Analysis for nicotine and cotinine in hair to determine cigarette smoker status.
Abstract
Noninvasive validation of cigarette smoking behavior is necessary for large population studies, especially with adolescents, where peer pressures can compromise self-report. Saliva and urine samples provide biological material for confirmation of recent nicotine intake by analysis for cotinine, the major metabolite of nicotine. However, detection of infrequent use of cigarettes can be missed in a single annual screen when participants have not smoked in the preceding week. We analyzed scalp hair from smokers and controls, to see whether hair could provide reliable samples for determining nicotine uptake. The amounts of nicotine and cotinine we detected in these samples correlated with individual smoking habits and exposures.
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In the follicular phase of the menstrual cycle, the dominant ovarian follicle produces the majority of circulating estrogens.
“In the follicular phase ofthe menstrual cycle, the ovarian follicle that gains dominance produces the majority of circulating es- trogens (29).”
From Nicotine, cotinine, and anabasine inhibit aromatase in human trophoblast in vitro. (1986) · cites this paper as [29]
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Nicotine, cotinine, and anabasine inhibit aromatase in human trophoblast in vitro.
Barbieri, R. L., Gochberg, J., & Ryan, K. J. (1986) · Journal of Clinical Investigation · doi:10.1172/jci112494 · Cited by 197 · see citing works
Nachweis von Arznei-und anderen Fremdstoffen in Haaren
Schütz, H., Ahrens, B., Erdmann, F., & Rochholz, G. (1993) · Pharmazie in unserer Zeit · doi:10.1002/pauz.19930220205 · Cited by 15 · see citing works
- Authors
- Haley, N. J., & Hoffmann, D.
- Venue
- Clinical Chemistry
- Publisher
- Oxford University Press (OUP)
- Published
- 1985-10-01
- Volume
- 31
- Issue
- 10
- Pages
- 1598-1600
- ISSN
- 0009-9147 (ISSN-L)
- 1530-8561
- OpenAlex
- W1880163345
- Cited by
- 108
- References
- 0
- Citations by year
- 2025: 1 · 2023: 1 · 2022: 2 · 2021: 1 · 2020: 3 · 2019: 2 · 2015: 5 · 2014: 1 · 2013: 2
- FWCI
- 1.13
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- academic.oup.com/journals/pages/open_access/funder_policies/chorus/standard_publication_model (vor)
- Locations
- Clinical Chemistry (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Cancer Institute (P01CA029580, 2PO1 CA29580)
- Topics
- Health Sciences › Medicine › Physiology › Smoking Behavior and Cessation
- Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Toxicology › Forensic Toxicology and Drug Analysis
- Physical Sciences › Chemistry › Analytical Chemistry › Analytical chemistry methods development
- Keywords
- nicotine, cotinine, scalp hair, non-invasive biomarkers, adolescent smoking, self-report reliability, hair analysis
- MeSH terms
- Cotinine, Detergents, Hair, Humans, Male, Nicotine, Pyrrolidinones, Smoking, Specimen Handling
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