Non-coding RNAs in vascular disease – from basic science to clinical applications: scientific update from the Working Group of Myocardial Function of the European Society of Cardiology
Open accessAbstract
Non-coding RNAs are increasingly recognized not only as regulators of various biological functions but also as targets for a new generation of RNA therapeutics and biomarkers. We hereby review recent insights relating to non-coding RNAs including microRNAs (e.g. miR-126, miR-146a), long non-coding RNAs (e.g. MIR503HG, GATA6-AS, SMILR), and circular RNAs (e.g. cZNF292) and their role in vascular diseases. This includes identification and therapeutic use of hypoxia-regulated non-coding RNAs and endogenous non-coding RNAs that regulate intrinsic smooth muscle cell signalling, age-related non-coding RNAs, and non-coding RNAs involved in the regulation of mitochondrial biology and metabolic control. Finally, we discuss non-coding RNA species with biomarker potential.This article is part of the Mini Review Series from the Varenna 2017 meeting of the Working Group of Myocardial Function of the European Society of Cardiology.
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Non-coding RNAs also control VSMC plasticity, evidenced by the effect of specific miRNAs and long non-coding RNAs on VSMC biology and function.
“Non-coding RNAs also control VSMC plasticity 235,236 evidenced by the effect of specific miRNAs and long non-coding RNAs on VSMC biology and function 237,238 .”
From Vascular smooth muscle cells in atherosclerosis (2019) · cites this paper as [236]
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Flagged first, then by citations
- Authors
- Fiedler, J., Baker, A. H., Dimmeler, S., Heymans, S., Mayr, M., & Thum, T.
- Affiliations
- Medizinische Hochschule Hannover (DE)
- The Queen's Medical Research Institute (GB)
- Goethe University Frankfurt (DE)
- Maastricht University Medical Centre (NL)
- King's College London (GB)
- Corresponding author
- Thum, Thomas
- Venue
- Cardiovascular Research
- Publisher
- Oxford University Press (OUP)
- Published
- 2018-05-23
- Volume
- 114
- Issue
- 10
- Pages
- 1281-1286
- ISSN
- 0008-6363 (ISSN-L)
- 1755-3245
- PMC
- PMC6054241
- OpenAlex
- W2803165459
- Cited by
- 40
- References
- 41
- Citations by year
- 2025: 1 · 2024: 3 · 2023: 8 · 2022: 8 · 2021: 7 · 2020: 9 · 2019: 2 · 2018: 2
- FWCI
- 0.52
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Cardiovascular Research (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Research Publications (Maastricht University) (publishedVersion, other-oa)
- Lirias (KU Leuven) (submittedVersion)
- Edinburgh Research Explorer (University of Edinburgh) (submittedVersion, other-oa)
- Research Publications (Maastricht University) (submittedVersion, other-oa)
- Funders
- German Ministry for Education and Research (01EO1302)
- Leducq Fondation
- MIRVAD
- British Heart Foundation Chair of Translational Cardiovascular Sciences
- European Research Council Advanced
- VASCMIR
- British Heart Foundation
- BHF (CH/16/3/32406, RG/16/14/32397)
- National Institute of Health Research
- NIHR
- Biomedical Research Centre based at Guy’s and St Thomas’
- NHS Foundation Trust and King’s College London
- King’s College Hospital
- Competence Centers for Excellent Technologies
- Austrian Research Promotion Agency
- Research Center of Excellence (843536)
- BMVIT
- Federal Ministry for Transport, Innovation and Technology
- BMWFW
- Ministry of Science, Research and Economy
- Wirtschaftsagentur Wien
- Standortagentur Tirol
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › MicroRNA in disease regulation
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Cancer-related molecular mechanisms research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Circular RNAs in diseases
- Keywords
- non-coding RNA, vascular disease, microRNA, long non-coding RNA, circular RNA, miR-126, miR-146a, mitochondrial biology, metabolic regulation, biomarkers, RNA therapeutics
- MeSH terms
- Circulating MicroRNA, RNA, Circular, Age Factors, Animals, Blood Vessels, Energy Metabolism, Gene Expression Regulation, Genetic Markers, Humans, Prognosis, Risk Factors, RNA, Vascular Diseases, Signal Transduction, Cell Hypoxia, RNA, Untranslated, Cellular Microenvironment, RNA, Long Noncoding
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