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Results of an international round robin for serum and whole-blood folate
Abstract
Because of the increasing significance of folate nutriture to public health, a "round robin" interlaboratory comparison study was conducted to assess differences among methods. Twenty research laboratories participated in a 3-day analysis of six serum and six whole-blood pools. Overall means, SDs, and CVs derived from these results were compared within and across method types. Results reported for serum and whole-blood folate demonstrated overall CVs of 27.6% and 35.7%, respectively, across pools and two- to ninefold differences in concentrations between methods, with the greatest variation occurring at critical low folate concentrations. Although results for serum pools were less variable than those for whole-blood pools, substantial intermethod variation still occurred. The overall results underscore the urgent need for developing and validating reference methods for serum and whole-blood folate and for properly characterized reference materials. For evaluating study or clinical data, method-specific reference ranges (established with clinical confirmation of values for truly folate-deficient individuals) must be used.
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Citations
Cited by
Vitamin B12 and folate deficiency in later life
Clarke, R., Grimley Evans, J., Schneede, J., Nexo, E., Bates, C., Fletcher, A., Prentice, A., Johnston, C., Ueland, P. M., Refsum, H., et al. (2004) · Age and Ageing · doi:10.1093/ageing/afg109 · Cited by 357
Fenech, M. (2012) · Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis · doi:10.1016/j.mrfmmm.2011.11.003 · Cited by 294
Serum Folate and Cardiovascular Disease Mortality Among US Men and Women
Loria, C. M., Ingram, D. D., Feldman, J. J., Wright, J. D., & Madans, J. H. (2000) · Archives of Internal Medicine · doi:10.1001/archinte.160.21.3258 · Cited by 98
Metadata
- Authors
- Gunter, E. W., Bowman, B. A., Caudill, S. P., Twite, D. B., Adams, M. J., & Sampson, E. J.
- Venue
- Clinical Chemistry
- Publisher
- Oxford University Press (OUP)
- Published
- 1996-10-01
- Volume
- 42
- Issue
- 10
- Pages
- 1689-1694
- ISSN
- 0009-9147 (ISSN-L)
- 1530-8561
- OpenAlex
- W1932011029
- Cited by
- 165
- References
- 0
- FWCI
- 7.38
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: Results of an international round robin for serum and whole-blood folate. https://app.cochat.ai/papers/10.1093/clinchem/42.10.1689
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- Gunter, E. W., Bowman, B. A., Caudill, S. P., Twite, D. B., Adams, M. J., & Sampson, E. J. (1996). Results of an international round robin for serum and whole-blood folate. Clinical Chemistry. https://doi.org/10.1093/clinchem/42.10.1689
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