.006 · Cited by 67 · see citing works
Dietary behaviour, food and nutrient intake of pregnant women in a rural community in Burkina Faso
Huybregts, L., Roberfroid, D., Kolsteren, P. W., & Camp, J. H. V. (2009) · Maternal and Child Nutrition · doi:10.1111/j.1740-8709.2008.00180.x · Cited by 66 · see citing works
Clinically Unapparent Infantile Thiamin Deficiency in Vientiane, Laos
Khounnorath, S., Chamberlain, K., Taylor, A. M., Soukaloun, D., Mayxay, M., Lee, S. J., Phengdy, B., Luangxay, K., Sisouk, K., Soumphonphakdy, B., et al. (2011) · PLoS neglected tropical diseases · doi:10.1371/journal.pntd.0000969 · Cited by 65 · see citing works
Ghosh‐Jerath, S., Devasenapathy, N., Singh, A., Shankar, A. H., & ZODPEY, S. P. (2015) · Reproductive Health · doi:10.1186/s12978-015-0008-9 · Cited by 64 · see citing works
Nutrient Intakes of Pregnant Women and their Associated Factors in Eight Cities of China
Liu, F.-L., Zhang, Y., Vinyes-Parès, G., Reidy, K., Zhao, W., Zhao, A., Chen, C., Ning, C., Zheng, Y., & Wang, P. (2015) · Chinese Medical Journal · doi:10.4103/0366-6999.159354 · Cited by 63 · see citing works
Steyn, N. P., Wolmarans, P., Nel, J. H., & Bourne, L. T. (2007) · Public Health Nutrition · doi:10.1017/s136898000700033x · Cited by 63 · see citing works
Analysis of Practical Identifiability of a Viral Infection Model
Nguyễn, V. K., Klawonn, F., Mikolajczyk, R., & Hernandez-Vargas, E. A. (2016) · PLoS ONE · doi:10.1371/journal.pone.0167568 · Cited by 62 · see citing works
Dietary and socio-economic factors associated with beriberi in breastfed Lao infants
Soukaloun, D., Kounnavong, S., Pengdy, B., Boupha, B., Durondej, S., OLNESS, K. N., Newton, P. N., & White, N. J. (2003) · Annals of Tropical Paediatrics · doi:10.1179/027249303322296493 · Cited by 61 · see citing works
Neurological disorders associated with cassava diet: a review of putative etiological mechanisms
Adamolekun, B. (2011) · Metabolic Brain Disease · doi:10.1007/s11011-011-9237-y · Cited by 61 · see citing works
Thiamine Deficiency in Infancy: Long-Term Follow-Up
Mimouni-Bloch, A., Goldberg‐Stern, H., Straussberg, R., Brezner, A., Heyman, E., Inbar, D., Kivity, S., Zvulunov, A., Sztarkier, I., Fogelman, R., et al. (2014) · Pediatric Neurology · doi:10.1016/j.pediatrneurol.2014.05.010 · Cited by 60 · see citing works
Whitfield, K. C., Karakochuk, C. D., Liu, Y., McCann, A., Talukder, A., Kroeun, H., Ward, M., McNulty, H., Lynd, L. D., Kitts, D. D., et al. (2015) · Journal of Nutrition · doi:10.3945/jn.114.203604 · Cited by 60 · see citing works
Microfluidics-based point-of-care test for serodiagnosis of Lyme Disease
Nayak, S., Sridhara, A. A., Melo, R., Richer, L. M., Chee, N. H., Kim, J., Linder, V., Steinmiller, D., Sia, S. K., & Gomes-Solecki, M. J. C. (2016) · Scientific Reports · doi:10.1038/srep35069 · Cited by 60 · see citing works
Subcellular localization and compartmentation of thiamine derivatives in rat brain
Bettendorff, L., Wins, P., & Lesourd, M. (1994) · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research · doi:10.1016/0167-4889(94)90018-3 · Cited by 59 · see citing works
A Review of Cutoffs for Nutritional Biomarkers.
Raghavan, R., Sakr-Ashour, F. A., & Bailey, R. L. (2016) · Advances in Nutrition · doi:10.3945/an.115.009951 · Cited by 59 · see citing works
Hlaing, L. M., Fahmida, U., Htet, M. K., Utomo, B., Firmansyah, A., & Ferguson, E. (2015) · British Journal Of Nutrition · doi:10.1017/s000711451500481x · Cited by 58 · see citing works
Nguyen, P. H., Young, M. F., González-Casanova, I., Pham, H. Q., Nguyen, H. K., Truong, T. V., Nguyen, S., Harding, K., Reinhart, G. A., Martorell, R., et al. (2016) · PLoS ONE · doi:10.1371/journal.pone.0167416 · Cited by 58 · see citing works
Inadequacy of nutrients intake among pregnant women in the Deep South of Thailand
Sukchan, P., Liabsuetrakul, T., Chongsuvivatwong, V., Songwathana, P., Sornsrivichai, V., & Kuning, M. (2010) · BMC Public Health · doi:10.1186/1471-2458-10-572 · Cited by 57 · see citing works
Stuetz, W., Carrara, V. I., McGready, R. M., Lee, S. J., Erhardt, J. G., Breuer, J., Biesalski, H. K., & Nosten, F. H. (2011) · European Journal of Nutrition · doi:10.1007/s00394-011-0226-z · Cited by 57 · see citing works
Whitfield, K. C., Smith, G., Chamnan, C., Karakochuk, C. D., Sophonneary, P., Kuong, K., Dijkhuizen, M. A., Hong, R., Berger, J., Green, T., et al. (2017) · PLoS neglected tropical diseases · doi:10.1371/journal.pntd.0005814 · Cited by 57 · see citing works
(1996) · CRC Press eBooks · doi:10.1201/9781439821954 · Cited by 56 · see citing works
Biochemical evidence of thiamine depletion during the Cuban neuropathy epidemic, 1992–1993
Matos, C. M., Rodríguez-Ojea, A., Chi, N., Jiménez, S., Zulueta, D., & Bates, C. (1996) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/64.3.347 · Cited by 55 · see citing works
BERIBERI CAUSED BY ANTITHIAMIN FACTORS IN FOOD AND ITS PREVENTION*
Vimokesant, S., Kunjara, S., Rungruangsak, K., Nakornchai, S., & Panijpan, B. (1982) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1982.tb31191.x · Cited by 55 · see citing works
Dietary pattern and usual nutrient intakes of Peruvian women during pregnancy
Sacco, L., Caulfield, L. E., Zavaleta, N., & Retamozo, L. (2003) · European Journal of Clinical Nutrition · doi:10.1038/sj.ejcn.1601716 · Cited by 55 · see citing works
Thiamine deficiency in infants: MR findings in the brain.
