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Noninvasive Glucose Monitoring in Diabetic Patients: A Preliminary Evaluation
Abstract
Noninvasive monitoring of blood/tissue glucose concentrations has been successfully accomplished in individual diabetic subjects by using near-infrared (NIR) spectroscopy coupled with chemometric methods. Three different spectrometer configurations were tested: a) a Fourier-transform infrared spectrometer with an indium antimonide detector; b) a grating monochromator equipped with a silicon (Si) array detector, without fiber optics; and c) a grating monochromator equipped with an Si detector, with fiber-optic sampling. NIR spectra were obtained from diabetic subjects by transmission through the finger during a meal-tolerance test. The maximum range of observed plasma glucose concentrations obtained from the blood samples was 2.5-27 mmol/L. The NIR spectra were processed by using the chemometric multivariate calibration methods of partial least squares and principal component regression. The best calibration yielded a cross-validated average absolute error in glucose concentration of 1.1 mmol/L. This predictive ability suggests that noninvasive glucose determinations by NIR/chemometrics is a viable analytical method.
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Cited by
Sacks, D. B., Arnold, M., Bakris, G. L., Bruns, D. E., Horvath, A. R., Kirkman, M. S., Lernmark, A., Metzger, B. E., & Nathan, D. M. (2011) · Clinical Chemistry · doi:10.1373/clinchem.2010.161596 · Cited by 1,360
Maier, J. S., Walker, S. A., Fantini, S., Franceschini, M. A., & Gratton, E. (1994) · Optics Letters · doi:10.1364/ol.19.002062 · Cited by 318
Noninvasive Blood Glucose Monitoring With Optical Coherence Tomography
Larin, K. V., Eledrisi, M. S., Motamedi, M., & Esenaliev, R. O. (2002) · Diabetes Care · doi:10.2337/diacare.25.12.2263 · Cited by 293
Pullano, S. A., Greco, M., Bianco, M. G., Foti, D., Brunetti, A., & Fiorillo, A. S. (2022) · Theranostics · doi:10.7150/thno.64035 · Cited by 210
Wearable-band type visible-near infrared optical biosensor for non-invasive blood glucose monitoring
Rachim, V. P., & Chung, W.-Y. (2019) · Sensors and Actuators B Chemical · doi:10.1016/j.snb.2019.01.121 · Cited by 200
Metadata
- Authors
- Robinson, M. R., Eaton, R. P., Haaland, D. M., Koepp, G. W., Thomas, E. V., Stallard, B. R., & Robinson, P. L.
- Venue
- Clinical Chemistry
- Publisher
- Oxford University Press (OUP)
- Published
- 1992-09-01
- Volume
- 38
- Issue
- 9
- Pages
- 1618-1622
- ISSN
- 0009-9147 (ISSN-L)
- 1530-8561
- OpenAlex
- W2149482687
- Cited by
- 284
- References
- 0
- FWCI
- 9.26
- Type
- journal article
- Language
- en
- Open access
- closed
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- Robinson, M. R., Eaton, R. P., Haaland, D. M., Koepp, G. W., Thomas, E. V., Stallard, B. R., & Robinson, P. L. (1992). Noninvasive Glucose Monitoring in Diabetic Patients: A Preliminary Evaluation. Clinical Chemistry. https://doi.org/10.1093/clinchem/38.9.1618
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