The DOI matches its Crossref record; 57 of the 57 references it cites were found in a registry or an index.
Neutrophil Extracellular Traps Sustain Inflammatory Signals in Ulcerative Colitis
Open accessAbstract
BACKGROUND AND AIMS: In ulcerative colitis [UC], mucosal damage occurs in areas that are infiltrated with neutrophils. The antimicrobial function of neutrophils relies in part on the formation of extracellular web-like structures, named neutrophil extracellular traps [NETs]. The formation and/or clearance of aberrant NETs have been associated with several immune diseases. Here we investigated the role of NETs in UC-related inflammation. METHODS: The expression of NET-associated proteins was evaluated in colonic biopsies of patients with Crohn's disease [CD], UC and in normal controls [NC] by Western blotting, immunofluorescence and immunohistochemistry. Colonic biopsies of UC patients were analysed before and after anti-tumour necrosis factor α [anti-TNF-α] treatment. The capacity of neutrophils to produce NETs upon activation was tested in vitro. UC lamina propria mononuclear cells [LPMCs] were cultured with NETs in the presence or absence of an extracellular signal-regulated kinase-1/2 [ERK1/2] inhibitor and inflammatory cytokine induction was assessed by real-time polymerase chain reaction and enzyme-linked immunosorbent assay. We also characterized the contribution of NETs in dextran sodium sulfate [DSS]-induced colitis. RESULTS: NET-associated proteins were over-expressed in inflamed colon of UC patients as compared to CD patients and NC. Circulating neutrophils of UC patients produced NETs in response to TNF-α stimulation, and reduced expression of NET-related proteins and diminished NET formation were seen in patients receiving successful treatment with anti-TNF-α. Treatment of UC LPMCs with NETs activated ERK1/2, thus enhancing TNF-α and interleukin-1β [IL-1β] production. NETs were induced in mice with DSS-colitis and in vivo inhibition of NET release attenuated colitis. CONCLUSIONS: Our data show that NET release occurs in UC and suggest a role for NETs in sustaining mucosal inflammation in this disorder.
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Neutrophil Extracellular Traps Kill Bacteria
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Neutrophil recruitment and function in health and inflammation
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Platelet TLR4 activates neutrophil extracellular traps to ensnare bacteria in septic blood
Clark, S. R., Ma, A. C., Tavener, S. A., McDonald, B., Goodarzi, Z., Kelly, M. M., Patel, K. D., Chakrabarti, S., McAvoy, E., Sinclair, G. D., et al. (2007) · Nature Medicine · doi:10.1038/nm1565 · Cited by 2,309
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Immunopathogenesis of IBD: current state of the art
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PAD4 is essential for antibacterial innate immunity mediated by neutrophil extracellular traps
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Cited by
Kobayashi, T., Siegmund, B., Le Berre, C., Wei, S. C., Ferrante, M., Shen, B., Bernstein, C. N., Danese, S., Peyrin-Biroulet, L., & Hibi, T. (2020) · Nature Reviews Disease Primers · doi:10.1038/s41572-020-0205-x · Cited by 1,649
Le Berre, C., Honap, S., & Peyrin-Biroulet, L. (2023) · The Lancet · doi:10.1016/s0140-6736(23)00966-2 · Cited by 1,643
Neutrophils in chronic inflammatory diseases
Herrero-Cervera, A., Soehnlein, O., & Kenne, E. (2022) · Cellular & Molecular Immunology · doi:10.1038/s41423-021-00832-3 · Cited by 695
A Review of Neutrophil Extracellular Traps (NETs) in Disease: Potential Anti-NETs Therapeutics
Mutua, V., & Gershwin, L. J. (2021) · Clinical Reviews in Allergy & Immunology · doi:10.1007/s12016-020-08804-7 · Cited by 639
Pathophysiology of Inflammatory Bowel Disease: Innate Immune System
Saez, A., Herrero-Fernandez, B., Gomez-Bris, R., Sánchez-Martinez, H., & Gonzalez-Granado, J. M. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24021526 · Cited by 580
Metadata
- Authors
- Dinallo, V., Marafini, I., Di Fusco, D., Laudisi, F., Franzè, E., Di Grazia, A., Figliuzzi, M. M., Caprioli, F., Stolfi, C., Monteleone, I., & Monteleone, G.
- Venue
- Journal of Crohn's and Colitis
- Publisher
- Oxford University Press (OUP)
- Published
- 2019-02-03
- Volume
- 13
- Issue
- 6
- Pages
- 772-784
- ISSN
- 1873-9946 (ISSN-L)
- 1876-4479
- OpenAlex
- W2913284233
- Cited by
- 320
- References
- 57
- FWCI
- 7.21
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Dinallo, V., Marafini, I., Di Fusco, D., Laudisi, F., Franzè, E., Di Grazia, A., Figliuzzi, M. M., Caprioli, F., Stolfi, C., Monteleone, I., & Monteleone, G. (2019). Neutrophil Extracellular Traps Sustain Inflammatory Signals in Ulcerative Colitis. Journal of Crohn's and Colitis. https://doi.org/10.1093/ecco-jcc/jjy215
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