Glypican-1 identifies cancer exosomes and detects early pancreatic cancer
Open accessAbstract
Exosomes are lipid-bilayer-enclosed extracellular vesicles that contain proteins and nucleic acids. They are secreted by all cells and circulate in the blood. Specific detection and isolation of cancer-cell-derived exosomes in the circulation is currently lacking. Using mass spectrometry analyses, we identify a cell surface proteoglycan, glypican-1 (GPC1), specifically enriched on cancer-cell-derived exosomes. GPC1(+) circulating exosomes (crExos) were monitored and isolated using flow cytometry from the serum of patients and mice with cancer. GPC1(+) crExos were detected in the serum of patients with pancreatic cancer with absolute specificity and sensitivity, distinguishing healthy subjects and patients with a benign pancreatic disease from patients with early- and late-stage pancreatic cancer. Levels of GPC1(+) crExos correlate with tumour burden and the survival of pre- and post-surgical patients. GPC1(+) crExos from patients and from mice with spontaneous pancreatic tumours carry specific KRAS mutations, and reliably detect pancreatic intraepithelial lesions in mice despite negative signals by magnetic resonance imaging. GPC1(+) crExos may serve as a potential non-invasive diagnostic and screening tool to detect early stages of pancreatic cancer to facilitate possible curative surgical therapy.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Detection of nucleic acid cargo within circulating extracellular microvesicles (including exosomes) provides an alternative avenue for assessing the genomic landscape of PDAC.
“Of note, in addition to cell-free DNA, recent studies have also shown that detection of nucleic acid cargo within circulating extracellular microvesicles (including exosomes) provides an alternative avenue for assessing the genomic landscape of PDAC.51,52”
From Artificial Intelligence and Early Detection of Pancreatic Cancer: 2020 Summative Review (2021) · cites this paper as [52]
Detection of nucleic acid cargo within circulating extracellular microvesicles (including exosomes) provides an alternative avenue for assessing the genomic landscape of PDAC.
“Of note, in addition to cell-free DNA, recent studies have also shown that detection of nucleic acid cargo within circulating extracellular microvesicles (including exosomes) provides an alternative avenue for assessing the genomic landscape of PDAC.51,52”
From Artificial Intelligence and Early Detection of Pancreatic Cancer: 2020 Summative Review (2021) · cites this paper as [51]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
1 retracted
RETRACTED: MicroRNA signatures of tumor-derived exosomes as diagnostic biomarkers of ovarian cancer
Taylor, D. D., & Gerçel-Taylor, Ç. (2008) · Gynecologic Oncology · doi:10.1016/j.ygyno.2008.04.033 · Cited by 2,289 · see citing works
RetractedAnalysis of Relative Gene Expression Data Using Real-Time Quantitative PCR and the 2−ΔΔCT Method
Livak, K. J., & Schmittgen, T. D. (2001) · Methods · doi:10.1006/meth.2001.1262 · Cited by 180,860 · see citing works
DeLong, E. R., DeLong, D. M., & Clarke-Pearson, D. L. (1988) · Biometrics · doi:10.2307/2531595 · Cited by 22,649 · see citing works
Spencer, P. M., Cameron, J. L., & Lin, L. (2000) · Cited by 7,202 · see citing works
Isolation and Characterization of Exosomes from Cell Culture Supernatants and Biological Fluids
Théry, C., Amigorena, S., Raposo, G., & Clayton, A. (2006) · Current Protocols in Cell Biology · doi:10.1002/0471143030.cb0322s30 · Cited by 5,766 · see citing works
Exosomes: composition, biogenesis and function
Théry, C., Zitvogel, L., & Amigorena, S. (2002) · Nature reviews. Immunology · doi:10.1038/nri855 · Cited by 5,355 · see citing works
Skog, J., Würdinger, T., van Rijn, S., Meijer, D. H., Gainche, L., Curry, W. T., Carter, B. S., Krichevsky, A. M., & Breakefield, X. O. (2008) · Nature Cell Biology · doi:10.1038/ncb1800 · Cited by 5,001 · see citing works
Membrane vesicles as conveyors of immune responses
Théry, C., Ostrowski, M., & Segura, É. (2009) · Nature reviews. Immunology · doi:10.1038/nri2567 · Cited by 3,869 · see citing works
Mutation of the mouse klotho gene leads to a syndrome resembling ageing
Kuro-o, M., Matsumura, Y., Aizawa, H., Kawaguchi, H., Suga, T., Utsugi, T., Ohyama, Y., Kurabayashi, M., Kaname, T., Kume, E., et al. (1997) · Nature · doi:10.1038/36285 · Cited by 3,837 · see citing works
Melanoma exosomes educate bone marrow progenitor cells toward a pro-metastatic phenotype through MET
Peinado, H., Alečković, M., Lavotshkin, S., Matei, I., Costa-Silva, B., Moreno-Bueno, G., Hergueta-Redondo, M., Williams, C., García-Santos, G., Ghajar, C. M., et al. (2012) · Nature Medicine · doi:10.1038/nm.2753 · Cited by 3,715 · see citing works
Ceramide Triggers Budding of Exosome Vesicles into Multivesicular Endosomes
Trajković, K., Hsu, C., Chiantia, S., Rajendran, L., Wenzel, D., Wieland, F., Schwille, P., Brügger, B., & Simons, M. (2008) · Science · doi:10.1126/science.1153124 · Cited by 3,639 · see citing works
VennDiagram: a package for the generation of highly-customizable Venn and Euler diagrams in R
Chen, H., & Boutros, P. C. (2011) · BMC Bioinformatics · doi:10.1186/1471-2105-12-35 · Cited by 3,150 · see citing works
Rab27a and Rab27b control different steps of the exosome secretion pathway
Ostrowski, M., Carmo, N., Krumeich, S., Fanget, I., Raposo, G., Savina, A., Moita, C. F., Schauer, K., Hume, A. N., Freitas, R. P., et al. (2009) · Nature Cell Biology · doi:10.1038/ncb2000 · Cited by 2,761 · see citing works
