The DOI matches its Crossref record; 11 of the 11 references it cites were found in a registry or an index.
Simultaneous liquid-chromatographic determination of 3,4-dihydroxyphenylglycol, catecholamines, and 3,4-dihydroxyphenylalanine in plasma, and their responses to inhibition of monoamine oxidase.
Abstract
This is a reversed-phase liquid-chromatographic method, with electrochemical detection, for simultaneously measuring, in plasma, the concentrations of the catecholamine precursor dihydroxyphenylalanine (DOPA); the endogenous catecholamines norepinephrine, epinephrine, and dopamine; and the deaminated catecholamine metabolites dihydroxyphenylacetic acid (DOPAC) and dihydroxyphenylglycol (DHPG). We used this method to assess effects of monoamine oxidase (EC 1.4.3.4) inhibition in humans. Plasma DHPG concentrations as determined by the present method (mean 826, SEM 61 ng/L) were similar to those found by other methods. Inhibition of monoamine oxidase (by administering deprenyl or tranylcypromine) decreased plasma DHPG by greater than 65%, plasma DOPAC by greater than 50%, and plasma DOPA by about 20%, without consistently affecting norepinephrine or epinephrine. Simultaneous measurement of DOPA, catecholamines, and DHPG may be useful for examining the synthesis, release, and intraneuronal metabolism of norepinephrine. The assay method is rapid, reliable, and simple, and it provides a more comprehensive assessment of noradrenergic nervous function than does measurement only of catecholamines.
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Cites
Goldstein, D. S., Feuerstein, G., Izzo, J. L., Kopin, I. J., & Keiser, H. R. (1981) · Life Sciences · doi:10.1016/0024-3205(81)90139-9 · Cited by 467
Self-citationA kinetic analysis of the extraneuronal uptake and metabolism of catecholamines
TRENDELENBURG, U. (2005) · Springer eBooks · doi:10.1007/bfb0030896 · Cited by 100
Measurement of regional neuronal removal of norepinephrine in man.
Goldstein, D. S., Zimlichman, R., Stull, R., Folio, J., Levinson, P. D., Keiser, H. R., & Kopin, I. J. (1985) · Journal of Clinical Investigation · doi:10.1172/jci111939 · Cited by 65
Self-citationAssessment of norepinephrine secretion and production.
Hoeldtke, R. D., Cilmi, K. M., Reichard, G., Boden, G. H., & Owen, O. E. (1983) · PubMed · Cited by 62
Goldstein, D. S., Stull, R., Zimlichman, R., Levinson, P. D., Smith, H., & Keiser, H. R. (1984) · Clinical Chemistry · doi:10.1093/clinchem/30.5.815 · Cited by 61
Self-citationKopin, I. J., Polinsky, R. J., Oliver, J., Oddershede, I. R., & Ebert, M. H. (1983) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem-57-3-632 · Cited by 50
Self-citationBROWN, M. J. (1984) · European Journal of Clinical Investigation · doi:10.1111/j.1365-2362.1984.tb00706.x · Cited by 50
Jackman, G. P., Snell, J. A., Skews, H., & Bobik, A. (1982) · Life Sciences · doi:10.1016/0024-3205(82)90550-1 · Cited by 28
Izzo, J. L., Thompson, D. A., & Horwitz, D. L. (1985) · Life Sciences · doi:10.1016/0024-3205(85)90593-4 · Cited by 27
Plasma Levels of Catecholamines and Dihydroxyphenylglycol during Antidepressant Drug Treatment
Robinson, D. S., Johnson, G. A., Nies, A., CORCELLA, J., Cooper, T. B., ALBRIGHT, D., & Howard, D. B. (1983) · Journal of Clinical Psychopharmacology · doi:10.1097/00004714-198310000-00003 · Cited by 20
Cited by
Biochemical Diagnosis of Pheochromocytoma: Which Test Is Best?
Lenders, J. W. M., Pacak, K., Walther, M. M., Linehan, W. M., Mannelli, M., Friberg, P., Keiser, H. R., Goldstein, D. S., & Eisenhofer, G. (2002) · JAMA · doi:10.1001/jama.287.11.1427 · Cited by 1,134
Self-citationBiochemical Diagnosis of Pheochromocytoma: How to Distinguish True- from False-Positive Test Results
Eisenhofer, G., Goldstein, D. S., Walther, M. M., Friberg, P., Lenders, J. W. M., Keiser, H. R., & Pacak, K. (2003) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2002-030005 · Cited by 492
Self-citationCardiac Sympathetic Nerve Function in Congestive Heart Failure
Eisenhofer, G., Friberg, P., Rundqvist, B., Quyyumi, A. A., Lambert, G., Kaye, D. M., Kopin, I. J., Goldstein, D. S., & Esler, M. D. (1996) · Circulation · doi:10.1161/01.cir.93.9.1667 · Cited by 453
Self-citationHabib, K. E., Weld, K. P., Rice, K. C., Pushkas, J., Champoux, M., Listwak, S., Webster, E. L., Atkinson, A. J., Schulkin, J., Contoreggi, C., et al. (2000) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.97.11.6079 · Cited by 403
Substantial Production of Dopamine in the Human Gastrointestinal Tract
Eisenhofer, G., Åneman, A., Friberg, P., Hooper, D., Fåndriks, L., Lonroth, H., Hunyady, B., & Mezey, E. (1997) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.82.11.4339 · Cited by 394
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Metadata
- Authors
- Eisenhofer, G., Goldstein, D. S., Stull, R., Keiser, H. R., Sunderland, T., Murphy, D. L., & Kopin, I. J.
- Venue
- Clinical Chemistry
- Publisher
- Oxford University Press (OUP)
- Published
- 1986-11-01
- Volume
- 32
- Issue
- 11
- Pages
- 2030-2033
- ISSN
- 0009-9147 (ISSN-L)
- 1530-8561
- OpenAlex
- W1907985808
- Cited by
- 477
- References
- 11
- FWCI
- 10.37
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: Simultaneous liquid-chromatographic determination of 3,4-dihydroxyphenylglycol, catecholamines, and 3,4-dihydroxyphenylalanine in plasma, and their responses to inhibition of monoamine oxidase. https://app.cochat.ai/papers/10.1093/clinchem/32.11.2030
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- Eisenhofer, G., Goldstein, D. S., Stull, R., Keiser, H. R., Sunderland, T., Murphy, D. L., & Kopin, I. J. (1986). Simultaneous liquid-chromatographic determination of 3,4-dihydroxyphenylglycol, catecholamines, and 3,4-dihydroxyphenylalanine in plasma, and their responses to inhibition of monoamine oxidase. Clinical Chemistry. https://doi.org/10.1093/clinchem/32.11.2030
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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