More than just a focus: The chromatin response to DNA damage and its role in genome integrity maintenance

Glioma stem cells promote radioresistance by preferential activation of the DNA damage response

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DNA double-stranded breaks induce histone H2AX phosphorylation on serine 139

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The DNA Damage Response: Making It Safe to Play with Knives

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Inhibition of Poly(ADP-Ribose) Polymerase in Tumors from <i>BRCA</i> Mutation Carriers

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ATM and ATR Substrate Analysis Reveals Extensive Protein Networks Responsive to DNA Damage

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53BP1 Inhibits Homologous Recombination in Brca1-Deficient Cells by Blocking Resection of DNA Breaks

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A guide to super-resolution fluorescence microscopy

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Dynamics of DNA damage response proteins at DNA breaks: a focus on protein modifications

Polo, S. E., & Jackson, S. P. (2011) · Genes &amp; Development · doi:10.1101/gad.2021311 · Cited by 1,092 · see citing works

53BP1 loss rescues BRCA1 deficiency and is associated with triple-negative and BRCA-mutated breast cancers

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Structural Basis for the Methylation State-Specific Recognition of Histone H4-K20 by 53BP1 and Crb2 in DNA Repair

Botuyan, M. V., Lee, J., Ward, I. M., Kim, J., Thompson, J. R., Chen, J., & Mer, G. (2006) · Cell · doi:10.1016/j.cell.2006.10.043 · Cited by 973 · see citing works

Systematic Protein Location Mapping Reveals Five Principal Chromatin Types in Drosophila Cells

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RNF168 Binds and Amplifies Ubiquitin Conjugates on Damaged Chromosomes to Allow Accumulation of Repair Proteins

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Methylated lysine 79 of histone H3 targets 53BP1 to DNA double-strand breaks

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The PARP Side of the Nucleus: Molecular Actions, Physiological Outcomes, and Clinical Targets

Krishnakumar, R., & Kraus, W. L. (2010) · Molecular Cell · doi:10.1016/j.molcel.2010.06.017 · Cited by 836 · see citing works

The RIDDLE Syndrome Protein Mediates a Ubiquitin-Dependent Signaling Cascade at Sites of DNA Damage

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ATM-Dependent Chromatin Changes Silence Transcription In cis to DNA Double-Strand Breaks

Shanbhag, N. M., Rafalska-Metcalf, I. U., Balane-Bolivar, C., Janicki, S. M., & Greenberg, R. A. (2010) · Cell · doi:10.1016/j.cell.2010.04.038 · Cited by 737 · see citing works

Chromatin Challenges during DNA Replication and Repair

Groth, A., Rocha, W., Verreault, A., & Almouzni, G. (2007) · Cell · doi:10.1016/j.cell.2007.01.030 · Cited by 733 · see citing works

53BP1 nuclear bodies form around DNA lesions generated by mitotic transmission of chromosomes under replication stress

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Human HDAC1 and HDAC2 function in the DNA-damage response to promote DNA nonhomologous end-joining

Miller, K. M., Tjeertes, J. V., Coates, J., Legube, G., Polo, S. E., Britton, S., & Jackson, S. P. (2010) · Nature Structural &amp; Molecular Biology · doi:10.1038/nsmb.1899 · Cited by 629 · see citing works

Replication stress induces sister-chromatid bridging at fragile site loci in mitosis

Chan, K., Palmai‐Pallag, T., Ying, S., & Hickson, I. D. (2009) · Nature Cell Biology · doi:10.1038/ncb1882 · Cited by 614 · see citing works

Poly(ADP-ribose)–Dependent Regulation of DNA Repair by the Chromatin Remodeling Enzyme ALC1

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CtIP-BRCA1 modulates the choice of DNA double-strand-break repair pathway throughout the cell cycle

Yun, M. H., & Hiom, K. (2009) · Nature · doi:10.1038/nature07955 · Cited by 556 · see citing works

Tyrosine dephosphorylation of H2AX modulates apoptosis and survival decisions

Cook, P. J., Ju, B. G., Telese, F., Wang, X., Glass, C. K., & Rosenfeld, M. G. (2009) · Nature · doi:10.1038/nature07849 · Cited by 534 · see citing works

A chromatin localization screen reveals poly (ADP ribose)-regulated recruitment of the repressive polycomb and NuRD complexes to sites of DNA damage

Chou, D. M., Adamson, B., Dephoure, N. E., Tan, X., Nottke, A. C., Hurov, K. E., Gygi, S. P., Colaiácovo, M. P., & Elledge, S. J. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1012946107 · Cited by 529 · see citing works