Lötvall, J. O., Hill, A. F., Hochberg, F. H., Buzás, E. I., Vizio, D. D., Gardiner, C., Gho, Y. S., Kurochkin, I. V., Mathivanan, S., Quesenberry, P. J., et al. (2014) · Journal of Extracellular Vesicles · doi:10.3402/jev.v3.26913 · Cited by 2,710 · see citing works
Özdemir, B. C., Pentcheva-Hoang, T., Carstens, J. L., Zheng, X., Wu, C.-C., Simpson, T. R., Laklai, H., Sugimoto, H., Kahlert, C., Novitskiy, S. V., et al. (2014) · Cancer Cell · doi:10.1016/j.ccr.2014.04.005 · Cited by 2,681 · see citing works
Self-citationHidalgo, M. (2010) · New England Journal of Medicine · doi:10.1056/nejmra0901557 · Cited by 2,570 · see citing works
Distant metastasis occurs late during the genetic evolution of pancreatic cancer
Yachida, S., Jones, S., Bozic, I., Antal, T., Leary, R., Fu, B., Kamiyama, M., Hruban, R. H., Eshleman, J. R., Nowak, M. A., et al. (2010) · Nature · doi:10.1038/nature09515 · Cited by 2,502 · see citing works
Preinvasive and invasive ductal pancreatic cancer and its early detection in the mouse
Hingorani, S. R., Petricoin, E. F., Maitra, A., Rajapakse, V., King, C., Jacobetz, M. A., Ross, S., Conrads, T. P., Veenstra, T. D., Hitt, B. A., et al. (2003) · Cancer Cell · doi:10.1016/s1535-6108(03)00309-x · Cited by 2,471 · see citing works
Intercellular transfer of the oncogenic receptor EGFRvIII by microvesicles derived from tumour cells
Al-Nedawi, K. N. I., Meehan, B., Micallef, J., Lhotak, V., May, L. L., Guha, A., & Rak, J. W. (2008) · Nature Cell Biology · doi:10.1038/ncb1725 · Cited by 2,037 · see citing works
Non-invasive analysis of acquired resistance to cancer therapy by sequencing of plasma DNA
Murtaza, M., Dawson, S.-J., Tsui, D. W. Y., Gale, D., Forshew, T., Piskorz, A. M., Parkinson, C., Chin, S.-F., Kingsbury, Z., Wong, A. S. C., et al. (2013) · Nature · doi:10.1038/nature12065 · Cited by 1,624 · see citing works
ASCO 2006 Update of Recommendations for the Use of Tumor Markers in Gastrointestinal Cancer
Locker, G. Y., Hamilton, S. R., Harris, J. E., Jessup, J. M., Kemeny, N. E., Macdonald, J. S., Somerfield, M. R., Hayes, D. F., & Bast, R. C. (2006) · Journal of Clinical Oncology · doi:10.1200/jco.2006.08.2644 · Cited by 1,592 · see citing works
Exosomes Mediate Stromal Mobilization of Autocrine Wnt-PCP Signaling in Breast Cancer Cell Migration
Luga, V., Zhang, L., Viloria-Petit, A. M., Ogunjimi, A. A., Inanlou, M. R., Chiu, E., Buchanan, M., Hosein, A. N., Basik, M., & Wrana, J. L. (2012) · Cell · doi:10.1016/j.cell.2012.11.024 · Cited by 1,311 · see citing works
Atheroprotective communication between endothelial cells and smooth muscle cells through miRNAs
Hergenreider, E., Heydt, S., Tréguer, K., Boettger, T., Horrevoets, A. J. G., Zeiher, A. M., Scheffer, M. P., Frangakis, A. S., Yin, X., Mayr, M., et al. (2012) · Nature Cell Biology · doi:10.1038/ncb2441 · Cited by 1,307 · see citing works
Pan, B., Teng, K., Wu, C., Adam, M., & Johnstone, R. M. (1985) · The Journal of Cell Biology · doi:10.1083/jcb.101.3.942 · Cited by 1,242 · see citing works
Non-Invasive Analysis of Acquired Resistance to Cancer Therapy By Sequencing of Plasma Dna
(2014) · Annals of Oncology · doi:10.1093/annonc/mdu312.5 · Cited by 1,174 · see citing works
Pancreatic cancer biology and genetics
Bardeesy, N. M., & DePinho, R. A. (2002) · Nature reviews. Cancer · doi:10.1038/nrc949 · Cited by 1,144 · see citing works
Malignant effusions and immunogenic tumour-derived exosomes
André, F., Schartz, N. E. C., Movassagh, M., Flament, C., Pautier, P., Morice, P., Pomel, C., Lhommé, C., Escudier, B. J., Chevalier, T. L., et al. (2002) · The Lancet · doi:10.1016/s0140-6736(02)09552-1 · Cited by 953 · see citing works
Kahlert, C., Melo, S., Protopopov, A., Tang, J., Seth, S., Koch, M., Zhang, J.-H., Weitz, J., Chin, L., Futreal, A., et al. (2014) · Journal of Biological Chemistry · doi:10.1074/jbc.c113.532267 · Cited by 896 · see citing works
Self-citationExosomes in Tumor Microenvironment Influence Cancer Progression and Metastasis
Kahlert, C., & Kalluri, R. (2013) · Journal of molecular medicine · doi:10.1007/s00109-013-1020-6 · Cited by 842 · see citing works
Self-citationMicrovesicles derived from activated platelets induce metastasis and angiogenesis in lung cancer
Janowska‐Wieczorek, A., Wysoczynski, M., Kijowski, J., Marquez‐Curtis, L. A., Machaliński, B., Ratajczak, J., & Ratajczak, M. Z. (2004) · International Journal of Cancer · doi:10.1002/ijc.20657 · Cited by 768 · see citing works
Long-Term Survival After Curative Resection for Pancreatic Ductal Adenocarcinoma
Conlon, K. C., Klimstra, D. S., & Brennan, M. F. (1996) · Annals of Surgery · doi:10.1097/00000658-199603000-00007 · Cited by 711 · see citing works
KRAS, Hedgehog, Wnt and the twisted developmental biology of pancreatic ductal adenocarcinoma
Morris, J. P., Wang, S. C., & Hebrok, M. (2010) · Nature reviews. Cancer · doi:10.1038/nrc2899 · Cited by 567 · see citing works
National Failure to Operate on Early Stage Pancreatic Cancer
Bilimoria, K. Y., Bentrem, D. J., Ko, C. Y., Stewart, A. K., Winchester, D. P., & Talamonti, M. (2007) · Annals of Surgery · doi:10.1097/sla.0b013e3180691579 · Cited by 554 · see citing works
Potential role of HER2‐overexpressing exosomes in countering trastuzumab‐based therapy
Ciravolo, V., Huber, V., Ghedini, G. C., Venturelli, E., Bianchi, F., Campiglio, M., Morelli, D., Villa, A., Mina, P. D., Ménard, S., et al. (2011) · Journal of Cellular Physiology · doi:10.1002/jcp.22773 · Cited by 514 · see citing works
Beckler, M. D., Higginbotham, J. N., Franklin, J. L., Ham, A. L., Halvey, P. J., Imasuen, I., Whitwell, C. A., Li, M., Liebler, D. C., & Coffey, R. J. (2012) · Molecular & Cellular Proteomics · doi:10.1074/mcp.m112.022806 · Cited by 514 · see citing works
Radioimmunometric assay for a monoclonal antibody-defined tumor marker, CA 19-9.