Kornreich, L., Bron-Harlev, E., Hoffmann, C., Schwarz, M., Konen, O., Schoenfeld, T., Straussberg, R., Nahum, E., Abu‐Kishk, I., Eshel, G. M., et al. (2005) · PubMed Central · Cited by 54 · see citing works
Bhat, J. I., Rather, H., Ahangar, A. A., Qureshi, U. A., Dar, P. M. U. D., Ahmed, Q. I., Charoo, B. A., & Ali, S. W. (2016) · Indian Heart Journal · doi:10.1016/j.ihj.2016.07.015 · Cited by 53 · see citing works
Stability and retention of micronutrients in fortified rice prepared using different cooking methods
Wieringa, F. T., Laillou, A., Guyondet, C., Jallier, V., Moench‐Pfanner, R., & Berger, J. (2014) · Annals of the New York Academy of Sciences · doi:10.1111/nyas.12497 · Cited by 52 · see citing works
Thiamine responsive acute life threatening metabolic acidosis in exclusively breast-fed infants
Qureshi, U. A., Sami, A., Qureshi, U. A., Ahmad, K., Iqbal, J., Wani, N. A., Mir, Z. I., & Ali, I. (2015) · Nutrition · doi:10.1016/j.nut.2015.08.007 · Cited by 50 · see citing works
Thiamin biofortification of crops
Goyer, A. (2016) · Current Opinion in Biotechnology · doi:10.1016/j.copbio.2016.09.005 · Cited by 50 · see citing works
Persson, V., Winkvist, A., Hartini, T. N. S., Greiner, T. H., Hakimi, M., & Stenlund, H. C. (2001) · Journal of Nutrition · doi:10.1093/jn/131.2.325 · Cited by 49 · see citing works
Lavoie, J., & Butterworth, R. F. (1995) · Alcoholism Clinical and Experimental Research · doi:10.1111/j.1530-0277.1995.tb00991.x · Cited by 49 · see citing works
Studies on Human Lactation Part III
Deodhar, A. D., Rajalakshmi, R., & Ramakrishnan, C. V. (1964) · Acta Paediatrica · doi:10.1111/j.1651-2227.1964.tb07204.x · Cited by 48 · see citing works
Anta, R. M. O., Martínez, R. M., Andrés, P., Arias, L. M., & López-Sobaler, A. M. (2004) · British Journal Of Nutrition · doi:10.1079/bjn20041153 · Cited by 47 · see citing works
Relative validation of a quantitative FFQ for use in Brazilian pregnant women
Barbieri, P., Nishimura, R., Crivellenti, L. C., & Sartorelli, D. S. (2012) · Public Health Nutrition · doi:10.1017/s1368980012003783 · Cited by 46 · see citing works
Adamolekun, B. (2010) · Journal of the Neurological Sciences · doi:10.1016/j.jns.2010.06.016 · Cited by 46 · see citing works
Wirth, J. P., Laillou, A., Rohner, F., Northrop‐Clewes, C. A., Macdonald, B., & Moench‐Pfanner, R. (2012) · Food and Nutrition Bulletin · doi:10.1177/15648265120334s304 · Cited by 44 · see citing works
Puts, J., de Groot, M. J. M., Haex, M., & Jakobs, B. S. (2015) · PLoS ONE · doi:10.1371/journal.pone.0132018 · Cited by 44 · see citing works
Wernicke encephalopathy in children and adolescents
Lallas, M., & Desai, J. D. (2014) · World Journal of Pediatrics · doi:10.1007/s12519-014-0506-9 · Cited by 44 · see citing works
Bailey, A. L., Finglas, P. M., Wright, A. J. A., & Southon, S. (1994) · British Journal Of Nutrition · doi:10.1079/bjn19940014 · Cited by 43 · see citing works
Hess, S. Y., Brown, K. H., Sablah, M., Engle‐Stone, R., Aaron, G. J., & Baker, S. K. (2013) · Food and Nutrition Bulletin · doi:10.1177/156482651303400104 · Cited by 41 · see citing works
Epilepsy in children with infantile thiamine deficiency
Fattal‐Valevski, A., Mimouni-Bloch, A., Kivity, S., Heyman, E., Brezner, A., Straussberg, R., Inbar, D., Kramer, U., & Goldberg‐Stern, H. (2009) · Neurology · doi:10.1212/wnl.0b013e3181b121f5 · Cited by 41 · see citing works
Outbreak of Beriberi in a Prison in Côte D'Ivoire
Ahoua, L., Etienne, W., Fermon, F., Godain, G., Brown, V., Kadjo, K., Bouaffou, K., Legros, D., & Guerin, P. J. (2007) · Food and Nutrition Bulletin · doi:10.1177/156482650702800304 · Cited by 40 · see citing works
A New Approach to Erythrocyte Transketolase Measurement
Warnock, L. G. (1970) · Journal of Nutrition · doi:10.1093/jn/100.9.1057 · Cited by 40 · see citing works
OUTBREAK OF BERI-BERI IN THE GAMBIA
Tang, C., Wells, J. C., Rolfe, M., & Cham, K. (1989) · The Lancet · doi:10.1016/s0140-6736(89)90383-8 · Cited by 40 · see citing works
Thiamine pharmacokinetics in Cambodian mothers and their breastfed infants
Coats, D., Frank, E. L., Reid, J. M., Ou, K., Chea, M., Mengkheang, K., Preou, C., Enders, F., Fischer, P. R., & Topazian, M. D. (2013) · American Journal of Clinical Nutrition · doi:10.3945/ajcn.113.062737 · Cited by 40 · see citing works
Lee, S. J., Aranyosi, A. J., Wong, M. D., Hong, J. H., Lowe, J., Chan, C., Garlock, D., Shaw, S., Beattie, P. D., Kratochvil, Z., et al. (2015) · Biosensors and Bioelectronics · doi:10.1016/j.bios.2015.11.060 · Cited by 40 · see citing works
Perinatal Consumption of Thiamine-Fortified Fish Sauce in Rural Cambodia
Whitfield, K. C., Karakochuk, C. D., Kroeun, H., Hampel, D., Ly, S., Chan, B. B., Borath, M., Sophonneary, P., McLean, J., Talukder, A., et al. (2016) · Archives of Pediatrics and Adolescent Medicine · doi:10.1001/jamapediatrics.2016.2065 · Cited by 40 · see citing works
Handbook of Food Fortification and Health
(2013) · Springer eBooks · doi:10.1007/978-1-4614-7076-2 · Cited by 40 · see citing works
Soukaloun, D., Lee, S. J., Chamberlain, K., Taylor, A. M., Mayxay, M., Sisouk, K., Soumphonphakdy, B., Latsavong, K., Akkhavong, K., Phommachanh, D., et al. (2011) · PLoS neglected tropical diseases · doi:10.1371/journal.pntd.0000971 · Cited by 39 · see citing works
Thiamine Deficiency and Cardiac Dysfunction in Cambodian Infants
Porter, S. G., Coats, D., Fischer, P. R., Ou, K., Frank, E. L., Sreang, P., Saing, S., Topazian, M. D., Enders, F., & Cabalka, A. K. (2014) · The Journal of Pediatrics · doi:10.1016/j.jpeds.2014.01.049 · Cited by 37 · see citing works
Agriculture Diversification in the Mekong Delta: Farmers’ Motives and Contributions to Livelihoods
Bosma, R. H., Udo, H. M. J., Verreth, J. A. J., Visser, L. E., & Nam, C. Q. (2005) · Socio-Environmental Systems Modeling · doi:10.22004/ag.econ.165780 · Cited by 37 · see citing works
The effect of subclinical infantile thiamine deficiency on motor function in preschool children
Harel, Y., Zuk, L., Guindy, M., Nakar, O., Lotan, D., & Fattal‐Valevski, A. (2017) · Maternal and Child Nutrition · doi:10.1111/mcn.12397 · Cited by 37 · see citing works
Multiple micronutrient fortification of salt
Vinodkumar, M., & Rajagopalan, S. (2007) · European Journal of Clinical Nutrition · doi:10.1038/sj.ejcn.1602955 · Cited by 36 · see citing works
Maternal thiamine deficiency: still a problem in some world communities
Butterworth, R. F. (2001) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/74.6.712 · Cited by 35 · see citing works
Outbreak of Beriberi among African Union Troops in Mogadishu, Somalia
Watson, J. T., Bushra, H. E. E., Lebo, E. J., Bwire, G., Kiyengo, J., Emukule, G. O., Omballa, V., Tole, J., Muvunyi, Z., Breiman, R. F., et al. (2011) · PLoS ONE · doi:10.1371/journal.pone.0028345 · Cited by 35 · see citing works
Thiamin deficiency and uncomplicated falciparum malaria in Laos
Mayxay, M., Taylor, A. M., Khanthavong, M., Keola, S., Pongvongsa, T., Phompida, S., Phetsouvanh, R., White, N. J., & Newton, P. N. (2007) · Tropical Medicine & International Health · doi:10.1111/j.1365-3156.2006.01804.x · Cited by 34 · see citing works
High Prevalence of Infantile Encephalitic Beriberi with Overlapping Features of Leigh's Disease
Rao, S. N., Mani, S., Madap, K., Kumar, M. V. K., Singh, L., & Chandak, G. R. (2008) · Journal of Tropical Pediatrics · doi:10.1093/tropej/fmn031 · Cited by 33 · see citing works
Dary, O., & Jariseta, Z. R. (2012) · Food and Nutrition Bulletin · doi:10.1177/15648265120333s207 · Cited by 32 · see citing works
Vuilleumier, J. P., Keller, H., & Keck, E. (1990) · PubMed · Cited by 32 · see citing works
Pig production in Vietnam - a review.
Lemke, U., Mergenthaler, M., Roessler, R., Huyen, L. T. T., Herold, P., Kaufmann, B., & Zárate, A. V. (2008) · CABI Reviews · doi:10.1079/pavsnnr20083023 · Cited by 31 · see citing works
Vanier, N. L., Paraginski, R. T., Berrios, J. D. J., Oliveira, L. D. C., & Elias, M. C. (2015) · Journal of Food Composition and Analysis · doi:10.1016/j.jfca.2015.02.008 · Cited by 31 · see citing works
Agriculture Diversification in the Mekong Delta: Farmers' Motives and Contributions to Livelihoods
Bosma, R. H., Udo, H. M. J., Verreth, J. A. J., Visser, L. E., & Nam, C. Q. (2005) · Asian Journal of Agriculture and Development · doi:10.37801/ajad2005.2.1-2.5 · Cited by 31 · see citing works
Dietary Patterns among Pregnant Women in the West-North of Iran
Esmaillzadeh, A., Samareh, S., & Azadbakht, L. (2008) · Pakistan Journal of Biological Sciences · doi:10.3923/pjbs.2008.793.796 · Cited by 30 · see citing works
Low Thiamine Levels in Children With Type 1 Diabetes and Diabetic Ketoacidosis
Rosner, E. A., Strezlecki, K. D., Clark, J. A., & Lieh-Lai, M. W. (2015) · Pediatric Critical Care Medicine · doi:10.1097/pcc.0000000000000302 · Cited by 30 · see citing works
Wyatt, D. T., Nelson, D., & Hillman, R. E. (1991) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/53.2.530 · Cited by 30 · see citing works
Fish Sauce, Soy Sauce, and Vegetable Oil Fortification in Cambodia: Where do we Stand to Date?
Theary, C., Panagides, D., Laillou, A., Vonthanak, S., Kanarath, C., Chhea, C., Sambath, P., Sowath, S., & Moench‐Pfanner, R. (2013) · Food and Nutrition Bulletin · doi:10.1177/15648265130342s108 · Cited by 28 · see citing works
Prenatal diet, nutrient intake and pregnancy outcome in urban Ecuadorian primiparas.
