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Cited by 507

The DOI matches its Crossref record; 131 of the 131 references it cites were found in a registry or an index.

Smooth muscle cell fate and plasticity in atherosclerosis

Open access
Allahverdian, Sima, Chaabane, Chiraz, Boukais, Kamel, Francis, Gordon A, Bochaton-Piallat, Marie-Luce·2018·Cardiovascular Research

Abstract

Current knowledge suggests that intimal smooth muscle cells (SMCs) in native atherosclerotic plaque derive mainly from the medial arterial layer. During this process, SMCs undergo complex structural and functional changes giving rise to a broad spectrum of phenotypes. Classically, intimal SMCs are described as dedifferentiated/synthetic SMCs, a phenotype characterized by reduced expression of contractile proteins. Intimal SMCs are considered to have a beneficial role by contributing to the fibrous cap and thereby stabilizing atherosclerotic plaque. However, intimal SMCs can lose their properties to such an extent that they become hard to identify, contribute significantly to the foam cell population, and acquire inflammatory-like cell features. This review highlights mechanisms of SMC plasticity in different stages of native atherosclerotic plaque formation, their potential for monoclonal or oligoclonal expansion, as well as recent findings demonstrating the underestimated deleterious role of SMCs in this disease.

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Crossref · 10.1093/cvr/cvy022

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Metadata

Authors
Allahverdian, S., Chaabane, C., Boukais, K., Francis, G. A., & Bochaton-Piallat, M.-L.
Venue
Cardiovascular Research
Published
2018-01-27
Volume
114
Issue
4
Pages
540-550
ISSN
  • 0008-6363 (ISSN-L)
  • 1755-3245
OpenAlex
W2791004319
Cited by
507
References
131
FWCI
14.83
Type
journal article
Language
en
Open access
bronze

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CoChat. (2026). Citation check: Smooth muscle cell fate and plasticity in atherosclerosis. https://app.cochat.ai/papers/10.1093/cvr/cvy022
The paper
Allahverdian, S., Chaabane, C., Boukais, K., Francis, G. A., & Bochaton-Piallat, M.-L. (2018). Smooth muscle cell fate and plasticity in atherosclerosis. Cardiovascular Research. https://doi.org/10.1093/cvr/cvy022

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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.