The DOI matches its Crossref record; 6 of the 6 references it cites were found in a registry or an index.
Use of high-resolution proton nuclear magnetic resonance spectroscopy for rapid multi-component analysis of urine.
Abstract
Numerous low-Mr metabolites--including creatinine, citrate, hippurate, glucose, ketone bodies, and various amino acids--have been identified in 400- and 500-MHz proton nuclear magnetic resonance (1H NMR) spectra of intact human urine. The presence of many of these was related to the specific condition of the donors: humans in different physiological states (resting, fasting, or post-exercise) and pathological conditions (e.g., diabetes mellitus, cadmium-induced renal dysfunction). We have also monitored the metabolism of simple nonendogenous compounds (methanol and ethanol) and of acetaminophen. The pH-dependencies of the NMR chemical shifts of some urine components are reported. Our studies show that high-resolution 1H NMR spectroscopy provides a fast, simple method for "fingerprint" identification of urinary compounds. In some cases, analytes can be quantified by standard additions or by comparing integrated peak areas for the metabolites with those for creatinine. Determinations of creatinine by 1H NMR spectroscopy compared well with those by an independent chemical assay based on the Jaffé reaction.
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Cites
Fundamentals of Clinical Chemistry.
(1977) · Annals of Internal Medicine · doi:10.7326/0003-4819-87-1-142_1 · Cited by 2,561
Nicholson, J. K., O'Flynn, M. P., Sadler, P. J., Macleod, A. F., Juul, S. M., & Sönksen, P. H. (1984) · Biochemical Journal · doi:10.1042/bj2170365 · Cited by 277
Self-citationSelective excitation in Fourier transform nuclear magnetic resonance
Morris, G. A., & Freeman, R. (2011) · Journal of Magnetic Resonance · doi:10.1016/j.jmr.2011.08.031 · Cited by 204
Spin-echo Fourier transform nuclear magnetic resonance spectroscopy
Rabenstein, D. L., & Nakashima, T. T. (1979) · Analytical Chemistry · doi:10.1021/ac50050a003 · Cited by 93
Acetaminophen Metabolism in Man, as Determined by High-Resolution Liquid Chromatography
Mrochek, J. E., Katz, S., Christie, W. H., & Dinsmore, S. R. (1974) · Clinical Chemistry · doi:10.1093/clinchem/20.8.1086 · Cited by 89
Traube, M., BOCK, J. L., & BOYER, J. L. (1983) · Annals of Internal Medicine · doi:10.7326/0003-4819-98-2-171 · Cited by 57
Cited by
Metabonomics: a platform for studying drug toxicity and gene function
Nicholson, J. K., Connelly, J., Lindon, J. C., & Holmes, E. (2002) · Nature Reviews Drug Discovery · doi:10.1038/nrd728 · Cited by 1,914
Self-citationDumas, M.-E., Barton, R. H., Toye, A., Cloarec, O., Blancher, C., Rothwell, A., Fearnside, J., Tatoud, R., Blanc, V., Lindon, J. C., et al. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0601056103 · Cited by 1,042
Self-citationANOVA-simultaneous component analysis (ASCA): a new tool for analyzing designed metabolomics data
Smilde, A. K., Jansen, J. J., Hoefsloot, H. C. J., Lamers, R.-J. A. N., van der Greef, J., & Timmerman, M. E. (2005) · Bioinformatics · doi:10.1093/bioinformatics/bti476 · Cited by 665
Luminescent Gold Nanoparticles with Efficient Renal Clearance
Zhou, C., Long, M., Qin, Y., Sun, X., & Zheng, J. (2011) · Angewandte Chemie International Edition · doi:10.1002/anie.201007321 · Cited by 490
NMR‐based metabonomic approaches for evaluating physiological influences on biofluid composition
Bollard, M. E., Stanley, E. G., Lindon, J. C., Nicholson, J. K., & Holmes, E. (2005) · NMR in Biomedicine · doi:10.1002/nbm.935 · Cited by 473
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Metadata
- Authors
- Bales, J. R., Higham, D. P., Howe, I., Nicholson, J. K., & Sadler, P. J.
- Venue
- Clinical Chemistry
- Publisher
- Oxford University Press (OUP)
- Published
- 1984-03-01
- Volume
- 30
- Issue
- 3
- Pages
- 426-432
- ISSN
- 0009-9147 (ISSN-L)
- 1530-8561
- OpenAlex
- W1821683595
- Cited by
- 296
- References
- 6
- FWCI
- 3.44
- Type
- journal article
- Language
- en
- Open access
- closed
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- Bales, J. R., Higham, D. P., Howe, I., Nicholson, J. K., & Sadler, P. J. (1984). Use of high-resolution proton nuclear magnetic resonance spectroscopy for rapid multi-component analysis of urine. Clinical Chemistry. https://doi.org/10.1093/clinchem/30.3.426
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