Villano, B. C. D., Brennan, S. P., Brock, P., Bucher, C., Liu, V., McClure, M. O., Rake, B., Space, S., Westrick, B., Schoemaker, H. J. P., et al. (1983) · Clinical Chemistry · doi:10.1093/clinchem/29.3.549 · Cited by 502 · see citing works
Wilson, I. D., Nicholson, J. K., Castro‐Perez, J. M., Granger, J. H., Johnson, K. A., Smith, B. W., & Plumb, R. S. (2005) · Journal of Proteome Research · doi:10.1021/pr049769r · Cited by 421 · see citing works
Imaging diagnosis of pancreatic cancer: A state-of-the-art review
Lee, E. S. (2014) · World Journal of Gastroenterology · doi:10.3748/wjg.v20.i24.7864 · Cited by 401 · see citing works
Malignant ascites-derived exosomes of ovarian carcinoma patients contain CD24 and EpCAM
Runz, S., Keller, S., Rupp, C., Stoeck, A., Issa, Y., Koensgen, D., Mustea, A., Sehouli, J., Kristiansen, G., & Altevogt, P. (2007) · Gynecologic Oncology · doi:10.1016/j.ygyno.2007.08.064 · Cited by 400 · see citing works
Exosomes/microvesicles: mediators of cancer-associated immunosuppressive microenvironments
Taylor, D. D., & Gerçel-Taylor, Ç. (2011) · Seminars in Immunopathology · doi:10.1007/s00281-010-0234-8 · Cited by 386 · see citing works
Ijichi, H., Chytil, A., Gorska, A. E., Aakre, M. E., Fujitani, Y., Fujitani, S., Wright, C. V. E., & Moses, H. L. (2006) · Genes & Development · doi:10.1101/gad.1475506 · Cited by 379 · see citing works
Kleeff, J. H., Ishiwata, T., Kumbasar, A., Friess, H., Büchler, M. W., Lander, A. D., & Korc, M. (1998) · Journal of Clinical Investigation · doi:10.1172/jci4105 · Cited by 369 · see citing works
Chen, W. W., Balaj, L., Liau, L. M., Samuels, M. L., Kotsopoulos, S. K., Maguire, C. A., LoGuidice, L., Soto, H., Garrett, M. C., Zhu, L. D., et al. (2013) · Molecular Therapy — Nucleic Acids · doi:10.1038/mtna.2013.28 · Cited by 342 · see citing works
Mears, R., Craven, R. A., Hanrahan, S. J., Totty, N., Upton, C., Young, S. L., Patel, P. M., Selby, P. J., & Banks, R. E. (2004) · PROTEOMICS · doi:10.1002/pmic.200400876 · Cited by 335 · see citing works
Matsuda, K., Maruyama, H., Guo, F., Kleeff, J. H., Itakura, J., Matsumoto, Y., Lander, A. D., & Korc, M. (2001) · PubMed · Cited by 289 · see citing works
Analysis of exosome release and its prognostic value in human colorectal cancer
Silva, J., García‐Barberán, V., Rodríguez, M. E., Compte, M., Cisneros, E., Veguillas, P., Garcia, J. M., Domínguez, G., Campos‐Martín, Y., Cuevas, J., et al. (2011) · Genes Chromosomes and Cancer · doi:10.1002/gcc.21926 · Cited by 287 · see citing works
David, G., Lories, V., Decock, B., Marynen, P., Cassiman, J. J., & BERGHE, H. V. D. (1990) · The Journal of Cell Biology · doi:10.1083/jcb.111.6.3165 · Cited by 286 · see citing works
Circulating tumour-derived microvesicles in plasma of gastric cancer patients
Baran, J., Baj‐Krzyworzeka, M., Węglarczyk, K., Szatanek, R., Zembala, M., Barbasz, J., Czupryna, A., Szczepanik, A., & Zembala, M. (2009) · Cancer Immunology Immunotherapy · doi:10.1007/s00262-009-0808-2 · Cited by 267 · see citing works
Serum Biomarker Panels for the Detection of Pancreatic Cancer
Brand, R. E., Nolen, B. M., Zeh, H. J., Allen, P. J., Eloubeidi, M. A., Goldberg, M. J., Elton, E., Arnoletti, J. P., Christein, J. D., Vickers, S. M., et al. (2011) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-10-0248 · Cited by 240 · see citing works
Murphy, S. J., Hart, S. N., Lima, J. F., Kipp, B. R., Klebig, M. L., Winters, J. L., Szabo, C., Zhang, L., Eckloff, B. W., Petersen, G. M., et al. (2013) · Gastroenterology · doi:10.1053/j.gastro.2013.07.049 · Cited by 199 · see citing works
Glypican-1 modulates the angiogenic and metastatic potential of human and mouse cancer cells
Aikawa, T., Whipple, C. A., Lopez, M. E., Gunn, J. R., Young, A., Lander, A. D., & Korc, M. (2008) · Journal of Clinical Investigation · doi:10.1172/jci32412 · Cited by 188 · see citing works
Cancer biomarkers: Written in blood
Yong, E. (2014) · Nature · doi:10.1038/511524a · Cited by 166 · see citing works
Glypican-1 Is Frequently Overexpressed in Human Gliomas and Enhances FGF-2 Signaling in Glioma Cells
Su, G., Meyer, K. K., Nandini, C., Qiao, D., Salamat, S. M., & Friedl, A. (2006) · American Journal Of Pathology · doi:10.2353/ajpath.2006.050800 · Cited by 149 · see citing works
Rickes, S., Unkrodt, K., Neye, H., OCRAN, K. W., & Wermke, W. (2002) · Scandinavian Journal of Gastroenterology · doi:10.1080/003655202761020605 · Cited by 127 · see citing works
Long-term survival after curative resection for pancreatic ductal adenocarcinoma
Sakar, B., Aykan, N. F., Sağlam, S., & Üstüner, Z. (2004) · Journal of Clinical Oncology · doi:10.1200/jco.2004.22.90140.4227 · Cited by 123 · see citing works
Biomarkers for pancreatic cancer: promising new markers and options beyond CA 19-9
Ballehaninna, U. K., & Chamberlain, R. S. (2013) · Tumor Biology · doi:10.1007/s13277-013-1033-3 · Cited by 108 · see citing works
Characterization of soluble and exosomal forms of the EGFR released from pancreatic cancer cells
Adamczyk, K. A., Klein‐Scory, S., Tehrani, M. M., Warnken, U. H., Schmiegel, W., Schnölzer, M., & Schwarte‐Waldhoff, I. (2011) · Life Sciences · doi:10.1016/j.lfs.2011.06.020 · Cited by 106 · see citing works
