The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
New Insights into the Role of Nuclear Factor-κB, a Ubiquitous Transcription Factor in the Initiation of Diseases
Abstract
Nuclear factor-κB (NF-κB) is a ubiquitous transcription factor that governs the expression of genes encoding cytokines, chemokines, growth factors, cell adhesion molecules, and some acute phase proteins in health and in various disease states. NF-κB is activated by several agents, including cytokines, oxidant free radicals, inhaled particles, ultraviolet irradiation, and bacterial or viral products. Inappropriate activation of NF-κB has been linked to inflammatory events associated with autoimmune arthritis, asthma, septic shock, lung fibrosis, glomerulonephritis, atherosclerosis, and AIDS. In contrast, complete and persistent inhibition of NF-κB has been linked directly to apoptosis, inappropriate immune cell development, and delayed cell growth. Therefore, development of modulatory strategies targeting this transcription factor may provide a novel therapeutic tool for the treatment or prevention of various diseases.
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Cites
A cytokine-responsive IκB kinase that activates the transcription factor NF-κB
DiDonato, J. A., Hayakawa, M., Rothwarf, D. M., Zandi, E., & Karin, M. (1997) · Nature · doi:10.1038/41493 · Cited by 2,125
Cited by
Phosphorylation meets ubiquitination: the control of NF-κB activity
Karin, M., & Ben-Neriah, Y. (2000) · Annual Review of Immunology · doi:10.1146/annurev.immunol.18.1.621 · Cited by 4,766
NF-κB: a key role in inflammatory diseases
Tak, P. P., & Firestein, G. S. (2001) · Journal of Clinical Investigation · doi:10.1172/jci11830 · Cited by 3,918
Molecular inflammation: Underpinnings of aging and age-related diseases
Chung, H. Y., Cesari, M., Anton, S., Marzetti, E., Giovannini, S., Seo, A. Y., Carter, C., Yu, B. P., & Leeuwenburgh, C. (2009) · Ageing Research Reviews · doi:10.1016/j.arr.2008.07.002 · Cited by 1,203
Metal-induced oxidative stress and signal transduction
Leonard, S. S., Harris, G. K., & Shi, X. (2004) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2004.09.010 · Cited by 663
Self-citationEicosapentaenoic Acid Prevents LPS-Induced TNF-α Expression by Preventing NF-κB Activation
Zhao, Y., Joshi-Barve, S., Barve, S., & Chen, L. H. (2004) · Journal of the American College of Nutrition · doi:10.1080/07315724.2004.10719345 · Cited by 405
Metadata
- Authors
- Chen, F., Castranova, V., Shi, X., & Demers, L. M.
- Venue
- Clinical Chemistry
- Publisher
- Oxford University Press (OUP)
- Published
- 1999-01-01
- Volume
- 45
- Issue
- 1
- Pages
- 7-17
- ISSN
- 0009-9147 (ISSN-L)
- 1530-8561
- OpenAlex
- W2162248918
- Cited by
- 718
- References
- 1
- FWCI
- 13.86
- Type
- journal article
- Language
- en
- Open access
- closed
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- Chen, F., Castranova, V., Shi, X., & Demers, L. M. (1999). New Insights into the Role of Nuclear Factor-κB, a Ubiquitous Transcription Factor in the Initiation of Diseases. Clinical Chemistry. https://doi.org/10.1093/clinchem/45.1.7
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
