Molecular inflammation: Underpinnings of aging and age-related diseases
Open accessAbstract
Recent scientific studies have advanced the notion of chronic inflammation as a major risk factor underlying aging and age-related diseases. In this review, low-grade, unresolved, molecular inflammation is described as an underlying mechanism of aging and age-related diseases, which may serve as a bridge between normal aging and age-related pathological processes. Accumulated data strongly suggest that continuous (chronic) upregulation of pro-inflammatory mediators (e.g., TNF-alpha, IL-1beta, IL-6, COX-2, iNOS) are induced during the aging process due to an age-related redox imbalance that activates many pro-inflammatory signaling pathways, including the NF-kappaB signaling pathway. These pro-inflammatory molecular events are discussed in relation to their role as basic mechanisms underlying aging and age-related diseases. Further, the anti-inflammatory actions of aging-retarding caloric restriction and exercise are reviewed. Thus, the purpose of this review is to describe the molecular roles of age-related physiological functional declines and the accompanying chronic diseases associated with aging. This new view on the role of molecular inflammation as a mechanism of aging and age-related pathogenesis can provide insights into potential interventions that may affect the aging process and reduce age-related diseases, thereby promoting healthy longevity.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Chronic inflammation is a cause or an important contributor to virtually every major age-related disease, both degenerative and hyperplastic.
“Chronic inflammation, of course, is a cause of—or an important contributor to—virtually every major age-related disease, both degenerative and hyperplastic (109–111).”
From Aging, Cellular Senescence, and Cancer (2013) · cites this paper as [109]
The Introduction calls chronic inflammation a major underlying condition of many age-related diseases, including degenerative conditions and cancer. The Conclusion likewise describes it as a primary factor underlying numerous age-related diseases. Neither passage supports the stronger claim that it contributes to virtually every major age-related disease. (LLM, conf=0.86)
Experimental — accuracy not yet measuredLow-level, chronic, sterile inflammation is a hallmark of aging that initiates or promotes most, if not all, major age-related diseases.
“Low-level, chronic, “sterile” inflammation is a hallmark of aging that initiates or promotes most, if not all, major age-related diseases (Franceschi et al., 2007; Chung et al., 2009).”
From Four faces of cellular senescence (2011) · cites this paper as Chung et al., 2009
The Introduction describes chronic, low-grade inflammation as a possible link between aging and the pathogenesis of many age-related diseases; the Conclusion calls it a primary factor underlying aging and numerous age-related diseases. The copy does not characterize the inflammation as “sterile,” and its references to many or numerous diseases do not substantiate “most, if not all.” Page numbers were not available in the indexed passages. (LLM, conf=0.86)
Experimental — accuracy not yet measuredMost age-related pathologies stem from low level chronic inflammation referred to as inflammaging or sterile inflammation, which can also result in premature aging.
“most of the age-related pathologies stem from low level chronic inflammation referred to as inflammaging or sterile inflammation which can also result in premature aging (Franceschi et al., 2007; Chung et al., 2009; Franceschi and Campisi, 2014; Jurk et al., 2014).”
From Mechanisms of Cellular Senescence: Cell Cycle Arrest and Senescence Associated Secretory Phenotype (2021) · cites this paper as Chung et al., 2009
NF-κB regulates the expression of myokines such as TNF-α and IL-6, inducing chronic low-grade inflammation and apoptosis, increasing catabolic pathway activity and decreasing anabolic pathway activity in skeletal muscle, promoting loss of muscle mass and strength.
“NF-κB regulates the expression of myokines such as TNF-α and IL-6, inducing chronic low-grade inflammation and apoptosis. These conditions increase catabolic pathway activity and decrease anabolic pathway activity in skeletal muscle, promoting the loss of muscle mass and strength [76, 114].”
From The critical role of oxidative stress in sarcopenic obesity (2021) · cites this paper as [114]
Persistent inflammation contributes to the development of several diseases, such as insulin resistance, dementia, rheumatoid arthritis, atherosclerosis, and cancer.
“Chronic inflammation is an underlying cause of several pathological disorders including insulin resistance, dementia, rheumatoid arthritis, atherosclerosis, and cancer [1, 2].”
From Edible blue-green algae reduce the production of pro-inflammatory cytokines by inhibiting NF-κB pathway in macrophages and splenocytes (2013) · cites this paper as [1]
A consistent observation of aging in humans and animals is a persistent low-level increase in serum markers of inflammation, such as C-reactive protein and interleukin-6.
“A consistent observation of aging in humans and animals is a persistent low level increase in serum markers of inflammation, such as C-reactive protein and interleukin-6.(Chung, Cesari, Anton, Marzetti, Giovannini, Seo, Carter, Yu, and Leeuwenburgh 2009)”
From Successful aging: Advancing the science of physical independence in older adults (2015) · cites this paper as Chung et al. 2009
Dietary restriction can promote anti-inflammatory action.
“anti-inflammatory action(Chung, Cesari, Anton, Marzetti, Giovannini, Seo, Carter, Yu, and Leeuwenburgh 2009)”
From Successful aging: Advancing the science of physical independence in older adults (2015) · cites this paper as Chung, Cesari, Anton, Marzetti, Giovannini, Seo, Carter, Yu, and Leeuwenburgh 2009
Aberrant immune responses in the aged can exacerbate inflammation, possibly contributing to cancer, cardiovascular disease, stroke, Alzheimer's disease and dementia.
“Furthermore, aberrant immune responses in the aged can exacerbate inflammation, possibly contributing to other scourges of old age: cancer, cardiovascular disease, stroke, Alzheimer's disease and dementia [84].”
From Evolution of the immune system in humans from infancy to old age (2015) · cites this paper as [84]
The resulting low-grade inflammation probably contributes to atherosclerosis, dementia and cancer, inextricably linking inflammation and ageing of other tissues.
“The resulting low-grade inflammation probably contributes to atherosclerosis, dementia and cancer, inextricably linking inflammation and ageing of other tissues [84,98].”
From Evolution of the immune system in humans from infancy to old age (2015) · cites this paper as [84]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
Coussens, L. M., & Werb, Z. (2002) · Nature · doi:10.1038/nature01322 · Cited by 15,111 · see citing works
Obesity is associated with macrophage accumulation in adipose tissue
Weisberg, S. P., McCann, D., Desai, M., Rosenbaum, M., Leibel, R. L., & Ferrante, A. W. (2003) · Journal of Clinical Investigation · doi:10.1172/jci200319246 · Cited by 10,041 · see citing works
Aging: a theory based on free radical and radiation chemistry
Harman, D. (1956) · Journal of Gerontology · doi:10.1093/geronj/11.3.298 · Cited by 8,567 · see citing works
Inflammation in atherosclerosis
Libby, P. (2002) · Nature · doi:10.1038/nature01323 · Cited by 8,315 · see citing works
Xu, H., Barnes, G. T., Yang, Q., Tan, G., Yang, D., Chou, C. J., Sole, J., Nichols, A., Ross, J. S., Tartaglia, L. A., et al. (2003) · Journal of Clinical Investigation · doi:10.1172/jci200319451 · Cited by 6,760 · see citing works
Ford, E. S., Giles, W. H., & Dietz, W. H. (2002) · JAMA · doi:10.1001/jama.287.3.356 · Cited by 6,698 · see citing works
Pearson, T. A., Mensah, G. A., Alexander, R. W., Anderson, J. L., Cannon, R. O., Criqui, M., Fadl, Y. Y., Fortmann, S. P., Hong, Y., Myers, G. L., et al. (2003) · Circulation · doi:10.1161/01.cir.0000052939.59093.45 · Cited by 6,401 · see citing works
Chen, X., Xiu, M., Xing, J., Yu, S., Min, D., & Guo, F. (2017) · Cellular Physiology and Biochemistry · doi:10.1159/000479439 · Cited by 5,759 · see citing works
Cardiovascular Morbidity and Mortality Associated With the Metabolic Syndrome
Isomaa, B., Almgren, P., Tuomi, T., Forsén, B., Lahti, K., Nissén, M., Taskinen, M.-R., & Groop, L. (2001) · Diabetes Care · doi:10.2337/diacare.24.4.683 · Cited by 4,760 · see citing works
Global mortality, disability, and the contribution of risk factors: Global Burden of Disease Study
Murray, C. J., & Lopez, A. D. (1997) · The Lancet · doi:10.1016/s0140-6736(96)07495-8 · Cited by 4,492 · see citing works
Correlative Memory Deficits, Aβ Elevation, and Amyloid Plaques in Transgenic Mice
Hsiao, K., Chapman, P., Nilsen, S., Eckman, C., Harigaya, Y., Younkin, S., Yang, F., & Cole, G. (1996) · Science · doi:10.1126/science.274.5284.99 · Cited by 4,210 · see citing works
Janssen, I., Heymsfield, S. B., & Ross, R. (2002) · Journal of the American Geriatrics Society · doi:10.1046/j.1532-5415.2002.50216.x · Cited by 3,139 · cited 2× · see citing works
“While an important correlate of impairment and physical disability in older persons (Villareal et al., 2004), it is associated with a decrease in muscular strength and endurance and a loss of autonomy in older persons (Janssen et al., 2002).”
