The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Interference with clinical laboratory analyses
Abstract
Interference by endogenous and exogenous substances with assays for clinical analytes is a common problem in laboratory medicine. For this review, we defined interference as "the effect of a substance present in the sample that alters the correct value of the result, usually expressed as concentration or activity, for an analyte." There are four major endogenous compounds that consistently interfere with laboratory results: hemoglobin, bilirubin, lipids, and paraproteins. The major exogenous sources of interference are drugs prescribed for the patient; and there are several excellent compendia of the effect of drugs on clinical laboratory tests. We recommend determining whether the interference is dependent or independent of the analyte for the assay. Further, we propose an approach to the identification and resolution of an interference problem for the clinical laboratory and make recommendations to manufacturers.
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Cites
Evaluation of an enzymatic method for determining creatinine in plasma.
Crocker, H., Shephard, M. D., & White, G. H. (1988) · Journal of Clinical Pathology · doi:10.1136/jcp.41.5.576 · Cited by 49
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Influence of hemolysis on routine clinical chemistry testing
Lippi, G., Luca Salvagno, G., Montagnana, M., Brocco, G., & Cesare Guidi, G. (2006) · Clinical Chemistry and Laboratory Medicine (CCLM) · doi:10.1515/cclm.2006.054 · Cited by 344
Antibody interference in thyroid assays: a potential for clinical misinformation
Després, N., & Grant, A. M. (1998) · Clinical Chemistry · doi:10.1093/clinchem/44.3.440 · Cited by 262
Linking laboratory and medication data: new opportunities for pharmacoepidemiological research
ten Berg, M. J., Huisman, A., van den Bemt, P. M. L. A., Schobben, A. F. A. M., Egberts, A. C. G., & van Solinge, W. W. (2007) · Clinical Chemical Laboratory Medicine · doi:10.1515/cclm.2007.009 · Cited by 156
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Metadata
- Authors
- Kroll, M. H., & Elin, R. J.
- Venue
- Clinical Chemistry
- Publisher
- Oxford University Press (OUP)
- Published
- 1994-11-01
- Volume
- 40
- Issue
- 11
- Pages
- 1996-2005
- ISSN
- 0009-9147 (ISSN-L)
- 1530-8561
- OpenAlex
- W2159204915
- Cited by
- 269
- References
- 1
- FWCI
- 1.28
- Type
- journal article
- Language
- en
- Open access
- closed
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- Kroll, M. H., & Elin, R. J. (1994). Interference with clinical laboratory analyses. Clinical Chemistry. https://doi.org/10.1093/clinchem/40.11.1996
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
