Associations of C-Reactive Protein With Measures of Obesity, Insulin Resistance, and Subclinical Atherosclerosis in Healthy, Middle-Aged Women
Open accessAbstract
Abstract —Obesity, the insulin resistance syndrome, and atherosclerosis are closely linked and may all be determinants of an increased acute-phase response. In this study, we examined the relationship of C-reactive protein (CRP) with measures of obesity, variables of the insulin resistance syndrome, and intima-media thickness of the common carotid arteries in 186 healthy, middle-aged women selected from the general population. Associations were assessed by regression analysis. CRP was strongly associated with body mass index (BMI) and waist circumference. CRP was also associated with other variables of the insulin resistance syndrome, including blood pressure, insulin, high density lipoprotein cholesterol, triglycerides, apolipoprotein A1 (inversely), plasminogen activator inhibitor-1 antigen, and tissue-type plasminogen activator antigen. Associations between CRP and the variables of the insulin resistance syndrome disappeared after controlling for BMI but remained significant for plasminogen activator inhibitor-1 antigen only. The association of CRP with common carotid artery intima-media thickness was weak and limited to ever-smokers. BMI explained 29.7% of the variance of CRP, whereas common carotid artery intima-media thickness explained only 3.7%. The results of this population-based study indicate that adiposity is strongly associated with CRP in healthy, middle-aged women. In this population, BMI accounted for the relationship between CRP and other variables of the insulin resistance syndrome. Further studies should determine whether losing weight ameliorates the inflammatory state.
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Slightly elevated serum levels of C-reactive protein (IL-6-dependent) are closely interrelated with insulin resistance.
“This is confirmed by studies that describe a close interrelation of slightly elevated serum levels of C-reactive protein (IL-6-dependent) and a key element of the energy re-allocation program, namely insulin resistance [9,10].”
From Interaction of the endocrine system with inflammation: a function of energy and volume regulation (2014) · cites this paper as [9]
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- Authors
- Hak, A. E., Stehouwer, C. D. A., Bots, M. L., Polderman, K. H., Schalkwijk, C. G., Westendorp, I. C. D., Hofman, A., & Witteman, J. C. M.
- Affiliations
- University Medical Center Utrecht (NL)
- From the Department of Epidemiology and Biostatistics (A.E.H., M.L.B., I.C.D.W., A.H., J.C.M.W.), Erasmus University Medical School, Rotterdam; the Department of Internal Medicine (C.D.A.S., K.H.P.), University Hospital Vrije Universiteit and Institute for Cardiovascular Research Vrije Universiteit, Amsterdam; the Julius Center for Patient Oriented Research (M.L.B.), University Medical Center Utrecht, Utrecht; and the Department of Clinical Chemistry (C.G.S.), University Hospital Vrije Universiteit...
- Venue
- Arteriosclerosis, Thrombosis, and Vascular Biology
- Published
- 1999-08
- Volume
- 19
- Issue
- 8
- Pages
- 1986-1991
- ISSN
- 1079-5642 (ISSN-L)
- 1524-4636
- OpenAlex
- W2162483087
- Cited by
- 525
- References
- 47
- Citations by year
- 2026: 2 · 2025: 5 · 2024: 6 · 2023: 5 · 2022: 7 · 2021: 15 · 2020: 6 · 2019: 4 · 2018: 6 · 2017: 10 · 2016: 13 · 2015: 12 · 2014: 17 · 2013: 14 · 2012: 19
- FWCI
- 21.67
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Arteriosclerosis Thrombosis and Vascular Biology (publishedVersion)
- PubMed (publishedVersion)
- EUR Research Repository (Erasmus University Rotterdam) (publishedVersion, other-oa)
- EUR Research Repository (Erasmus University Rotterdam) (submittedVersion, other-oa)
- RePub (Erasmus University Rotterdam) (submittedVersion, other-oa)
- Funders
- Nederlandse Organisatie voor Wetenschappelijk Onderzoek
- Topics
- Health Sciences › Medicine › Epidemiology › Adipokines, Inflammation, and Metabolic Diseases
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes, Cardiovascular Risks, and Lipoproteins
- Health Sciences › Medicine › Surgery › Lipoproteins and Cardiovascular Health
- Keywords
- C-reactive protein, obesity, metabolic syndrome, subclinical atherosclerosis, carotid intima-media thickness, middle-aged women, body mass index, waist circumference, adiposity, acute phase response, plasminogen activator inhibitor-1, tissue plasminogen activator, smoking, inflammation
- MeSH terms
- Adult, Arteriosclerosis, Body Height, Body Weight, C-Reactive Protein, Female, Humans, Insulin Resistance, Middle Aged, Obesity, Smoking, Body Mass Index, Carotid Artery, Common, Tunica Intima, Tunica Media, Premenopause, Postmenopause
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