Weigel, M. M., Nárváez, W. M., López, A., Félix, C., & López, P. (1991) · PubMed · Cited by 28 · see citing works
Rosalind, S. G., & Cavalli-Sforza, T. (2012) · Food and Nutrition Bulletin · doi:10.1177/15648265120333s210 · Cited by 27 · see citing works
Beriberi outbreak among commercial fishermen, Thailand 2005.
Doungngern, P., Kesornsukhon, S., Kanlayanaphotporn, J., Wanadurongwan, S., & Songchitsomboon, S. (2007) · PubMed · Cited by 27 · see citing works
Thiamine Deficiency and Associated Clinical Disorders
McCandless, D. W. (2009) · Contemporary clinical neuroscience · doi:10.1007/978-1-60761-311-4 · Cited by 27 · see citing works
Ihara, H., Matsumoto, T., Shino, Y., & Hashizume, N. (2005) · Journal of Clinical Laboratory Analysis · doi:10.1002/jcla.20079 · Cited by 26 · see citing works
Outbreak of Beriberi in an Indian Population of the Upper Amazon Region, Roraima State, Brazil, 2008
Cerroni, M. P., Barrado, J. C. D. S., da Nóbrega, A. A., Lins, A. B. M., da Silva, I. P., Mangueira, R. R., da Cruz, R. H., Mendes, S. M. F., & Sobel, J. (2010) · American Journal of Tropical Medicine and Hygiene · doi:10.4269/ajtmh.2010.10-0345 · Cited by 26 · see citing works
Piammongkol, S., Marks, G. C., Williams, G. M., & Chongsuvivatwong, V. (2004) · PubMed · Cited by 25 · see citing works
Hoad, K., Johnson, L. A., Woollard, G. A., Walmsley, T. A., Briscoe, S., Jolly, L., Gill, J., & Greaves, R. F. (2013) · Clinical Biochemistry · doi:10.1016/j.clinbiochem.2013.01.020 · Cited by 25 · see citing works
The role of thiamine in HIV infection
Lương, K. V. Q., & NGUYEN, L. T. H. (2012) · International Journal of Infectious Diseases · doi:10.1016/j.ijid.2012.11.019 · Cited by 25 · see citing works
Panwar, B., & Punia, D. (1998) · International Journal of Food Sciences and Nutrition · doi:10.3109/09637489809089414 · Cited by 25 · see citing works
High-Throughput Detection of Thiamine Using Periplasmic Binding Protein-Based Biorecognition
Edwards, K. A., Seog, W. J., Han, L., Feder, S., Kraft, C. E., & Baeumner, A. J. (2016) · Analytical Chemistry · doi:10.1021/acs.analchem.6b02092 · Cited by 25 · see citing works
Thiamine deficiency in tachypnoeic Cambodian infants
Keating, E. M., Nget, P., Kea, S., Suy, K., Leng, D., Phearom, S., Enders, F., Cheryk, L. A., Topazian, M. D., Fischer, P. R., et al. (2015) · Paediatrics and International Child Health · doi:10.1080/20469047.2015.1109226 · Cited by 24 · see citing works
Davis, R. E., Icke, G. C., Thom, J. Y., & Riley, W. J. (1984) · Journal of Nutritional Science and Vitaminology · doi:10.3177/jnsv.30.475 · Cited by 23 · see citing works
B-vitamin interventions for women and children in low-income populations
Swaminathan, S., Thomas, T. S., & Kurpad, A. V. (2015) · Current Opinion in Clinical Nutrition & Metabolic Care · doi:10.1097/mco.0000000000000166 · Cited by 23 · see citing works
Nutrient intake and food consumption among pregnant women from an agricultural region of Morocco
Belgnaoui, S., & Belahsen, R. (2006) · International Journal of Food Sciences and Nutrition · doi:10.1080/09637480500465261 · Cited by 23 · see citing works
Adamolekun, B., McCandless, D. W., & Butterworth, R. F. (1997) · Metabolic Brain Disease · doi:10.1007/bf02674669 · Cited by 23 · see citing works
Urban beri-beri in The Gambia, West Africa
Rolfe, M., Walker, R. W., Samba, K., & Cham, K. (1993) · Transactions of the Royal Society of Tropical Medicine and Hygiene · doi:10.1016/0035-9203(93)90449-z · Cited by 23 · see citing works
Floridi, A., Pupita, M., Palmerini, C. A., Fini, C., & Fidanza, A. (1984) · PubMed · Cited by 23 · see citing works
Infantile encephalitic beriberi: magnetic resonance imaging findings
Wani, N. A., Qureshi, U. A., Jehangir, M., Ahmad, K., & Ahmad, W. (2015) · Pediatric Radiology · doi:10.1007/s00247-015-3437-2 · Cited by 22 · see citing works
Organoleptic qualities and acceptability of fortified rice in two Southeast Asian countries
Van, T. K., Burja, K., Tran, N. T., Kong, K., Berger, J., Gardner, M., Dijkhuizen, M. A., Hop, L. T., Tuyên, L. D., & Wieringa, F. T. (2014) · Annals of the New York Academy of Sciences · doi:10.1111/nyas.12506 · Cited by 22 · see citing works
Thiamine status after major trauma
McConachie, I., & Haskew, A. E. (1988) · Intensive Care Medicine · doi:10.1007/bf00256767 · Cited by 22 · see citing works
Beri-Beri and thiamine deficiency in HIV infection
Mouly, S. J. (1996) · AIDS · doi:10.1097/00002030-199607000-00024 · Cited by 22 · see citing works
Kesler, A., Stolovitch, C., Hoffmann, C., Avni, I., & Morad, Y. (2005) · Journal of Neuro-Ophthalmology · doi:10.1097/01.wno.0000177293.06727.d5 · Cited by 22 · see citing works
Nutrients intake as determinants of blood lead and cadmium levels in Colombian pregnant women
Suárez‐Ortegón, M. F., Mosquera, M., Caicedo, D. M., de Plata, C. A., & Méndez, F. (2013) · American Journal of Human Biology · doi:10.1002/ajhb.22375 · Cited by 22 · see citing works
Outbreak of Beri-Beri in a Prison in West Africa
de Montmollin, D., MacPhail, J., McMahon, J., & Coninx, R. (2002) · Tropical Doctor · doi:10.1177/004947550203200419 · Cited by 21 · see citing works
Thiamine deficiency in ill children
Kauffman, G., Coats, D., Seab, S., Topazian, M. D., & Fischer, P. R. (2011) · American Journal of Clinical Nutrition · doi:10.3945/ajcn.111.018457 · Cited by 21 · see citing works
Iodized Salt in Cambodia: Trends from 2008 to 2014
Laillou, A., Borath, M., Un, S. O., & Chea, C. (2015) · Nutrients · doi:10.3390/nu7064189 · Cited by 21 · see citing works
Iron status and dietary intake of Chinese pregnant women with anaemia in the third trimester
Ma, A., Chen, X.-C., Zheng, M., Wang, Y., Rong-xian, X., & Juesheng, L. (2002) · Asia Pacific Journal of Clinical Nutrition · doi:10.1046/j.1440-6047.2002.00274.x · Cited by 20 · see citing works
Nti, C. A., Larweh, P. M., & Gyemfua‐Yeboah, Y. (2002) · International Journal of Consumer Studies · doi:10.1046/j.1470-6431.2002.00211.x · Cited by 20 · see citing works
Infantile Wernicke's encephalopathy
Qureshi, U. A., Wani, N. A., Ahmad, K., Irshad, M., & Ali, I. (2015) · Archives of Disease in Childhood · doi:10.1136/archdischild-2014-307949 · Cited by 20 · see citing works
Legal Framework for Food Fortification: Examples from Vietnam and Indonesia
Dijkhuizen, M. A., Wieringa, F. T., Soekarjo, D. D., Van, K. T., & Laillou, A. (2013) · Food and Nutrition Bulletin · doi:10.1177/15648265130342s113 · Cited by 20 · see citing works
Whitfield, K. C., Karakochuk, C. D., Kroeun, H., Ly, S., Chan, B. B., Borath, M., Sophonneary, P., Moore, K., Tong, J., McLean, J., et al. (2016) · The Journal of Pediatrics · doi:10.1016/j.jpeds.2016.10.066 · Cited by 20 · see citing works
A Large Outbreak of Thiamine Deficiency Among Illegal Gold Miners in French Guiana
Mosnier, E., Niemetzky, F., Stroot, J., de Santi, V. P., Brousse, P., Guarmit, B., Blanchet, D., Ville, M., Abboud, P., Djossou, F., et al. (2017) · The American Society of Tropical Medicine and Hygiene · doi:10.4269/ajtmh.15-0906 · Cited by 19 · see citing works
Epidemiology and clinical presentation of a seasonal ataxia in Western Nigeria
Adamolekun, B., & Ndububa, D. A. (1994) · Journal of the Neurological Sciences · doi:10.1016/0022-510x(94)90017-5 · Cited by 18 · see citing works
Seeing double: the low carb diet
McKenna, L. A., Drummond, R. S., Drummond, S., Talwar, D., & Lean, M. E. (2013) · BMJ · doi:10.1136/bmj.f2563 · Cited by 18 · see citing works
Thurnham, D. I., Cathcart, A. E., & Livingstone, M. B. E. (2011) · Nutrients · doi:10.3390/nu3010135 · Cited by 17 · see citing works
Outbreak of Beriberi Among Illegal Mainland Chinese Immigrants at a Detention Center in Taiwan
Chen, K.-T. (2003) · Public Health Reports · doi:10.1093/phr/118.1.59 · Cited by 16 · see citing works
Therapeutic effect of vitamin B complex on an ataxic syndrome in Western Nigeria
Monekosso, G. L., Annan, W. G., & Ashby, P. H. (1964) · Transactions of the Royal Society of Tropical Medicine and Hygiene · doi:10.1016/0035-9203(64)90091-4 · Cited by 16 · see citing works
Infant Botulism: Is There an Association With Thiamine Deficiency?
