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Clindamycin-Associated Colitis: A Prospective Study
Abstract
A prospective study of 200 consecutive patients receiving clindamycin (Cleocin HCl®*) for various reasons showed a 21% incidence of diarrhea and a 10% incidence of pseudomembranous colitis. The total dosage of clindamycin before the onset of diarrhea and the clinical syndrome associated with the diarrhea were of little help in differentiating those patients with or without pseudomembranous colitis. Pseudomembranous colitis developed most frequently after orally administered clindamycin, but was also seen with clindamycin parenterally administered. Early proctoscopic examination is necessary to diagnose colitis and is the most accurate means of detecting pseudomembranes; rectal biopsy results can confirm the diagnosis and delineate the degree of inflammation present. When the diagnosis is made soon after the onset of diarrhea, and the antibiotic is stopped, the pseudomembranous colitis seems to be self-limiting with no mortality.
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Cited by
McDonald, L. C., Gerding, D. N., Johnson, S., Bakken, J. S., Carroll, K. C., Coffin, S. E., Dubberke, E. R., Garey, K. W., Gould, C. V., Kelly, C., et al. (2018) · Clinical Infectious Diseases · doi:10.1093/cid/cix1085 · Cited by 2,690
Clostridium difficile— More Difficult Than Ever
Kelly, C. P., & LaMont, J. T. (2008) · New England Journal of Medicine · doi:10.1056/nejmra0707500 · Cited by 1,313
Shifting the balance: antibiotic effects on host–microbiota mutualism
Willing, B. P., Russell, S. L., & Finlay, B. B. (2011) · Nature Reviews Microbiology · doi:10.1038/nrmicro2536 · Cited by 747
Carey-Ann, B. D., & Carroll, K. C. (2013) · Clinical Microbiology Reviews · doi:10.1128/cmr.00016-13 · Cited by 423
Bartlett, J. G. (1994) · Clinical Infectious Diseases · doi:10.1093/clinids/18.supplement_4.s265 · Cited by 309
Metadata
- Authors
- TEDESCO, F. J., BARTON, R. W., & ALPERS, D. H.
- Venue
- Annals of Internal Medicine
- Publisher
- American College of Physicians
- Published
- 1974-10-01
- Volume
- 81
- Issue
- 4
- Pages
- 429-433
- ISSN
- 0003-4819 (ISSN-L)
- 1539-3704
- OpenAlex
- W2045373518
- Cited by
- 606
- References
- 0
- FWCI
- 77.97
- Type
- journal article
- Language
- en
- Open access
- closed
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- TEDESCO, F. J., BARTON, R. W., & ALPERS, D. H. (1974). Clindamycin-Associated Colitis: A Prospective Study. Annals of Internal Medicine. https://doi.org/10.7326/0003-4819-81-4-429
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