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Lipids, lipoproteins, and apoproteins in serum during infection.
Abstract
We studied the alterations in the concentrations of total cholesterol, high-density lipoprotein cholesterol, triglycerides, and apoproteins A and B in serum of 54 patients hospitalized for various reasons, who developed sepsis during their stay. Forty of these patients required intensive care, 14 did not. Another group of patients with the same underlying pathological conditions was used as a control. We found the following: Sepsis causes the concentrations of total cholesterol, high-density lipoprotein cholesterol, and apoproteins A and B in serum to decrease, whereas triglycerides increase. However, these changes are not related to the infectious agent, the underlying illness, or the clinical situation of the patients. The return of serum lipids to more normal concentrations parallels the recovery from sepsis. The positive correlation between the drastically decreased concentrations of high-density lipoprotein cholesterol and the severe hypoalbuminemia in these patients suggests a common pathway for these two abnormalities.
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Citations
Cited by
Grunfeld, C. (1992) · Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.74.5.1045 · Cited by 848
Hak, A. E., Stehouwer, C. D. A., Bots, M. L., Polderman, K. H., Schalkwijk, C. G., Westendorp, I. C. D., Hofman, A., & Witteman, J. C. M. (1999) · Arteriosclerosis, Thrombosis, and Vascular Biology · doi:10.1161/01.atv.19.8.1986 · Cited by 525
Gender differences in cardiovascular disease
Gao, Z., Chen, Z., Sun, A., & Deng, X. (2019) · Medicine in Novel Technology and Devices · doi:10.1016/j.medntd.2019.100025 · Cited by 373
Feingold, K., Staprans, I., Memon, R., Moser, A., Shigenaga, J., Doerrler, W., Dinarello, C., & Grunfeld, C. (1992) · Journal of Lipid Research · doi:10.1016/s0022-2275(20)41334-3 · Cited by 346
Harris, H. W., Grunfeld, C., Feingold, K. R., & Rapp, J. H. (1990) · Journal of Clinical Investigation · doi:10.1172/jci114765 · Cited by 320
Metadata
- Authors
- Alvarez, C., & Ramos, A.
- Venue
- Clinical Chemistry
- Publisher
- Oxford University Press (OUP)
- Published
- 1986-01-01
- Volume
- 32
- Issue
- 1
- Pages
- 142-145
- ISSN
- 0009-9147 (ISSN-L)
- 1530-8561
- OpenAlex
- W1835166549
- Cited by
- 281
- References
- 0
- FWCI
- 3.40
- Type
- journal article
- Language
- en
- Open access
- closed
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- Alvarez, C., & Ramos, A. (1986). Lipids, lipoproteins, and apoproteins in serum during infection. Clinical Chemistry. https://doi.org/10.1093/clinchem/32.1.142
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
