The DOI matches its Crossref record; 6 of the 6 references it cites were found in a registry or an index.
Proton-nuclear-magnetic-resonance studies of serum, plasma and urine from fasting normal and diabetic subjects
Open accessAbstract
Resonances for the ketone bodies 3-D-hydroxybutyrate, acetone and acetoacetate are readily detected in serum, plasma and urine samples from fasting and diabetic subjects by 1H n.m.r. spectroscopy at 400 MHz. Besides the simultaneous observation of metabolites, the major advantage of n.m.r. is that little or no pretreatment of samples is required. N.m.r. determinations of 3-D-hydroxybutyrate, acetoacetate, lactate, valine and alanine were compared with determinations made with conventional assays at six 2-hourly intervals after insulin withdrawal from a diabetic subject. The n.m.r. results closely paralleled those of other assays although, by n.m.r., acetoacetate levels continued to rise rather than reaching a plateau 4h after insulin withdrawal. The 3-D-hydroxybutyrate/acetoacetate ratio in urine during withdrawal gradually increased to the value observed in plasma (3.0 +/- 0.2) as determined by n.m.r. The acetoacetate/acetone ratio in urine (17 +/- 6) was much higher than in plasma (2.5 +/- 0.7). Depletion of a mobile pool of fatty acids in plasma during fasting, as seen by n.m.r., paralleled that seen during insulin withdrawal. These fatty acids were thought to be largely in chylomicrons, acylglycerols and lipoproteins, and were grossly elevated in plasma samples from a non-insulin-dependent diabetic and in cases of known hyperlipidaemia.
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Cites
Enzymic determination of d(−)-β-hydroxybutyric acid and acetoacetic acid in blood
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Hormone-fuel interrelationships during fasting.
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High resolution 1H n.m.r. studies of vertebrate blood and plasma
Nicholson, J. K., Buckingham, M. J., & Sadler, P. J. (1983) · Biochemical Journal · doi:10.1042/bj2110605 · Cited by 255
Self-citationKetoacidosis in Pancreatectomized Man
Barnes, A. J., Bloom, S. R., Alberti, K. G. M. M., Smythe, P., ALFORD, F. P., & Chisholm, D. J. (1977) · New England Journal of Medicine · doi:10.1056/nejm197706022962202 · Cited by 107
Free fatty acid estimation by a semi-automated fluorimetric method
Carruthers, M. E., & Young, D. A. (1973) · Clinica Chimica Acta · doi:10.1016/0009-8981(73)90231-3 · Cited by 67
Cited by
Beckonert, O., Keun, H. C., Ebbels, T. M. D., Bundy, J., Holmes, E., Lindon, J. C., & Nicholson, J. K. (2007) · Nature Protocols · doi:10.1038/nprot.2007.376 · Cited by 2,109
Self-citationMetabonomics: a platform for studying drug toxicity and gene function
Nicholson, J. K., Connelly, J., Lindon, J. C., & Holmes, E. (2002) · Nature Reviews Drug Discovery · doi:10.1038/nrd728 · Cited by 1,914
Self-citationUnderstanding 'Global' Systems Biology: Metabonomics and the Continuum of Metabolism
Nicholson, J. K., & Wilson, I. D. (2003) · Nature Reviews Drug Discovery · doi:10.1038/nrd1157 · Cited by 1,116
Self-citationDumas, M.-E., Barton, R. H., Toye, A., Cloarec, O., Blancher, C., Rothwell, A., Fearnside, J., Tatoud, R., Blanc, V., Lindon, J. C., et al. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0601056103 · Cited by 1,042
Self-citationDona, A. C., Jiménez, B., Schäfer, H., Humpfer, E., Spraul, M., Lewis, M. R., Pearce, J. T. M., Holmes, E., Lindon, J. C., & Nicholson, J. K. (2014) · Analytical Chemistry · doi:10.1021/ac5025039 · Cited by 540
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Metadata
- Authors
- Nicholson, J. K., O'Flynn, M. P., Sadler, P. J., Macleod, A. F., Juul, S. M., & Sönksen, P. H.
- Venue
- Biochemical Journal
- Publisher
- Portland Press Ltd.
- Published
- 1984-01-15
- Volume
- 217
- Issue
- 2
- Pages
- 365-375
- ISSN
- 0264-6021 (ISSN-L)
- 1470-8728
- OpenAlex
- W1815311081
- Cited by
- 277
- References
- 6
- FWCI
- 4.73
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Nicholson, J. K., O'Flynn, M. P., Sadler, P. J., Macleod, A. F., Juul, S. M., & Sönksen, P. H. (1984). Proton-nuclear-magnetic-resonance studies of serum, plasma and urine from fasting normal and diabetic subjects. Biochemical Journal. https://doi.org/10.1042/bj2170365
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