The DOI matches its Crossref record; 17 of the 17 references it cites were found in a registry or an index.
Vitamin B12 and folate deficiency in later life
Abstract
OBJECTIVES: to examine the prevalence of vitamin B12 deficiency and folate deficiency in later life in representative samples of the elderly population in the United Kingdom. DESIGN: a population-based cross-sectional analysis of 3,511 people aged 65 years or older from three studies was used to estimate the age-specific prevalence of vitamin B12 deficiency and of folate deficiency. Vitamin B12 deficiency is conventionally diagnosed if serum vitamin B12 < 150 pmol/l ('low vitamin B12'). We defined 'metabolically significant vitamin B12 deficiency' as vitamin B12 < 200 pmol/l and blood total homocysteine >20 micro mol/l. Folate deficiency, which usually refers to serum folate <5 nmol/l, was defined as 'metabolically significant' if serum folate was <7 nmol/l and homocysteine >20 micro mol/l. RESULTS: the prevalence of vitamin B12 deficiency, whether defined as low vitamin B12 or metabolically significant vitamin B12 deficiency increased with age in all three studies, from about 1 in 20 among people aged 65-74 years to 1 in 10 or even greater among people aged 75 years or greater. The prevalence of folate deficiency also increased with age, and was similar to that for vitamin B12 deficiencies, but only about 10% of people with low vitamin B12 levels also had low folate levels. CONCLUSION: the high prevalence of vitamin B12 and folate deficiency observed in older people indicates a particular need for vigilance for deficiency of these vitamins. Reliable detection and treatment of vitamin deficiency could reduce the risk of deficiency-related disability in old age.
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Brown, R. A., Hastie, T. J., & Tibshirani, R. J. (1991) · Biometrics · doi:10.2307/2532174 · Cited by 8,176
Hastie, T., & Tibshirani, R. (2014) · Wiley StatsRef: Statistics Reference Online · doi:10.1002/9781118445112.stat03141 · Cited by 3,156
Folate, Vitamin B12, and Serum Total Homocysteine Levels in Confirmed Alzheimer Disease
Clarke, R., Smith, A. D., Jobst, K. A., Refsum, H., Sutton, L., & Ueland, P. M. (1998) · Archives of Neurology · doi:10.1001/archneur.55.11.1449 · Cited by 1,408
Self-citationTotal homocysteine in plasma or serum: methods and clinical applications
Ueland, P. M., Refsum, H., Stabler, S. P., Malinow, M. R., Andersson, A., & Allen, R. H. (1993) · Clinical Chemistry · doi:10.1093/clinchem/39.9.1764 · Cited by 981
Self-citationMolloy, A. M., & Scott, J. M. (1997) · Methods in Enzymology · doi:10.1016/s0076-6879(97)81007-5 · Cited by 433
Self-citationKlee, G. G. (2000) · Clinical Chemistry · doi:10.1093/clinchem/46.8.1277 · Cited by 384
Rapid, fully automated measurement of plasma homocyst(e)ine with the Abbott IMx analyzer
Shipchandler, M. T., & Moore, E. G. (1995) · Clinical Chemistry · doi:10.1093/clinchem/41.7.991 · Cited by 379
The National Diet and Nutrition Survey: people aged 65 years and over
Smithers, G., Finch, S., Doyle, W., Lowe, C., Bates, C. J., Prentice, A., & Clarke, P. C. (1998) · Nutrition & Food Science · doi:10.1108/00346659810209791 · Cited by 339
Self-citationScreening for vitamin B-12 and folate deficiency in older persons
Clarke, R., Refsum, H., Birks, J., Evans, J. G., Johnston, C., Sherliker, P., Ueland, P. M., Schneede, J., McPartlin, J., Nexo, E., et al. (2003) · The American Journal of Clinical Nutrition · doi:10.1093/ajcn/77.5.1241 · Cited by 235
Self-citationMansoor, M. A., Bergmark, C., Svardal, A. M., Lønning, P. E., & Ueland, P. M. (1995) · Arteriosclerosis, Thrombosis, and Vascular Biology · doi:10.1161/01.atv.15.2.232 · Cited by 229
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Green, R., Allen, L. H., Bjørke-Monsen, A.-L., Brito, A., Guéant, J.-L., Miller, J. W., Molloy, A. M., Nexo, E., Stabler, S., Toh, B.-H., et al. (2017) · Nature Reviews Disease Primers · doi:10.1038/nrdp.2017.40 · Cited by 970
Self-citationSystematic genome assessment of B-vitamin biosynthesis suggests co-operation among gut microbes
Magnúsdóttir, S., Ravcheev, D., de Crécy-Lagard, V., & Thiele, I. (2015) · Frontiers in Genetics · doi:10.3389/fgene.2015.00148 · Cited by 876
Vitamin B12, folic acid, and the nervous system
Reynolds, E. (2006) · The Lancet Neurology · doi:10.1016/s1474-4422(06)70598-1 · Cited by 860
Diet, cognition, and alzheimer’s disease: food for thought
Otaegui-Arrazola, A., Amiano, P., Elbusto, A., Urdaneta, E., & Martínez-Lage, P. (2014) · European Journal of Nutrition · doi:10.1007/s00394-013-0561-3 · Cited by 214
Nutrition in the age-related disablement process
Inzitari, M., Doets, E., Bartali, B., Benetou, V., Di Bari, M., Visser, M., Volpato, S., Gambassi, G., Topinkova, E., De Groot, L., et al. (2011) · The Journal of nutrition, health and aging · doi:10.1007/s12603-011-0053-1 · Cited by 148
Metadata
- Authors
- Clarke, R., Grimley Evans, J., Schneede, J., Nexo, E., Bates, C., Fletcher, A., Prentice, A., Johnston, C., Ueland, P. M., Refsum, H., Sherliker, P., Birks, J., Whitlock, G., Breeze, E., & Scott, J. M.
- Venue
- Age and Ageing
- Publisher
- Oxford University Press (OUP)
- Published
- 2003-12-28
- Volume
- 33
- Issue
- 1
- Pages
- 34-41
- ISSN
- 0002-0729 (ISSN-L)
- 1468-2834
- OpenAlex
- W2134584460
- Cited by
- 357
- References
- 17
- FWCI
- 8.05
- Type
- journal article
- Language
- en
- Open access
- closed
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