BackgroundKim, H. J., Park, S. Y., Choi, Y. J., Han, S. J., Lee, K. W., & Kim, D. J. (2013) · Hormone Research in Paediatrics · doi:10.1159/000348848 · Cited by 3,061 · see citing works
PearsonT, A., MensahG, A., & AlexanderR, W. (2003) · Journal of Cardiopulmonary Rehabilitation · doi:10.1097/00008483-200305000-00016 · Cited by 2,937 · see citing works
Adipose tissue, adipokines, and inflammation
Fantuzzi, G. (2005) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2005.02.023 · Cited by 2,606 · see citing works
Sarcopenia: origins and clinical relevance
Rosenberg, I. H. (1997) · The Journal of Nutrition · doi:10.1093/jn/127.5.990s · Cited by 2,399 · see citing works
Zandi, E., Rothwarf, D. M., Delhase, M., Hayakawa, M., & Karin, M. (1997) · Cell · doi:10.1016/s0092-8674(00)80406-7 · Cited by 1,814 · see citing works
Thioredoxin and Glutaredoxin Systems
Holmgren, A. (1989) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)71625-6 · Cited by 1,804 · see citing works
Mitogenic Signaling Mediated by Oxidants in Ras-Transformed Fibroblasts
Irani, K., Xia, Y., Zweier, J. L., Sollott, S. J., Der, C. J., Fearon, E. R., Sundaresan, M., Finkel, T., & Goldschmidt-Clermont, P. J. (1997) · Science · doi:10.1126/science.275.5306.1649 · Cited by 1,588 · see citing works
Cardiovascular Medicine at the Turn of the Millennium: Triumphs, Concerns, and Opportunities
D, E. B. M. (1997) · New England Journal of Medicine · doi:10.1056/nejm199711063371906 · Cited by 1,428 · see citing works
Molecular basis of sun-induced premature skin ageing and retinoid antagonism
Fisher, G. J., Datta, S. C., Talwar, H. S., Wang, Z.-Q., Varani, J., Kang, S., & Voorhees, J. J. (1996) · Nature · doi:10.1038/379335a0 · Cited by 1,410 · see citing works
IKKβ/NF-κB Activation Causes Severe Muscle Wasting in Mice
Cai, D., Frantz, J. D., Tawa, N. E., Melendez, P. A., Oh, B.-C., Lidov, H. G. W., Hasselgren, P.-O., Frontera, W. R., Lee, J., Glass, D. J., et al. (2004) · Cell · doi:10.1016/j.cell.2004.09.027 · Cited by 1,367 · see citing works
Inflammation as a Cardiovascular Risk Factor
Willerson, J. T., & Ridker, P. M. (2004) · Circulation · doi:10.1161/01.cir.0000129535.04194.38 · Cited by 1,304 · see citing works
MCGEER, P., & MCGEER, E. (1995) · Brain Research Reviews · doi:10.1016/0165-0173(95)00011-9 · Cited by 1,287 · see citing works
Wyss-Coray (2006) · doi:10.1038/nm1484 · Cited by 1,284 · see citing works
Age-Associated Increased Interleukin-6 Gene Expression, Late-Life Diseases, and Frailty
Ershler, W. B., & Keller, E. T. (2000) · Annual Review of Medicine · doi:10.1146/annurev.med.51.1.245 · Cited by 1,282 · see citing works
Obesity and the role of adipose tissue in inflammation and metabolism
Greenberg, A. S., & Obin, M. S. (2006) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/83.2.461s · Cited by 1,271 · see citing works
Inflammation in Neurodegenerative Disease—A Double-Edged Sword
Wyss-Coray, T., & Mucke, L. (2002) · Neuron · doi:10.1016/s0896-6273(02)00794-8 · Cited by 1,235 · see citing works
Inflammation and insulin resistance
de Luca, C., & Olefsky, J. M. (2008) · FEBS Letters · doi:10.1016/j.febslet.2007.11.057 · Cited by 1,161 · see citing works
Body Composition in Healthy Aging
BAUMGARTNER, R. N. (2000) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2000.tb06498.x · Cited by 1,078 · see citing works
Moreira, A. L., Sampaio, E. P., Zmuidzinas, A., Frindt, P., Smith, K. A., & Kaplan, G. (1993) · The Journal of Experimental Medicine · doi:10.1084/jem.177.6.1675 · Cited by 1,041 · see citing works
Pro-inflammatory cytokines and adipose tissue
Coppack, S. W. (2001) · Proceedings of The Nutrition Society · doi:10.1079/pns2001110 · Cited by 1,008 · see citing works
Synovial tissue inflammation in early and late osteoarthritis
Benito, M. J., Veale, D. J., FitzGerald, O., van den Berg, W. B., & Bresnihan, B. (2005) · Annals of the Rheumatic Diseases · doi:10.1136/ard.2004.025270 · Cited by 1,003 · see citing works
Morley, J. E., Baumgartner, R., Roubenoff, R., Mayer, J., & Nair, K. S. (2001) · Journal of Laboratory and Clinical Medicine · doi:10.1067/mlc.2001.113504 · Cited by 938 · see citing works
Inflammatory mediators in the elderly
Krabbe, K. S., Pedersen, M., & Bruunsgaard, H. (2004) · Experimental Gerontology · doi:10.1016/j.exger.2004.01.009 · Cited by 928 · see citing works
Kamei, N., Tobe, K., Suzuki, R., Ohsugi, M., Watanabe, T., Kubota, N., Ohtsuka-Kowatari, N., Kumagai, K., Sakamoto, K. Q., Kobayashi, M., et al. (2006) · Journal of Biological Chemistry · doi:10.1074/jbc.m601284200 · Cited by 918 · see citing works
Pou, K. M., Massaro, J. M., Hoffmann, U., Vasan, R. S., Maurovich‐Horvat, P., Larson, M. G., Keaney, J. F., Meigs, J. B., Lipinska, I., Kathiresan, S., et al. (2007) · Circulation · doi:10.1161/circulationaha.107.710509 · Cited by 898 · see citing works
Monocyte chemoattractant protein-1 in human atheromatous plaques.
Nelken, N. A., Coughlin, S. R., Gordon, D., & Wilcox, J. N. (1991) · Journal of Clinical Investigation · doi:10.1172/jci115411 · Cited by 878 · see citing works
Ibuprofen Suppresses Plaque Pathology and Inflammation in a Mouse Model for Alzheimer's Disease
Lim, G. P., Yang, F., Chu, T., Chen, P., Beech, W. K., Teter, B., Tran, T., Ubeda, O. J., Ashe, K. H., Frautschy, S. A., et al. (2000) · Journal of Neuroscience · doi:10.1523/jneurosci.20-15-05709.2000 · Cited by 876 · see citing works
Serum IL‐6 Level and the Development of Disability in Older Persons
Ferrucci, L., Harris, T. B., Guralnik, J. M., Tracy, R. P., Corti, M., Cohen, H. J., Penninx, B., Pahor, M., Wallace, R., & Havlik, R. J. (1999) · Journal of the American Geriatrics Society · doi:10.1111/j.1532-5415.1999.tb01583.x · Cited by 809 · see citing works
Function of C-reactive protein
Clos, T. W. D. (2000) · Annals of Medicine · doi:10.3109/07853890009011772 · Cited by 808 · see citing works
Activated transcription factor nuclear factor-kappa B is present in the atherosclerotic lesion.
Brand, K., Page, S., Rogler, G., Bartsch, A., Brandl, R., Knuechel, R., Page, M., Kaltschmidt, C., Baeuerle, P. A., & Neumeier, D. (1996) · Journal of Clinical Investigation · doi:10.1172/jci118598 · Cited by 799 · see citing works
Alamanos, Y., Voulgari, P. V., & Drosos, A. A. (2006) · Seminars in Arthritis and Rheumatism · doi:10.1016/j.semarthrit.2006.08.006 · Cited by 783 · see citing works
Davies, M. J., Gordon, J. L., Gearing, A. J. H., Pigott, R., Woolf, N., Katz, D. R., & Kyriakopoulos, A. (1993) · The Journal of Pathology · doi:10.1002/path.1711710311 · Cited by 777 · see citing works
Osteoclasts: What Do They Do and How Do They Do It?
Teitelbaum, S. L. (2007) · The American Journal of Pathology · doi:10.2353/ajpath.2007.060834 · Cited by 730 · see citing works
Chen, F., Castranova, V., Shi, X., & Demers, L. M. (1999) · Clinical Chemistry · doi:10.1093/clinchem/45.1.7 · Cited by 719 · see citing works
Early inflammation and dementia: A 25‐year follow‐up of the Honolulu‐Asia aging study
Schmidt, R., Schmidt, H., Curb, J. D., Masaki, K., White, L. R., & Launer, L. J. (2002) · Annals of Neurology · doi:10.1002/ana.10265 · Cited by 710 · see citing works
The Yin and Yang of Oxidation in the Development of the Fatty Streak
Navab, M., Berliner, J. A., Watson, A. D., Hama, S. Y., Territo, M., Lusis, A. J., Shih, D. M., Lenten, B. J. V., Frank, J. S., Demer, L. L., et al. (1996) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.16.7.831 · Cited by 699 · see citing works
Aging and proinflammatory cytokines
Bruunsgaard, H., Pedersen, M., & Pedersen, B. K. (2001) · Current Opinion in Hematology · doi:10.1097/00062752-200105000-00001 · Cited by 690 · see citing works
Oxidants and antioxidants in exercise
Sen, C. K. (1995) · Journal of Applied Physiology · doi:10.1152/jappl.1995.79.3.675 · Cited by 628 · see citing works
Balkwill, F. R., & Coussens, L. M. (2004) · Nature · doi:10.1038/431405a · Cited by 627 · see citing works
Libby, P., & Simon, D. I. (2001) · Circulation · doi:10.1161/01.cir.103.13.1718 · Cited by 605 · see citing works
Ford, E. S., Giles, W. H., & Dietz, W. H. (2002) · Obstetrical & Gynecological Survey · doi:10.1097/00006254-200209000-00017 · Cited by 580 · see citing works
Harman-Boehm, I., Blüher, M., Redel, H., Sion-Vardy, N., Ovadia, S., Avinoach, E., Shai, I., Klöting, N., Stumvoll, M., Bashan, N., et al. (2007) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2006-1811 · Cited by 574 · see citing works
Requirement of NF-κB Activation to Suppress p53-Independent Apoptosis Induced by Oncogenic Ras
Mayo, M. W., Wang, C.-Y., Cogswell, P. C., Rogers-Graham, K., Lowe, S. W., Der, C. J., & Baldwin, A. S. (1997) · Science · doi:10.1126/science.278.5344.1812 · Cited by 532 · see citing works
Solinas, G., Vilcu, C., Neels, J. G., Bandyopadhyay, G. K., Luo, J.-L., Naugler, W., Grivennikov, S., Wynshaw-Boris, A., Scadeng, M., Olefsky, J. M., et al. (2007) · Cell Metabolism · doi:10.1016/j.cmet.2007.09.011 · Cited by 513 · see citing works
Berkman, L. F., Seeman, T. E., Albert, M., Blazer, D. G., Kahn, R. L., Mohs, R. C., Finch, C. E., Schneider, E. L., Cotman, C. W., McClearn, G. E., et al. (1993) · Journal of Clinical Epidemiology · doi:10.1016/0895-4356(93)90112-e · Cited by 499 · see citing works
Physical Activity and Hemostatic and Inflammatory Variables in Elderly Men
Wannamethee, S. G., Lowe, G. D. O., Whincup, P. H., Rumley, A., Walker, M., & Lennon, L. (2002) · Circulation · doi:10.1161/01.cir.0000016346.14762.71 · Cited by 487 · see citing works
Inflammatory networks in ageing, age-related diseases and longevity
Vasto, S., Candore, G., Balistreri, C. R., Caruso, M., Colonna‐Romano, G., Grimaldi, M. P., Listı̀, F., Nuzzo, D., Lio, D., & Caruso, C. (2006) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2006.11.015 · Cited by 481 · see citing works
Colbert, L. H., Visser, M., Simonsick, E. M., Tracy, R. P., Newman, A. B., Kritchevsky, S. B., Pahor, M., Taaffe, D. R., Brach, J. S., Rubin, S., et al. (2004) · Journal of the American Geriatrics Society · doi:10.1111/j.1532-5415.2004.52307.x · Cited by 464 · see citing works
Age Changes in Body Composition Revealed by Computed Tomography
Borkan, G. A., Hults, D. E., Gerzof, S. G., Robbins, A. H., & Silbert, C. K. (1983) · Journal of Gerontology · doi:10.1093/geronj/38.6.673 · Cited by 460 · see citing works
The combined role of P- and E-selectins in atherosclerosis.
