The DOI matches its Crossref record; 87 of the 87 references it cites were found in a registry or an index.
Early atherosclerosis in humans: role of diffuse intimal thickening and extracellular matrix proteoglycans
Abstract
This review attempts to define the early events that lead to lesions of human atherosclerosis based on careful morphological studies in human autopsy specimens. In contrast to most small laboratory animals, diffuse intimal thickening (DIT) is present in human arteries before atherosclerosis develops, particularly in the atherosclerosis-prone arteries such as coronary arteries and abdominal aorta. In the earliest stage of atherosclerosis, lipids deposit eccentrically in the deep layer of DIT to form Type I lesions. These layers are enriched in extracellular matrix (ECM) proteoglycans such as biglycan. Following lipid deposition, macrophages appear in these regions and foam cells are observed (Type II lesions). Such observations support the 'response-to-retention' hypothesis that states that a principle early event in the pathogenesis of human atherosclerosis is the trapping and retention of lipoproteins by ECM proteoglycans followed by infiltration and accumulation of macrophages.
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Cites
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Self-citationIntraplaque Hemorrhage and Progression of Coronary Atheroma
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The Response-to-Retention Hypothesis of Early Atherogenesis
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Subendothelial retention of atherogenic lipoproteins in early atherosclerosis
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Cited by
Borén, J., Chapman, M. J., Krauss, R. M., Packard, C. J., Bentzon, J. F., Binder, C. J., Daemen, M. J., Demer, L. L., Hegele, R. A., Nicholls, S. J., et al. (2020) · European Heart Journal · doi:10.1093/eurheartj/ehz962 · Cited by 1,601
Vascular smooth muscle cells in atherosclerosis
Basatemur, G. L., Jørgensen, H. F., Clarke, M. C. H., Bennett, M. R., & Mallat, Z. (2019) · Nature Reviews Cardiology · doi:10.1038/s41569-019-0227-9 · Cited by 1,099
Allahverdian, S., Chehroudi, A. C., McManus, B. M., Abraham, T., & Francis, G. A. (2014) · Circulation · doi:10.1161/circulationaha.113.005015 · Cited by 748
Pathophysiology of native coronary, vein graft, and in-stent atherosclerosis
Yahagi, K., Kolodgie, F. D., Otsuka, F., Finn, A. V., Davis, H. R., Joner, M., & Virmani, R. (2016) · Nature Reviews Cardiology · doi:10.1038/nrcardio.2015.164 · Cited by 548
Borén, J., & Williams, K. J. (2016) · Current Opinion in Lipidology · doi:10.1097/mol.0000000000000330 · Cited by 524
Metadata
- Authors
- Nakashima, Y., Wight, T. N., & Sueishi, K.
- Venue
- Cardiovascular Research
- Publisher
- Oxford University Press (OUP)
- Published
- 2008-03-18
- Volume
- 79
- Issue
- 1
- Pages
- 14-23
- ISSN
- 0008-6363 (ISSN-L)
- OpenAlex
- W2150750426
- Cited by
- 299
- References
- 87
- FWCI
- 5.09
- Type
- journal article
- Language
- en
- Open access
- closed
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- Nakashima, Y., Wight, T. N., & Sueishi, K. (2008). Early atherosclerosis in humans: role of diffuse intimal thickening and extracellular matrix proteoglycans. Cardiovascular Research. https://doi.org/10.1093/cvr/cvn099
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
