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Cited by 405

The DOI matches its Crossref record; 9 of the 9 references it cites were found in a registry or an index.

Multidrug-Resistant Salmonella typhi: A Worldwide Epidemic

Open access
Rowe, Bernard, Ward, Linda R., Threlfall, E. John·1997·Clinical Infectious Diseases
DOI 10.1093/clinids/24.supplement_1.s106
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Abstract

Since 1989, strains of Salmonella typhi resistant to chloramphenicol, ampicillin, and trimethoprim (i.e., multidrug-resistant [MDR] strains) have been responsible for numerous outbreaks in countries in the Indian subcontinent, Southeast Asia, and Africa. MDR strains have also been isolated with increasing frequency from immigrant workers in countries in the Arabian Gulf, as well as in developed countries from returning travelers. In all MDR strains so far examined, multiple resistance has been encoded by plasmids of the H1 incompatibility group. As a result of the widespread dissemination of such strains, chloramphenicol can no longer be regarded as the first-line drug for typhoid fever. Because strains are also resistant to ampicillin and trimethoprim, the efficacy of these antibiotics has also been impaired, and ciprofloxacin is now the drug of choice for typhoid fever. Chromosomally encoded resistance to ciprofloxacin has now been observed in a small number of strains isolated in the United Kingdom from patients returning from the Indian subcontinent, and in at least one case the patient did not respond to treatment with this antibiotic. It is regrettable that resistance to ciprofloxacin has now emerged in MDR S. typhi, and it is of paramount importance to limit the unnecessary use of this vital drug so that its efficacy should not be further jeopardized.

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Crossref · 10.1093/clinids/24.supplement_1.s106

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Metadata

Authors
Rowe, B., Ward, L. R., & Threlfall, E. J.
Venue
Clinical Infectious Diseases
Publisher
Oxford University Press (OUP)
Published
1997-01-01
Volume
24
Issue
Supplement_1
Pages
S106-S109
ISSN
  • 1058-4838 (ISSN-L)
  • 1537-6591
DOI
10.1093/clinids/24.supplement_1.s106
OpenAlex
W2080528409
Cited by
405
References
9
FWCI
32.06
Type
journal article
Language
en
Open access
bronze

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CoChat. (2026). Citation check: Multidrug-Resistant Salmonella typhi: A Worldwide Epidemic. https://app.cochat.ai/papers/10.1093/clinids/24.supplement_1.s106
The paper
Rowe, B., Ward, L. R., & Threlfall, E. J. (1997). Multidrug-Resistant Salmonella typhi: A Worldwide Epidemic. Clinical Infectious Diseases. https://doi.org/10.1093/clinids/24.supplement_1.s106

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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.