Dong, Z. M., Chapman, S. M., Brown, A. A., Frenette, P. S., Hynes, R. O., & Wagner, D. D. (1998) · Journal of Clinical Investigation · doi:10.1172/jci3001 · Cited by 460 · see citing works
Physical frailty and body composition in obese elderly men and women
Villareal, D. T., Banks, M., Siener, C., Sinacore, D. R., & Klein, S. (2004) · Obesity Research · doi:10.1038/oby.2004.111 · Cited by 459 · see citing works
A High Plasma Concentration of TNF- Is Associated With Dementia in Centenarians
Brüünsgaard, H., Andersen‐Ranberg, K., Jeune, B., Pedersen, B. K., Skinhøj, P., & Pedersen, B. K. (1999) · The Journals of Gerontology Series A · doi:10.1093/gerona/54.7.m357 · Cited by 458 · see citing works
Role of NFkappaB in the mortality of sepsis.
Bohrer, H., Qiu, F., Zimmermann, T. P., Zhang, Y., Jllmer, T., Männel, D. N., Böttiger, B. W., Stern, D., Waldherr, R., Saeger, H.-D., et al. (1997) · Journal of Clinical Investigation · doi:10.1172/jci119648 · Cited by 454 · see citing works
Cogswell, P. C., D, D. C. G., Funkhouser, W. K., & Baldwin, A. S. (2000) · Oncogene · doi:10.1038/sj.onc.1203412 · Cited by 452 · see citing works
Sarcopenia and its implications for the elderly
Roubenoff, R. (2000) · European Journal of Clinical Nutrition · doi:10.1038/sj.ejcn.1601024 · Cited by 448 · see citing works
Aging and oxidative stress: Modulation by dietary restriction
Yu, B. P. (1996) · Free Radical Biology and Medicine · doi:10.1016/0891-5849(96)00162-1 · Cited by 443 · see citing works
Self-citationZhu, X.-W., Raina, A., Rottkamp, C., Aliev, G., Perry, G., Boux, H., & Smith, M. A. (2001) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.2001.00046.x · Cited by 440 · see citing works
The molecular inflammatory process in aging
Chung, H. Y., Sung, B., Jung, K. J., Zou, Y., & Yu, B. P. (2006) · Antioxidants & Redox Signaling · doi:10.1089/ars.2006.8.572 · Cited by 437 · see citing works
Cesari, M., Kritchevsky, S. B., Baumgartner, R., Atkinson, H. H., Penninx, B. W. J. H., Lenchik, L., Palla, S. L., Ambrosius, W. T., Tracy, R. P., & Pahor, M. (2005) · American Journal of Clinical Nutrition · doi:10.1093/ajcn.82.2.428 · Cited by 422 · see citing works
Self-citationThe Role of Inflammation and Cytokines in Brain Injury
Arvin, B. M., Neville, L. F., Barone, F. C., & Feuerstein, G. (1996) · Neuroscience & Biobehavioral Reviews · doi:10.1016/0149-7634(95)00026-7 · Cited by 417 · see citing works
Davies, K. J. A., & Goldberg, A. L. (1987) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)47552-7 · Cited by 412 · see citing works
Yamashita, T., Yao, Z., Li, F., Zhang, Q., Badell, I., Schwarz, E., Takeshita, S., Wagner, E., Noda, M., Matsuo, K., et al. (2007) · Journal of Biological Chemistry · doi:10.1074/jbc.m610701200 · Cited by 412 · see citing works
Nuclear factor‐κB and the hepatic inflammation‐fibrosis‐cancer axis†
Elsharkawy, A. M., & Mann, D. A. (2007) · Hepatology · doi:10.1002/hep.21802 · Cited by 400 · see citing works
Targeting Signal‐Transducer‐and‐Activator‐of‐Transcription‐3 for Prevention and Therapy of Cancer
Aggarwal, B. B., Sethi, G., Ahn, K. S., Sandur, S. K., Pandey, M. K., Kunnumakkara, A. B., Sung, B., & Ichikawa, H. (2006) · Annals of the New York Academy of Sciences · doi:10.1196/annals.1378.063 · Cited by 399 · see citing works
Roubenoff, R., Parise, H., Payette, H., Abad, L. W., D’Agostino, R. B., Jacques, P. F., Wilson, P. W. F., Dinarello, C. A., & Harris, T. B. (2003) · The American Journal of Medicine · doi:10.1016/j.amjmed.2003.05.001 · Cited by 397 · see citing works
A requirement for NF-kappa B activation in Bcr-Abl-mediated transformationPreprint
Reuther, J. Y., Reuther, G. W., Cortez, D., Pendergast, A. M., & Baldwin, A. S. (1998) · Genes & Development · doi:10.1101/gad.12.7.968 · Cited by 392 · see citing works
Molecular mechanisms of aging-associated inflammation.
Sarkar, D., & Fisher, P. (2006) · Cancer Letters · doi:10.1016/j.canlet.2005.04.009 · Cited by 379 · see citing works
NF-κB as a therapeutic target in chronic inflammation: recent advances
Makarov, S. S. (2000) · Molecular Medicine Today · doi:10.1016/s1357-4310(00)01814-1 · Cited by 379 · see citing works
Anker, S. D. (1999) · European Heart Journal · doi:10.1053/euhj.1998.1446 · Cited by 374 · see citing works
Surh, Y., Kundu, J. K., Na, H., & Lee, J. (2005) · Journal of Nutrition · doi:10.1093/jn/135.12.2993s · Cited by 361 · see citing works
Physical activity and plasma interleukin-6 in humans - effect of intensity of exercise
Ostrowski, K., Schjerling, P., & Pedersen, B. K. (2000) · European Journal of Applied Physiology · doi:10.1007/s004210000312 · Cited by 355 · see citing works
The role of IL-6 in mediating the anti-inflammatory effects of exercise.