Rothstein, D. M., Livak, M. F. A., Kishimoto, K., Ariyan, C. E., Qian, H.-Y., Fecteau, S., Sho, M., Deng, S., Zheng, X. X., Sayegh, M. H., et al. (2001) · The Journal of Immunology · doi:10.4049/jimmunol.166.1.322 · Cited by 93 · see citing works
Whipple, C. A., Young, A. L., & Korc, M. (2011) · Oncogene · doi:10.1038/onc.2011.430 · Cited by 78 · see citing works
Rachagani, S., Senapati, S., Chakraborty, S., Ponnusamy, M. P., Sushil Kumar, K., Smith, L., Jain, M., & Batra, S. K. (2011) · British Journal of Cancer · doi:10.1038/bjc.2011.31 · Cited by 77 · see citing works
Strategies for early detection of resectable pancreatic cancer
Okano, K. (2014) · World Journal of Gastroenterology · doi:10.3748/wjg.v20.i32.11230 · Cited by 50 · see citing works
The Clinical Utility of Biomarkers in the Management of Pancreatic Adenocarcinoma
Jazieh, K., Foote, M. B., & Diaz, L. A. (2014) · Seminars in Radiation Oncology · doi:10.1016/j.semradonc.2013.11.007 · Cited by 15 · see citing works
Schmid, A. M., Braumüller, H., Wehrl, H. F., Röcken, M., & Pichler, B. J. (2012) · Molecular Imaging and Biology · doi:10.1007/s11307-012-0548-0 · Cited by 6 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
The biology <b>,</b> function <b>,</b> and biomedical applications of exosomes
Kalluri, R., & LeBleu, V. S. (2020) · Science · doi:10.1126/science.aau6977 · Cited by 10,770 · see citing works
Self-citationShedding light on the cell biology of extracellular vesicles
van Niel, G., D'Angelo, G., & Raposo, G. (2018) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm.2017.125 · Cited by 8,369 · see citing works
Kowal, J., Arras, G., Colombo, M., Jouve, M., Morath, J. P., Primdal-Bengtson, B., Dingli, F., Loew, D., Tkach, M., & Théry, C. (2016) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1521230113 · Cited by 3,426 · see citing works
Doyle, L. M., & Wang, M. Z. (2019) · Cells · doi:10.3390/cells8070727 · Cited by 3,271 · see citing works
Glycosylation in cancer: mechanisms and clinical implications
Pinho, S. S., & Reis, C. A. (2015) · Nature reviews. Cancer · doi:10.1038/nrc3982 · Cited by 3,096 · see citing works
Exosomal PD-L1 contributes to immunosuppression and is associated with anti-PD-1 response
Chen, G., Huang, A. C., Zhang, W., Zhang, G., Wu, M., Xu, W., Yu, Z., Yang, J., Wang, B., Sun, H., et al. (2018) · Nature · doi:10.1038/s41586-018-0392-8 · Cited by 2,813 · see citing works
Pegtel, D. M., & Gould, S. J. (2019) · Annual Review of Biochemistry · doi:10.1146/annurev-biochem-013118-111902 · Cited by 2,682 · see citing works
Exosomes facilitate therapeutic targeting of oncogenic KRAS in pancreatic cancer
Kamerkar, S., LeBleu, V. S., Sugimoto, H., Yang, S., Ruivo, C. F., Melo, S. A., Lee, J. J., & Kalluri, R. (2017) · Nature · doi:10.1038/nature22341 · Cited by 2,639 · see citing works
Self-citationCurrent knowledge on exosome biogenesis and release
Hessvik, N. P., & Llorente, A. (2018) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-017-2595-9 · Cited by 2,362 · see citing works
Zheng, X., Carstens, J. L., Kim, J., Scheible, M., Kaye, J. A., Sugimoto, H., Wu, C.-C., LeBleu, V. S., & Kalluri, R. (2015) · Nature · doi:10.1038/nature16064 · Cited by 2,018 · see citing works
Self-citationExtracellular Vesicles in Cancer: Cell-to-Cell Mediators of Metastasis
Becker, A., Thakur, B. K., Weiss, J. M., Kim, H. S., Peinado, H., & Lyden, D. (2016) · Cancer Cell · doi:10.1016/j.ccell.2016.10.009 · Cited by 2,003 · see citing works
Kleeff, J., Korc, M., Apte, M., La Vecchia, C., Johnson, C. D., Biankin, A. V., Neale, R. E., Tempero, M., Tuveson, D. A., Hruban, R. H., et al. (2016) · Nature Reviews Disease Primers · doi:10.1038/nrdp.2016.22 · Cited by 1,982 · see citing works
Progress in Exosome Isolation Techniques
Li, P., Kaslan, M., Lee, S. H., Yao, J. D., & Gao, Z. (2017) · Theranostics · doi:10.7150/thno.18133 · Cited by 1,970 · see citing works
Pre-metastatic niches: organ-specific homes for metastases
Peinado, H., Zhang, H., Matei, I. R., Costa-Silva, B., Hoshino, A., Rodrigues, G., Psaila, B., Kaplan, R. N., Bromberg, J. F., Kang, Y., et al. (2017) · Nature Reviews Cancer · doi:10.1038/nrc.2017.6 · Cited by 1,889 · see citing works
The biology and function of exosomes in cancer
Kalluri, R. (2016) · Journal of Clinical Investigation · doi:10.1172/jci81135 · Cited by 1,849 · see citing works
Self-citationNew Technologies for Analysis of Extracellular Vesicles
Shao, H., Im, H., Castro, C. M., Breakefield, X. O., Weissleder, R., & Lee, H. (2018) · Chemical Reviews · doi:10.1021/acs.chemrev.7b00534 · Cited by 1,672 · see citing works
Current and future perspectives of liquid biopsies in genomics-driven oncology
Heitzer, E., Haque, I. S., Roberts, C. E. S., & Speicher, M. R. (2019) · Nature Reviews Genetics · doi:10.1038/s41576-018-0071-5 · Cited by 1,557 · see citing works
Extracellular vesicles as tools and targets in therapy for diseases
Kumar, M. A., Baba, S. K., Sadida, H. Q., Al-Marzooqi, S. K., Jerobin, J., Altemani, F. H., Algehainy, N. A., Alanazi, M. A., Abou‐Samra, A., Kumar, R., et al. (2024) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-024-01735-1 · Cited by 1,447 · see citing works
Extracellular vesicles in cancer — implications for future improvements in cancer care
Xu, R., Rai, A., Chen, M., Suwakulsiri, W., Greening, D. W., & Simpson, R. J. (2018) · Nature Reviews Clinical Oncology · doi:10.1038/s41571-018-0036-9 · Cited by 1,435 · see citing works
