Cited by 98Antioxidant Activity and Oxidative StressParaoxonase enzyme and polymorphismsFatty Acid Research and Health

Vitamin E in the prevention of cardiovascular disease: the importance of proper patient selection

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Vardi, Moshe, Levy, Nina S., Levy, Andrew P.·2013·Journal of Lipid Research

Abstract

Vitamin E is a naturally occurring fat-soluble antioxidant which has been proposed as a treatment for both primary and secondary protection against cardiovascular (CV) events. Promising data from observational epidemiological studies associating higher vitamin E dietary intake with lower risk of CV events have not been validated in randomized controlled clinical trials assessing the effect of vitamin E on CV outcomes. While the pendulum of medical opinion has swung to suggest that high dose vitamin E supplements have no place in the treatment and prevention of CV disease, new data is emerging that allows identification of a specific target population for this treatment, namely patients with diabetes mellitus and the haptoglobin genotype 2-2. This review details the scientific basis and clinical evidence related to the effect of vitamin E on CV outcomes, and the importance of proper patient selection in gaining therapeutic benefit from this intervention.

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Crossref · 10.1194/jlr.r026641

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Authors
Vardi, M., Levy, N. S., & Levy, A. P.
Affiliations
  • Harvard University (US)
  • Technion – Israel Institute of Technology (IL)
Corresponding author
Levy, Andrew P.
Venue
Journal of Lipid Research
Publisher
Elsevier BV
Published
2013-09
Volume
54
Issue
9
Pages
2307-2314
ISSN
0022-2275 (ISSN-L)
OpenAlex
W2029249245
Cited by
98
References
81
Citations by year
2026: 4 · 2025: 8 · 2024: 15 · 2023: 4 · 2022: 8 · 2021: 5 · 2020: 8 · 2019: 10 · 2018: 7 · 2017: 5 · 2016: 9 · 2015: 10 · 2014: 4 · 2013: 1
FWCI
0.78
Type
journal article
Language
en
Open access
Locations
  • Journal of Lipid Research (publishedVersion, cc-by)
  • Europe PMC (PubMed Central) (publishedVersion)
  • PubMed Central (publishedVersion)
  • PubMed (publishedVersion)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
Funders
National Institute of Diabetes and Digestive and Kidney Diseases (R01DK085226)
Topics
  • Health Sciences › Medicine › Biochemistry › Antioxidant Activity and Oxidative Stress
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Clinical Biochemistry › Paraoxonase enzyme and polymorphisms
  • Health Sciences › Nursing › Nutrition and Dietetics › Fatty Acid Research and Health
Keywords
vitamin E, cardiovascular disease prevention, patient selection, diabetes mellitus, haptoglobin genotype, antioxidant supplementation, cardiovascular outcomes, dietary vitamin E intake, randomized controlled trials
MeSH terms
Cardiovascular Diseases, Clinical Trials as Topic, Haptoglobins, Humans, Vitamin E, Patient Selection, Diabetes Complications, Precision Medicine

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