Petersen, A. M. W., & Pedersen, B. K. (2006) · PubMed · Cited by 354 · see citing works
S ARCOPENIA , W EIGHT L OSS , AND N UTRITIONAL F RAILTY IN THE E LDERLY
Bales, C. W., & Ritchie, C. S. (2002) · Annual Review of Nutrition · doi:10.1146/annurev.nutr.22.010402.102715 · Cited by 347 · see citing works
Cesari, M., Kritchevsky, S. B., Baumgartner, R., et al. (2005) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/82.2.428 · Cited by 345 · see citing works
Self-citationInduction of leptin resistance through direct interaction of C-reactive protein with leptin
Chen, K., Li, F., Li, J., Cai, H., Strom, S., Bisello, A., Kelley, D. E., Friedman-Einat, M., Skibinski, G. A., McCrory, M. A., et al. (2006) · Nature Medicine · doi:10.1038/nm1372 · Cited by 325 · see citing works
The secretory function of adipocytes in the physiology of white adipose tissue
Wang, P., Mariman, E., Renes, J., & Keijer, J. (2008) · Journal of Cellular Physiology · doi:10.1002/jcp.21386 · Cited by 318 · see citing works
Relationships among inflammatory cytokines, obesity, and insulin sensitivity in the horse1,2
Vick, M. M., Adams, A. A., Murphy, B. A., Sessions, D. R., Horohov, D. W., Cook, R. F., Shelton, B. J., & Fitzgerald, B. P. (2007) · Journal of Animal Science · doi:10.2527/jas.2006-673 · Cited by 307 · see citing works
The Inflammation Hypothesis of Aging: Molecular Modulation by Calorie Restriction
Chung, H. Y., Kim, H. J., Kim, J. W., & Yu, B. P. (2001) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2001.tb05662.x · Cited by 305 · see citing works
Self-citationPredicting death from tumour necrosis factor-alpha and interleukin-6 in 80-year-old people
BRUUNSGAARD, H., LADELUND, S., PEDERSEN, A. N., SCHROLL, M., JØRGENSEN, T., & PEDERSEN, B. K. (2003) · Clinical and Experimental Immunology · doi:10.1046/j.1365-2249.2003.02137.x · Cited by 300 · see citing works
Molecular inflammation hypothesis of aging based on the anti‐aging mechanism of calorie restriction
Chung, H. Y., Kim, H. J., Kim, K. W., Choi, J. S., & Yu, B. P. (2002) · Microscopy Research and Technique · doi:10.1002/jemt.10203 · Cited by 297 · see citing works
Self-citationPhysical Activity and Hemostatic and Inflammatory Variables in Elderly Men
Wannamethee, S. G. (2002) · Circulation · doi:10.1161/hc1502.107117 · Cited by 296 · see citing works
Mechanisms of Disease: inflammation and the origins of cancer
Moss, S. F., & Blaser, M. J. (2005) · Nature Clinical Practice Oncology · doi:10.1038/ncponc0081 · Cited by 292 · see citing works
Nuclear factor–kB in rheumatoid synovium. Localization of P50 and P65
Handel, M. L., Mcmorrow, L. B., & Gravallese, E. M. (1995) · Arthritis & Rheumatism · doi:10.1002/art.1780381209 · Cited by 289 · see citing works
Genetics, pathogenesis and complications of osteopetrosis
Fattore, A. D., Cappariello, A., & Teti, A. M. (2007) · Bone · doi:10.1016/j.bone.2007.08.029 · Cited by 284 · see citing works
Phillips, T., & Leeuwenburgh, C. (2005) · The FASEB Journal · doi:10.1096/fj.04-2870fje · Cited by 283 · see citing works
Self-citationJohnson-Tidey, R. R., McGregor, J. L., Taylor, P., & Poston, R. N. (1994) · PubMed Central · Cited by 282 · see citing works
Sarcopenia: Effects on Body Composition and Function
Roubenoff, R. (2003) · The Journals of Gerontology Series A: Biological Sciences and Medical Sciences · doi:10.1093/gerona/58.11.m1012 · Cited by 282 · see citing works
Anorexia, sarcopenia, and aging
Morley, J. E. (2001) · Nutrition · doi:10.1016/s0899-9007(01)00574-3 · Cited by 276 · see citing works
Hiscock, N. J., Chan, S. M. H., Bisucci, T., Darby, I. A., & Febbraio, M. A. (2004) · The FASEB Journal · doi:10.1096/fj.03-1259fje · Cited by 273 · see citing works
Aigner, T. G., Söder, S., Gebhard, P. M., McAlinden, A., & Haag, J. (2007) · Nature Clinical Practice Rheumatology · doi:10.1038/ncprheum0534 · Cited by 270 · see citing works
Leng, S. X., Cappola, A. R., Andersen, R. E., Blackman, M. R., Koenig, K., Blair, M., & Walston, J. D. (2004) · Aging Clinical and Experimental Research · doi:10.1007/bf03324545 · Cited by 270 · see citing works
Nielsen, A. R., Mounier, R., Plomgaard, P., Mortensen, O. H., Penkowa, M., Speerschneider, T., Pilegaard, H., & Pedersen, B. K. (2007) · The Journal of Physiology · doi:10.1113/jphysiol.2007.139618 · Cited by 266 · see citing works
Gao, Z., Zuberi, A. R., Quon, M. J., Dong, Z., & Ye, J. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m300423200 · Cited by 258 · see citing works
The biochemistry of aging muscle
Carmeli, E., Coleman, R., & Reznick, A. Z. (2002) · Experimental Gerontology · doi:10.1016/s0531-5565(01)00220-0 · Cited by 257 · see citing works
Cellular and molecular aspects of gastric cancer
Smith, M. G. (2006) · World Journal of Gastroenterology · doi:10.3748/wjg.v12.i19.2979 · Cited by 251 · see citing works
Absence of P-selectin delays fatty streak formation in mice.
Johnson, R. C., Chapman, S. M., Dong, Z. M., Ordovás, J. M., Mayadas, T. N., Herz, J., Hynes, R. O., Schaefer, E. J., & Wagner, D. D. (1997) · Journal of Clinical Investigation · doi:10.1172/jci119231 · Cited by 250 · see citing works
Inflammation and Endometrial Cancer: A Hypothesis
Modugno, F., Ness, R. B., Chen, C., & Weiss, N. S. (2005) · Cancer Epidemiology Biomarkers & Prevention · doi:10.1158/1055-9965.epi-05-0493 · Cited by 250 · see citing works
Bastard, J.-P., Jardel, C., Delattre, J., Hainque, B., Bruckert, E., & Oberlin, F. (1999) · Circulation · doi:10.1161/circ.99.16.2219/c · Cited by 244 · see citing works
C-Reactive Protein, Inflammation, and Innate Immunity
Mortensen, R. F. (2001) · Immunologic Research · doi:10.1385/ir:24:2:163 · Cited by 238 · see citing works
Koh, J., Khang, Y., Jung, C.-H., Bae, S., Kim, D. J., Chung, Y., & Kim, G. S. (2005) · Osteoporosis International · doi:10.1007/s00198-005-1840-5 · Cited by 235 · see citing works
Wang, B., Jenkins, J. R., & Trayhurn, P. (2004) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00475.2004 · Cited by 233 · see citing works
Muscle-derived interleukin-6: lipolytic, anti-inflammatory and immune regulatory effects
Pedersen, B. K., Steensberg, A., Keller, P., Keller, C., Fischer, C., Hiscock, N., van Hall, G., Plomgaard, P., & Febbraio, M. A. (2003) · Pflügers Archiv - European Journal of Physiology · doi:10.1007/s00424-002-0981-z · Cited by 228 · see citing works
Quinn, L. S., Anderson, B. G., Drivdahl, R. H., Alvarez, B., & Argilés, J. M. (2002) · Experimental Cell Research · doi:10.1006/excr.2002.5624 · Cited by 226 · see citing works
Spaulding, C. C., Walford, R. L., & Effros, R. B. (1997) · Mechanisms of Ageing and Development · doi:10.1016/s0047-6374(96)01824-6 · Cited by 224 · see citing works
Inflammation of the brain in Alzheimer's disease: implications for therapy
McGeer, P. L., & McGeer, E. G. (1999) · Journal of Leukocyte Biology · doi:10.1002/jlb.65.4.409 · Cited by 218 · see citing works
Helenius, M. (1996) · Journal of Molecular and Cellular Cardiology · doi:10.1006/jmcc.1996.0045 · Cited by 217 · see citing works
Nutrition Interventions in Aging and Age‐Associated Disease
Meydani, M. (2001) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2001.tb05652.x · Cited by 208 · see citing works
Oxidative stress and mitochondrial function with aging – the effects of calorie restriction
Merry, B. J. (2003) · Aging Cell · doi:10.1046/j.1474-9728.2003.00074.x · Cited by 207 · see citing works
(1998) · PubMed · Cited by 203 · see citing works
Gupta, A. K., Rosenberger, S. F., & Bowden, G. T. (1999) · Carcinogenesis · doi:10.1093/carcin/20.11.2063 · Cited by 202 · see citing works
The effect of age on cyclooxygenase-2 gene expression
Kim, H., Kim, K., Yu, B., & Chung, H. (2000) · Free Radical Biology and Medicine · doi:10.1016/s0891-5849(99)00274-9 · Cited by 199 · see citing works
Self-citationTownsend, K. P., & Praticò, D. (2005) · The FASEB Journal · doi:10.1096/fj.04-3620rev · Cited by 196 · see citing works
Influence of Physical Activity on Serum IL-6 and IL-10 Levels in Healthy Older Men
Jankord, R., & Jemioło, B. (2004) · Medicine & Science in Sports & Exercise · doi:10.1249/01.mss.0000128186.09416.18 · Cited by 196 · see citing works
Germolec, D. R., Frawley, R. P., & Evans, E. (2009) · Methods in molecular biology · doi:10.1007/978-1-60761-401-2_5 · Cited by 194 · see citing works
IL-6 signalling in exercise and disease
Pedersen, B. K. (2007) · Biochemical Society Transactions · doi:10.1042/bst0351295 · Cited by 187 · see citing works
Metabolic Syndrome and Cognitive Disorders
Yaffe, K. S. (2007) · Alzheimer Disease & Associated Disorders · doi:10.1097/wad.0b013e318065bfd6 · Cited by 186 · see citing works
Radak, Z. O., Chung, H. Y., Naıto, H., Takahashi, R., Jung, K. J., Kim, H., & Goto, S. (2004) · The FASEB Journal · doi:10.1096/fj.03-0509fje · Cited by 173 · see citing works
Self-citationModulation of redox-sensitive transcription factors by calorie restriction during aging
