DDRprot: a database of DNA damage response-related proteins
Open accessAbstract
The DNA Damage Response (DDR) signalling network is an essential system that protects the genome's integrity. The DDRprot database presented here is a resource that integrates manually curated information on the human DDR network and its sub-pathways. For each particular DDR protein, we present detailed information about its function. If involved in post-translational modifications (PTMs) with each other, we depict the position of the modified residue/s in the three-dimensional structures, when resolved structures are available for the proteins. All this information is linked to the original publication from where it was obtained. Phylogenetic information is also shown, including time of emergence and conservation across 47 selected species, family trees and sequence alignments of homologues. The DDRprot database can be queried by different criteria: pathways, species, evolutionary age or involvement in (PTM). Sequence searches using hidden Markov models can be also used.Database URL: http://ddr.cbbio.es.
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Activated ATR phosphorylates downstream mediators including Chk1, AKAP12, MK2, p53, ATRIP, and XPA.
“Activated ATR kinase phosphorylates many downstream mediators/effectors which include checkpoint kinase 1 (Chk1), A-kinase-anchoring protein 12 (AKAP12), p38/mitogen-activated protein kinase-activated protein (MAPKAP) kinase 2 (MK2), the tumor suppressor protein p53, ATRIP and XPA 27, 31–33.”
From Xeroderma Pigmentosa Group A (XPA), Nucleotide Excision Repair and Regulation by ATR in Response to Ultraviolet Irradiation (2017) · cites this paper as [32]
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Lukas, J., Lukas, C., & Bartek, J. (2011) · Nature Cell Biology · doi:10.1038/ncb2344 · Cited by 645 · see citing works
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Musich, P. R., Li, Z., & Zou, Y. (2017) · Advances in Experimental Medicine and Biology · doi:10.1007/978-3-319-56017-5_4 · Cited by 23 · see citing works
- Authors
- Andrés-León, E., Cases, I., Arcas, A., & Rojas, A. M.
- Affiliations
- Instituto de Biomedicina de Sevilla (ES)
- Corresponding author
- Rojas, Ana M.
- Venue
- Database
- Publisher
- Oxford University Press (OUP)
- Published
- 2016
- Volume
- 2016
- Pages
- baw123
- ISSN
- 1758-0463 (ISSN-L)
- PMC
- PMC5004197
- OpenAlex
- W2514094657
- Cited by
- 12
- References
- 1
- Citations by year
- 2025: 1 · 2023: 2 · 2021: 3 · 2020: 2 · 2019: 1 · 2017: 3
- FWCI
- 0.69
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- cc-by
- Locations
- Database (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- RISalud Institutional Health Repository of Andalucía (submittedVersion, cc-by)
- DIGITAL.CSIC (Spanish National Research Council (CSIC)) (submittedVersion, cc-by)
- HighWire Press Open Archive (submittedVersion)
- Funders
- European Commission (FP7-REGPOT-2012-2013-1)
- Ministerio de Ciencia e Innovación
- FP7 Research Potential of Convergence Regions (REGPOT-2012-2013-1)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › DNA Repair Mechanisms
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Genomics and Phylogenetic Studies
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Protein Structure and Dynamics
- Keywords
- DNA damage response, protein databases, post-translational modification, protein-protein interaction network, phylogenetic analysis, protein annotation, genome stability, hidden Markov models, sequence homology search
- MeSH terms
- Protein Domains, Animals, DNA Damage, Humans, Phylogeny, Species Specificity, Databases, Protein
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