Clinical Applications of Circulating Tumor Cells and Circulating Tumor DNA as Liquid Biopsy
Alix-Panabières, C., & Pantel, K. (2016) · Cancer Discovery · doi:10.1158/2159-8290.cd-15-1483 · Cited by 1,394 · see citing works
Characteristics and Significance of the Pre-metastatic Niche
Liu, Y., & Cao, X. (2016) · Cancer Cell · doi:10.1016/j.ccell.2016.09.011 · Cited by 1,287 · see citing works
EV-TRACK: transparent reporting and centralizing knowledge in extracellular vesicle research
EV-TRACK Consortium, Van Deun, J., Mestdagh, P., Agostinis, P., Akay, Ö., Anand, S., Anckaert, J., Martinez, Z. A., Baetens, T., Beghein, E., et al. (2017) · Nature Methods · doi:10.1038/nmeth.4185 · Cited by 1,284 · see citing works
Exosome Theranostics: Biology and Translational Medicine
He, C., Zheng, S., Luo, Y., & Wang, B. (2017) · Theranostics · doi:10.7150/thno.21945 · Cited by 1,259 · see citing works
Microenvironment-induced PTEN loss by exosomal microRNA primes brain metastasis outgrowth
Zhang, L., Zhang, S., Yao, J., Lowery, F. J., Zhang, Q., Huang, W.-C., Li, P., Li, M., Wang, X., Zhang, C., et al. (2015) · Nature · doi:10.1038/nature15376 · Cited by 1,080 · see citing works
Gurunathan, S., Kang, M.-H., Jeyaraj, M., Qasim, M., & Kim, J. (2019) · Cells · doi:10.3390/cells8040307 · Cited by 1,135 · see citing works
A guide to the composition and functions of the extracellular matrix
Karamanos, N. K., Theocharis, A. D., Piperigkou, Z., Manou, D., Passi, A. G., Skandalis, S. S., Vynios, D. H., Orian‐Rousseau, V., Ricard‐Blum, S., Schmelzer, C. E. H., et al. (2021) · FEBS Journal · doi:10.1111/febs.15776 · Cited by 1,100 · see citing works
Exosomes: Therapy delivery tools and biomarkers of diseases
Barile, L., & Vassalli, G. (2017) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2017.02.020 · Cited by 1,038 · see citing works
Zeng, Z., Li, Y., Pan, Y., Lan, X.-L., Song, F., Sun, J., Zhou, K., Liu, X., Ren, X., Wang, F., et al. (2018) · Nature Communications · doi:10.1038/s41467-018-07810-w · Cited by 995 · see citing works
Exosomes in cancer development, metastasis, and immunity
Zhang, L., & Yu, D. (2019) · Biochimica et Biophysica Acta (BBA) - Reviews on Cancer · doi:10.1016/j.bbcan.2019.04.004 · Cited by 967 · see citing works
Exosomes as a new frontier of cancer liquid biopsy
Yu, D. B., Li, Y., Wang, M., Gu, J., Xu, W., Cai, H., Fang, X., & Zhang, X. (2022) · Molecular Cancer · doi:10.1186/s12943-022-01509-9 · Cited by 901 · see citing works
Extracellular vesicle isolation and characterization: toward clinical application
Xu, R., Greening, D. W., Zhu, H., Takahashi, N., & Simpson, R. J. (2016) · Journal of Clinical Investigation · doi:10.1172/jci81129 · Cited by 879 · see citing works
Early Detection of Pancreatic Cancer: Opportunities and Challenges
Singhi, A. D., Koay, E. J., Chari, S. T., & Maitra, A. (2019) · Gastroenterology · doi:10.1053/j.gastro.2019.01.259 · Cited by 841 · see citing works
Liquid biopsy: a step closer to transform diagnosis, prognosis and future of cancer treatments
Lone, S. N., Nisar, S., Masoodi, T., Singh, M. K., Rizwan, A., Hashem, S., El-Rifai, W. M., Bedognetti, D., Batra, S. K., Haris, M., et al. (2022) · Molecular Cancer · doi:10.1186/s12943-022-01543-7 · Cited by 841 · see citing works
Innovative approaches for cancer treatment: current perspectives and new challenges
Pucci, C., Martinelli, C., & Ciofani, G. (2019) · ecancermedicalscience · doi:10.3332/ecancer.2019.961 · Cited by 832 · see citing works
Wang, X., Luo, G., Zhang, K., Cao, J., Huang, C., Jiang, T., Liu, B., Su, L., & Qiu, Z. (2018) · Cancer Research · doi:10.1158/0008-5472.can-17-3841 · Cited by 768 · see citing works
Extracellular Vesicles and Nanoparticles: Emerging Complexities
Jeppesen, D. K., Zhang, Q., Franklin, J. L., & Coffey, R. J. (2023) · Trends in Cell Biology · doi:10.1016/j.tcb.2023.01.002 · Cited by 705 · see citing works
Application of exosomes as liquid biopsy in clinical diagnosis
Zhou, B., Xu, K., Zheng, X., Chen, T., Wang, J., Song, Y., Shao, Y., & Zheng, S. (2020) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-020-00258-9 · Cited by 685 · see citing works
Zhao, Z., Yang, Y., Zeng, Y., & He, M. (2015) · Lab on a Chip · doi:10.1039/c5lc01117e · Cited by 681 · see citing works
The role of extracellular vesicles in cancer
Kalluri, R., & McAndrews, K. M. (2023) · Cell · doi:10.1016/j.cell.2023.03.010 · Cited by 678 · see citing works
Self-citationMicrofluidics for exosome isolation and analysis: enabling liquid biopsy for personalized medicine
Contreras-Naranjo, J. C., Wu, H., & Ugaz, V. M. (2017) · Lab on a Chip · doi:10.1039/c7lc00592j · Cited by 650 · see citing works
Zang, J., Lu, D., & Xu, A. (2018) · Journal of Neuroscience Research · doi:10.1002/jnr.24356 · Cited by 647 · see citing works
Patel, G. K., Khan, M. A., Zubair, H., Srivastava, S. K., Khushman, M. M., Singh, S., & Singh, A. P. (2019) · Scientific Reports · doi:10.1038/s41598-019-41800-2 · Cited by 645 · see citing works
Tian, Y., Gong, M., Hu, Y., Liu, H., Zhang, W., Zhang, M., Hu, X., Aubert, D., Zhu, S., Wu, L., et al. (2020) · Journal of Extracellular Vesicles · doi:10.1080/20013078.2019.1697028 · Cited by 643 · see citing works
Dendritic cell-derived exosomes for cancer therapy.