Kim, H. J., Jung, K. J., Yu, B. P., Cho, C. G., Choi, J. S., & Chung, H. Y. (2002) · Mechanisms of Ageing and Development · doi:10.1016/s0047-6374(02)00094-5 · Cited by 166 · see citing works
Self-citationCritical Evaluation of the Free Radical Theory of Aging
Yu, B. P., & Yang, R. (1996) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1996.tb39047.x · Cited by 165 · see citing works
Self-citationGarc�a-Mart�nez, C., López-Soriano, F. J., & Argilés, J. M. A. (1993) · Molecular and Cellular Biochemistry · doi:10.1007/bf00926829 · Cited by 160 · see citing works
Adaptive mechanisms to oxidative stress during aging
Yu, B. P., & Chung, H. Y. (2006) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2006.01.023 · Cited by 153 · see citing works
Self-citationModulation of PPAR in Aging, Inflammation, and Calorie Restriction
Sung, B., Park, S., Yu, B., & Chung, H. Y. (2004) · The Journals of Gerontology Series A · doi:10.1093/gerona/59.10.b997 · Cited by 143 · see citing works
Self-citationLykkesfeldt, J., Hagen, T. M., Vinarsky, V., & Ames, B. N. (1998) · The FASEB Journal · doi:10.1096/fasebj.12.12.1183 · Cited by 142 · see citing works
Physical Activity, Inflammation, and Muscle Loss
Roubenoff, R. (2007) · Nutrition Reviews · doi:10.1111/j.1753-4887.2007.tb00364.x · Cited by 142 · see citing works
Age-related changes in the regulation of transcription factor NF-κB in rat brain
Korhonen, P., Helenius, M., & Salminen, A. (1997) · Neuroscience Letters · doi:10.1016/s0304-3940(97)00190-0 · Cited by 138 · see citing works
Spindler, S. R. (2005) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2005.03.016 · Cited by 136 · see citing works
Prospects for Cardiovascular Research
Lefkowitz, R. J. (2001) · JAMA · doi:10.1001/jama.285.5.581 · Cited by 136 · see citing works
High-Sensitivity C-Reactive Protein and Fracture Risk in Elderly Women
Pasco, J. A., Kotowicz, M. A., Henry, M. J., Nicholson, G. C., Spilsbury, H. J., Box, J. D., & Schneider, H. G. (2006) · JAMA · doi:10.1001/jama.296.11.1353 · Cited by 134 · see citing works
Possible beneficial role of exercise in modulating low‐grade inflammation in the elderly
Pedersen, B. K., & Brüünsgaard, H. (2003) · Scandinavian Journal of Medicine and Science in Sports · doi:10.1034/j.1600-0838.2003.20218.x · Cited by 134 · see citing works
Activation of p38 MAPK is a key step in tumor necrosis factor–mediated inflammatory bone destruction
Zwerina, J., Hayer, S., Redlich, K., Bobacz, K., Kollias, G., Smolen, J. S., & Schett, G. A. (2006) · Arthritis & Rheumatism · doi:10.1002/art.21626 · Cited by 132 · see citing works
Yarnell, J., Patterson, C., Thomas, H. F., et al. (2000) · Journal of Epidemiology and Community Health · doi:10.1136/jech.54.5.344 · Cited by 125 · see citing works
Kyrkanides, S., O’Banion, M. K., Whiteley, P. E., Daeschner, J., & Olschowka, J. A. (2001) · Journal of Neuroimmunology · doi:10.1016/s0165-5728(01)00404-0 · Cited by 118 · see citing works
Reversible Effects of Long-Term Caloric Restriction on Protein Oxidative Damage
Forster, M. J., Sohal, B. H., & Sohal, R. S. (2000) · The Journals of Gerontology Series A · doi:10.1093/gerona/55.11.b522 · Cited by 118 · see citing works
Alzheimer disease and neuroinflammation
McGeer, P. L., McGeer, E. G., & Yasojima, K. (2000) · Springer eBooks · doi:10.1007/978-3-7091-6781-6_8 · Cited by 117 · see citing works
Han, K. H., Han, K. O., Green, S. R., & Quehenberger, O. (1999) · Journal of Lipid Research · doi:10.1016/s0022-2275(20)33509-4 · Cited by 116 · see citing works
Marzetti, E., Lawler, J. M., Hiona, A., Manini, T., Seo, A. Y., & Leeuwenburgh, C. (2008) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2007.05.028 · Cited by 113 · see citing works
Self-citationInflammatory factors in age-related muscle wasting
Roth, S. M., Metter, E. J., Ling, S. M., & Ferrucci, L. (2006) · Current Opinion in Rheumatology · doi:10.1097/01.bor.0000245722.10136.6d · Cited by 111 · see citing works
Interleukin‐10: an anti‐inflammatory cytokine with therapeutic potential
Pretolani, M. (1999) · Clinical & Experimental Allergy · doi:10.1046/j.1365-2222.1999.00456.x · Cited by 110 · see citing works
Figueras, M., Busquets, S., Carbó, N., Barreiro, E., Almendro, V., Argilés, J. M. A., & López-Soriano, F. J. (2004) · FEBS Letters · doi:10.1016/j.febslet.2004.05.066 · Cited by 108 · see citing works
The New Adipose Tissue and Adipocytokines
Bulcão, C., Ferreira, S. R. G., Giuffrida, F. M. A., & Ribeiro‐Filho, F. F. (2006) · Current Diabetes Reviews · doi:10.2174/157339906775473617 · Cited by 108 · see citing works
IL-1 and TNF-induced bone resorption is mediated by p38 mitogen activated protein kinase.
Kumar, S., Votta, B. J., Rieman, D. J., Badger, A. M., Gowen, M., & Lee, J. C. (2001) · Journal of Cellular Physiology · doi:10.1002/jcp.1082 · Cited by 107 · see citing works
Alteration of soluble adhesion molecules during aging and their modulation by calorie restriction
Zou, Y., Jung, K. J., Kim, J. W., Yu, B. P., & Chung, H. Y. (2004) · The FASEB Journal · doi:10.1096/fj.03-0849fje · Cited by 106 · see citing works
Self-citationFree Radicals and Inflammation
(2000) · Birkhäuser Basel eBooks · doi:10.1007/978-3-0348-8482-2 · Cited by 104 · see citing works
Physical Activity, Inflammation, and Muscle Loss
Roubenoff, R. (2007) · Nutrition Reviews · doi:10.1301/nr.2007.dec.s208-s212 · Cited by 104 · see citing works
Cellular and molecular mechanisms of aging
Dice, J. F. (1993) · Physiological Reviews · doi:10.1152/physrev.1993.73.1.149 · Cited by 103 · see citing works
Charters, Y., & Grimble, R. F. (1989) · Biochemical Journal · doi:10.1042/bj2580493 · Cited by 102 · see citing works
Calorie restriction attenuates inflammatory responses to myocardial ischemia-reperfusion injury
Chandrasekar, B., Nelson, J. F., Colston, J. T., & Freeman, G. L. (2001) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.2001.280.5.h2094 · Cited by 102 · see citing works
Fat distribution and storage: how much, where, and how?
Weiss, R. (2007) · European Journal of Endocrinology · doi:10.1530/eje-07-0125 · Cited by 102 · see citing works
Modulation of glutathione and thioredoxin systems by calorie restriction during the aging process
Cho, C. G. (2003) · Experimental Gerontology · doi:10.1016/s0531-5565(03)00005-6 · Cited by 96 · see citing works
Aging bone and cartilage: cross-cutting issues
Carrington, J. L. (2004) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2004.12.041 · Cited by 95 · see citing works
Sabbioni, G., Ambs, S., Wogan, G. N., et al. (1990) · Carcinogenesis · doi:10.1093/carcin/11.11.2063 · Cited by 94 · see citing works
McCormick, R. K. (2007) · PubMed · Cited by 94 · see citing works
Unregulated inflammation shortens human functional longevity
Brod, S. A. (2000) · Inflammation Research · doi:10.1007/s000110050632 · Cited by 91 · see citing works
Brüünsgaard, H. (2006) · PubMed · Cited by 90 · see citing works
Baek, B. S., Kwon, H. J., Lee, K. H., et al. (1999) · Archives of Pharmacal Research · doi:10.1007/bf02979058 · Cited by 88 · see citing works
Robinson, L. E., Buchholz, A. C., & Mazurak, V. C. (2007) · Applied Physiology, Nutrition, and Metabolism · doi:10.1139/h07-087 · Cited by 86 · see citing works
Kalani, R., Judge, S., Carter, C., Pahor, M., & Leeuwenburgh, C. (2006) · The Journals of Gerontology Series A · doi:10.1093/gerona/61.3.211 · Cited by 85 · see citing works
Self-citationKohrt, W. M. (2000) · PubMed · Cited by 85 · see citing works
Chae, G.-N., & Kwak, S. (2003) · Experimental & Molecular Medicine · doi:10.1038/emm.2003.56 · Cited by 84 · see citing works
Adipocytokines: Fat-Derived Humoral Mediators of Metabolic Homeostasis
Staiger, H., & Häring, H. (2005) · Experimental and Clinical Endocrinology & Diabetes · doi:10.1055/s-2004-830555 · Cited by 82 · see citing works
Non-steroidal Anti-inflammatory Drugs and Cyclooxygenase in Alzheimer s Disease
Hoozemans, J. J. M., Veerhuis, R., Rozemüller, A. J. M., & Eikelenboom, P. (2003) · Current Drug Targets · doi:10.2174/1389450033490902 · Cited by 81 · see citing works
Inflammation and Atherosclerosis
Steffens, S., & Mach, F. (2004) · Herz · doi:10.1007/s00059-004-2634-9 · Cited by 77 · see citing works
Yun, A. J., & Lee, P. Y. (2004) · Medical Hypotheses · doi:10.1016/s0306-9877(03)00326-8 · Cited by 76 · see citing works
Carter, C. S., Hofer, T., Seo, A. Y., & Leeuwenburgh, C. (2007) · Applied Physiology, Nutrition, and Metabolism · doi:10.1139/h07-085 · Cited by 74 · see citing works
Self-citationInflammation and Alzheimer's disease
Jones, R. W. (2001) · The Lancet · doi:10.1016/s0140-6736(01)05667-7 · Cited by 73 · see citing works
Wang, G., Deng, Z.-D., Ni, J., & Qu, Z. (1997) · Atherosclerosis · doi:10.1016/s0021-9150(97)00109-3 · Cited by 73 · see citing works
Sumitomo, M., Tachibana, M., Ozu, C., Asakura, H., Murai, M., Hayakawa, M., Nakamura, H., Takayanagi, A., & Shimizu, N. (1999) · Human Gene Therapy · doi:10.1089/10430349950019174 · Cited by 73 · see citing works