Ringe, H., Schuelke, M., Weber, S., Dorner, B. G., Kirchner, S., & Dorner, M. B. (2014) · PEDIATRICS · doi:10.1542/peds.2013-3378 · Cited by 16 · see citing works
Clinical correlates and outcome of Shoshin Beriberi
Saya, R., Baikunje, S., Prakash, P., Subramanyam, K., & Patil, V. (2012) · North American Journal of Medical Sciences · doi:10.4103/1947-2714.102003 · Cited by 16 · see citing works
Jaruratanasirikul, S., Sangsupawanich, P., Kor‐anantakul, O., Chanvitan, P., Sriplung, H., & Patanasin, T. (2009) · The Journal of Maternal-Fetal & Neonatal Medicine · doi:10.3109/14767050903019668 · Cited by 16 · see citing works
Wani, N. A., Qureshi, U. A., Ahmad, K., & Choh, N. A. (2016) · American Journal of Neuroradiology · doi:10.3174/ajnr.a4756 · Cited by 16 · see citing works
Le béribéri, maladie nutritionnelle récurrente en milieu carcéral en Côte-d’Ivoire
Aké‐Tano, O., Konan, E., Tetchi, E. O., Ekou, F. K., Ekra, D. K., Coulibaly, A., & Dagnan, N. S. (2011) · Bulletin de la Société de pathologie exotique · doi:10.1007/s13149-011-0136-6 · Cited by 15 · see citing works
Nutritional Status of Rural Pregnant Women of Haryana State, Northern India
Jood, S., Bishnoi, S., & Khetarpaul, N. (2002) · Nutrition and Health · doi:10.1177/026010600201600206 · Cited by 15 · see citing works
Thurnham, D. I. (2013) · Elsevier eBooks · doi:10.1016/b978-0-12-375083-9.00266-x · Cited by 15 · see citing works
Perfil epidemiológico do beribéri notificado de 2006 a 2008 no Estado do Maranhão, Brasil
Padilha, E. M., Fujimori, E., Borges, A. L. V., Sato, A. P. S., Gomes, M. N., Branco, M. D. R. F. C., dos Santos, H. J., & Lermen, N. (2011) · Cadernos de Saúde Pública · doi:10.1590/s0102-311x2011000300006 · Cited by 14 · see citing works
Sultan, S., Anjum, F. M., Butt, M. S., Huma, N., & Suleria, H. A. R. (2014) · Journal of the Science of Food and Agriculture · doi:10.1002/jsfa.6634 · Cited by 13 · see citing works
Nutritional profile of selected expectant mothers and the cost of pregnancy.
Purushothaman, V., Kupputhai, U., & Nd, M. (1988) · PubMed · Cited by 13 · see citing works
Beriberi heart disease in Durban. A retrospective study.
Dp, N. (1987) · PubMed · Cited by 13 · see citing works
A diagnosis and treatment gap for thiamine deficiency disorders in sub‐Saharan Africa?
Adamolekun, B., & Hiffler, L. (2017) · Annals of the New York Academy of Sciences · doi:10.1111/nyas.13509 · Cited by 13 · see citing works
Seasonal ataxia: a case report of a disappearing disease
Moyo, A. A., Fawale, B., Adeyoyin, K., Nnaemeka, A. A., Oluwatoyin, G., & Oladeji, A. O. (2014) · African Health Sciences · doi:10.4314/ahs.v14i3.38 · Cited by 12 · see citing works
Micronutrient Fortification of Food: Issues for Asia
Smith, G. (2015) · Journal of Nutritional Science and Vitaminology · doi:10.3177/jnsv.61.s183 · Cited by 12 · see citing works
Nutritional and anthropometric assessment of a sample of pregnant women and young children in Palau
Pobocik, R. S., Heathcote, G. M., Spiers, J., & Otto, C. (2000) · Asia Pacific Journal of Clinical Nutrition · doi:10.1046/j.1440-6047.2000.00144.x · Cited by 11 · see citing works
Ramos-Hernández, R. I., Romero-Quechol, G., Morales, H. R., & Pérez‐Cuevas, R. (2005) · PubMed · Cited by 10 · see citing works
Thiamine deficiency and parasitic infection in rural Thai children.
Khampitak, T., Knowles, J., Yongvanit, P., Sithithaworn, P., Tangrassameeprasert, R., Boonsiri, P., & Satarug, S. (2006) · PubMed · Cited by 10 · see citing works
Suspected Thiamine Deficiency in Angola
Duce, M., Escribà, J. M., Aumatell, C. M., Farías, P., Fernández, E. V., & de la Rosa, O. (2003) · Cited by 10 · see citing works
Outbreak of beriberi among illegal mainland Chinese immigrants at a detention center in Taiwan
Chen, K., Twu, S., Chiou, S.-T., et al. (2003) · Public Health Reports · doi:10.1016/s0033-3549(04)50217-0 · Cited by 10 · see citing works
Darcel, F., Roussin, C., Vallat, J. M., Charlin, C., Tournebize, P., & Doussiet, E. (2009) · PubMed · Cited by 9 · see citing works
Nosten, F. H. (2015) · Paediatrics and International Child Health · doi:10.1080/20469047.2015.1109246 · Cited by 9 · see citing works
Dzed, L., Dorji, T., to, D. Y. P., Dhakal, G. P., Yangchen, P., & Wangmo, K. (2015) · Bhutan Health Journal · doi:10.47811/bhj.08 · Cited by 9 · see citing works
Hiffler, L., Adamolekun, B., Fischer, P. R., & Fattal‐Vavleski, A. (2017) · Annals of the New York Academy of Sciences · doi:10.1111/nyas.13458 · Cited by 9 · see citing works
Zhang, F., Yi, C., Fang, G., & Sakutombo, D. N. J. P. (2010) · PubMed · Cited by 8 · see citing works
Xin, Y., Wan, D., Chu, Q., Li, A., & Gao, X. (2011) · PubMed · Cited by 7 · see citing works
SOCIODEMOGRAPHIC AND DIETARY CORRELATES OF ANEMIA IN PREGNANT WOMEN IN PERU
Gyorkos, T. W., Shenker, H., Larocque, R., UGAZ, M. D. R., & Gotuzzo, E. (2004) · Ecology of Food and Nutrition · doi:10.1080/03670240490888722 · Cited by 7 · see citing works
Laillou, A., Pfanner, S., Theary, C., Chea, C., Borath, M., Sambath, P., Vonthanak, S., & Wieringa, F. T. (2016) · Nutrients · doi:10.3390/nu8020094 · Cited by 7 · see citing works
Impact of nutrition education on food and nutrient intake of pregnant women.
Paramjit, Chawla, K., & Puri, R. (1996) · PubMed · Cited by 5 · see citing works
Fortification of Fish Sauce and Soy Sauce
Chavasit, V., Tuntipopipat, S., & Watanapaisantrakul, R. (2013) · Springer eBooks · doi:10.1007/978-1-4614-7110-3_10 · Cited by 5 · see citing works
Thiamin intakes and erythrocyte thiamin levels in eleven-year-old children in the Western Cape.
van der Westhuyzen, J., Steyn, N. P., Icke, G. C., & Davis, R. (1988) · PubMed · Cited by 5 · see citing works
Flagged first, then by citations
2 of the 211 references couldn’t be matched to a known paper.
Research works printed but not linked: 6
- [27]Turck, D., J.‐L. Bresson, A. Flynn, et al 2016 EFSA scientific opinion on dietary reference values for thiamin. EFSA J. 14: e04653. PMC13088889 42006014
- [65]Khounnorath, S., K. Chamberlain, A.M. Taylor, et al 2011 Clinically unapparent infantile thiamin deficiency in Vientiane, Laos. PLoS Negl. Trop. Dis. 5: 19– 21. PMC3050987 21423705
- [136]Institute of Medicine. 1998 Dietary Reference Intakes for Thiamin, Riboflavin, Niacin, Vitamin B6, Folate, Vitamin B12, Pantothenic acid, Biotin, and Choline. Washington, DC: National Academies Press. 23193625
- [140]Otten J., Hellwig J. & Meyers L., Eds. 2006 Dietary Reference Intakes: the Essential Guide to Nutrient Requirements. Washington, DC National Academies Press.
- [149]World Health Organization. 2014 Guideline: fortification of food‐grade salt with iodine for the prevention and control of iodine deficiency disorders. World Health Organization, Geneva. 25473709
- [217]Isela, R., R. Hernández, G.R. Quechol, et al 2005 Alimentación y estado nutricio de mujeres embarazadas derechohabientes del Instituto Mexicano del Seguro Social en un área suburbana de la Ciudad de México. Ginecol. Obs. Mex. 73: 3– 10. 15847143
Cited by
Sorted by citations
Berger, M. M., Shenkin, A., Schweinlin, A., Amrein, K., Augsburger, M., Biesalski, H.-K., Bischoff, S. C., Casaer, M. P., Gundogan, K., Lepp, H.-L., et al. (2022) · Clinical Nutrition · doi:10.1016/j.clnu.2022.02.015 · Cited by 615 · see citing works
Tardy, A.-L., Pouteau, E., Marquez, D., Yilmaz, C., & Scholey, A. (2020) · Nutrients · doi:10.3390/nu12010228 · Cited by 541 · see citing works
“Even the children who initially appeared unaffected subsequently displayed a range of cognitive dysfunction, including delayed language acquisition, language impairment and dyslexia, poor coordination skills, and learning disabilities; quoted in [99].”
