The DOI matches its Crossref record; 12 of the 12 references it cites were found in a registry or an index.
ESC Working Group Cellular Biology of the Heart: Position Paper: improving the preclinical assessment of novel cardioprotective therapies
Open accessAbstract
Ischaemic heart disease (IHD) remains the leading cause of death and disability worldwide. As a result, novel therapies are still needed to protect the heart from the detrimental effects of acute ischaemia-reperfusion injury, in order to improve clinical outcomes in IHD patients. In this regard, although a large number of novel cardioprotective therapies discovered in the research laboratory have been investigated in the clinical setting, only a few of these have been demonstrated to improve clinical outcomes. One potential reason for this lack of success may have been the failure to thoroughly assess the cardioprotective efficacy of these novel therapies in suitably designed preclinical experimental animal models. Therefore, the aim of this Position Paper by the European Society of Cardiology Working Group Cellular Biology of the Heart is to provide recommendations for improving the preclinical assessment of novel cardioprotective therapies discovered in the research laboratory, with the aim of increasing the likelihood of success in translating these new treatments into improved clinical outcomes.
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Citations
Cites
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“underpowered.(18) It cannot be assumed that studies in the cardioprotection field would fare much better.”
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Myocardial Protection at a Crossroads: The Need for Translation Into Clinical Therapy
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Cited by
Myocardial ischaemia–reperfusion injury and cardioprotection in perspective
Heusch, G. (2020) · Nature Reviews Cardiology · doi:10.1038/s41569-020-0403-y · Cited by 1,234
Self-citationKalogeris, T., Baines, C. P., Krenz, M., & Korthuis, R. J. (2016) · Comprehensive Physiology · doi:10.1002/cphy.c160006 · Cited by 718
Heusch, G., & Gersh, B. J. (2016) · European Heart Journal · doi:10.1093/eurheartj/ehw224 · Cited by 676
Self-citationIschaemic conditioning and reperfusion injury
Hausenloy, D. J., & Yellon, D. M. (2016) · Nature Reviews Cardiology · doi:10.1038/nrcardio.2016.5 · Cited by 579
Self-citationvan Hout, G. P. J., Bosch, L., Ellenbroek, G. H. J. M., de Haan, J. J., van Solinge, W. W., Cooper, M. A., Arslan, F., de Jager, S. C. A., Robertson, A. A. B., Pasterkamp, G., et al. (2016) · European Heart Journal · doi:10.1093/eurheartj/ehw247 · Cited by 331
Metadata
- Authors
- Lecour, S., Botker, H. E., Condorelli, G., Davidson, S. M., Garcia-Dorado, D., Engel, F. B., Ferdinandy, P., Heusch, G., Madonna, R., Ovize, M., Ruiz-Meana, M., Schulz, R., Sluijter, J. P. G., Van Laake, L. W., Yellon, D. M., & Hausenloy, D. J.
- Venue
- Cardiovascular Research
- Publisher
- Oxford University Press (OUP)
- Published
- 2014-10-24
- Volume
- 104
- Issue
- 3
- Pages
- 399-411
- ISSN
- 0008-6363 (ISSN-L)
- OpenAlex
- W2137442910
- Cited by
- 164
- References
- 12
- FWCI
- 14.18
- Type
- journal article
- Language
- en
- Open access
- hybrid
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- CoChat. (2026). Citation check: ESC Working Group Cellular Biology of the Heart: Position Paper: improving the preclinical assessment of novel cardioprotective therapies. https://app.cochat.ai/papers/10.1093/cvr/cvu225
- The paper
- Lecour, S., Botker, H. E., Condorelli, G., Davidson, S. M., Garcia-Dorado, D., Engel, F. B., Ferdinandy, P., Heusch, G., Madonna, R., Ovize, M., Ruiz-Meana, M., Schulz, R., Sluijter, J. P. G., Van Laake, L. W., Yellon, D. M., & Hausenloy, D. J. (2014). ESC Working Group Cellular Biology of the Heart: Position Paper: improving the preclinical assessment of novel cardioprotective therapies. Cardiovascular Research. https://doi.org/10.1093/cvr/cvu225
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