Marzetti, E., Groban, L., Wohlgemuth, S. E., Lees, H. A., Lin, M., Jobe, H., Giovannini, S., Leeuwenburgh, C., & Carter, C. S. (2007) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00620.2007 · Cited by 72 · see citing works
Self-citationMammalian cell transformation and aneuploidy induced by five bisphenols
Tsutsui, T., Tamura, Y., Suzuki, A., Hirose, Y., Kobayashi, M., Nishimura, H., Metzler, M., & Barrett, J. C. (2000) · International Journal of Cancer · doi:10.1002/(sici)1097-0215(20000415)86:2 · Cited by 70 · see citing works
Seo, A. Y., Hofer, T., Sung, B., Judge, S., Chung, H. Y., & Leeuwenburgh, C. (2006) · Antioxidants and Redox Signaling · doi:10.1089/ars.2006.8.529 · Cited by 69 · see citing works
Self-citationUpregulation of Aortic Adhesion Molecules During Aging
Zou, Y., Yoon, S. Y., Jung, K. J., Kim, C. H., Son, T. G., Kim, M.-S., Kim, Y. J., Lee, J., Yu, B. P., & Chung, H. Y. (2006) · The Journals of Gerontology Series A · doi:10.1093/gerona/61.3.232 · Cited by 69 · see citing works
Self-citationBody composition and metabolic rate in rat during a continuous infusion of cachectin
Hoshino, E., Pichard, C., Greenwood, C. E., Kuo, G. C., Cameron, R., Kurian, R., Kearns, J. P., Allard, J. P., & Jeejeebhoy, K. N. (1991) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.1991.260.1.e27 · Cited by 67 · see citing works
The inflammatory process in aging
Yu, B. P., & Chung, H. Y. (2006) · Reviews in Clinical Gerontology · doi:10.1017/s0959259807002110 · Cited by 65 · see citing works
Self-citationTHE ROLE OF REDOX‐ACTIVE AMINO ACIDS IN THE PHOTOSYNTHETIC WATER‐OXIDIZING COMPLEX
Barry, B. A. (1993) · Photochemistry and Photobiology · doi:10.1111/j.1751-1097.1993.tb02275.x · Cited by 62 · see citing works
Merat, S., Fruebis, J., Sutphin, M. S., Silvestre, M., & Reaven, P. D. (2000) · The Journals of Gerontology Series A · doi:10.1093/gerona/55.2.b85 · Cited by 61 · see citing works
Cardiac Hemangioma of the Left Atrial Appendage: CT and MR Findings
Oshima, H., Hara, M., Kono, T., et al. (2003) · Journal of Thoracic Imaging · doi:10.1097/00005382-200307000-00012 · Cited by 55 · see citing works
Mitochondrion-mediated apoptosis in HIV-1 infection
Badley, A. D., Roumier, T., Lum, J. J., et al. (2003) · Trends in Pharmacological Sciences · doi:10.1016/s0165-6147(03)00125-1 · Cited by 53 · see citing works
Hoffmann, R., Stellbrink, E., Schröder, J. W., Gräwe, A., Vogel, G., Blindt, R., Kelm, M., & Radke, P. W. (2007) · The American Journal of Cardiology · doi:10.1016/j.amjcard.2007.06.021 · Cited by 50 · see citing works
Inflammation and dementia: epidemiologic evidence
Peila, R., & Launer, L. J. (2006) · Acta Neurologica Scandinavica · doi:10.1111/j.1600-0404.2006.00693.x · Cited by 47 · see citing works
Reactive oxygen/nitrogen species and acute inflammation: A physiological process
Bodamyali, T., Stevens, C. R., Blake, D. R., & Winyard, P. G. (2000) · Birkhäuser Basel eBooks · doi:10.1007/978-3-0348-8482-2_2 · Cited by 46 · see citing works
Superoxides Relay Ras Protein's Oncogenic Message
Pennisi, E. (1997) · Science · doi:10.1126/science.275.5306.1567 · Cited by 46 · see citing works
The interaction of supersaturated calcium phosphate solutions with apatitic substrates
Eanes, E. D. (1976) · Calcified Tissue International · doi:10.1007/bf02546399 · Cited by 45 · see citing works
Saito, T., Oda, Y., Sugimachi, K., et al. (2001) · American Journal Of Pathology · doi:10.1016/s0002-9440(10)63063-5 · Cited by 45 · see citing works
Dietary modulation of prostanoid synthesis in the aging process: role of cyclooxygenase-2
Chung, H. Y., Kim, H.-J., Shim, K. H., & Kim, K.-W. (1999) · Mechanisms of Ageing and Development · doi:10.1016/s0047-6374(99)00061-5 · Cited by 44 · see citing works
Self-citationGene Expression of Cyclooxygenase in the Aging Heart
Kim, J. W., Baek, B. S., Kim, Y. K., Herlihy, J. T., Ikeno, Y., Yu, B., & Chung, H. Y. (2001) · The Journals of Gerontology Series A · doi:10.1093/gerona/56.8.b350 · Cited by 44 · see citing works
Self-citationAge-Related Increase of Brain Cyclooxygenase Activity and Dietary Modulation of Oxidative Status
Baek, B. S., Kim, J. W., Lee, J. H., Kwon, H. J., Kim, N. D., Kang, H. S., Yoo, M. A., Yu, B., & Chung, H. Y. (2001) · The Journals of Gerontology Series A · doi:10.1093/gerona/56.10.b426 · Cited by 43 · see citing works
Self-citationAmyloid β-peptide is produced by cultured cells during normal metabolism: A reprise
Selkoe, D. J. (2006) · Journal of Alzheimer s Disease · doi:10.3233/jad-2006-9s319 · Cited by 39 · see citing works
Vega, V. L., de Cabo, R., & Maio, A. D. (2004) · Shock · doi:10.1097/01.shk.0000133590.09659.a1 · Cited by 37 · see citing works
Flagged first, then by citations
Research works printed but not linked: 1
- Chung HY Cheng KQ Chung GJ 2004 Molecular inflammation in aging process Nippon Ronen Igakkai Zasshi 41 357 364 15387272
Cited by
Sorted by citations
Aging, Cellular Senescence, and Cancer
Campisi, J. (2013) · Annual Review of Physiology · doi:10.1146/annurev-physiol-030212-183653 · Cited by 2,954 · see citing works
Four faces of cellular senescence
Rodier, F., & Campisi, J. (2011) · Journal of Cell Biology · doi:10.1083/jcb.201009094 · Cited by 2,016 · see citing works
Cellular senescence and the senescent secretory phenotype: therapeutic opportunities
Tchkonia, T., Zhu, Y., van Deursen, J., Campisi, J., & Kirkland, J. L. (2013) · Journal of Clinical Investigation · doi:10.1172/jci64098 · Cited by 1,774 · see citing works
Evolution of the immune system in humans from infancy to old age
Simon, A. K., Hollander, G. A., & McMichael, A. (2015) · Proceedings of the Royal Society B: Biological Sciences · doi:10.1098/rspb.2014.3085 · Cited by 1,796 · see citing works
Miller, G. E., Chen, E., & Parker, K. J. (2011) · Psychological Bulletin · doi:10.1037/a0024768 · Cited by 1,785 · see citing works
Mechanisms of Cellular Senescence: Cell Cycle Arrest and Senescence Associated Secretory Phenotype
Kumari, R., & Jat, P. (2021) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2021.645593 · Cited by 1,622 · see citing works
mTOR is a key modulator of ageing and age-related disease
Johnson, S. C., Rabinovitch, P. S., & Kaeberlein, M. (2013) · Nature · doi:10.1038/nature11861 · Cited by 1,676 · see citing works
Neuroinflammation: The Devil Is in the Details
DiSabato, D. J., Quan, N., & Godbout, J. P. (2016) · Journal of Neurochemistry · doi:10.1111/jnc.13607 · Cited by 1,640 · see citing works
Age and Age-Related Diseases: Role of Inflammation Triggers and Cytokines
Rea, I. M., Gibson, D. S., McGilligan, V., McNerlan, S. E., Alexander, H. D., & Ross, O. A. (2018) · Frontiers in Immunology · doi:10.3389/fimmu.2018.00586 · Cited by 1,267 · see citing works
NF-κB Restricts Inflammasome Activation via Elimination of Damaged Mitochondria
Zhong, Z., Umemura, A., Sanchez-Lopez, E., Liang, S., Shalapour, S., Wong, J., He, F., Boassa, D., Perkins, G., Ali, S. R., et al. (2016) · Cell · doi:10.1016/j.cell.2015.12.057 · Cited by 1,197 · see citing works
Xu, M., Tchkonia, T., Ding, H., Ogrodnik, M., Lubbers, E. R., Pirtskhalava, T., White, T. A., Johnson, K. O., Stout, M. B., Mezera, V., et al. (2015) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1515386112 · Cited by 915 · see citing works
Role of ROS and Nutritional Antioxidants in Human Diseases
Liu, Z., Ren, Z., Zhang, J., Chuang, C.-C., Kandaswamy, E., Zhou, T., & Zuo, L. (2018) · Frontiers in Physiology · doi:10.3389/fphys.2018.00477 · Cited by 860 · see citing works
Inflammation and sarcopenia: A systematic review and meta-analysis
Bano, G., Trevisan, C., Carraro, S., Solmi, M., Luchini, C., Stubbs, B., Manzato, E., Sergi, G., & Veronese, N. (2017) · Maturitas · doi:10.1016/j.maturitas.2016.11.006 · Cited by 801 · see citing works
Chronic inflammation induces telomere dysfunction and accelerates ageing in mice
Jurk, D., Wilson, C., Passos, J. F., Oakley, F., Correia-Melo, C., Greaves, L., Saretzki, G., Fox, C., Lawless, C., Anderson, R., et al. (2014) · Nature Communications · doi:10.1038/ncomms5172 · Cited by 814 · see citing works
Oxidative Stress, Molecular Inflammation and Sarcopenia
Meng, S.-J., & Yu, L.-J. (2010) · International Journal of Molecular Sciences · doi:10.3390/ijms11041509 · Cited by 637 · see citing works
Mitochondrial dysfunction and sarcopenia of aging: from signaling pathways to clinical trials
Marzetti, E., Calvani, R., Cesari, M., Buford, T. W., Lorenzi, M., Behnke, B. J., & Leeuwenburgh, C. (2013) · The International Journal of Biochemistry & Cell Biology · doi:10.1016/j.biocel.2013.06.024 · Cited by 627 · see citing works
Self-citationTaking a good look at free radicals in the aging process
Hekimi, S., Lapointe, J., & Wen, Y. (2011) · Trends in Cell Biology · doi:10.1016/j.tcb.2011.06.008 · Cited by 606 · see citing works
Wenz, T., Rossi, S. G., Rotundo, R. L., Spiegelman, B. M., & Moraes, C. T. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0911570106 · Cited by 600 · see citing works