BackgroundInfluentialBiological Properties of Vitamins of the B-Complex, Part 1: Vitamins B1, B2, B3, and B5
Hrubša, M., Siatka, T., Najmanová, I., Vopršalová, M., Krčmová, L. K., Matoušová, K., Javorská, L., Macáková, K., Mercolini, L., Remião, F., et al. (2022) · Nutrients · doi:10.3390/nu14030484 · Cited by 277 · see citing works
Thiamine deficiency disorders: a clinical perspective
Smith, T. J., Johnson, C. R., Koshy, R. M., Hess, S. Y., Qureshi, U. A., Mynak, M. L., & Fischer, P. R. (2020) · Annals of the New York Academy of Sciences · doi:10.1111/nyas.14536 · Cited by 231 · see citing works
Neurological, Psychiatric, and Biochemical Aspects of Thiamine Deficiency in Children and Adults
Dhir, S., Tarasenko, M., Napoli, E., & Giulivi, C. (2019) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2019.00207 · Cited by 231 · see citing works
“org reflect thiamine metabolic function (102) or a direct association to its levels in the tissues.”
BackgroundThe importance of thiamine (vitamin B1) in plant health: From crop yield to biofortification
Fitzpatrick, T. B., & Chapman, L. (2020) · Journal of Biological Chemistry · doi:10.1074/jbc.rev120.010918 · Cited by 177 · see citing works
“These extreme forms of thiamine deficiency can ultimately cause death (84).”
BackgroundMethodInfluentialPublic Health Aspects in the Prevention and Control of Vitamin Deficiencies
Darnton-Hill, I. (2019) · Current Developments in Nutrition · doi:10.1093/cdn/nzz075 · Cited by 96 · see citing works
“Thiamin insufficiency (as assessed by low blood-thiamin statuses) is endemic among several Southeast Asian countries: Cambodia (70–100% of infants and 27–100% of reproductive-age women); Laos (13% of hospitalized infants); and Thailand (16–25% of children and 30% of elderly adults) (11).”
BackgroundThiamine deficiency in fishes: causes, consequences, and potential solutions
Harder, A. M., Ardren, W. R., Evans, A. N., Futia, M. H., Kraft, C. E., Marsden, J. E., Richter, C. A., Rinchard, J., Tillitt, D. E., & Christie, M. R. (2018) · Reviews in Fish Biology and Fisheries · doi:10.1007/s11160-018-9538-x · Cited by 94 · see citing works
Johnson, C. R., Fischer, P. R., Thacher, T. D., Topazian, M. D., Bourassa, M. W., & Combs, G. F. (2019) · Nutrition and Health · doi:10.1177/0260106019830847 · Cited by 79 · see citing works
Hiding in Plain Sight: Modern Thiamine Deficiency
Marrs, C., & Lonsdale, D. (2021) · Cells · doi:10.3390/cells10102595 · Cited by 79 · see citing works
“Published reference intervals for whole-blood TPP vary widely across labs, however, from a lower limit of 63–105 nmol/L to an upper limit of 171–229 nmol/L [3].”
BackgroundInfluentialGwathmey, K. G., & Grogan, J. (2019) · Muscle & Nerve · doi:10.1002/mus.26783 · Cited by 81 · see citing works
“Assessment of function and biologic activity may be further tested via the activity of erythrocyte transketolase (TK) in the erythrocyte TK activation assay, although this is not widely available.(7,35) It is important to test defi-”
BackgroundThiamine (vitamin B1) in septic shock: a targeted therapy
Moskowitz, A. L., & Donnino, M. W. (2020) · Journal of Thoracic Disease · doi:10.21037/jtd.2019.12.82 · Cited by 62 · see citing works
“In areas of the developing world, outbreaks of thiamine deficiency are known to occur as a result of inadequate nutritional support (9).”
BackgroundInfluentialSambon, M., Wins, P., & Bettendorff, L. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22115418 · Cited by 67 · see citing works
“However, TD-disorders are complex and can adopt various forms [9].”
BackgroundJones, K. S., Parkington, D. A., Cox, L., & Koulman, A. (2020) · Annals of the New York Academy of Sciences · doi:10.1111/nyas.14547 · Cited by 60 · see citing works
“(1) xylulose-5-phosphate + ribose-5-phosphate sedoheptulose-7-phosphate + glyceraldehyde-3phosphate (2) xylulose-5-phosphate + erthyose-4-phosphate fructose-6-phosphate + glyceraldehyde-3phosphate”
BackgroundMethodInfluentialNutritional Optic Neuropathies: State of the Art and Emerging Evidences
Roda, M., di Geronimo, N., Pellegrini, M., & Schiavi, C. (2020) · Nutrients · doi:10.3390/nu12092653 · Cited by 59 · see citing works
“Thiamine esters and other metabolites are found in blood and urine [48].”
BackgroundAntioxidants in Potatoes: A Functional View on One of the Major Food Crops Worldwide
Hellmann, H. A., Goyer, A., & Navarre, D. A. (2021) · Molecules · doi:10.3390/molecules26092446 · Cited by 59 · see citing works
Bager, P., Hvas, C. L., Rud, C. L., & Dahlerup, J. F. (2020) · Alimentary Pharmacology & Therapeutics · doi:10.1111/apt.16166 · Cited by 55 · see citing works
Brown, K. H., Moore, S. E., Hess, S. Y., McDonald, C. M., Jones, K. S., Meadows, S., Manger, M. S., Coates, J., Alayón, S., & Osendarp, S. J. M. (2021) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/nqab173 · Cited by 53 · see citing works
“Thiamine RBC or whole blood thiamine diphosphate, RBC transketolase activity Global Thiamine Alliance (35)”
BackgroundCardiovascular disease in low- and middle-income countries associated with environmental factors
Sliwa, K. S., Viljoen, C. A., Stewart, S., Miller, M. R., Prabhakaran, D., Kumar, R., Thienemann, F., Piniero, D., Prabhakaran, P., Narula, J., et al. (2024) · European Journal of Preventive Cardiology · doi:10.1093/eurjpc/zwad388 · Cited by 48 · see citing works
Thiamine deficiency unrelated to alcohol consumption in high‐income countries: a literature review
Gomes, F., Bergeron, G., Bourassa, M. W., & Fischer, P. R. (2021) · Annals of the New York Academy of Sciences · doi:10.1111/nyas.14569 · Cited by 47 · see citing works
Lindschinger, M., Tatzber, F., Schimetta, W., Schmid, I., Lindschinger, B., Cvirn, G., Stanger, O., Lamont, E., & Wonisch, W. (2019) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2019/6082613 · Cited by 46 · see citing works
“Sufficient supply is also required among others, for children [26], celiac disease patients [27], or alcoholics [28].”
BackgroundLucas, F. L. R., Piso, T. R. C., van der Heide, N. J., Galenkamp, N. S., Hermans, J. H., Wloka, C., & Maglia, G. (2021) · Angewandte Chemie International Edition · doi:10.1002/anie.202107807 · Cited by 45 · see citing works
The Relevance of Thiamine Evaluation in a Practical Setting
Pacei, F., Tesone, A., Nazzareno, L., Laudi, E., Cretti, A., Pnini, S., Varesco, F., & Colombo, C. (2020) · Nutrients · doi:10.3390/nu12092810 · Cited by 60 · see citing works
“Thiamine, also called vitamin B1 or aneurin, is a water-soluble vitamin, and it is an essential micronutrient for human beings [1].”
BackgroundMicronutrient Depletion in Heart Failure: Common, Clinically Relevant and Treatable
Cvetinovic, N., Loncar, G., Isakovic, A. M., von Haehling, S., Doehner, W., Lainščak, M., & Farkaš, J. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20225627 · Cited by 43 · see citing works
“Thiamin (B1) * 25–75 ng/mL 75–195 nmol/L [24]”
Vora, B., Green, E. A. E., Khuri, N., Bällgren, F., Sirota, M., & Giacomini, K. M. (2019) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/nqz255 · Cited by 42 · see citing works
(FAF), E. P. O. F. A. A. F., Younes, M., Aquilina, G., Castle, L., Engel, K., Fowler, P. J., Fernández, M. J. F., Fürst, P., Gundert‐Remy, U., Gürtler, R., et al. (2022) · EFSA Journal · doi:10.2903/j.efsa.2022.7594 · Cited by 42 · see citing works
Rakotoambinina, B., Hiffler, L., & Gomes, F. (2021) · Annals of the New York Academy of Sciences · doi:10.1111/nyas.14669 · Cited by 41 · see citing works
Walker, C., Ryu, S., Giannone, R. J., Garcia, S., & Trinh, C. T. (2019) · Applied and Environmental Microbiology · doi:10.1128/aem.02299-19 · Cited by 40 · see citing works
Jia, W., Wang, H., Li, C., Shi, J., Yong, F., & Jia, H. (2024) · Journal of Translational Medicine · doi:10.1186/s12967-024-04969-3 · Cited by 39 · see citing works
“Vitamin B1 deficiency also has been linked to various neurodegenerative disorders, including Alzheimer’s disease, Parkinson’s disease, and Huntington’s disease [14, 15].”
