The DOI matches its Crossref record; 67 of the 67 references it cites were found in a registry or an index.
Vitamin A, Immunity, and Infection
Abstract
Although a role for vitamin A in immunity to infectious diseases has long been suggested, only in the last decade have epidemiological, immunologic, and molecular studies yielded substantial evidence for a central role. The recent discovery of retinoic acid and retinoid X receptors has provided a molecular basis for the action of vitamin A and its metabolites at the level of gene activation. At least a dozen clinical trials have now demonstrated that vitamin A supplementation reduces severe morbidity and mortality from infectious diseases among children who have acute measles or who are from areas in which vitamin A deficiency is endemic. Vitamin A deficiency is an immunodeficiency disorder characterized by widespread alterations in immunity, including pathological alterations in mucosal surfaces, impaired antibody responses to challenge with protein antigens, changes in lymphocyte subpopulations, and altered T- and B-cell function. Vitamin A and its metabolites are immune enhancers that have been shown to potentiate antibody responses to T cell-dependent antigens, increase lymphocyte proliferation responses to antigens and mitogens, inhibit apoptosis, and restore the integrity and function of mucosal surfaces. Vitamin A and related retinoids may have potential applications in therapy for some infectious diseases.
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Citations
Cites
The Steroid and Thyroid Hormone Receptor Superfamily
Evans, R. M. (1988) · Science · doi:10.1126/science.3283939 · Cited by 7,439
A human retinoic acid receptor which belongs to the family of nuclear receptors
Petkovich, M., Brand, N. J., Krust, A., & Chambon, P. (1987) · Nature · doi:10.1038/330444a0 · Cited by 2,214
Identification of a receptor for the morphogen retinoic acid
Giguere, V., Ong, E. S., Segui, P., & Evans, R. M. (1987) · Nature · doi:10.1038/330624a0 · Cited by 1,965 · cited 1×
“Within the nucleus, retinoic acid influences gene activation through specific receptors that belong to the superfamily of thyroid and steroid receptors [7-13].”
Background9-cis retinoic acid is a high affinity ligand for the retinoid X receptor
Heyman, R. A., Mangelsdorf, D. J., Dyck, J. A., Stein, R. B., Eichele, G., Evans, R. M., & Thaller, C. (1992) · Cell · doi:10.1016/0092-8674(92)90479-v · Cited by 1,780 · cited 2×
“In developing countries, case-fatality rates of 10%-20% are not uncommon, and the consequences of a measles episode may include diarrhea, pneumonia, encephalitis, blindness, and delayed morbidity and mortality [ 1 11-113].”
BackgroundKliewer, S. A., Umesono, K., Mangelsdorf, D. J., & Evans, R. M. (1992) · Nature · doi:10.1038/355446a0 · Cited by 1,489
Nuclear receptor that identifies a novel retinoic acid response pathway
Mangelsdorf, D. J., Ong, E. S., Dyck, J. A., & Evans, R. M. (1990) · Nature · doi:10.1038/345224a0 · Cited by 1,488
Schwartz, R. H. (1992) · Cell · doi:10.1016/s0092-8674(05)80055-8 · Cited by 1,293
9-Cis retinoic acid stereoisomer binds and activates the nuclear receptor RXRα
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Identification of a second human retinoic acid receptor
Brand, N., Petkovich, M., Krust, A., Chambon, P., de Thé, H., Marchio, A., Tiollais, P., & Dejean, A. (1988) · Nature · doi:10.1038/332850a0 · Cited by 1,022
Cited by
Iddir, M., Brito, A., Dingeo, G., Fernandez Del Campo, S. S., Samouda, H., La Frano, M. R., & Bohn, T. (2020) · Nutrients · doi:10.3390/nu12061562 · Cited by 786
Role of Vitamin A in the Immune System
Huang, Z., Liu, Y., Qi, G., Brand, D., & Zheng, S. (2018) · Journal of Clinical Medicine · doi:10.3390/jcm7090258 · Cited by 597
Human health implications of environmental contaminants in Arctic Canada: a review
Van Oostdam, J., Gilman, A., Dewailly, E., Usher, P., Wheatley, B., Kuhnlein, H., Neve, S., Walker, J., Tracy, B., Feeley, M., et al. (1999) · Science of The Total Environment · doi:10.1016/s0048-9697(99)00036-4 · Cited by 502
West, K. P., Katz, J., Khatry, S. K., LeClerq, S. C., Pradhan, E. K., Shrestha, S. R., Connor, P. B., Dali, S. M., Christian, P., Pokhrel, R. P., et al. (1999) · BMJ · doi:10.1136/bmj.318.7183.570 · Cited by 485
Biomarkers of Nutrition for Development (BOND)-Vitamin A Review
Tanumihardjo, S. A., Russell, R. M., Stephensen, C. B., Gannon, B. M., Craft, N. E., Haskell, M. J., Lietz, G., Schulze, K., & Raiten, D. J. (2016) · The Journal of Nutrition · doi:10.3945/jn.115.229708 · Cited by 451
Metadata
- Authors
- Semba, R. D.
- Venue
- Clinical Infectious Diseases
- Publisher
- Oxford University Press (OUP)
- Published
- 1994-09-01
- Volume
- 19
- Issue
- 3
- Pages
- 489-499
- ISSN
- 1058-4838 (ISSN-L)
- 1537-6591
- OpenAlex
- W1999352792
- Cited by
- 297
- References
- 67
- FWCI
- 6.01
- Type
- journal article
- Language
- en
- Open access
- closed
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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