RetractedSleep Loss Can Cause Death through Accumulation of Reactive Oxygen Species in the Gut
Vaccaro, A., Kaplan Dor, Y., Nambara, K., Pollina, E. A., Lin, C., Greenberg, M. E., & Rogulja, D. (2020) · Cell · doi:10.1016/j.cell.2020.04.049 · Cited by 541 · see citing works
New insights into the role of mitochondria in aging: mitochondrial dynamics and more
Seo, A. Y., Joseph, A.-M., Dutta, D., Hwang, J. C. Y., Aris, J. P., & Leeuwenburgh, C. (2010) · Journal of Cell Science · doi:10.1242/jcs.070490 · Cited by 522 · see citing works
Self-citationRavussin, E., Redman, L. M., Rochon, J., Das, S. K., Fontana, L., Kraus, W. E., Romashkan, S., Williamson, D. A., Meydani, S. N., Villareal, D. T., et al. (2015) · The Journals of Gerontology Series A: Biological Sciences and Medical Sciences · doi:10.1093/gerona/glv057 · Cited by 489 · see citing works
NF-κB inhibition delays DNA damage–induced senescence and aging in mice
Tilstra, J. S., Robinson, A. R., Wang, J., Gregg, S. Q., Clauson, C. L., Reay, D. P., Nasto, L. A., St Croix, C. M., Usas, A., Vo, N., et al. (2012) · Journal of Clinical Investigation · doi:10.1172/jci45785 · Cited by 462 · see citing works
Han, X., Sun, S., Sun, Y., Song, Q., Zhu, J., Song, N., Chen, M., Sun, T., Xia, M., Ding, J., et al. (2019) · Autophagy · doi:10.1080/15548627.2019.1596481 · Cited by 408 · see citing works
(Dis)Trust your gut: the gut microbiome in age-related inflammation, health, and disease
Buford, T. W. (2017) · Microbiome · doi:10.1186/s40168-017-0296-0 · Cited by 409 · see citing works
Hall, B. M., Balan, V., Gleiberman, A. S., Strom, E., Krasnov, P., Virtuoso, L. P., Rydkina, E., Vujcic, S., Balan, K., Gitlin, I. I., et al. (2017) · Aging · doi:10.18632/aging.101268 · Cited by 407 · see citing works
Cellular senescence: putting the paradoxes in perspective
Campisi, J. (2011) · Current Opinion in Genetics & Development · doi:10.1016/j.gde.2010.10.005 · Cited by 368 · see citing works
Hall, B. M., Balan, V., Gleiberman, A. S., Strom, E., Krasnov, P., Virtuoso, L. P., Rydkina, E., Vujcic, S., Balan, K., Gitlin, I., et al. (2016) · Aging · doi:10.18632/aging.100991 · Cited by 357 · see citing works
Human T Cell Aging and the Impact of Persistent Viral Infections
Fülöp, T., Larbi, A., & Pawelec, G. (2013) · Frontiers in Immunology · doi:10.3389/fimmu.2013.00271 · Cited by 347 · see citing works
Cellular senescence in renal ageing and disease
Sturmlechner, I., Durik, M., Sieben, C. J., Baker, D. J., & van Deursen, J. M. (2017) · Nature Reviews Nephrology · doi:10.1038/nrneph.2016.183 · Cited by 345 · see citing works
Aging and Immune Function: Molecular Mechanisms to Interventions
Ponnappan, S., & Ponnappan, U. (2011) · Antioxidants & Redox Signaling · doi:10.1089/ars.2010.3228 · Cited by 339 · see citing works
Vascular biology of ageing—Implications in hypertension
Harvey, A., Montezano, A. C., & Touyz, R. M. (2015) · Journal of Molecular and Cellular Cardiology · doi:10.1016/j.yjmcc.2015.04.011 · Cited by 330 · see citing works
Flavonoids as Cytokine Modulators: A Possible Therapy for Inflammation-Related Diseases
Leyva-López, N., Gutierrez-Grijalva, E., Ambriz-Perez, D., & Heredia, J. (2016) · International Journal of Molecular Sciences · doi:10.3390/ijms17060921 · Cited by 337 · see citing works
Exercise modulates oxidative stress and inflammation in aging and cardiovascular diseases
Sallam, N., & Laher, I. (2016) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2016/7239639 · Cited by 334 · see citing works
Willcox, D. C., Willcox, B. J., Todoriki, H., & Suzuki, M. (2009) · Journal of the American College of Nutrition · doi:10.1080/07315724.2009.10718117 · Cited by 311 · see citing works
Matsumoto, M., Kurihara, S., Kibe, R., Ashida, H., & Benno, Y. (2011) · PLoS ONE · doi:10.1371/journal.pone.0023652 · Cited by 290 · see citing works
Successful aging: Advancing the science of physical independence in older adults
Anton, S. D., Woods, A. J., Ashizawa, T., Barb, D., Buford, T. W., Carter, C. S., Clark, D. J., Cohen, R. A., Corbett, D. B., Cruz-Almeida, Y., et al. (2015) · Ageing Research Reviews · doi:10.1016/j.arr.2015.09.005 · Cited by 292 · see citing works
Self-citationCellular senescence and the aging brain
Chinta, S. J., Woods, G., Rane, A., Demaria, M., Campisi, J., & Andersen, J. K. (2015) · Experimental Gerontology · doi:10.1016/j.exger.2014.09.018 · Cited by 282 · see citing works
NAD metabolism: Implications in aging and longevity
Yaku, K., Okabe, K., & Nakagawa, T. (2018) · Ageing Research Reviews · doi:10.1016/j.arr.2018.05.006 · Cited by 269 · see citing works
Healthy aging diets other than the Mediterranean: A focus on the Okinawan diet
Willcox, D. C., Scapagnini, G., & Willcox, B. J. (2014) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2014.01.002 · Cited by 273 · see citing works
Impact of cellular senescence signature on ageing research
Sikora, E., Arendt, T., Bennett, M., & Narita, M. (2011) · Ageing Research Reviews · doi:10.1016/j.arr.2010.10.002 · Cited by 264 · see citing works
Fabbri, E., An, Y., Zoli, M., Simonsick, E. M., Guralnik, J. M., Bandinelli, S., Boyd, C. M., & Ferrucci, L. (2015) · The Journals of Gerontology: Series A · doi:10.1093/gerona/glu127 · Cited by 240 · see citing works
Glucocorticoids suppress selected components of the senescence‐associated secretory phenotype
Laberge, R., Zhou, L., Sarantos, M. R., Rodier, F., Freund, A., de Keizer, P. L. J., Liu, S., Demaria, M., Cong, Y., Kapahi, P., et al. (2012) · Aging Cell · doi:10.1111/j.1474-9726.2012.00818.x · Cited by 229 · see citing works
Changes in Regenerative Capacity through Lifespan
Yun, M. (2015) · International Journal of Molecular Sciences · doi:10.3390/ijms161025392 · Cited by 216 · see citing works
Renna, M. E., O'Toole, M. S., Spaeth, P. E., Lekander, M., & Mennin, D. S. (2018) · Depression and Anxiety · doi:10.1002/da.22790 · Cited by 220 · see citing works
Parkinson’s disease as a result of aging
Rodriguez, M., Rodriguez‐Sabate, C., Morales, I., Sanchez, A., & Sabate, M. (2015) · Aging Cell · doi:10.1111/acel.12312 · Cited by 214 · see citing works
‘Adipaging’: ageing and obesity share biological hallmarks related to a dysfunctional adipose tissue
Pérez, L. M., Pareja‐Galeano, H., Sanchis‐Gomar, F., Emanuele, E., Lucia, A., & Gálvez, B. G. (2016) · The Journal of Physiology · doi:10.1113/jp271691 · Cited by 215 · see citing works
Revisiting Metchnikoff: Age-related alterations in microbiota-gut-brain axis in the mouse
Scott, K. A., Ida, M., Peterson, V. L., Prenderville, J. A., Moloney, G. M., Izumo, T., Murphy, K., Murphy, A., Ross, R. P., Stanton, C., et al. (2017) · Brain, Behavior, and Immunity · doi:10.1016/j.bbi.2017.02.004 · Cited by 202 · see citing works
Characterization of the direct targets of<scp>FOXO</scp>transcription factors throughout evolution
Webb, A. E., Kundaje, A., & Brunet, A. (2016) · Aging Cell · doi:10.1111/acel.12479 · Cited by 182 · see citing works
Sarcopenic obesity and endocrinal adaptation with age
Sakuma, K., & Yamaguchi, A. (2013) · International Journal of Endocrinology · doi:10.1155/2013/204164 · Cited by 189 · see citing works
Zhang, Y., Unnikrishnan, A., Deepa, S. S., Liu, Y., Li, Y., Ikeno, Y., Sosnowska, D., Van Remmen, H., & Richardson, A. (2017) · Redox Biology · doi:10.1016/j.redox.2016.10.014 · Cited by 185 · see citing works
Assessing cell and organ senescence biomarkers
de Jesus, B. B., & Blasco, M. A. (2012) · Circulation Research · doi:10.1161/circresaha.111.247866 · Cited by 187 · see citing works
Speisman, R. B., Kumar, A., Rani, A., Foster, T. C., & Ormerod, B. K. (2013) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2012.09.013 · Cited by 187 · see citing works
Ma, J., Hong, Y., Zheng, N., Xie, G., Lyu, Y., Gu, Y., Xi, C., Chen, L., Wu, G., Li, Y., et al. (2020) · Gut Microbes · doi:10.1080/19490976.2020.1763770 · Cited by 171 · see citing works
Brubaker, A. L., Rendon, J. L., Ramirez, L., Choudhry, M. A., & Kovacs, E. J. (2013) · The Journal of Immunology · doi:10.4049/jimmunol.1201213 · Cited by 181 · see citing works
Axonal Degeneration during Aging and Its Functional Role in Neurodegenerative Disorders
Salvadores, N., Sanhueza, M., Manque, P., & Court, F. A. (2017) · Frontiers in Neuroscience · doi:10.3389/fnins.2017.00451 · Cited by 182 · see citing works
Inflammation and age-associated skeletal muscle deterioration (sarcopaenia)
Wang, J., Leung, K.-S., Chow, S. K.-H., & Cheung, W.-H. (2017) · Journal of Orthopaedic Translation · doi:10.1016/j.jot.2017.05.006 · Cited by 173 · see citing works
Chinta, S. J., Lieu, C. A., DeMaria, M., Laberge, R. ‐., Campisi, J., & Andersen, J. K. (2013) · Journal of Internal Medicine · doi:10.1111/joim.12029 · Cited by 165 · see citing works
“These cells normally provide structural, metabolic and trophic support to neurons [8, 10, 11].”
Epigenetic clock analyses of cellular senescence and ageing.
