The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Separation of beta-carotene and lycopene geometrical isomers in biological samples
Abstract
The analysis of beta-carotene and lycopene, the two predominant carotenoids in human serum and tissues, was extended to the level of geometrical (cis-trans) isomers by using an improved reversed-phase HPLC methodology. We separated five geometrical isomers of beta-carotene and seven of lycopene in human serum and tissues. 13-cis-beta-Carotene was identified as the predominant cisisomer in human serum, contributing about 5% to total beta-carotene. In tissue, however, considerable amounts of 9-cis- and traces of 15-cis-beta-carotene were also detected. In contrast to beta-carotene, the lycopene isomer patterns in human serum and tissues are quite similar.
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Cites
9-cis retinoic acid is a high affinity ligand for the retinoid X receptor
Heyman, R. A., Mangelsdorf, D. J., Dyck, J. A., Stein, R. B., Eichele, G., Evans, R. M., & Thaller, C. (1992) · Cell · doi:10.1016/0092-8674(92)90479-v · Cited by 1,780 · cited 1×
“The observation of receptors for cis-isomers of retinoic acid (14, 15) has stimulated interest also in cis-isomers of carotenoids.”
Background
Cited by
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Marine Carotenoids: Biological Functions and Commercial Applications
Vílchez, C., Forján, E., Cuaresma, M., Bédmar, F., Garbayo, I., & Vega, J. M. (2011) · Marine Drugs · doi:10.3390/md9030319 · Cited by 328
Stahl, W., Heinrich, U., Jungmann, H., Sies, H., & Tronnier, H. (2000) · The American Journal of Clinical Nutrition · doi:10.1093/ajcn/71.3.795 · Cited by 317
Self-citationNutritional protection against skin damage from sunlight
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Metadata
- Authors
- Stahl, W., Sundquist, A. R., Hanusch, M., Schwarz, W., & Sies, H.
- Venue
- Clinical Chemistry
- Publisher
- Oxford University Press (OUP)
- Published
- 1993-05-01
- Volume
- 39
- Issue
- 5
- Pages
- 810-814
- ISSN
- 0009-9147 (ISSN-L)
- 1530-8561
- OpenAlex
- W2143583175
- Cited by
- 161
- References
- 1
- FWCI
- 4.27
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: Separation of beta-carotene and lycopene geometrical isomers in biological samples. https://app.cochat.ai/papers/10.1093/clinchem/39.5.810
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- Stahl, W., Sundquist, A. R., Hanusch, M., Schwarz, W., & Sies, H. (1993). Separation of beta-carotene and lycopene geometrical isomers in biological samples. Clinical Chemistry. https://doi.org/10.1093/clinchem/39.5.810
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