Pitt, J. M., André, F., Amigorena, S., Soria, J.-C., Eggermont, A., Kroemer, G., & Zitvogel, L. (2016) · Journal of Clinical Investigation · doi:10.1172/jci81137 · Cited by 583 · see citing works
Exosomes─Nature’s Lipid Nanoparticles, a Rising Star in Drug Delivery and Diagnostics
Tenchov, R., Sasso, J. M., Wang, X., Liaw, W., Chen, C., & Zhou, Q. A. (2022) · ACS Nano · doi:10.1021/acsnano.2c08774 · Cited by 627 · see citing works
Review on Strategies and Technologies for Exosome Isolation and Purification
Chen, J., Li, P., Zhang, T., Xu, Z., Huang, X., Wang, R., & Du, L. (2022) · Frontiers in Bioengineering and Biotechnology · doi:10.3389/fbioe.2021.811971 · Cited by 585 · see citing works
High‐speed centrifugation induces aggregation of extracellular vesicles
Linares, R., Tan, S., Gounou, C., Arraud, N., & Brisson, A. R. (2015) · Journal of Extracellular Vesicles · doi:10.3402/jev.v4.29509 · Cited by 572 · see citing works
Exosomes and tumor-mediated immune suppression
Whiteside, T. L. (2016) · Journal of Clinical Investigation · doi:10.1172/jci81136 · Cited by 570 · see citing works
The biology, function, and applications of exosomes in cancer
Liu, J., Ren, L., Li, S., Li, W., Zheng, X., Yang, Y., Fu, W., Yi, J., Wang, J., & Du, G. (2021) · Acta Pharmaceutica Sinica B · doi:10.1016/j.apsb.2021.01.001 · Cited by 564 · see citing works
Exosome-delivered EGFR regulates liver microenvironment to promote gastric cancer liver metastasis
Zhang, H., Deng, T., Liu, R., Bai, M., Zhou, L., Wang, X., Li, S., Wang, X., Yang, H., Li, J., et al. (2017) · Nature Communications · doi:10.1038/ncomms15016 · Cited by 561 · see citing works
Sódar, B. W., Kittel, Á., Pálóczi, K., Vukman, K. V., Osteikoetxea, X., Szabó-Taylor, K., Nemeth, A. H., Sperlágh, B., Baranyai, T., Giricz, Z., et al. (2016) · Scientific Reports · doi:10.1038/srep24316 · Cited by 557 · see citing works
Ultrasensitive detection of circulating exosomes with a 3D-nanopatterned microfluidic chip
Zhang, P., Zhou, X. M., He, M., Shang, Y., Tetlow, A. L., Godwin, A. K., & Zeng, Y. (2019) · Nature Biomedical Engineering · doi:10.1038/s41551-019-0356-9 · Cited by 550 · see citing works
NONCODEV5: a comprehensive annotation database for long non-coding RNAs
Fang, S., Zhang, L., Guo, J., Niu, Y., Wu, Y., Li, H., Zhao, L., Li, X., Teng, X., Sun, X., et al. (2017) · Nucleic Acids Research · doi:10.1093/nar/gkx1107 · Cited by 548 · see citing works
The evolving translational potential of small extracellular vesicles in cancer
Möller, A., & Lobb, R. J. (2020) · Nature reviews. Cancer · doi:10.1038/s41568-020-00299-w · Cited by 541 · see citing works
Liquid Biopsies in Cancer Diagnosis, Monitoring, and Prognosis
Rubis, G. D., Krishnan, S. R., & Bebawy, M. (2019) · Trends in Pharmacological Sciences · doi:10.1016/j.tips.2019.01.006 · Cited by 533 · see citing works
Isolation and characterization of exosomes for cancer research
Zhu, L., Sun, H., Wang, S., Huang, S., Zheng, Y., Wang, C., Hu, B., Qin, W., Zou, T., Fu, Y., et al. (2020) · Journal of Hematology & Oncology · doi:10.1186/s13045-020-00987-y · Cited by 529 · see citing works
Genetics and biology of pancreatic ductal adenocarcinoma
Ying, H., Dey, P., Yao, W., Kimmelman, A. C., Draetta, G. F., Maitra, A., & DePinho, R. A. (2016) · Genes & Development · doi:10.1101/gad.275776.115 · Cited by 527 · see citing works
Extracellular vesicles: masters of intercellular communication and potential clinical interventions
Pitt, J. M., Kroemer, G., & Zitvogel, L. (2016) · Journal of Clinical Investigation · doi:10.1172/jci87316 · Cited by 522 · see citing works
Guo, S., Tao, S., Yin, W., Qi, X., Yuan, T., & Zhang, C. (2016) · Theranostics · doi:10.7150/thno.16803 · Cited by 519 · see citing works
Technical challenges of working with extracellular vesicles
Ramirez, M. I., de Amorim, M. G., Gadelha, C., Milic, I., Welsh, J. A., Freitas, V. M., Nawaz, M., Akbar, N., Couch, Y., Makin, L., et al. (2017) · Nanoscale · doi:10.1039/c7nr08360b · Cited by 518 · see citing works
Implementing Genome-Driven Oncology
Hyman, D. M., Taylor, B. S., & Baselga, J. M. (2017) · Cell · doi:10.1016/j.cell.2016.12.015 · Cited by 505 · see citing works
The significance of exosomes in the development and treatment of hepatocellular carcinoma
Li, X., Li, C., Zhang, L., Wu, M. Y., Cao, K., Jiang, F., Chen, D., Li, N., & Li, W. (2020) · Molecular Cancer · doi:10.1186/s12943-019-1085-0 · Cited by 503 · see citing works
Boriachek, K., Islam, M. N., Möller, A., Salomón, C., Nguyen, N., Hossain, M. S. A., Yamauchi, Y., & Shiddiky, M. J. A. (2017) · Small · doi:10.1002/smll.201702153 · Cited by 499 · see citing works
Pi, F., Binzel, D. W., Lee, T. J., Li, Z., Sun, M., Rychahou, P. G., Li, H., Haque, F., Wang, S., Croce, C. M., et al. (2017) · Nature Nanotechnology · doi:10.1038/s41565-017-0012-z · Cited by 495 · see citing works
Allenson, K., Castillo, J., San Lucas, F. A., Scelo, G., Kim, D. U., Bernard, V., Davis, G., Kumar, T., Katz, M., Overman, M. J., et al. (2017) · Annals of Oncology · doi:10.1093/annonc/mdx004 · Cited by 493 · see citing works