Lowe, D., Horvath, S., & Raj, K. (2016) · Oncotarget · doi:10.18632/oncotarget.7383 · Cited by 147 · see citing works
Erickson, M. A., Hartvigson, P. E., Morofuji, Y., Owen, J. B., Butterfield, D. A., & Banks, W. A. (2012) · Journal of Neuroinflammation · doi:10.1186/1742-2094-9-150 · Cited by 145 · see citing works
Sarcopenia and cachexia: the adaptations of negative regulators of skeletal muscle mass
Sakuma, K., & Yamaguchi, A. (2012) · Journal of Cachexia Sarcopenia and Muscle · doi:10.1007/s13539-011-0052-4 · Cited by 137 · see citing works
Role of inflammation in the aging bones
Abdelmagid, S. M., Barbe, M. F., & Safadi, F. F. (2015) · Life Sciences · doi:10.1016/j.lfs.2014.11.011 · Cited by 134 · see citing works
Dietary phytochemicals and neuro-inflammaging: from mechanistic insights to translational challenges
Davinelli, S., Maes, M., Corbi, G., Zarrelli, A., Willcox, D. C., & Scapagnini, G. (2016) · Immunity & Ageing · doi:10.1186/s12979-016-0070-3 · Cited by 122 · see citing works
Zhao, J., Zhang, L., Lu, A., Han, Y., Colangelo, D., Bukata, C., Scibetta, A., Yousefzadeh, M. J., Li, X., Gurkar, A. U., et al. (2020) · Aging · doi:10.18632/aging.102863 · Cited by 122 · see citing works
Dimensions of religious involvement and leukocyte telomere length
Hill, T. D., Ellison, C. G., Burdette, A. M., Taylor, J., & Friedman, K. L. (2016) · Social Science & Medicine · doi:10.1016/j.socscimed.2016.04.032 · Cited by 116 · see citing works
Shivappa, N., Stubbs, B., Hébert, J. R., Cesari, M., Schofield, P., Soysal, P., Maggi, S., & Veronese, N. (2018) · Journal of the American Medical Directors Association · doi:10.1016/j.jamda.2017.08.006 · Cited by 104 · see citing works
Self-citationMetabolic effects of resveratrol: Addressing the controversies
Bitterman, J. L., & Chung, J. H. (2015) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-014-1808-8 · Cited by 109 · see citing works
Ku, C. S., Pham, T. X., Park, Y., Kim, B., Shin, M. S., Kang, I., & Lee, J. (2013) · Biochimica et Biophysica Acta (BBA) - General Subjects · doi:10.1016/j.bbagen.2013.01.018 · Cited by 109 · see citing works
Tsukamoto, H., Senju, S., Matsumura, K., Swain, S. L., & Nishimura, Y. (2015) · Nature Communications · doi:10.1038/ncomms7702 · Cited by 104 · see citing works
Impact of Protein Intake in Older Adults with Sarcopenia and Obesity: A Gut Microbiota Perspective
Prokopidis, K., Cervo, M. M., Gandham, A., & Scott, D. (2020) · Nutrients · doi:10.3390/nu12082285 · Cited by 99 · see citing works
Larouche, E., Hudon, C., & Goulet, S. (2015) · Behavioural Brain Research · doi:10.1016/j.bbr.2014.05.058 · Cited by 93 · see citing works
Hostinar, C. E., Nusslock, R., & Miller, G. E. (2018) · Journal of Clinical Child & Adolescent Psychology · doi:10.1080/15374416.2016.1266647 · Cited by 90 · see citing works
Adjibade, M., Andreeva, V. A., Lemogne, C., Touvier, M., Shivappa, N., Hébert, J. R., Wirth, M. D., Hercberg, S., Galan, P., Julia, C., et al. (2017) · The Journal of Nutrition · doi:10.3945/jn.116.245167 · Cited by 91 · see citing works
Cesari, M., Vellas, B., & Gambassi, G. (2013) · Experimental Gerontology · doi:10.1016/j.exger.2012.10.004 · Cited by 83 · see citing works
Self-citationThe critical role of oxidative stress in sarcopenic obesity
Gonzalez, A., Simon, F., Achiardi, O., Vilos, C., Cabrera, D., & Cabello-Verrugio, C. (2021) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2021/4493817 · Cited by 79 · see citing works
Balcioglu, Y. H., & Kirlioglu, S. S. (2020) · Psychiatry Investigation · doi:10.30773/pi.2020.0185 · Cited by 80 · see citing works
The protective effect of 18β-Glycyrrhetinic acid against UV irradiation induced photoaging in mice
Kong, S.-Z., Chen, H.-M., Yu, X.-T., Zhang, X., Feng, X.-X., Kang, X.-H., Li, W.-J., Huang, N., Luo, H., & Su, Z.-R. (2015) · Experimental Gerontology · doi:10.1016/j.exger.2014.12.008 · Cited by 73 · see citing works
Sleep Deprivation and Divergent Toll-like Receptor-4 Activation of Cellular Inflammation in Aging
Carroll, J. E., Carrillo, C., Olmstead, R., Witarama, T., Breen, E. C., Yokomizo, M., Seeman, T. E., & Irwin, M. R. (2015) · Sleep · doi:10.5665/sleep.4398 · Cited by 67 · see citing works
Persistent JunB activation in fibroblasts disrupts stem cell niche interactions enforcing skin aging
Maity, P., Singh, K., Krug, L., Koroma, A., Hainzl, A., Bloch, W., Kochanek, S., Wlaschek, M., Schorpp-Kistner, M., Angel, P., et al. (2021) · Cell Reports · doi:10.1016/j.celrep.2021.109634 · Cited by 56 · see citing works
Actions of 17β-estradiol and testosterone in the mitochondria and their implications in aging
Vasconsuelo, A., Milanesi, L., & Boland, R. (2013) · Ageing Research Reviews · doi:10.1016/j.arr.2013.09.001 · Cited by 55 · see citing works
Muller, G. C., Gottlieb, M. G. V., Luz Correa, B., Filho, I. G., Moresco, R. N., & Bauer, M. E. (2015) · Cellular Immunology · doi:10.1016/j.cellimm.2015.05.006 · Cited by 55 · see citing works
Anti-Neuroinflammatory Potential of Polyphenols by Inhibiting NF-Κb to Halt Alzheimer's Disease
Uddin, M. S., Hasana, S., Ahmad, J., Hossain, M. F., Rahman, M. M., Behl, T., Rauf, A., Ahmad, A., Hafeez, A., Perveen, A., et al. (2021) · Current Pharmaceutical Design · doi:10.2174/1381612826666201118092422 · Cited by 49 · see citing works
Zampino, M., Brennan, N. A., Kuo, P.-L., Spencer, R. G., Fishbein, K. W., Simonsick, E. M., & Ferrucci, L. (2020) · GeroScience · doi:10.1007/s11357-020-00208-x · Cited by 43 · see citing works
Neuroprotective mechanisms of mangiferin in neurodegenerative diseases
Liu, T., Song, Y., & Hu, A. (2021) · Drug Development Research · doi:10.1002/ddr.21783 · Cited by 43 · see citing works
Transgenic expression of cyclooxygenase-2 (COX2) causes premature aging phenotypes in mice
Kim, J., Vaish, V., Feng, M., Field, K., Chatzistamou, I., & Shim, M. (2016) · Aging · doi:10.18632/aging.101060 · Cited by 41 · see citing works
Veronese, N., Stubbs, B., Koyanagi, A., Hébert, J. R., Cooper, C., Caruso, M. G., Guglielmi, G., Reginster, J. Y., Rizzoli, R., Maggi, S., et al. (2018) · Osteoporosis International · doi:10.1007/s00198-017-4251-5 · Cited by 36 · see citing works
Zoccarato, F., Cavallini, L., & Alexandre, A. (2009) · Journal of Bioenergetics and Biomembranes · doi:10.1007/s10863-009-9238-2 · Cited by 31 · see citing works
Jung, Y.-E., & Kang, K. Y. (2019) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2019.104397 · Cited by 29 · see citing works
Stress-induced (Premature) senescence
Debacq-Chainiaux, F., Ben Ameur, R., Bauwens, E., Dumortier, E., Toutfaire, M., & Toussaint, O. (2016) · Healthy Ageing and Longevity · doi:10.1007/978-3-319-26239-0_13 · Cited by 31 · see citing works
S-Allyl Cysteine: A Potential Compound against Skeletal Muscle Atrophy
Gupta, P., Dutt, V., Kaur, N., Kalra, P., Gupta, S., Dua, A., Dabur, R., Saini, V., & Mittal, A. (2020) · Biochimica et Biophysica Acta (BBA) - General Subjects · doi:10.1016/j.bbagen.2020.129676 · Cited by 25 · see citing works
- Authors
- Chung, H. Y., Cesari, M., Anton, S., Marzetti, E., Giovannini, S., Seo, A. Y., Carter, C., Yu, B. P., & Leeuwenburgh, C.
- Affiliations
- University of Florida (US)
- The University of Texas at San Antonio Health Science Center (US)
- Corresponding author
- Chung, Hae Young
- Leeuwenburgh, Christiaan
- ORCID
- Venue
- Ageing Research Reviews
- Publisher
- Elsevier BV
- Published
- 2009-01
- Volume
- 8
- Issue
- 1
- Pages
- 18-30
- ISSN
- 1568-1637 (ISSN-L)
- PMC
- PMC3782993
- OpenAlex
- W2005822229
- Cited by
- 1,203
- References
- 224
- Citations by year
- 2026: 34 · 2025: 41 · 2024: 71 · 2023: 66 · 2022: 70 · 2021: 87 · 2020: 98 · 2019: 80 · 2018: 75 · 2017: 76 · 2016: 86 · 2015: 85 · 2014: 62 · 2013: 76 · 2012: 59
- FWCI
- 3.84
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Ageing Research Reviews (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- American Heart Association
- University of Florida
- Pusan National University
- National Institutes of Health
- National Institute on Aging (AG17994, R01AG017994, AG-21042, R01AG021042, P30AG028740)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Aging › Genetics, Aging, and Longevity in Model Organisms
- Health Sciences › Medicine › Rehabilitation › Exercise and Physiological Responses
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Clinical Biochemistry › Advanced Glycation End Products research
- Keywords
- chronic inflammation, aging, age-related diseases, pro-inflammatory mediators, TNF-α, IL-1β, interleukin-6, cyclooxygenase-2, inducible nitric oxide synthase, redox imbalance, NF-κB signaling, caloric restriction, physical activity, healthy longevity
- MeSH terms
- Aging, Animals, Disease, Humans, Inflammation, Models, Biological, Oxidation-Reduction, Oxidative Stress, Inflammation Mediators, MAP Kinase Signaling System
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