BackgroundBariatric Surgery in Adolescents: To Do or Not to Do?
Calcaterra, V., Cena, H., Pelizzo, G., Porri, D., Regalbuto, C., Vinci, F., Destro, F., Vestri, E., Verduci, E., Bosetti, A., et al. (2021) · Children · doi:10.3390/children8060453 · Cited by 39 · see citing works
Bahardoust, M., Eghbali, F., Shahmiri, S. S., Alijanpour, A., Yarigholi, F., Valizadeh, R., Madankan, A., Pouraskari, A. B., Ashtarinezhad, B., Farokhi, H., et al. (2022) · Obesity Surgery · doi:10.1007/s11695-022-06178-7 · Cited by 38 · see citing works
“In five studies, nausea and vomiting were reported as the initial symptoms of the thiamin deficiency (22, 24, 25, 29, 31).”
BackgroundSambon, M., Вячеславовна, Г. А., Demelenne, A., Alhama-Riba, J., Coumans, B., Lakaye, B., Wins, P., Fillet, M., Anthony, D. C., Strekalova, T. V., et al. (2020) · Biomedicines · doi:10.3390/biomedicines8090361 · Cited by 39 · see citing works
“Thiamine deficiency disorders are life-threatening conditions requiring a rapid treatment to restore thiamine levels to physiological values [6].”
BackgroundAdole, V. A., Pawar, T. B., & Jagdale, B. S. (2020) · Journal of Sulfur Chemistry · doi:10.1080/17415993.2020.1817456 · Cited by 38 · see citing works
Association between diabetes and thiamine status - A systematic review and meta-analysis
Ziegler, D., Reiners, K., Strom, A., & Obeid, R. (2023) · Metabolism · doi:10.1016/j.metabol.2023.155565 · Cited by 39 · see citing works
Olanbiwoninu, A. A., Greppi, A., Awotundun, T. A., Adebayo, E. A., Spano, G., Mora, D., & Russo, P. (2023) · Food Bioscience · doi:10.1016/j.fbio.2023.102996 · Cited by 41 · see citing works
Infantile Thiamine Deficiency: New Insights into an Old Disease
Nazir, M., Lone, R., & Charoo, B. A. (2019) · Indian Pediatrics · doi:10.1007/s13312-019-1592-5 · Cited by 36 · see citing works
Thiamine fortification strategies in low‐ and middle‐income settings: a review
Whitfield, K. C., Smith, T. J., Rohner, F., Wieringa, F. T., & Green, T. (2021) · Annals of the New York Academy of Sciences · doi:10.1111/nyas.14565 · Cited by 35 · see citing works
Bifidobacterium deficit in United States infants drives prevalent gut dysbiosis
Jarman, J. B., Torres, P. J., Stromberg, S. P., Sato, H., Stack, C., Ladrillono, A., Pace, S., Jiménez, N. M., Haselbeck, R. J., Insel, R. A., et al. (2025) · Communications Biology · doi:10.1038/s42003-025-08274-7 · Cited by 35 · see citing works
“Notably, C3 has shifted bileacidmetabolism,akeydriverofmaturationofthegutmicrobiomeanda correlativefactorininfantcholestasis 72,73 ,andreducedthiamineproduction, an essential micronutrient 74 .”
Sastry, U. M. K. R., Jayranganath, M., Kumar, R., Ghosh, S., Bharath, A., Subramanian, A. P., Managuli, A., Gangadhara, M., & Manjunath, C. N. (2020) · Archives of Disease in Childhood · doi:10.1136/archdischild-2019-318777 · Cited by 34 · see citing works
Infantile thiamine deficiency in South and Southeast Asia: An age‐old problem needing new solutions
Smith, T. J., & Hess, S. Y. (2021) · Nutrition Bulletin · doi:10.1111/nbu.12481 · Cited by 33 · see citing works
“Distributing thiamine supplements to women from the third trimester of pregnancy and during breastfeeding should therefore be considered in high-risk regions, and is currently being implemented in both Laos (Government of Lao PDR 2015) and Myanmar (Whitfield et al.2018), although, at present, there is no data on effic…”
BackgroundMethodInfluentialPhan, J., Nair, D., Jain, S., Montagne, T., Flores, D. V., Nguyen, A., Dietsche, S., Gombar, S., & Cotter, P. (2021) · mSystems · doi:10.1128/msystems.01215-21 · Cited by 33 · see citing works
Thiamine deficiency in pregnancy and lactation: implications and present perspectives
Kareem, O., Nisar, S., Tanvir, M., Muzaffer, U., & Bader, G. N. (2023) · Frontiers in Nutrition · doi:10.3389/fnut.2023.1080611 · Cited by 33 · see citing works
“There are two principal methods of evaluating the thiamine status: assessment of the degree of ThDP saturation of a thiaminedependent enzyme [erythrocyte transketolase (ETK) assay] and evaluation of the metabolites of thiamine inaccessible tissues (81).”
BackgroundMethodInfluentialDudek, I., Hajduga, D., Sieńko, C., Maani, A., Sitarz, R., Sitarz, M., & Forma, A. (2020) · Current Pathobiology Reports · doi:10.1007/s40139-020-00214-w · Cited by 32 · see citing works
Insights Into Thiamine Supplementation in Patients With Septic Shock
Costa, N. A., Pereira, A. G., Sugizaki, C. S. D. A., Vieira, N. M., Garcia, L. R., de Paiva, S. A. R., Zornoff, L. A. M., Azevedo, P. S., Polegato, B. F., & Minicucci, M. F. (2022) · Frontiers in Medicine · doi:10.3389/fmed.2021.805199 · Cited by 31 · see citing works
Adesemoye, E. T., Sanni, A. I., Spano, G., Capozzi, V., & Fragasso, M. (2025) · Fermentation · doi:10.3390/fermentation11020103 · Cited by 27 · see citing works
Micronutrient deficiencies and their public health implications for South-East Asia
Wieringa, F. T., Dijkhuizen, M. A., & Berger, J. (2019) · Current Opinion in Clinical Nutrition & Metabolic Care · doi:10.1097/mco.0000000000000603 · Cited by 27 · see citing works
Jensen, O., Matthaei, J., Blome, F. G., Schwab, M. G., Tzvetkov, M. V., & Brockmöller, J. (2019) · Clinical Pharmacology & Therapeutics · doi:10.1002/cpt.1666 · Cited by 27 · see citing works
Vitamin B1 Thiamine Deficiency
Wiley, K., & Gupta, M. (2021) · StatPearls · Cited by 26 · see citing works
Metabolic engineering provides insight into the regulation of thiamin biosynthesis in plants
Strobbe, S., Verstraete, J., Stove, C. P., & Straeten, D. V. D. (2021) · PLANT PHYSIOLOGY · doi:10.1093/plphys/kiab198 · Cited by 25 · see citing works
“Unfortunately, thiamin deficiency is a persisting global health problem, affecting many populations in Southeast Asia, as well as the elderly population in the Western world (Hoffman, 2016; Whitfield et al., 2018; Johnson et al., 2019).”
Insufficiency of B vitamins with its possible clinical implications
Tanaka, K., Ao, M., & Kuwabara, A. (2020) · Journal of Clinical Biochemistry and Nutrition · doi:10.3164/jcbn.20-56 · Cited by 23 · see citing works
Gallant, J., Chan, K. L., Green, T., Wieringa, F. T., Leemaqz, S., Ngik, R., Measelle, J. R., Baldwin, D. A., Borath, M., Sophonneary, P., et al. (2021) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/nqab052 · Cited by 24 · see citing works
“The daily increase of 1.2 mg would likely benefit other mothers in other rice-consuming nations, such as Laos, Myanmar, and parts of India such as Assam (1).”
BackgroundMethodInfluentialPharmacological thiamine levels as a therapeutic approach in Alzheimer's disease
Gibson, G. E., Feldman, H., Zhang, S., Flowers, S. A., & Luchsinger, J. A. (2022) · Frontiers in Medicine · doi:10.3389/fmed.2022.1033272 · Cited by 24 · see citing works
Transporters in vitamin uptake and cellular metabolism: impacts on health and disease
Yuan, Y., & Chen, L. (2025) · Life Metabolism · doi:10.1093/lifemeta/loaf008 · Cited by 25 · see citing works
“This underscores the importance of monitoring thiamine levels globally, even in areas where severe manifestations are rare [16].”
Suwanwong, Y., & Somchai Boonpangrak, A. (2021) · European Polymer Journal · doi:10.1016/j.eurpolymj.2021.110835 · Cited by 23 · see citing works
Association Between Vitamin Deficiencies and Ophthalmological Conditions
Pereira, A., Adekunle, R. D., Zaman, M., & Wan, M. J. (2023) · Clinical ophthalmology · doi:10.2147/opth.s401262 · Cited by 23 · see citing works
“Additionally, patients who have had bariatric surgery or are on either long-term peritoneal dialysis or parental feeds are also at risk.(20) Both women and men are affected by beriberi equally; however, pregnant women and infants are at higher risk.”
