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Household Contact Study of Bordetella pertussis Infections
Abstract
Household contacts of primary pertussis cases were evaluated. Infection was determined by culture, direct fluorescent antibody assay, and serological criteria. Agglutinin titers and values of ELISA IgG and IgA antibodies to lymphocytosis-promoting factor, filamentous hemagglutinin, and pertactin were determined. In 39 households 255 subjects were exposed; 114 remained well (group 1), 53 had mild illness (group 2), and 88 had pertussis (group 3). The infection rates were 46% (group 1), 43% (group 2), and 80% (group 3). In a subgroup of subjects seen within 14-28 days of exposure, it was found that none with clinical pertussis had a value of IgG antibody to pertactin in acute-phase sera of > or = 50 ELISA units (EU) per mL or an agglutinin titer of > 256. Of the primary cases, 53% were > or = 13 years of age. These data point out the importance of Bordetella pertussis infections in adolescents and adults as a source of infection in young children. Our subgroup data suggest that high values of antibody to pertactin and high agglutinin titers may be predictive of protection against clinical pertussis.
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Citations
Cited by
Warfel, J. M., Zimmerman, L. I., & Merkel, T. J. (2014) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1314688110 · Cited by 644
A search for serologic correlates of immunity to Bordetella pertussis cough illnesses
Cherry, J. D., Gornbein, J., Heininger, U., & Stehr, K. (1998) · Vaccine · doi:10.1016/s0264-410x(98)00226-6 · Cited by 434
Self-citationPertussis: Microbiology, Disease, Treatment, and Prevention
Kilgore, P. E., Salim, A. M., Zervos, M. J., & Schmitt, H.-J. (2016) · Clinical Microbiology Reviews · doi:10.1128/cmr.00083-15 · Cited by 434
Morbidity of Pertussis in Adolescents and Adults
De Serres, G., Shadmani, R., Duval, B., Boulianne, N., Déry, P., Douville Fradet, M., Rochette, L., & Halperin, S. A. (2000) · The Journal of Infectious Diseases · doi:10.1086/315648 · Cited by 344
Metadata
- Authors
- Deen, J. L., Mink, C. M., Cherry, J. D., Christenson, P. D., Pineda, E. F., Lewis, K., Blumberg, D. A., & Ross, L. A.
- Venue
- Clinical Infectious Diseases
- Publisher
- Oxford University Press (OUP)
- Published
- 1995-11-01
- Volume
- 21
- Issue
- 5
- Pages
- 1211-1219
- ISSN
- 1058-4838 (ISSN-L)
- 1537-6591
- OpenAlex
- W2149991696
- Cited by
- 189
- References
- 0
- FWCI
- 3.81
- Type
- journal article
- Language
- en
- Open access
- closed
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- Deen, J. L., Mink, C. M., Cherry, J. D., Christenson, P. D., Pineda, E. F., Lewis, K., Blumberg, D. A., & Ross, L. A. (1995). Household Contact Study of Bordetella pertussis Infections. Clinical Infectious Diseases. https://doi.org/10.1093/clinids/21.5.1211
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