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Cited by 1,156

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Epidemiology, Clinical Presentation, Laboratory Diagnosis, Antimicrobial Resistance, and Antimicrobial Management of Invasive Salmonella Infections

Open access
Crump, John A., Sjölund-Karlsson, Maria, Gordon, Melita A., Parry, Christopher M.·2015·Clinical Microbiology Reviews

Abstract

SUMMARY: Salmonella enterica infections are common causes of bloodstream infection in low-resource areas, where they may be difficult to distinguish from other febrile illnesses and may be associated with a high case fatality ratio. Microbiologic culture of blood or bone marrow remains the mainstay of laboratory diagnosis. Antimicrobial resistance has emerged in Salmonella enterica, initially to the traditional first-line drugs chloramphenicol, ampicillin, and trimethoprim-sulfamethoxazole. Decreased fluoroquinolone susceptibility and then fluoroquinolone resistance have developed in association with chromosomal mutations in the quinolone resistance-determining region of genes encoding DNA gyrase and topoisomerase IV and also by plasmid-mediated resistance mechanisms. Resistance to extended-spectrum cephalosporins has occurred more often in nontyphoidal than in typhoidal Salmonella strains. Azithromycin is effective for the management of uncomplicated typhoid fever and may serve as an alternative oral drug in areas where fluoroquinolone resistance is common. In 2013, CLSI lowered the ciprofloxacin susceptibility breakpoints to account for accumulating clinical, microbiologic, and pharmacokinetic-pharmacodynamic data suggesting that revision was needed for contemporary invasive Salmonella infections. Newly established CLSI guidelines for azithromycin and Salmonella enterica serovar Typhi were published in CLSI document M100 in 2015.

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Crossref · 10.1128/cmr.00002-15

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Metadata

Authors
Crump, J. A., Sjölund-Karlsson, M., Gordon, M. A., & Parry, C. M.
Venue
Clinical Microbiology Reviews
Published
2015-10
Volume
28
Issue
4
Pages
901-937
ISSN
  • 0893-8512 (ISSN-L)
  • 1098-6618
OpenAlex
W2158084007
Cited by
1,156
References
17
FWCI
74.43
Type
journal article
Language
en
Open access
bronze

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CoChat. (2026). Citation check: Epidemiology, Clinical Presentation, Laboratory Diagnosis, Antimicrobial Resistance, and Antimicrobial Management of Invasive Salmonella Infections. https://app.cochat.ai/papers/10.1128/cmr.00002-15
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Crump, J. A., Sjölund-Karlsson, M., Gordon, M. A., & Parry, C. M. (2015). Epidemiology, Clinical Presentation, Laboratory Diagnosis, Antimicrobial Resistance, and Antimicrobial Management of Invasive Salmonella Infections. Clinical Microbiology Reviews. https://doi.org/10.1128/cmr.00002-15

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