Tian, Y., Ma, L., Gong, M., Su, G., Zhu, S., Zhang, W., Wang, S., Li, Z., Chen, C., Li, L., et al. (2018) · ACS Nano · doi:10.1021/acsnano.7b07782 · Cited by 492 · see citing works
Song, Y., Dou, H., Li, X., Zhao, X., Li, Y., Liu, D., Ji, J., Liu, F., Ding, L., Ni, Y., et al. (2017) · Stem Cells · doi:10.1002/stem.2564 · Cited by 490 · see citing works
Kugeratski, F. G., Hodge, K., Lilla, S., McAndrews, K. M., Zhou, X., Hwang, R. F., Zanivan, S. R., & Kalluri, R. (2021) · Nature Cell Biology · doi:10.1038/s41556-021-00693-y · Cited by 490 · see citing works
Self-citationAptamer/AuNP Biosensor for Colorimetric Profiling of Exosomal Proteins
Jiang, Y. Y., Shi, M., Liu, Y., Wan, S., Cui, C., Zhang, L., & Tan, W. (2017) · Angewandte Chemie International Edition · doi:10.1002/anie.201703807 · Cited by 486 · see citing works
Liquid Biopsies, What We Do Not Know (Yet)
Bardelli, A., & Pantel, K. (2017) · Cancer Cell · doi:10.1016/j.ccell.2017.01.002 · Cited by 482 · see citing works
Evidence-Based Clinical Use of Nanoscale Extracellular Vesicles in Nanomedicine
Fais, S., O’Driscoll, L., Borras, F. E., Buzas, E., Camussi, G., Cappello, F., Carvalho, J., Cordeiro da Silva, A., Del Portillo, H., El Andaloussi, S., et al. (2016) · ACS Nano · doi:10.1021/acsnano.5b08015 · Cited by 481 · see citing works
Field-Free Isolation of Exosomes from Extracellular Vesicles by Microfluidic Viscoelastic Flows
Liu, C., Guo, J., Tian, F., Yang, N., Yan, F., Ding, Y., Wei, J., Hu, G., Nie, G., & Sun, J. (2017) · ACS Nano · doi:10.1021/acsnano.7b02277 · Cited by 477 · see citing works
Syn, N. L. X., Wang, L., Sethi, G., Thiery, J. P., & Goh, B. C. (2016) · Trends in Pharmacological Sciences · doi:10.1016/j.tips.2016.04.006 · Cited by 475 · see citing works
Wang, S., Zhang, L., Wan, S., Cansız, S., Cui, C., Liu, Y., Cai, R., Hong, C., Teng, I., Shi, M., et al. (2017) · ACS Nano · doi:10.1021/acsnano.7b00373 · Cited by 474 · see citing works
Phosphoproteins in extracellular vesicles as candidate markers for breast cancer
Chen, I.-H., Xue, L., Hsu, C., Paez, S. J., Pan, L., Aguilar, H. A., Wendt, M. K., Iliuk, A. B., Zhu, J., & Tao, W. A. (2017) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1618088114 · Cited by 472 · see citing works
Integrated Magneto–Electrochemical Sensor for Exosome Analysis
Jeong, S., Park, J., Pathania, D., Castro, C. M., Weissleder, R., & Lee, H. (2016) · ACS Nano · doi:10.1021/acsnano.5b07584 · Cited by 468 · see citing works
Li, W., Liu, Y., Zhang, P., Tang, Y., Zhou, M., Jiang, W., Zhang, X., Wu, G., & Zhou, Y. (2018) · ACS Applied Materials & Interfaces · doi:10.1021/acsami.7b17620 · Cited by 459 · see citing works
Comparison of isolation methods of exosomes and exosomal RNA from cell culture medium and serum
Tang, Y., Huang, Y., Zheng, L., Qin, S., Xu, X.-P., An, T., Xu, Y., Wu, Y.-S., Hu, X., Ping, B., et al. (2017) · International Journal of Molecular Medicine · doi:10.3892/ijmm.2017.3080 · Cited by 455 · see citing works
Clinical utility of circulating non-coding RNAs — an update
Anfossi, S., Babayan, A., Pantel, K., & Călin, G. A. (2018) · Nature Reviews Clinical Oncology · doi:10.1038/s41571-018-0035-x · Cited by 453 · see citing works
Role of exosomal proteins in cancer diagnosis
Li, W., Li, C., Zhou, T., Liu, X., Liu, X., Li, X., & Chen, D. (2017) · Molecular Cancer · doi:10.1186/s12943-017-0706-8 · Cited by 451 · see citing works
Exosome-mediated siRNA delivery to suppress postoperative breast cancer metastasis
Zhao, L., Gu, C., Gan, Y. H., Shao, L., Chen, H., & Zhu, H. (2019) · Journal of Controlled Release · doi:10.1016/j.jconrel.2019.12.005 · Cited by 443 · see citing works
Exosome Biochemistry and Advanced Nanotechnology for Next‐Generation Theranostic Platforms
Yang, B., Chen, Y., & Shi, J. (2019) · Advanced Materials · doi:10.1002/adma.201802896 · Cited by 435 · see citing works
Precision diagnostics: moving towards protein biomarker signatures of clinical utility in cancer
Borrebaeck, C. A. K. (2017) · Nature reviews. Cancer · doi:10.1038/nrc.2016.153 · Cited by 435 · see citing works
Exosome detection via the ultrafast-isolation system: EXODUS
Chen, Y., Zhu, Q., Cheng, L., Wang, Y., Li, M., Yang, Q., Hu, L., Lou, D., Li, J., Dong, X., et al. (2021) · Nature Methods · doi:10.1038/s41592-020-01034-x · Cited by 423 · see citing works
Zhang, Q., Jeppesen, D. K., Higginbotham, J. N., Graves‐Deal, R., Trinh, V. Q., Ramirez, M. A., Sohn, Y., Neininger, A. C., Taneja, N., McKinley, E. T., et al. (2021) · Nature Cell Biology · doi:10.1038/s41556-021-00805-8 · Cited by 423 · see citing works
Exosomes in the tumor microenvironment as mediators of cancer therapy resistance
Li, I., & Nabet, B. Y. (2019) · Molecular Cancer · doi:10.1186/s12943-019-0975-5 · Cited by 416 · see citing works
Exosomes: The next generation of endogenous nanomaterials for advanced drug delivery and therapy
Liao, W., Du, Y., Zhang, C., Pan, F., Yao, Y., Zhang, T., & Peng, Q. (2018) · Acta Biomaterialia · doi:10.1016/j.actbio.2018.12.045 · Cited by 416 · see citing works
Single-Exosome-Counting Immunoassays for Cancer Diagnostics