Mammalian SUMO E3-ligases PIAS1 and PIAS4 promote responses to DNA double-strand breaks

Galanty, Y., Belotserkovskaya, R., Coates, J., Polo, S. E., Miller, K. M., & Jackson, S. P. (2009) · Nature · doi:10.1038/nature08657 · Cited by 523 · see citing works

Double-Strand Breaks in Heterochromatin Move Outside of a Dynamic HP1a Domain to Complete Recombinational Repair

Chiolo, I., Minoda, A., Colmenares, S. U., Polyzos, A. A., Costes, S. V., & Karpen, G. H. (2011) · Cell · doi:10.1016/j.cell.2011.02.012 · Cited by 516 · see citing works

High‐resolution profiling of γH2AX around DNA double strand breaks in the mammalian genome

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Positional stability of single double-strand breaks in mammalian cells

Soutoglou, E., Dorn, J. F., Sengupta, K., Jasin, M., Nussenzweig, A., Ried, T., Danuser, G., & Misteli, T. (2007) · Nature Cell Biology · doi:10.1038/ncb1591 · Cited by 515 · see citing works

Roles of ATM and NBS1 in chromatin structure modulation and DNA double-strand break repair

Berkovich, E., Monnat, R. J., & Kastan, M. B. (2007) · Nature Cell Biology · doi:10.1038/ncb1599 · Cited by 477 · see citing works

Histone H3 methylation links DNA damage detection to activation of the tumour suppressor Tip60

Sun, Y., Jiang, X., Xu, Y., Ayrapetov, M. K., Moreau, L. A., Whetstine, J. R., & Price, B. D. (2009) · Nature Cell Biology · doi:10.1038/ncb1982 · Cited by 454 · see citing works

Histone H2B ubiquitylation disrupts local and higher-order chromatin compaction

Fierz, B., Chatterjee, C., McGinty, R. K., Bar‐Dagan, M., Raleigh, D. P., & Muir, T. W. (2011) · Nature Chemical Biology · doi:10.1038/nchembio.501 · Cited by 435 · see citing works

The SUMO modification pathway is involved in the BRCA1 response to genotoxic stress

Morris, J. R., Boutell, C., Epple, M., Densham, R. M., Weekes, D. B., Alamshah, A., Butler, L. R., Galanty, Y., Pangon, L., Kiuchi, T., et al. (2009) · Nature · doi:10.1038/nature08593 · Cited by 434 · see citing works

Poly(ADP-ribose)-binding zinc finger motifs in DNA repair/checkpoint proteins

Ahel, I., Ahel, D., Matsusaka, T., Clark, A. J., Pines, J., Boulton, S. J., & West, S. C. (2008) · Nature · doi:10.1038/nature06420 · Cited by 429 · see citing works

Cell-type-specific replication initiation programs set fragility of the FRA3B fragile site

Letessier, A., Millot, G. A., Koundrioukoff, S., Lachagès, A.-M., Vogt, N., Hansen, R. S., Malfoy, B., Brison, O., & Debatisse, M. (2011) · Nature · doi:10.1038/nature09745 · Cited by 426 · see citing works

WSTF regulates the H2A.X DNA damage response via a novel tyrosine kinase activity

Xiao, A., Li, H., Shechter, D., Ahn, S. H., Fabrizio, L. A., Erdjument‐Bromage, H., Ishibe-Murakami, S., Wang, B., Tempst, P., Hofmann, K., et al. (2008) · Nature · doi:10.1038/nature07668 · Cited by 417 · see citing works

MMSET regulates histone H4K20 methylation and 53BP1 accumulation at DNA damage sites

Pei, H., Zhang, L. M., Luo, K., Qin, Y., Chesi, M., Fei, Y. F., Bergsagel, P. L., Wang, L., You, Z., & Lou, Z. (2011) · Nature · doi:10.1038/nature09658 · Cited by 410 · see citing works

HP1-β mobilization promotes chromatin changes that initiate the DNA damage response

Ayoub, N., Jeyasekharan, A. D. D., Bernal, J. A., & Venkitaraman, A. R. (2008) · Nature · doi:10.1038/nature06875 · Cited by 404 · see citing works

Requirement of ATM-Dependent Monoubiquitylation of Histone H2B for Timely Repair of DNA Double-Strand Breaks

Moyal, L., Lerenthal, Y., Gana‐Weisz, M., Mass, G., So, S., Wang, S., Eppink, B., Chung, Y. M., Shalev, G., Shema, E., et al. (2011) · Molecular Cell · doi:10.1016/j.molcel.2011.02.015 · Cited by 402 · see citing works