BackgroundInfluentialVerstraete, J., & Stove, C. P. (2021) · Analytical Chemistry · doi:10.1021/acs.analchem.0c05018 · Cited by 22 · see citing works
Syed, A. R. S., Syed, A. A., Akram, A., Azam, M. S., Muzammil, M. A., Deepak, Ansari, A. I., Eqbal, F., Farooq, M. H., Khatri, M., et al. (2023) · Heart & Lung · doi:10.1016/j.hrtlng.2023.04.011 · Cited by 22 · see citing works
Pakeeza, Draz, M. U., Yaqub, A., Jafry, A. T., Khan, M., & Ajab, H. (2024) · RSC Advances · doi:10.1039/d4ra00555d · Cited by 22 · see citing works
Changes in the content of minerals, B-group vitamins and tocopherols in processed kale leaves
Korus, A. (2020) · Journal of Food Composition and Analysis · doi:10.1016/j.jfca.2020.103464 · Cited by 21 · see citing works
Widespread thiamine deficiency in California salmon linked to an anchovy-dominated marine prey base
Mantua, N. J., Bell, H., Todgham, A. E., Daniels, M. E., Rinchard, J., Ludwig, J. M., Field, J. C., Lindley, S. T., Rowland, F. E., Richter, C. A., et al. (2025) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2426011122 · Cited by 20 · see citing works
Ma, X., & Xu, S. (2022) · iScience · doi:10.1016/j.isci.2022.105614 · Cited by 20 · see citing works
“A recent study suggested that many populations worldwide are at risk of clinical or subclinical thiamine deficiencies, due to famine, reliance on thiamine-low staple crops, or food preparation practices, such as milling grains and washing milled rice.(4) More specifically, severe thiamine deficiency is recognized as a…”
Du, Y., Wang, M., Tong, M., Wu, D., Chu, J., & Yao, X. (2023) · Postharvest Biology and Technology · doi:10.1016/j.postharvbio.2023.112634 · Cited by 20 · see citing works
Hwabejire, H. O., Akpoghelie, P. O., Edo, G. I., Onoharigho, F. O., & Agbo, J. J. (2023) · Proceedings of the Indian National Science Academy · doi:10.1007/s43538-023-00219-0 · Cited by 20 · see citing works
Beekum, M. V., Berger, J., van Geystelen, J., Hondru, G., Som, S. V., Theary, C., Laillou, A., Poirot, E., Bork, K. A., Wieringa, F. T., et al. (2022) · Scientific Reports · doi:10.1038/s41598-022-22861-2 · Cited by 24 · see citing works
Nutritional Heart Disease and Cardiomyopathies
Sliwa, K. S., Viljoen, C. A., Hasan, B. S., & Ntusi, N. (2023) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2022.08.812 · Cited by 20 · see citing works
Bettendorff, L. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms241411296 · Cited by 21 · see citing works
“Stress was induced either by a modified swim test, the presence of a predator for five consecutive nights [48,49], or chronic ultrasound exposure for 20 days [50].”
BackgroundMethodInfluentialMeaselle, J. R., Baldwin, D. A., Gallant, J., Chan, K. L., Green, T., Wieringa, F. T., Borath, M., Sophonneary, P., Hampel, D., Shahab‐Ferdows, S., et al. (2021) · Annals of the New York Academy of Sciences · doi:10.1111/nyas.14610 · Cited by 19 · see citing works
Methods and approaches to estimate B vitamin status in dairy cows: Knowledge, gaps and advances
Girard, C. L., & Graulet, B. (2020) · Methods · doi:10.1016/j.ymeth.2020.05.021 · Cited by 19 · see citing works
Lin, S., Leppla, I. E., Yan, H., Probert, J. M., Randhawa, P. A., Leoutsakos, J., Probasco, J. C., & Neufeld, K. J. (2019) · Psychosomatics · doi:10.1016/j.psym.2019.08.002 · Cited by 18 · see citing works
Infantile thiamine deficiency: Redefining the clinical patterns
Qureshi, U. A., Bhat, A. S., Qureshi, U. A., Ahmad, K., Wani, N. A., Bashir, A., & Akram, M. (2020) · Nutrition · doi:10.1016/j.nut.2020.111097 · Cited by 18 · see citing works
Verstraete, J., & Stove, C. P. (2021) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/nqab146 · Cited by 18 · see citing works
Nutritional Fish Diseases in Aquaculture: A Human Health Hazard or Mythical Theory: An Overview
Syanya, F. J., Litabas, J. A., Mathia, W. M., & Ntakirutimana, R. (2023) · European Journal of Nutrition & Food Safety · doi:10.9734/ejnfs/2023/v15i81326 · Cited by 18 · see citing works
“Its phosphorylated form, thiamine diphosphate, serves as a cofactor for several enzymes involved in cellular metabolism [97].”
BackgroundBrown, K. H., Hess, S. Y., Moore, S. E., Combs, G. F., Cashman, K. D., McNulty, H., Allen, L. H., Krebs, N. F., Pfeiffer, C. M., Rybak, M. E., et al. (2025) · American Journal of Clinical Nutrition · doi:10.1016/j.ajcnut.2025.06.030 · Cited by 17 · see citing works
A fresh look at thiamine deficiency—new analyses by the global thiamine alliance
Bourassa, M. W., Bergeron, G., & Brown, K. H. (2021) · Annals of the New York Academy of Sciences · doi:10.1111/nyas.14594 · Cited by 17 · see citing works
Carrot and carotene and multiple health outcomes: an umbrella review of the evidence
Yi, X., Li, J. H., Liao, D., Peng, G., Zheng, X., Xu, H., Zhang, T., & Ai, J. (2023) · Journal of the Science of Food and Agriculture · doi:10.1002/jsfa.12425 · Cited by 17 · see citing works
Jones, K. S., Parkington, D. A., Bourassa, M. W., Cerami, C., & Koulman, A. (2023) · Annals of the New York Academy of Sciences · doi:10.1111/nyas.14962 · Cited by 17 · see citing works
Can thiamine substitution restore cognitive function in alcohol use disorder?
Listabarth, S., Vyssoki, B., Marculescu, R., Gleiß, A., Groemer, M., Trojer, A., Harrer, C., Weber, S., & König, D. (2023) · Alcohol and Alcoholism · doi:10.1093/alcalc/agad017 · Cited by 18 · see citing works
“WE) or for patients receiving TS as a prophylactic treatment in AUD have been agreed on (Whitfield et al. 2018).”
Rigutto‐Farebrother, J., & Zimmermann, M. B. (2024) · Nutrients · doi:10.3390/nu16152517 · Cited by 17 · see citing works
“Salt has also proven to be a successful and cost-efficient route to deliver diethylcarbamazine, which is safe and effective at protecting individuals from the devastating effects of lymphatic filariasis [49–51].”
BackgroundTRAM-LAG1-CLN8 family proteins are acyltransferases regulating phospholipid composition
Sheokand, P. K., James, A. M., Jenkins, B., Lysyganicz, P. K., Lacabanne, D., King, M. S., Kunji, E. R. S., Siniossoglou, S., Koulman, A., Murphy, M. P., et al. (2025) · Science Advances · doi:10.1126/sciadv.adr3723 · Cited by 16 · see citing works
Jeppesen, T. D., Madsen, K. L., Poulsen, N. S., Løkken, N., & Vissing, J. (2021) · Journal of Clinical Medicine · doi:10.3390/jcm10081796 · Cited by 16 · see citing works
Clergue‐Duval, V., Coulbault, L., Questel, F., Cabé, N., Lanièpce, A., Delage, C., Boudehent, C., Bloch, V., Segobin, S. H., Naassïla, M., et al. (2022) · Antioxidants · doi:10.3390/antiox11102078 · Cited by 16 · see citing works
“It is rarely impaired and is not an indicator of thiamine status [37,48].”
BackgroundMethodInfluentialGenetic basis of thiaminase I activity in a vertebrate, zebrafish Danio rerio
Richter, C. A., Evans, A. N., Heppell, S. A., Zajicek, J. L., & Tillitt, D. E. (2023) · Scientific Reports · doi:10.1038/s41598-023-27612-5 · Cited by 16 · see citing works
Kareem, O., Mufti, S., Nisar, S., Tanvir, M., Muzaffer, U., Ali, N., SHEIKH, I. A., & Bader, G. N. (2023) · PLoS neglected tropical diseases · doi:10.1371/journal.pntd.0011324 · Cited by 16 · see citing works
“This again is in consonance with the previous data that reports the presence of thiamine antagonists and thiaminases in various foods like pickles and tea, leading to insufficiency of thiamine in adults [31,51].”
BackgroundResultJarosz, Ł. S., Socała, K., Michalak, K., Wiater, A., Ciszewski, A., Majewska, M., Marek, A., Grądzki, Z., & Właź, P. (2023) · Psychopharmacology · doi:10.1007/s00213-023-06519-z · Cited by 16 · see citing works
“One such vitamin is thiamine (vitamin B 1 ), a deficiency of which causes metabolic disorders associated with a lack of production of enzymes such as pyruvate dehydrogenase and α-ketoglutarate dehydrogenase complex (Whitfield et al. 2018).”
