The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Serum cystatin C, determined by a rapid, automated particle-enhanced turbidimetric method, is a better marker than serum creatinine for glomerular filtration rate
Abstract
We describe a fully automated particle-enhanced turbidimetric assay for cystatin C in undiluted serum and EDTA-plasma. The throughput is 90 samples per hour and urgent samples can be analyzed in 7 min. The assay range (0.4-14.1 mg/L) covers the concentration range in health and disease. The within- and between-run imprecision is 0.9% and 2.2%, respectively. Analytical recovery of additions of recombinant cystatin C averaged 98%. Rheumatoid factors (< or = 323,000 IU/L), bilirubin (< or = 150 mumol/L), hemoglobin (< or = 1.2 g/L), and triglycerides (< or = 8.5 mmol/L) do not interfere in the assay. In view of the superior (by ROC analysis) diagnostic accuracy of serum concentrations of cystatin C for reduced glomerular filtration rate (GFR) in comparison with creatinine, cystatin C seems an attractive alternative to creatinine for estimation of GFR.
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Citations
Cites
The place of human γ-trace (cystatin C) amongst the cysteine proteinase inhibitors
Barrett, A. J., Davies, M. E., & Grubb, A. (1984) · Biochemical and Biophysical Research Communications · doi:10.1016/0006-291x(84)91302-0 · Cited by 294
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Cited by
Cystatin C as a marker of GFR—history, indications, and future research
Filler, G., Bökenkamp, A., Hofmann, W., Le Bricon, T., Martínez-Brú, C., & Grubb, A. (2005) · Clinical Biochemistry · doi:10.1016/j.clinbiochem.2004.09.025 · Cited by 734
Self-citationRisch, L., Herklotz, R., Blumberg, A., & Huber, A. R. (2001) · Clinical Chemistry · doi:10.1093/clinchem/47.11.2055 · Cited by 343
Grubb, A., Horio, M., Hansson, L.-O., Björk, J., Nyman, U., Flodin, M., Larsson, A., Bökenkamp, A., Yasuda, Y., Blufpand, H., et al. (2014) · Clinical Chemistry · doi:10.1373/clinchem.2013.220707 · Cited by 324
Self-citationBiochemistry and Clinical Role of Human Cystatin C
Mussap, M., & Plebani, M. (2004) · Critical Reviews in Clinical Laboratory Sciences · doi:10.1080/10408360490504934 · Cited by 313
Promoter-mediated, dexamethasone-induced increase in cystatin C production by HeLa cells
Bjarnadóttir, M., Grubb, A., & Ólafsson, Í. (1995) · Scandinavian Journal of Clinical and Laboratory Investigation · doi:10.3109/00365519509110261 · Cited by 157
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Metadata
- Authors
- Kyhse-Andersen, J., Schmidt, C., Nordin, G., Andersson, B., Nilsson-Ehle, P., Lindström, V, & Grubb, A.
- Venue
- Clinical Chemistry
- Publisher
- Oxford University Press (OUP)
- Published
- 1994-10-01
- Volume
- 40
- Issue
- 10
- Pages
- 1921-1926
- ISSN
- 0009-9147 (ISSN-L)
- 1530-8561
- OpenAlex
- W2100510417
- Cited by
- 511
- References
- 1
- FWCI
- 2.33
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: Serum cystatin C, determined by a rapid, automated particle-enhanced turbidimetric method, is a better marker than serum creatinine for glomerular filtration rate. https://app.cochat.ai/papers/10.1093/clinchem/40.10.1921
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- Kyhse-Andersen, J., Schmidt, C., Nordin, G., Andersson, B., Nilsson-Ehle, P., Lindström, V, & Grubb, A. (1994). Serum cystatin C, determined by a rapid, automated particle-enhanced turbidimetric method, is a better marker than serum creatinine for glomerular filtration rate. Clinical Chemistry. https://doi.org/10.1093/clinchem/40.10.1921
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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