Double Strand Breaks Can Initiate Gene Silencing and SIRT1-Dependent Onset of DNA Methylation in an Exogenous Promoter CpG Island

O'Hagan, H. M., Mohammad, H. P., & Baylin, S. B. (2008) · PLoS Genetics · doi:10.1371/journal.pgen.1000155 · Cited by 386 · see citing works

The Smc5–Smc6 complex and SUMO modification of Rad52 regulates recombinational repair at the ribosomal gene locus

Torres‐Rosell, J., Šunjevarić, I., Piccoli, G. D., Sacher, M., Eckert‐Boulet, N., Reid, R. J. D., Jentsch, S., Rothstein, R. J., Aragón, L., & Lisby, M. (2007) · Nature Cell Biology · doi:10.1038/ncb1619 · Cited by 379 · see citing works

DNA Damage-Dependent Acetylation and Ubiquitination of H2AX Enhances Chromatin Dynamics

Ikura, T., Tashiro, S., Kakino, A., Shima, H., Jacob, N. K., Amunugama, R., Yoder, K. E., Izumi, S., Kuraoka, I., Tanaka, K., et al. (2007) · Molecular and Cellular Biology · doi:10.1128/mcb.00579-07 · Cited by 376 · see citing works

Regulation of DNA‐damage responses and cell‐cycle progression by the chromatin remodelling factor CHD4

Polo, S. E., Kaidi, A., Baskcomb, L., Galanty, Y., & Jackson, S. P. (2010) · The EMBO Journal · doi:10.1038/emboj.2010.188 · Cited by 374 · cited 1× · see citing works

Poly(ADP-ribosyl)ation directs recruitment and activation of an ATP-dependent chromatin remodeler

Gottschalk, A. J., Timinszky, G., Kong, S. E., Jin, J., Cai, Y., Swanson, S. K., Washburn, M. P., Florens, L. A., Ladurner, A. G., Conaway, J. W., et al. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0906920106 · Cited by 358 · see citing works

Non-canonical inhibition of DNA damage-dependent ubiquitination by OTUB1

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Regulation of Homologous Recombination by RNF20-Dependent H2B Ubiquitination

Nakamura, K., Kato, A., Kobayashi, J., Yanagihara, H., Sakamoto, S., Oliveira, D. V. N. P., Shimada, M., Tauchi, H., Suzuki, H., Tashiro, S., et al. (2011) · Molecular Cell · doi:10.1016/j.molcel.2011.02.002 · Cited by 351 · see citing works

Replication stress induces 53BP1-containing OPT domains in G1 cells

Harrigan, J. A., Belotserkovskaya, R., Coates, J., Dimitrova, D. S., Polo, S. E., Bradshaw, C. R., Fraser, P., & Jackson, S. P. (2011) · The Journal of Cell Biology · doi:10.1083/jcb.201011083 · Cited by 344 · see citing works

PARP-3 and APLF Function Together to Accelerate Nonhomologous End-Joining

Rulten, S. L., Fisher, A. E. O., Robert, I., Zuma, M. C., Rouleau, M., Ju, L., Poirier, G. G., Reina‐San‐Martin, B., & Caldecott, K. W. (2011) · Molecular Cell · doi:10.1016/j.molcel.2010.12.006 · Cited by 326 · see citing works

RAD18 transmits DNA damage signalling to elicit homologous recombination repair

Huang, J., Huen, M. S. Y., Kim, H., Leung, C. C. Y., Glover, J. N. M., Yu, X., & Chen, J. (2009) · Nature Cell Biology · doi:10.1038/ncb1865 · Cited by 309 · see citing works

A Selective Requirement for 53BP1 in the Biological Response to Genomic Instability Induced by Brca1 Deficiency

Cao, L., Xu, X., Bunting, S. F., Liu, J., Wang, R.-H., Cao, L. L., Wu, J. J., Peng, T.-N., Chen, J., Nussenzweig, A., et al. (2009) · Molecular Cell · doi:10.1016/j.molcel.2009.06.037 · Cited by 308 · see citing works

The influence of heterochromatin on DNA double strand break repair: Getting the strong, silent type to relax

Goodarzi, A. A., Jeggo, P., & Lobrich, M. (2010) · DNA Repair · doi:10.1016/j.dnarep.2010.09.013 · Cited by 305 · see citing works

Epigenetic Instability due to Defective Replication of Structured DNA

Sarkies, P., Reams, C., Simpson, L. J., & Sale, J. E. (2010) · Molecular Cell · doi:10.1016/j.molcel.2010.11.009 · Cited by 302 · see citing works

