The DOI matches its Crossref record; 93 of the 93 references it cites were found in a registry or an index.
Therapeutic strategies targeting the endothelial glycocalyx: acute deficits, but great potential
Abstract
Damage of the endothelial glycocalyx, which ranges from 200 to 2000 nm in thickness, decreases vascular barrier function and leads to protein extravasation and tissue oedema, loss of nutritional blood flow, and an increase in platelet and leucocyte adhesion. Thus, its protection or the restoration of an already damaged glycocalyx seems to be a promising therapeutic target both in an acute critical care setting and in the treatment of chronic vascular disease. Drugs that can specifically increase the synthesis of glycocalyx components, refurbish it, or selectively prevent its enzymatic degradation do not seem to be available. Pharmacological blockers of radical production may be useful to diminish the oxygen radical stress on the glycocalyx. Tenable options are the application of hydrocortisone (inhibiting mast-cell degranulation), use of antithrombin III (lowering susceptibility to enzymatic attack), direct inhibition of the cytokine tumour necrosis factor-alpha, and avoidance of the liberation of natriuretic peptides (as in volume loading and heart surgery). Infusion of human plasma albumin (to maintain mechanical and chemical stability of the endothelial surface layer) seems the easiest treatment to implement.
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1 retracted
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Cited by
Vascular Endothelial Cell Biology: An Update
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Vascular endothelium – Gatekeeper of vessel health
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The endothelial glycocalyx: a review of the vascular barrier
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Derangement of the endothelial glycocalyx in sepsis
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Foote, C. A., Soares, R. N., Ramirez‐Perez, F. I., Ghiarone, T., Aroor, A., Manrique‐Acevedo, C., Padilla, J., & Martinez‐Lemus, L. (2022) · Comprehensive Physiology · doi:10.1002/j.2040-4603.2022.tb00232.x · Cited by 89
Metadata
- Authors
- Becker, B. F., Chappell, D., Bruegger, D., Annecke, T., & Jacob, M.
- Venue
- Cardiovascular Research
- Publisher
- Oxford University Press (OUP)
- Published
- 2010-05-11
- Volume
- 87
- Issue
- 2
- Pages
- 300-310
- ISSN
- 0008-6363 (ISSN-L)
- OpenAlex
- W2064970256
- Cited by
- 438
- References
- 93
- FWCI
- 9.75
- Type
- journal article
- Language
- en
- Open access
- closed
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- Becker, B. F., Chappell, D., Bruegger, D., Annecke, T., & Jacob, M. (2010). Therapeutic strategies targeting the endothelial glycocalyx: acute deficits, but great potential. Cardiovascular Research. https://doi.org/10.1093/cvr/cvq137
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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