Liu, C., Xu, X., Li, B., Situ, B., Pan, W., Hu, Y., An, T., Yao, S., & Zheng, L. (2018) · Nano Letters · doi:10.1021/acs.nanolett.8b01184 · Cited by 407 · see citing works
Pseudotyping exosomes for enhanced protein delivery in mammalian cells
Meyer, C. C., Losacco, J., Stickney, Z., Li, L., Marriott, G., & Lü, B. (2017) · International Journal of Nanomedicine · doi:10.2147/ijn.s133430 · Cited by 405 · see citing works
Gurunathan, S., Kang, M.-H., & Kim, J. (2021) · International Journal of Nanomedicine · doi:10.2147/ijn.s291956 · Cited by 388 · see citing works
Liquid biopsies: the future of cancer early detection
Connal, S., Cameron, J. M., Sala, A., Brennan, P. M., Palmer, D. S., Palmer, J. D., Perlow, H. K., & Baker, M. J. (2023) · Journal of Translational Medicine · doi:10.1186/s12967-023-03960-8 · Cited by 387 · see citing works
The role of exosomes in cancer metastasis
Steinbichler, T. B., Dudás, J., Riechelmann, H., & Skvortsova, I. (2017) · Seminars in Cancer Biology · doi:10.1016/j.semcancer.2017.02.006 · Cited by 386 · see citing works
Lai, X., Wang, M., McElyea, S. D., Sherman, S., House, M. G., & Korc, M. (2017) · Cancer Letters · doi:10.1016/j.canlet.2017.02.019 · Cited by 386 · see citing works
Zhang, P., He, M., & Zeng, Y. (2016) · Lab on a Chip · doi:10.1039/c6lc00279j · Cited by 384 · see citing works
Molecular interactions at the surface of extracellular vesicles
Buzás, E. I., Tóth, E. Á., Sódar, B. W., & Szabó-Taylor, K. (2018) · Seminars in Immunopathology · doi:10.1007/s00281-018-0682-0 · Cited by 384 · see citing works
Rapid Isolation and Detection of Exosomes and Associated Biomarkers from Plasma
Ibsen, S. D., Wright, J., Lewis, J. M., Kim, S., Ko, S.-Y., Ong, J., Manouchehri, S., Vyas, A. D., Akers, J. C., Chen, C. C., et al. (2017) · ACS Nano · doi:10.1021/acsnano.7b00549 · Cited by 383 · see citing works
Chen, C., Rao, S., Ren, L., Hu, X., Tan, Y., Hu, Y., Luo, J., Liu, Y.-W., Yin, H., Huang, J., et al. (2018) · Theranostics · doi:10.7150/thno.22958 · Cited by 380 · see citing works
Early screening and diagnosis strategies of pancreatic cancer: a comprehensive review
Yang, J., Xu, R., Wang, C., Qiu, J., Ren, B., & You, L. (2021) · Cancer Communications · doi:10.1002/cac2.12204 · Cited by 379 · see citing works
Proteoglycan Chemical Diversity Drives Multifunctional Cell Regulation and Therapeutics
Karamanos, N. K., Piperigkou, Z., Theocharis, A. D., Watanabe, H., Franchi, M., Baud, S., Brézillon, S., Götte, M., Passi, A. G., Vigetti, D., et al. (2018) · Chemical Reviews · doi:10.1021/acs.chemrev.8b00354 · Cited by 372 · see citing works
Woo, H., Sunkara, V., Park, J., Kim, T.-H., Han, J.-R., Kim, C., Choi, H.-I., Kim, Y., & Cho, Y. (2017) · ACS Nano · doi:10.1021/acsnano.6b06131 · Cited by 371 · see citing works
- Authors
- Melo, S. A., Luecke, L. B., Kahlert, C., Fernandez, A. F., Gammon, S. T., Kaye, J., LeBleu, V. S., Mittendorf, E. A., Weitz, J., Rahbari, N., Reissfelder, C., Pilarsky, C., Fraga, M. F., Piwnica-Worms, D., & Kalluri, R.
- Affiliations
- The University of Texas MD Anderson Cancer Center (US)
- Technische Universität Dresden (DE)
- Consejo Superior de Investigaciones Científicas (ES)
- Corresponding author
- Kalluri, Raghu
- ORCID
- Venue
- Nature
- Published
- 2015-06-24
- Volume
- 523
- Issue
- 7559
- Pages
- 177-182
- ISSN
- 0028-0836 (ISSN-L)
- 1476-4687
- PMC
- PMC4825698
- OpenAlex
- W1500925570
- Cited by
- 2,880
- References
- 63
- Citations by year
- 2026: 129 · 2025: 200 · 2024: 253 · 2023: 305 · 2022: 277 · 2021: 371 · 2020: 320 · 2019: 271 · 2018: 269 · 2017: 234 · 2016: 195 · 2015: 52 · 2014: 1 · 2013: 1
- FWCI
- 108.75
- Type
- journal article
- Language
- en
- Update notices
- correction (2022-10-05)
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Nature (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- RePEc: Research Papers in Economics (submittedVersion)
- Consultation of the Doctoral Thesis Database (TESEO) (Ministerio de Educación, Cultura y Deporte) (submittedVersion, cc-by-nc-nd)
- Funders
- National Institutes of Health (5u24ca126577-05)
- National Cancer Institute (P30CA16672, U01CA151925, CA-16672, U24-CA-126577, P50CA094056, 5U24CA126577, R01CA155370, CA 155370, CA 151925, P30CA016672)
- National Institute of Diabetes and Digestive and Kidney Diseases (DK 081576, R01DK081576)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Extracellular vesicles in disease
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Cancer Genomics and Diagnostics
- Health Sciences › Medicine › Oncology › Pancreatic and Hepatic Oncology Research
- Keywords
- glypican-1, tumor-derived exosomes, extracellular vesicles, pancreatic cancer, early cancer detection, circulating exosomes, cell surface proteoglycans, KRAS mutation, non-invasive biomarkers, tumor burden
- MeSH terms
- Animals, Female, Humans, Male, Pancreatic Neoplasms, Proto-Oncogene Proteins, Biomarkers, Proto-Oncogene Proteins p21(ras), ras Proteins, NIH 3T3 Cells, HCT116 Cells, Cell Line, Tumor, Mice, Glypicans, Exosomes, MCF-7 Cells
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