BackgroundMaguire, D., Talwar, D. K., Burns, A., Catchpole, A., Stefanowicz, F. A., Robson, G., Ross, D. P., Young, D., Ireland, A., Forrest, E. H., et al. (2019) · Journal of Translational Medicine · doi:10.1186/s12967-019-02141-w · Cited by 16 · see citing works
Hess, S. Y., Smith, T. J., Fischer, P. R., Trehan, I., Hiffler, L., Arnold, C. D., Sitthideth, D., Tancredi, D. J., Schick, M., Yeh, J. Z., et al. (2020) · BMJ Open · doi:10.1136/bmjopen-2019-036539 · Cited by 16 · see citing works
Macro- and Micronutrients in Milk from Healthy Cambodian Mothers: Status and Interrelations
Whitfield, K. C., Shahab‐Ferdows, S., Kroeun, H., Sophonneary, P., Green, T., Allen, L. H., & Hampel, D. (2020) · Journal of Nutrition · doi:10.1093/jn/nxaa070 · Cited by 16 · see citing works
“Upper secondary 5 (7) 1 (4) 3 (12) 1 (5)”
BackgroundInfluentialBracci, E. L., Keogh, J. B., Milte, R., & Murphy, K. J. (2021) · British Journal Of Nutrition · doi:10.1017/s0007114521002282 · Cited by 16 · see citing works
“Thiamin is a water-soluble vitamin required for cell growth and development (105; 106; 107) .”
BackgroundBiochemical and medical aspects of vitamin B1 research
Makarchikov, A. F., Wins, P., & Bettendorff, L. (2025) · Neurochemistry International · doi:10.1016/j.neuint.2025.105962 · Cited by 15 · see citing works
Fortification of Sugar: A Call for Action
Iwuozor, K. O., Mbamalu, P. S., Olaniyi, B. O., Anyanwu, V. U., Emenike, E. C., & Adeniyi, A. G. (2022) · Sugar Tech · doi:10.1007/s12355-022-01183-7 · Cited by 15 · see citing works
“Within the past decade, thiamine deficiency has been recorded in Asia (Bhutan (Dzed et al. 2015; Tsheten et al. 2016), Vietnam (Nguyen et al. 2016), and Kiribati (Nilles et al. 2018)), Africa (Guinea (Whitfield et al. 2018)), and South America (French Guiana (Mosnier et al. 2017)).”
BackgroundThiamine: An indispensable regulator of paediatric neuro-cardiovascular health and diseases
Mallimoggala, Y. S. P., Biswas, M., Anburaj, S. E., Iqbal, F., Aroor, S., Suryakanth, V. B., & Lewis, L. (2024) · European Journal of Pediatrics · doi:10.1007/s00431-024-05756-4 · Cited by 15 · see citing works
“…gravidarum-induced acute thiamine deficiency; complete resolution of symptoms was achieved with 1000 mg/day IV thiamine supplementation for 3 days [13, 67]. d) Addressing malnutrition and food diversification: Consumption of diverse foodstuffs, especially a diet rich in legumes and vegetables,…”
BackgroundInfluentialIimura, Y., Andoh, S., Kawamata, T., Sato, A., Yokoyama, K., Imai, Y., Tojo, A., Nojima, M., Sugiura, M., & Kuroda, S. (2021) · Journal of Neurosciences in Rural Practice · doi:10.1055/s-0041-1735825 · Cited by 14 · see citing works
“28,29 A lack of thiamine leads to failure of the Krebs cycle.”
Nisar, S., Tanvir, M., Ganie, M. A., Kareem, O., Muzaffer, U., & Wani, I. A. (2022) · Nutrition · doi:10.1016/j.nut.2022.111730 · Cited by 14 · see citing works
Pumpkin, Cauliflower and Broccoli as New Carriers of Thiamine Compounds for Food Fortification
Szymandera-Buszka, K. E., Piechocka, J., Jankowska, A., Przeor, M., & Jędrusek‐Golińska, A. (2021) · Foods · doi:10.3390/foods10030578 · Cited by 14 · see citing works
“It is similar in the case of products such as tea, coffee, raw fish and crustaceans [9,17].”
BackgroundEvolutionary and ecological correlates of thiaminase in fishes
Rowland, F. E., Richter, C. A., Tillitt, D. E., & Walters, D. (2023) · Scientific Reports · doi:10.1038/s41598-023-44654-x · Cited by 13 · see citing works
Thiamine deficiency‐related neuropathy: A reversible entity from an endemic area
Nisar, S., Wani, I. Y., Altaf, U., Muzaffer, U., Kareem, O., Tanvir, M., & Ganie, M. A. (2023) · European Journal of Neurology · doi:10.1111/ene.16155 · Cited by 13 · see citing works
Khalid, W., Arshad, M. S., Nayik, G. A., Alfarraj, S. A., Ansari, M. J., & Guiné, R. P. F. (2022) · Molecules · doi:10.3390/molecules27238201 · Cited by 13 · see citing works
“It provides different nutrients (fatty acids, amino acids, vitamins and minerals) and phytochemicals (polyphenols, glucosinolates and carotenoids) to humans [12].”
BackgroundReynolds, G. L., Epps, S. J., Huntley, A. L., & Atan, D. (2022) · Nutrients · doi:10.3390/nu14153068 · Cited by 12 · see citing works
“Thiamine deficiency is often diagnosed clinically, without biochemical confirmation, because thiamine compounds are photosensitive and only stable for a few hours at room temperature, so specimens need to be transported on ice and in darkness, then rapidly frozen for storage [86].”
BackgroundVinnai, B. Á., Arianti, R., Győry, F., Bacsó, Z., Fésüs, L., & Kristóf, E. (2023) · Frontiers in Nutrition · doi:10.3389/fnut.2023.1207394 · Cited by 12 · see citing works
Serra, M. D. R., Mollace, R., Ritorto, G., Ussia, S., Altomare, C., Tavernese, A., Preianò, M., Palma, E., Muscoli, C., Mollace, V., et al. (2025) · International Journal of Molecular Sciences · doi:10.3390/ijms26093932 · Cited by 12 · see citing works
“…brown rice, and oats), pulses (e.g., beans, peas, and lentils), meat (mainly pork), fi sh (e.g., tuna or salmon), nuts or seeds (e.g., walnuts, almonds, or sun fl ower seeds), and vegetables (e.g., asparagus, spinach, and cauli fl ower), and supplements are key sources of thiamine (Figure 1) [2].”
- Authors
- Whitfield, K. C., Bourassa, M. W., Adamolekun, B., Bergeron, G., Bettendorff, L., Brown, K. H., Cox, L., Fattal‐Valevski, A., Fischer, P. R., Frank, E. L., Hiffler, L., Hlaing, L. M., Jefferds, M. E., Kapner, H., Kounnavong, S., Mousavi, M. P. S., Roth, D. E., Tsaloglou, M., Wieringa, F., & Combs, G. F.
- Affiliations
- Mount Saint Vincent University (CA)
- New York Academy of Sciences (US)
- University of Tennessee Health Science Center (US)
- University of Liège (BE)
- Gates Foundation (US)
- MRC Elsie Widdowson Laboratory (GB)
- Tel Aviv University (IL)
- Mayo Clinic (US)
- University of Utah (US)
- Médecins Sans Frontières (ES)
- Ministry of Health and Sports (MM)
- Centers for Disease Control and Prevention (US)
- Independent contractor New York New York
- Ministry of Health (LA)
- Harvard University (US)
- University of Toronto (CA)
- Diagnostics For All (US)
- Institut de Recherche pour le Développement (FR)
- Tufts University (US)
- Corresponding author
- Combs, Gerald F.
- ORCID
- Venue
- Annals of the New York Academy of Sciences
- Publisher
- Wiley
- Published
- 2018-08-27
- Volume
- 1430
- Issue
- 1
- Pages
- 3-43
- ISSN
- 0077-8923 (ISSN-L)
- 1749-6632
- PMC
- PMC6392124
- OpenAlex
- W2889058844
- Cited by
- 336
- References
- 211
- Citations by year
- 2026: 44 · 2025: 41 · 2024: 46 · 2023: 59 · 2022: 43 · 2021: 52 · 2020: 33 · 2019: 17 · 2018: 1
- FWCI
- 17.45
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Annals of the New York Academy of Sciences (publishedVersion, cc-by-nc)
- Europe PMC (PubMed Central) (publishedVersion, cc-by-nc)
- PubMed Central (publishedVersion, cc-by-nc)
- PubMed (publishedVersion)
- eScholarship (California Digital Library) (submittedVersion, cc-by-nc)
- Medecins Sans Frontieres Field Research (Medecins Sans Frontieres) (submittedVersion)
- Open Repository and Bibliography (University of Liège) (submittedVersion, cc-by)
- Funders
- Bill and Melinda Gates Foundation
- Topics
- Health Sciences › Medicine › Neurology › Alcoholism and Thiamine Deficiency
- Health Sciences › Nursing › Nutrition and Dietetics › Child Nutrition and Water Access
- Life Sciences › Agricultural and Biological Sciences › Food Science › Nutrition, Health, and Society Studies
- Keywords
- thiamine deficiency, beriberi, infantile beriberi, infant mortality, food fortification, thiamine supplementation, food balance sheets, grain milling, rice washing, micronutrient deficiency, prevalence, neurodevelopmental outcomes
- MeSH terms
- Food, Fortified, Humans, Public Health, Risk Factors, Thiamine Deficiency, Global Health, Prevalence, Dietary Supplements
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
