Evaluation of an enzymatic method for determining creatinine in plasma.
Open accessAbstract
An enzymatic kit method for the determination of plasma creatinine was optimised for use with a centrifugal analyser and its performance characteristics and practicability compared with an end point and a kinetic Jaffé-based method. The enzymatic method exhibited several advantages over Jaffé-based methods--namely, smaller sample size, rapid sample throughput (200 per hour), and improved specificity. Glucose, acetoacetate, and cefoxitin did not interfere with the enzymatic method, although bilirubin did cause a negative interference which depended on both creatinine and bilirubin concentrations. The enzymatic method has particular clinical application in neonates, diabetic ketotic patients, and those receiving cephalosporins.
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Creatinine was detected in sweat using a mixture of enzymes (creatininase, creatinase, and peroxidase) and a corresponding responsive dye (4-aminophenazone).
“Similarly, creatinine, a vital marker of hydration status and renal function, was detected in sweat using a mixture of enzymes (creatininase, creatinase, and peroxidase) and a corresponding responsive dye (4-aminophenazone) (Fig. 3E) (53).”
From A soft, wearable microfluidic device for the capture, storage, and colorimetric sensing of sweat (2016) · cites this paper as [53]
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Analytical Reviews in Clinical Biochemistry: The Estimation of Creatinine
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Kinetic serum creatinine assays. II. A critical evaluation and review.
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A soft, wearable microfluidic device for the capture, storage, and colorimetric sensing of sweat
Koh, A., Kang, D., Xue, Y., Lee, S., Pielak, R. M., Kim, J., Hwang, T., Min, S., Banks, A., Bastien, P., et al. (2016) · Science Translational Medicine · doi:10.1126/scitranslmed.aaf2593 · Cited by 1,308 · see citing works
- Authors
- Crocker, H., Shephard, M. D., & White, G. H.
- Affiliations
- Flinders Medical Centre (AU)
- ORCID
- Shephard, M D
- Venue
- Journal of Clinical Pathology
- Publisher
- BMJ
- Published
- 1988-05
- Volume
- 41
- Issue
- 5
- Pages
- 576-581
- ISSN
- 0021-9746 (ISSN-L)
- 1472-4146
- PMC
- PMC1141516
- OpenAlex
- W2037545204
- Cited by
- 49
- References
- 12
- Citations by year
- 2026: 2 · 2025: 2 · 2024: 3 · 2023: 2 · 2022: 2 · 2021: 3 · 2020: 5 · 2019: 3 · 2018: 1 · 2017: 1 · 2016: 2 · 2015: 2 · 2014: 4 · 2013: 2 · 2012: 2
- FWCI
- 0.61
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Journal of Clinical Pathology (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Physiology › Clinical Laboratory Practices and Quality Control
- Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Neonatal Health and Biochemistry
- Health Sciences › Medicine › Nephrology › Acute Kidney Injury Research
- Keywords
- serum creatinine, enzymatic creatinine assay, Jaffe method, centrifugal analyser, assay interference, bilirubin interference, neonates, diabetic ketoacidosis, cephalosporins, cefoxitin, sample throughput
- MeSH terms
- Acetoacetates, Adolescent, Bilirubin, Cefoxitin, Colorimetry, Creatinine, Female, Glucose, Humans, Infant, Methods, Reagent Kits, Diagnostic
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