The DOI matches its Crossref record; 25 of the 25 references it cites were found in a registry or an index.
Clostridium difficile Infection Associated with Antineoplastic Chemotherapy: A Review
Abstract
Colitis and infection due to Clostridium difficile have been reported in patients receiving antineoplastic chemotherapy for cancer without prior antibiotic treatment. Chemotherapeutic agents can alter the normal bowel flora and cause extensive intestinal inflammatory changes, potentiating both the growth of C. difficile and its production of toxin. This review includes all 23 known reported cases of C. difficile infection associated with antineoplastic chemotherapy and examines the pathogenesis, clinical features, and management of this condition. Chemotherapy-associated C. difficile colitis has been documented in association with a variety of neoplasms. Various classes of antineoplastic agents have been incriminated, methotrexate most commonly. A spectrum of illness ranging from mild to fulminant has been reported. Symptoms, management, and outcome have appeared to be no different than for antibiotic-associated cases, but the available data are limited. Chemotherapy-associated infection with C. difficile may be underreported because it is not suspected and/or because frequent concomitant use of antibiotics masks its true incidence. C. difficile infection should be kept in mind whenever a patient undergoing antineoplastic chemotherapy develops diarrhea. Prompt, appropriate diagnostic testing and early treatment may avert morbidity and death.
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Citations
Cites
Antibiotic-associated pseudomembranous colitis due to toxin-producing clostridia
Bartlett, J. G., Chang, T. W., Gurwith, M., Gorbach, S. L., & Onderdonk, A. B. (1978) · New England Journal of Medicine · doi:10.1056/nejm197803092981003 · Cited by 1,374
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CLOSTRIDIUM DIFFICILE AND THE ÆTIOLOGY OF PSEUDOMEMBRANOUS COLITIS
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Clindamycin-Associated Colitis: A Prospective Study
TEDESCO, F. J., BARTON, R. W., & ALPERS, D. H. (1974) · Annals of Internal Medicine · doi:10.7326/0003-4819-81-4-429 · Cited by 606
Clostridium difficile: its disease and toxins
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ANTIBIOTIC-INDUCED COLITIS IMPLICATION OF A TOXIN NEUTRALISED BY CLOSTRIDIUM SORDELLII ANTITOXIN
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Randomised controlled trial of vancomycin for pseudomembranous colitis and postoperative diarrhoea.
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ACQUISITION OF CLOSTRIDIUM DIFFICILE FROM THE HOSPITAL ENVIRONMENT1
KAATZ, G. W., GITLIN, S. D., SCHABERG, D. R., WILSON, K. H., KAUFFMAN, C. A., SEO, S. M., & FEKETY, R. (1988) · American Journal of Epidemiology · doi:10.1093/oxfordjournals.aje.a114921 · Cited by 247
ORAL VANCOMYCIN FOR ANTIBIOTIC-ASSOCIATED PSEUDOMEMBRANOUS COLITIS
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Cited by
McDonald, L. C., Gerding, D. N., Johnson, S., Bakken, J. S., Carroll, K. C., Coffin, S. E., Dubberke, E. R., Garey, K. W., Gould, C. V., Kelly, C., et al. (2018) · Clinical Infectious Diseases · doi:10.1093/cid/cix1085 · Cited by 2,690
Kelly, C. R., Ihunnah, C., Fischer, M., Khoruts, A., Surawicz, C., Afzali, A., Aroniadis, O., Barto, A., Borody, T., Giovanelli, A., et al. (2014) · American Journal of Gastroenterology · doi:10.1038/ajg.2014.133 · Cited by 636
Clostridium difficile-associated diarrhea and proton pump inhibitor therapy: a meta-analysis
Janarthanan, S., Ditah, I., Adler, D. G., & Ehrinpreis, M. N. (2012) · American Journal of Gastroenterology · doi:10.1038/ajg.2012.179 · Cited by 538
Neemann, K., Eichele, D. D., Smith, P. W., Bociek, R., Akhtari, M., & Freifeld, A. (2012) · Transplant Infectious Disease · doi:10.1111/tid.12017 · Cited by 107
Metadata
- Authors
- Anand, A., & Glatt, A. E.
- Venue
- Clinical Infectious Diseases
- Publisher
- Oxford University Press (OUP)
- Published
- 1993-07-01
- Volume
- 17
- Issue
- 1
- Pages
- 109-113
- ISSN
- 1058-4838 (ISSN-L)
- 1537-6591
- OpenAlex
- W2033486769
- Cited by
- 295
- References
- 25
- FWCI
- 4.20
- Type
- journal article
- Language
- en
- Open access
- closed
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- Anand, A., & Glatt, A. E. (1993). Clostridium difficile Infection Associated with Antineoplastic Chemotherapy: A Review. Clinical Infectious Diseases. https://doi.org/10.1093/clinids/17.1.109
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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