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Radioimmunometric assay for a monoclonal antibody-defined tumor marker, CA 19-9.
Abstract
We describe a solid-phase radioimmunometric sandwich assay for a new tumor marker defined by a monoclonal antibody (19-9). This antibody reacts with a carbohydrate antigenic determinant (CA 19-9) found at low concentrations in sera from healthy individuals but frequently increased in sera from patients with adenocarcinomas. The assay is sensitive and simple to perform. It requires duplicate 100-microL samples and may be performed in 6 h. The concentration of CA 19-9 in samples is determined by reference to a standard curve, which is essentially linear from 0 to 120 arbitrary units/mL. The average CV is approximately 10% in the range of 5.8 to 120 units/mL. The minimum detectable dose is 1.4 units/mL and analytical recovery of CA 19-9 is 97.6 to 100.6%. The average concentration of CA 19-9 in sera from 1020 healthy individuals was 8.4 (SD 7.4) units/mL; only 0.6% of such sera had concentrations greater than 37 units/mL. The assay has high specificity (98.5%), even among patients with benign diseases, and has high sensitivity (up to 79%) for patients with gastrointestinal adenocarcinomas, especially those of the pancreas.
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Cited by
Glypican-1 identifies cancer exosomes and detects early pancreatic cancer
Melo, S. A., Luecke, L. B., Kahlert, C., Fernandez, A. F., Gammon, S. T., Kaye, J., LeBleu, V. S., Mittendorf, E. A., Weitz, J., Rahbari, N., et al. (2015) · Nature · doi:10.1038/nature14581 · Cited by 2,880
A family of nonparametric statistics for comparing diagnostic markers with paired or unpaired data
WIEAND, S., GAIL, M. H., JAMES, B. R., & JAMES, K. L. (1989) · Biometrika · doi:10.1093/biomet/76.3.585 · Cited by 355
Metadata
- Authors
- Del Villano, B. C., Brennan, S., Brock, P., Bucher, C., Liu, V, McClure, M., Rake, B., Space, S., Westrick, B., Schoemaker, H., & Zurawski, V. R.
- Venue
- Clinical Chemistry
- Publisher
- Oxford University Press (OUP)
- Published
- 1983-03-01
- Volume
- 29
- Issue
- 3
- Pages
- 549-552
- ISSN
- 0009-9147 (ISSN-L)
- 1530-8561
- OpenAlex
- W1917001209
- Cited by
- 506
- References
- 0
- FWCI
- 19.11
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: Radioimmunometric assay for a monoclonal antibody-defined tumor marker, CA 19-9. https://app.cochat.ai/papers/10.1093/clinchem/29.3.549
- The paper
- Del Villano, B. C., Brennan, S., Brock, P., Bucher, C., Liu, V, McClure, M., Rake, B., Space, S., Westrick, B., Schoemaker, H., & Zurawski, V. R. (1983). Radioimmunometric assay for a monoclonal antibody-defined tumor marker, CA 19-9. Clinical Chemistry. https://doi.org/10.1093/clinchem/29.3.549
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Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
