Composition of interstitial fluid
Abstract
In several previous experiments to determine the composition of interstitial fluid, the results varied depending on the collecting technique, and the electrolyte concentrations differed from those of a hypothetical ultrafiltrate of plasma. In our approach, since a change of position from standing to supine is accompanied by hemodilution with interstitial fluid, we used the changes in hematocrit and composition of plasma in 20 subjects before and after lying down to calculate the composition of added interstitial fluid. The estimated protein concentration was 20.6 g/L, and the concentrations of total calcium and magnesium were low, in accord with a lower concentration of protein-bound calcium and magnesium. The activity of free cations was also lower, in agreement with a Donnan equilibrium potential of 1 mV across the endothelium. The concentration of leukocytes and platelets decreased according to the hemodilution, implying no escape or mobilization of these elements.
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ISF composition leads to reliable correlations between blood and ISF concentrations of many analytes, including electrolytes, metabolites, and proteins.
“This function, and the associated ISF composition, lead to reliable correlations between the blood and ISF concentrations of many analytes, including electrolytes (e.g., sodium, phosphate, magnesium, potassium or calcium), metabolites (e.g., glucose, alcohol, lactate or cortisol) and proteins65-69.”
From Wearable biosensors for healthcare monitoring (2019) · cites this paper as [67]
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References 12 · Cited by 309
- Authors
- Fogh-Andersen, N., Altura, B. M., Altura, B. T., & Siggaard-Andersen, O.
- Affiliations
- Department of Clinical Chemistry, Herlev Hospital, Denmark
- Herlev Hospital (DK)
- Venue
- Clinical Chemistry
- Publisher
- Oxford University Press (OUP)
- Published
- 1995-10-01
- Volume
- 41
- Issue
- 10
- Pages
- 1522-1525
- ISSN
- 0009-9147 (ISSN-L)
- 1530-8561
- OpenAlex
- W1937444536
- Cited by
- 309
- References
- 12
- Citations by year
- 2026: 15 · 2025: 27 · 2024: 27 · 2023: 25 · 2022: 26 · 2021: 27 · 2020: 33 · 2019: 22 · 2018: 17 · 2017: 10 · 2016: 10 · 2015: 10 · 2014: 11 · 2013: 6 · 2012: 6
- FWCI
- 0.22
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- academic.oup.com/journals/pages/open_access/funder_policies/chorus/standard_publication_model (vor)
- Locations
- Clinical Chemistry (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Physiology › Clinical Laboratory Practices and Quality Control
- Health Sciences › Medicine › Surgery › Hemodynamic Monitoring and Therapy
- Health Sciences › Medicine › Critical Care and Intensive Care Medicine › Trauma, Hemostasis, Coagulopathy, Resuscitation
- Keywords
- hemodilution, hematocrit, serum electrolytes, protein concentration, calcium, magnesium, protein-bound calcium, Donnan equilibrium, leukocytes, platelets, supine position
- MeSH terms
- Adult, Calcium, Cations, Erythrocyte Indices, Extracellular Space, Female, Hematocrit, Hemodilution, Humans, Hydrogen-Ion Concentration, Leukocyte Count, Magnesium, Male, Middle Aged, Phosphates, Platelet Count, Posture, Potassium, Proteins, Reference Values, Supine Position
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