53BP1 regulates DNA resection and the choice between classical and alternative end joining during class switch recombination

Bothmer, A., Robbiani, D. F., Feldhahn, N., Gazumyan, A., Nussenzweig, A., & Nussenzweig, M. C. (2010) · The Journal of Experimental Medicine · doi:10.1084/jem.20100244 · Cited by 283 · see citing works

Replication Stress Interferes with Histone Recycling and Predeposition Marking of New Histones

Jasencakova, Z., Scharf, A. N. D., Ask, K., Corpet, A., Imhof, A., Almouzni, G., & Groth, A. (2010) · Molecular Cell · doi:10.1016/j.molcel.2010.01.033 · Cited by 279 · see citing works

HERC2 coordinates ubiquitin-dependent assembly of DNA repair factors on damaged chromosomes

Bekker‐Jensen, S., Danielsen, J. M. R., Fugger, K., Gromova, I., Nerstedt, A., Lukas, C., Bártek, J., Lukas, J., & Mailand, N. (2009) · Nature Cell Biology · doi:10.1038/ncb2008 · Cited by 277 · see citing works

BMI1 Confers Radioresistance to Normal and Cancerous Neural Stem Cells through Recruitment of the DNA Damage Response Machinery

Facchino, S., Abdouh, M., Chatoo, W., & Bernier, G. (2010) · Journal of Neuroscience · doi:10.1523/jneurosci.1634-10.2010 · Cited by 275 · see citing works

BMI1-mediated histone ubiquitylation promotes DNA double-strand break repair

Ismail, I. H., Andrin, C., McDonald, D., & Hendzel, M. J. (2010) · The Journal of Cell Biology · doi:10.1083/jcb.201003034 · Cited by 270 · see citing works

PARP1 ADP-ribosylates lysine residues of the core histone tails

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Heterochromatin protein 1 is recruited to various types of DNA damage

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Heterochromatin is refractory to γ-H2AX modification in yeast and mammals

Kim, J., Kruhlak, M. J., Dotiwala, F., Nussenzweig, A., & Haber, J. E. (2007) · The Journal of Cell Biology · doi:10.1083/jcb.200612031 · Cited by 260 · see citing works

KAP-1 phosphorylation regulates CHD3 nucleosome remodeling during the DNA double-strand break response

Goodarzi, A. A., Kurka, T., & Jeggo, P. A. (2011) · Nature Structural &amp; Molecular Biology · doi:10.1038/nsmb.2077 · Cited by 255 · see citing works

DNA damage triggers nucleotide excision repair-dependent monoubiquitylation of histone H2APreprint

Bergink, S., Salomons, F. A., Hoogstraten, D., Groothuis, T. A., de Waard, H., Wu, J., Li, Y., Citterio, E., Houtsmuller, A. B., Neefjes, J., et al. (2006) · Genes & Development · doi:10.1101/gad.373706 · Cited by 247 · see citing works

Regulation of the Histone H4 Monomethylase PR-Set7 by CRL4Cdt2-Mediated PCNA-Dependent Degradation during DNA Damage

Oda, H., Hübner, M. R., Beck, D. B., Vermeulen, M., Hurwitz, J., Spector, D. L., & Reinberg, D. (2010) · Molecular Cell · doi:10.1016/j.molcel.2010.10.011 · Cited by 246 · see citing works

Regulation of DNA End Joining, Resection, and Immunoglobulin Class Switch Recombination by 53BP1

Bothmer, A., Robbiani, D. F., Di Virgilio, M., Bunting, S. F., Klein, I. A., Feldhahn, N., Barlow, J., Chen, H.-T., Bosque, D., Callen, E., et al. (2011) · Molecular Cell · doi:10.1016/j.molcel.2011.03.019 · Cited by 244 · see citing works

The NuRD chromatin–remodeling complex regulates signaling and repair of DNA damage

Smeenk, G., Wiegant, W. W., Vrolijk, H., Solari, A. P., Pastink, A., & van Attikum, H. (2010) · Journal of Cell Biology · doi:10.1083/jcb.201001048 · Cited by 243 · see citing works

The chromatin-remodeling factor CHD4 coordinates signaling and repair after DNA damage

Larsen, D. H., Poinsignon, C., Guðjόnsson, Þ., Dinant, C., Payne, M., Hari, F. J., Danielsen, J. M. R., Ménard, P., Sand, J. C., Stucki, M., et al. (2010) · The Journal of Cell Biology · doi:10.1083/jcb.200912135 · Cited by 240 · see citing works

