Within- and between-subject biological variations of follitropin, lutropin, testosterone, and sex-hormone-binding globulin in men
Abstract
The within-subject and between-subject biological variation of the serum concentrations of follitropin, lutropin, sex-hormone-binding globulin, and testosterone; the ratio between the serum concentrations of testosterone and sex-hormone-binding globulin; and the concentration of testosterone in saliva have been studied in a group of 20 men during 12 months. The between-subject coefficients of variation (CVs) were 36.0% for follitropin, 37.0% for lutropin, 42.7% for sex-hormone-binding globulin, 21.3% for testosterone in serum, 28.8% for testosterone in saliva, and 51.6% for the ratio between serum concentrations of testosterone and sex-hormone-binding globulin. The medians of the within-subject CVs for the respective analyses and ratio were 17.3%, 24.0%, 12.1%, 10.9%, 17.3%, and 9.4%. These data were used to calculate the desirable imprecision, the critical difference for significant change detection, and the index of individuality.
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Because of simplicity, ease of use, and high throughput, immunoassays were widely adopted in clinical practice, and most total testosterone reference ranges were established using them.
“Given their simplicity, ease of use, and high-throughput, immunoassays (IA) were widely adopted in clinical practice, with the majority of TT reference ranges established using these techniques.”
From Challenges in Testosterone Measurement, Data Interpretation, and Methodological Appraisal of Interventional Trials (2016) · cites this paper as [83]
Limitations of equilibrium dialysis include increased expense, dependence on total testosterone accuracy, and variations from radiotracer impurities, temperature control, and sample dilution.
“Limitations with this technique include increased expense, dependence on TT accuracy, and variations created by radiotracer impurities, temperature control, and sample dilution, among others.”
From Challenges in Testosterone Measurement, Data Interpretation, and Methodological Appraisal of Interventional Trials (2016) · cites this paper as [83]
Additional factors that may account for variability include specimen handling and preparation, calibration methods, specimen commutability, and interference from matrix material used to store and transport testosterone preparations.
“Additional factors, which may account for variability of results include specimen handling and preparation, calibration methods utilized, specimen commutability, and interference from the matrix material used to store and transport sample T preparations.”
From Challenges in Testosterone Measurement, Data Interpretation, and Methodological Appraisal of Interventional Trials (2016) · cites this paper as [83]
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- Authors
- Valero-Politi, J., & Fuentes-Arderiu, X.
- Affiliations
- Servei de Bioqímica Clínica, Hospital Prínceps d'Espanya, Barcelona
- ORCID
- Valero-Politi, J
- Venue
- Clinical Chemistry
- Publisher
- Oxford University Press (OUP)
- Published
- 1993-08-01
- Volume
- 39
- Issue
- 8
- Pages
- 1723-1725
- ISSN
- 0009-9147 (ISSN-L)
- 1530-8561
- OpenAlex
- W1794650315
- Cited by
- 39
- References
- 0
- Citations by year
- 2025: 1 · 2024: 1 · 2023: 1 · 2022: 1 · 2021: 3 · 2019: 1 · 2018: 3 · 2016: 4 · 2015: 1 · 2014: 1 · 2013: 2
- FWCI
- 0.22
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- academic.oup.com/journals/pages/open_access/funder_policies/chorus/standard_publication_model (vor)
- Locations
- Clinical Chemistry (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Physiology › Clinical Laboratory Practices and Quality Control
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Hormonal and reproductive studies
- Health Sciences › Medicine › Reproductive Medicine › Sperm and Testicular Function
- Keywords
- biological variation, within-person variability, interindividual variability, follicle-stimulating hormone, luteinizing hormone, testosterone, sex hormone-binding globulin, saliva testosterone, men, critical difference, index of individuality, imprecision
- MeSH terms
- Adult, Follicle Stimulating Hormone, Humans, Luteinizing Hormone, Male, Middle Aged, Reference Values, Saliva, Sex Hormone-Binding Globulin, Testosterone
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