Global chromatin compaction limits the strength of the DNA damage response

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RAP80-directed tuning of BRCA1 homologous recombination function at ionizing radiation-induced nuclear fociPreprint

Hu, Y., Scully, R., Sobhian, B., Xie, A., Shestakova, E. A., & Livingston, D. M. (2011) · Genes & Development · doi:10.1101/gad.2011011 · Cited by 232 · see citing works

The BRCA1-RAP80 Complex Regulates DNA Repair Mechanism Utilization by Restricting End Resection

Coleman, K. A., & Greenberg, R. A. (2011) · Journal of Biological Chemistry · doi:10.1074/jbc.m110.213728 · Cited by 224 · see citing works

The Rap80-BRCC36 de-ubiquitinating enzyme complex antagonizes RNF8-Ubc13-dependent ubiquitination events at DNA double strand breaks

Shao, G., Lilli, D. R., Patterson-Fortin, J., Coleman, K. A., Morrissey, D. E., & Greenberg, R. A. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0807485106 · Cited by 218 · see citing works

ATM damage response and XLF repair factor are functionally redundant in joining DNA breaks

Zha, S., Guo, C., Boboilă, C., Oksenych, V., Cheng, H.-L., Zhang, Y., Wesemann, D. R., Yuen, G. J., Patel, H., Goff, P. H., et al. (2010) · Nature · doi:10.1038/nature09604 · Cited by 209 · see citing works

Formation of Dynamic γ-H2AX Domains along Broken DNA Strands Is Distinctly Regulated by ATM and MDC1 and Dependent upon H2AX Densities in Chromatin

Savic, V., Yin, B., Maas, N. L., Bredemeyer, A. L., Carpenter, A. C., Helmink, B. A., Yang-Iott, K. S., Sleckman, B. P., & Bassing, C. H. (2009) · Molecular Cell · doi:10.1016/j.molcel.2009.04.012 · Cited by 204 · see citing works

HP1α recruitment to DNA damage by p150CAF-1 promotes homologous recombination repair

Baldeyron, C., Soria, G., Roche, D., Cook, A. J. L., & Almouzni, G. (2011) · Journal of Cell Biology · doi:10.1083/jcb.201101030 · Cited by 200 · see citing works

The p400 ATPase regulates nucleosome stability and chromatin ubiquitination during DNA repair

Xu, Y., Sun, Y., Jiang, X., Ayrapetov, M. K., Moskwa, P., Yang, S., Weinstock, D. M., & Price, B. D. (2010) · Journal of Cell Biology · doi:10.1083/jcb.201001160 · Cited by 194 · see citing works

MDC1 directs chromosome-wide silencing of the sex chromosomes in male germ cellsPreprint

Ichijima, Y., Ichijima, M., Lou, Z., Nussenzweig, A., Camerini‐Otero, R. D., Chen, J., Andreassen, P. R., & Namekawa, S. H. (2011) · Genes & Development · doi:10.1101/gad.2030811 · Cited by 192 · see citing works

Histone methyltransferase Dot1 and Rad9 inhibit single‐stranded DNA accumulation at DSBs and uncapped telomeres

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BRIT1/MCPH1 links chromatin remodelling to DNA damage response

Peng, G., Yim, E.-K., Dai, H., Jackson, A. P., van der Burgt, I., Pan, M., Hu, R., Li, K., & Lin, S. (2009) · Nature Cell Biology · doi:10.1038/ncb1895 · Cited by 186 · see citing works

A viral E3 ligase targets RNF8 and RNF168 to control histone ubiquitination and DNA damage responses

Lilley, C. E., Chaurushiya, M. S., Boutell, C., Landry, S., Suh, J., Panier, S., Everett, R. D., Stewart, G. S., Durocher, D., & Weitzman, M. D. (2010) · The EMBO Journal · doi:10.1038/emboj.2009.400 · Cited by 177 · see citing works

Chromatin dynamics and the repair of DNA double strand breaks

Xu, Y., & Price, B. D. (2011) · Cell Cycle · doi:10.4161/cc.10.2.14543 · Cited by 166 · see citing works

BBAP Monoubiquitylates Histone H4 at Lysine 91 and Selectively Modulates the DNA Damage Response

Yan, Q., Dutt, S., Xu, R., Graves, K., Juszczyński, P., Manis, J. P., & Shipp, M. A. (2009) · Molecular Cell · doi:10.1016/j.molcel.2009.08.019 · Cited by 165 · see citing works

DNA Repair Factor APLF Is a Histone Chaperone

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